
Reverse Stroke Damage (Within A 6-Hour Window)
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❝Each year in the US, over half a million people have a first stroke; however, up to 80% of strokes may be preventable.❞
~ American Stroke Association
Source: New guideline: Preventing a first stroke may be possible with screening, lifestyle changes
If you’re reading this and thinking that it happens to other people, older people perhaps… There is a first time for everything, and most people are caught off guard by their first stroke.
Which means our health plan in this regard needs to be in two parts:
- let’s try to not have a stroke in the first place (which involves not assuming we are invulnerable right now)
- let’s try to minimize any damage done, and hasten recovery, if stroke strikes.
With regard to the first part, we’ve written about that before, including: Don’t Get Caught Out By These “Nontraditional” Stroke Risk Factors
And our most comprehensive article on the topic of stroke avoidance: Reduce Your Stroke Risk
To be truly well-prepared, you can also bear in mind: 6 Signs Of Stroke (One Month In Advance)
But what if stroke strikes?
Firstly, know this:
What To Do If Having A Stroke Alone? ← with the caveat that, if you have a stroke, there’s a good chance you’ll forget all this. However, this is good to know anyway, in case someone else is having a stroke (and if you don’t live alone, it can be good for whoever is with you to know this too).
And now there’s a new recourse: a Japanese team of researchers (Dr. Masanori Itakura et al.) have developed a drug that (per preliminary testing*, in any case) prevents the usual kind of harm done by stroke, if administered up to 6 hours after the stroke in question.
*So far, it’s completed the animal testing stage. Next is human models, and then actual humans.
How does it work, you ask?
In human blood there’s a protein (an enzyme, in fact) called glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and it has a lot of important jobs to do, including DNA repair, tRNA export, transcription membrane trafficking, heme metabolism, regulation of kinases, as well as cellular apoptosis and necrosis—which latter may sound bad, but individual cell death is an important part of the overall organism’s ongoing life. And by “the overall organism”, we mean you.
However, in stroke, this causes problems when this protein aggregates (clumps together), and starts killing everything it touches. You can probably imagine how that’s a bad thing to have happening inside your brain.
To combat this, the researchers developed a peptide to inhibit the aggregation of GAPDH, and gave this the catchy name of GAPDH aggregation inhibitor peptide-17, or GAI-17 to its friends.
In mice, GAI-17 significantly mitigated brain cell death and paralysis even when given up to six hours* after a stroke. The drug showed no significant side effects, including no harm to the heart or blood vessels.
*It was tested at 3, 6, and 9 hours. In the first two cases (at 3hrs and 6hrs) it was very effective; in the latter case (at 9 hours), it performed only marginally better than control.
You can see the paper itself, and graphs of the results, here: Inhibition of GAPDH aggregation as a potential treatment for acute ischemic stroke
And a pop-science article with some additional speculation, here: Six-hour ‘undo’ button: GAI-17 rewinds stroke damage and may beat Alzheimer’s
Want to learn more?
Here’s a good way to get started, by asking the right questions:
12 Questions For Better Brain Health
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What Loneliness Does To Your Brain And Body
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Spoiler: it’s nothing good (but it can be addressed!)
Not something to be ignored
Loneliness raises the risk of heart disease by 29% and the risk of stroke by 32%. It also brings about higher susceptibility to illness (flu, COVID, chronic pain, etc), as well as poor sleep quality and cognitive decline, possibly leading to dementia. Not only that, but it also promotes inflammation, and premature death (comparable to smoking).
This is because the lack of meaningful social connections activates the body’s stress response, which in turn increases paranoia, suspicion, and social withdrawal—which makes it harder to seek the social interaction needed to alleviate it.
On a neurological level, cortisol levels become imbalanced, and a faltering dopamine response leads to impulsive behaviors (e.g., drinking, gambling) to try to make up for it. Decreased serotonin, oxytocin, and natural opioids reduce feelings of happiness and negate pain relief.
As for combatting it, the first-line remedy is the obvious one: connecting with others improves emotional and physical wellbeing. However, it is recommended to aim for deep, meaningful connections that make you happy rather than just socializing for its own sake. It’s perfectly possible to be lonely in a crowd, after all.
A second-line remedy is to simply mitigate the harm by means of such things as art therapy and time in nature—they can’t completely replace human connection, but they can at least improve the neurophysiological situation (which in turn, might be enough of a stop-gap solution to enable a return to human connection).
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
How To Beat Loneliness & Isolation
Take care!
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Seven Things To Do For Good Lung Health!
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YouTube Channel Wellness Check is challenging us all to do the following things. They’re framing it as a 30-day challenge, but honestly, there’s nothing here that isn’t worth doing for life
Here’s the list:
- Stop smoking (of course, smoking is bad for everything, but the lungs are one of its main areas of destruction)
- Good posture (a scrunched up chest is not the lungs’ best operating conditions!)
- Regular exercise (exercising your body in different ways exercises your lungs in different ways!)
- Monitor air quality (some environments are much better/worse than others, but don’t underestimate household air quality threats either)
- Avoid respiratory infections (shockingly, COVID is not great for your lungs, nor are the various other respiratory infections available)
- Check your O2 saturation levels (pulse oximeters like this one are very cheap to buy and easy to use)
- Prevent mucus and phlegm from accumulating (these things are there for reasons; the top reason is trapping pathogens, allergens, and general pollutants/dust etc; once those things are trapped, we don’t want that mucus there any more!)
Check out the video itself for more detail on each of these items:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to know more?
You might like our article about COPD:
Why Chronic Obstructive Pulmonary Disease (COPD) Is More Likely Than You Think
Take care!
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Reusing medical equipment is good for the planet. But is it safe?
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Even a short stay in hospital produces a large amount of waste. Just picture all the disposable items designed to be used once and thrown away: face masks, gloves, packaging, intravenous tubing, and even equipment such as stainless steel scissors.
This kind of single-use medical equipment was first introduced in high-income countries in the 1960s, thanks to advances in plastic manufacturing and a growing emphasis on infection prevention and control.
About 85% of the waste single-use products create is nonhazardous and can be recycled or disposed of without special processing. But a lot of the time it’s not sorted correctly. This means it is often mixed with hazardous waste that has to be incinerated before it is sent to landfill, which increases greenhouse gas emissions.
Our new study tested replacing just one kind of item – single-use absorbent pads, known as “blueys” – with a reusable version in the intensive care unit (ICU).
Blueys are pads made of layered tissue paper, with a plastic waterproof backing. They’re placed under patients to protect bedding and absorb bodily fluids such as blood and urine during patient care and other procedures.
We wanted to know how much waste could be diverted from landfill by replacing these single-use products with reusable linen – and importantly, whether it was safe and hygienic for patients. Here’s what we found.
Anchiy/Getty What our study looked at
Over two years, we examined data from 2,114 ICU patients at a Melbourne hospital – 46% of them (970 patients) before we introduced reusable linen, and 54% (1,114 patients) after.
For the first year (the “before” phase), single-use blueys were used. In the second year (the “after” phase), these were replaced with reusable pads, made from soft cotton with a breathable backing. These had a similar capacity to absorb liquids as the disposable version but – instead of being thrown away – they were washed and reused.
The study compared how many kilograms of waste were generated by single-use blueys in the first year, compared to the reusable linen.
We also explored whether reusable linen increased patients’ risk of pressure injuries, sometimes known as bed sores. These are wounds that develop when patients are immobile and spend a lot of time sitting or lying in one position, causing the skin to break down.
Patients in the ICU have a high risk of developing pressure injuries. These can delay recovery and prolong their stay in hospital.
To evaluate the change, we surveyed nurses who’d used the reusable pads. We also reviewed medical records to compare the prevalence of pressure injuries in the two groups, along with patient demographics such as age, sex and length of hospital stay.
Blueys are pads made of absorbent tissue and backed with plastic. Yusuke Ide/Getty What we found
There was no difference in pressure injuries between the two groups. This means reusable linen did not increase the risk of an ICU patient developing a pressure injury.
But it did save a lot of waste. In the year before introducing reusable pads, 21,554 disposable pads were used in this one hospital ward, generating almost half a tonne of waste from this single-use item alone.
Shifting to reusable linen effectively eliminated this waste, saving about half a tonne (496 kilograms) from going to landfill in one year alone.
Initially, some nurses expressed concerns about whether the reusable linen pads would affect patients’ skin. However, once the reusable pads were introduced and used for a few weeks, staff were highly satisfied. Many noted they were more sustainable and helped reduce waste, and recommended continuing to use them.
While our study didn’t look at infection risk specifically, 50 years of data from the United States and the United Kingdom has previously shown reusable linen does not increase the risk of infections when it is washed and sterilised properly.
For example, Australian laundry standards for infection control require reusable items to be washed at a certain temperature (above 65°C for at least ten minutes, or 71°C for at least three minutes) or treated with a chemical disinfectant when material is heat sensitive.
Why this research matters
Australia’s health-care system produces up to 7% of the country’s total greenhouse gas emissions. Hospitals are the single biggest contributor.
Given this is largely from direct patient care, making day-to-day routines more sustainable can have a big impact.
There are other benefits, too. During the early parts of the COVID pandemic, when there were often equipment shortages in supply chains, our research confirmed that using reusable personal protective equipment (PPE) was safe and could help ensure products remained available. It was also more sustainable and less costly.
One potential drawback of reusable health-care equipment is how much water is consumed cleaning and sterilising it. Our study didn’t assess this directly.
But in further research, we plan to do a life cycle assessment that compares single-use blueys and reusable linen.
This is a widely recognised way to assess the environmental impact of products from “cradle to grave”. The assessment considers the energy consumption, water use, greenhouse gas emissions and cost involved not only in the products’ manufacture, but also in their use and disposal. This includes the impact of washing and sterilising products versus sending items to landfill.
Health-care workers often face barriers to sustainable practice when caring for patients. But as frontline workers are managing the health consequences of climate change and environmental disasters, it’s vital they understand their role in promoting environmentally responsible care. Access to equipment that is safe, for both their patients and the planet, is essential.
Rochelle Wynne, Chair in Nursing, Western Health Deakin University Partnership, Deakin University; Forbes McGain, Associate Professor, The University of Melbourne, and Stacey Matthews, Research Fellow, School of Nursing and Midwifery, Deakin University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Norepinephrine vs Alzheimer’s Disease
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Norepinephrine (or noradrenaline, in the rest of the world outside of the US), is a hormone and neurotransmitter generally associated with stress, fight-or-flight responses, and hypertension.
Like any of our hormones, it has its place, and we wouldn’t do well without it (same deal for cortisol, which has a very bad reputation, but again, we do need it or else we would not, for example, wake up in the morning).
When it comes to neurochemistry, a shortage of norepinephrine can result in lethargic listlessness, which is why some antidepressants work on the noradrenergic* system (as opposed to the more common SSRIs, which work on the serotonergic system), to boost flagging norepinephrine levels and perk us** up.
*Yes, it’s called that even in the US where the hormone/neurotransmitter itself is called norepinephrine rather than noradrenaline.
**this article brought to you by the power of this writer taking mirtazapine, a selective norepinephrine reuptake inhibitor (SNRI) antidepressant, that thus increases the amount of available norepinephrine in her brain.
So… How does it protect against Alzheimer’s disease?
Dialing down the brain’s immune system
Because of the blood-brain barrier, there are many things that happen either only inside of, or only outside of, our brain—which because of the unique nature of the brain’s anatomy, means that we often have a specialized system doing the same job inside the brain as a different system does outside of the brain, but in a different way.
See for example how the glymphatic system (a portmanteau of glial cells and lymphatic system) in the brain does approximately the same job as the lymphatic system does in the rest of the body:
How To Clean Your Brain (Glymphatic Health Primer) ← this helps protect us against Alzheimer’s, Parkinson’s, and other neurodegenerative conditions
And those glial cells? Some of them do the job otherwise done by parts of our immune system that can’t operate inside our brain.
Specifically, microglia do approximately the same job inside our brain as macrophages do outside of it: “eating” things that shouldn’t be there—ranging from actual invading pathogens, to bits of debris that are also in the way.
That our brain has an immune response is, generally speaking, a good thing. But much like the immune system in the rest of our body, things can get out of hand.
As with how chronic inflammation (and/or autoimmune disorders) causes problems in the rest of the body, neuroinflammation can cause problems in the brain—not least of all: it can lead to Alzheimer’s.
The microglia are involved in the cleanup of the β-amyloid proteins that can otherwise build up into harmful plaque resulting in neuronal damage and with it, neurodegeneration), so calming them down a bit means they can do their actual assigned job better for longer.
Dr. Ania Majewska et al. did a study into how norepinephrine’s inhibitory effect via β2 adrenergic receptors (β2AR) in microglia has an anti-inflammatory effect, and found that it has potential as an Alzheimer’s preventative.
In their words, “β2AR manipulations can alter disease pathology”, which is a great example of how carefully scientists say things, but the series of declarations adds up to the same; we’ll quote some points directly from the paper’s abstract:
- NE inhibits surveillance activity of microglia, the brain’s resident immune cells, via their β2 adrenergic receptors (β2ARs)
- Microglial β2AR signaling is an important modulator of amyloid pathology.
- Endogenous β2AR signaling degenerates as a function of amyloid pathology and aging.
- In AD, microglia downregulate β2AR expression early and progressively.
- β2AR manipulations can alter disease pathology.
- Importantly, dampening microglial β2AR signaling worsened plaque load and the associated neuritic damage, while stimulating microglial β2AR signaling attenuated amyloid pathology.
- Our results suggest that microglial β2AR could be explored as a potential therapeutic target to modify AD pathology.
Translating from sciencese (if you’ll pardon that we’ll still use some big words, but only ones we’ve already explained):
Norepinephrine activates certain receptors in microglia, and those receptors tell the microglia to “keep calm & carry on”. In the case of Alzheimer’s disease, those receptors stop working correctly, leading to increased neuroinflammation. Thus, stimulating those receptors with norepinephrine reduces neuroinflammation, allowing the microglia to calmly carry on with their actual job of getting rid of the amyloid that leads to Alzheimer’s disease.
You can read the paper itself here:
Want to learn more?
Check out:
- An Accessible New Development Against Alzheimer’s (Dopamine vs Alzheimer’s)
- How To Reduce Your Alzheimer’s Risk
- Take Care Of Your Lymphatic System To Beat Cognitive Decline
- What’s Your Vascular Dementia Risk?
- Alzheimer’s Causative Factors To Avoid
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Heart Healthy Diet Plan – by Stephen William
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We’ve covered heart-healthy cooking books before, but variety is good, and boredom is an enemy of health, so let’s shake it up with a fresh stack of recipes!
After a brief overview of the relevant science (which if you’re a regular 10almonds reader, probably won’t be new to you), the author takes the reader on a 28-day journey. Yes, we know the subtitle says 30 days, but unless they carefully hid the other two days somewhere we didn’t find, there are “only” 28 inside. Perhaps the publisher heard it was a month and took creative license. Or maybe there’s a different edition. Either way…
Rather than merely giving a diet plan (though yes, he also does that), he gives a wide range of “spotlight ingredients”, such that many of the recipes, while great in and of themselves, can also be jumping-off points for those of us who like to take recipes and immediately do our own things to them.
Each day gets a breakfast, lunch, dinner, and he also covers drinks, desserts, and such like.
Notwithstanding the cover art being a lot of plants, the recipes are not entirely plant-based; there are a selection of fish dishes (and other seafood, e.g. shrimp) and also some dairy products (e.g. Greek yoghurt). The recipes are certainly very “plant-forward” though and many are just plants. If you’re a strict vegan though, this probably isn’t the book for you.
Bottom line: if you’d like to cook heart-healthy but are often stuck wondering “aaah, what to cook again today?”, then this is the book to get you out of any culinary creative block!
Click here to check out the Heart Healthy Diet Plan, and widen your heart-healthy repertoire!
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Good Health From Head To Toe
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It’s Q&A Day!
Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!
This newsletter has been growing a lot lately, and so have the questions/requests, and we love that! In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small
Q: I am now in the “aging” population. A great concern for me is Alzheimers. My father had it and I am so worried. What is the latest research on prevention?
Very important stuff! We wrote about this not long back:
- See: How To Reduce Your Alzheimer’s Risk
- See also: Brain Food? The Eyes Have It!
(one good thing to note is that while Alzheimer’s has a genetic component, it doesn’t appear to be hereditary per se. Still, good to be on top of these things, and it’s never too early to start with preventive measures!)
Q: Foods that help build stronger bones and cut inflammation? Thank you!
We’ve got you…
For stronger bones / To cut inflammation
That “stronger bones” article is about the benefits of collagen supplementation for bones, but there’s definitely more to say on the topic of stronger bones, so we’ll do a main feature on it sometime soon!
Q: Veganism, staying mentally sharp, best exercises for weight gain?
All great stuff! Let’s do a run-down:
- Veganism? As a health and productivity newsletter, we’ll only be focusing veganism’s health considerations, but it does crop up from time to time! For example:
- Which Plant Milk? (entirely about such)
- Plant vs Animal Protein (mostly about such)
- Making Friends With Your Gut (You Can Thank Us Later) (discusses one benefit of such)
- Staying mentally sharp? You might like the things-against-dementia pieces we linked to in the previous response!
- It’s also worth noting that some kinds of dementia, such as Alzheimer’s, can begin the neurodegenerative process 20 years before symptoms show, and can be influenced by lifestyle choices 20 years before that, so it’s definitely never too early be on top of these things!
- Best exercises for weight gain? We’ll do a main feature one of these days (filled with good science and evidence), but in few words meanwhile: core exercises, large muscle groups, heavy weights, few reps, build up slowly. Squats are King.
Q: I am interested in the following: Aging, Exercise, Diet, Relationships, Purpose, Lowering Stress
You’re going to love our Psychology Sunday editions of 10almonds! You might like some of these…
- Relationships: Seriously Useful Communication Skills!
- Purpose: Are You Flourishing? (There’s a Scale)
- Managing stress: Lower Your Cortisol! (Here’s Why & How)
- Also about managing stress: Sunday Stress-Buster
- Also applicable to stress: How To Set Your Anxiety Aside
Q: I’d like to know more about type 2 diabetic foot problems
You probably know that the “foot problems” thing has less to do with the feet and more to do with blood and nerves. So, why the feet?
The reason feet often get something like the worst of it, is because they are extremities, and in the case of blood sugars being too high for too long too often, they’re getting more damage as blood has to fight its way back up your body. Diabetic neuropathy happens when nerves are malnourished because the blood that should be keeping them healthy, is instead syrupy and sluggish.
We’ll definitely do a main feature sometime soon on keeping blood sugars healthy, for both types of diabetes plus pre-diabetes and just general advice for all.
In the meantime, here’s some very good advice on keeping your feet healthy in the context of diabetes. This one’s focussed on Type 1 Diabetes, but the advice goes for both:
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