Take Care Of Your Lymphatic System To Beat Cognitive Decline
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First of all, for any unfamiliar with the lymphatic system, it’s mostly the body’s clean-up system (as well as a big part of the body’s anticancer system).
See: The Lymphatic System Against Cancer & More
It may not be the most glamorous job, but it’s certainly an essential one.
There’s no lymph in the brain, but…
Because of the blood-brain barrier (BBB) that keeps the astonishingly sensitive brain as safe as it can from unwanted things, there are many aspects of our physiology that only happen inside the brain, or only happen outside of it, as the compounds in question may be too large to get through the BBB.
The lymphatic system is, in and of itself, an entirely outside-of-the-brain affair. So, how does stuff get cleaned out from the brain (such as beta-amyloid and alpha-synuclein clearance, to avoid Alzheimer’s and Parkinson’s, respectively)?
The glymphatic system (a portmanteau of glial cells doing the job of the lymphatic system) is the brain’s own cleanup crew, and we wrote about it here:
How To Clean Your Brain (Glymphatic Health Primer)
Why lymph still matters for the brain
Although the glymphatic system is doing a (hopefully) fine job of scrubbing up the brain, if the lymphatic system isn’t working at least as well, then this becomes the equivalent of what would happen if you at home were very attentive to taking the trash out, but the garbage disposal crews stopped doing their job, or did it much less well than they need to. Soon, you’d end up with a mountain of trash at home, even though you were doing your part correctly.
In short: the glymphatic system needs to pass the waste on somewhere, and the lymphatic system is its go-to.
You may be wondering about the role of blood in all of this, and the answer is that no part of any of the above systems can do its job without adequate oxygenation, and our blood also assists in the transport of things removed—which is one of the reasons why there are blood-based Alzheimer’s tests that can be done; they measure certain markers of neurodegeneration that become present in the blood having left the brain:
Early Dementia Screening From Your Blood & More ← the “and more” is actually quite interesting, but it’s the blood we’re interested in for this section
What can be done about it
Our first two links up above, about the lymphatic and glymphatic systems, respectively, also tell how to look after each of them, but we’ll mention a few salient pointers here.
For the lymphatic system:
- do lymphatic massage
- exercise, with a focus on maximizing movement
- eat an anti-inflammatory diet
For the glymphatic system:
- do vagal massage (Vagal! Not vaginal, which will not help! Or rather: it won’t help the glymphatic system, anyway)
- exercise, and/but also rest well (good quality sleep)
- eat omega-3 fatty acids
For more details and suggestions on each though, do check out:
Lymphatic health primer | Glymphatic health primer
How this was discovered
Until as recently as 2014, it was not known that there was any part of the lymphatic system around the brain, waiting to take things from the glymphatic system. Since then, research has slowly been done about the relationship between the two, how things work, and what affects what and how.
Most recently (the study was published two days ago, at time of writing this) it was discovered that, in mice at least, improving lymphatic function just outside of the brain (the meningeal lymphatic vessels, responsible for draining waste from the brain) improves memory.
Aged mice who underwent a process that rejuvenated the meningeal lymphatic vessels, performed better in memory tests afterwards.
How this worked, step-by-step:
- The mice were given a special protein that rejuvenated the meningeal lymphatic vessels¹
- The lymphatic vessels were then able to do their job better
- This meant that the glial cells of the glymphatic system were no longer drowning in excess stuff
- This reduced levels of a protein that says “help, too much stuff!” and starts inhibiting everything it can to try to cope²
- This meant that neural activity was no longer being suppressed, and memory improved
Technical bits for those who want it:
¹ We’re not being secretive about what this special protein was; it’s just that the special protein is called adeno-associated virus 1 cytomegalovirus murine vascular endothelial growth factor C, or “AAV1-CMV-mVEGF-C” for short, so for readability, “a special protein” does the job. Suffice it to say, a) you can’t exactly buy AAV1-CMV-mVEGF-C on Amazon, and b) you wouldn’t want it anyway, you’d want its close cousin AAV1-CMV-hVEGF-C (“m” for murine, i.e. mousey, vs “h” for human)
² This one’s just called interleukin-6 (IL-6); perhaps you’ve heard of interleukin; we’ve mentioned it sometimes before.
You can read the paper in its entirety here; if you don’t mind reading very technical stuff, it is very interesting:
Meningeal lymphatics-microglia axis regulates synaptic physiology
Enjoy!
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What are the most common symptoms of menopause? And which can hormone therapy treat?
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Despite decades of research, navigating menopause seems to have become harder – with conflicting information on the internet, in the media, and from health care providers and researchers.
Adding to the uncertainty, a recent series in the Lancet medical journal challenged some beliefs about the symptoms of menopause and which ones menopausal hormone therapy (also known as hormone replacement therapy) can realistically alleviate.
So what symptoms reliably indicate the start of perimenopause or menopause? And which symptoms can menopause hormone therapy help with? Here’s what the evidence says.
Remind me, what exactly is menopause?
Menopause, simply put, is complete loss of female fertility.
Menopause is traditionally defined as the final menstrual period of a woman (or person female at birth) who previously menstruated. Menopause is diagnosed after 12 months of no further bleeding (unless you’ve had your ovaries removed, which is surgically induced menopause).
Perimenopause starts when menstrual cycles first vary in length by seven or more days, and ends when there has been no bleeding for 12 months.
Both perimenopause and menopause are hard to identify if a person has had a hysterectomy but their ovaries remain, or if natural menstruation is suppressed by a treatment (such as hormonal contraception) or a health condition (such as an eating disorder).
What are the most common symptoms of menopause?
Our study of the highest quality menopause-care guidelines found the internationally recognised symptoms of the perimenopause and menopause are:
- hot flushes and night sweats (known as vasomotor symptoms)
- disturbed sleep
- musculoskeletal pain
- decreased sexual function or desire
- vaginal dryness and irritation
- mood disturbance (low mood, mood changes or depressive symptoms) but not clinical depression.
However, none of these symptoms are menopause-specific, meaning they could have other causes.
In our study of Australian women, 38% of pre-menopausal women, 67% of perimenopausal women and 74% of post-menopausal women aged under 55 experienced hot flushes and/or night sweats.
But the severity of these symptoms varies greatly. Only 2.8% of pre-menopausal women reported moderate to severely bothersome hot flushes and night sweats symptoms, compared with 17.1% of perimenopausal women and 28.5% of post-menopausal women aged under 55.
So bothersome hot flushes and night sweats appear a reliable indicator of perimenopause and menopause – but they’re not the only symptoms. Nor are hot flushes and night sweats a western society phenomenon, as has been suggested. Women in Asian countries are similarly affected.
You don’t need to have night sweats or hot flushes to be menopausal.
Maridav/ShutterstockDepressive symptoms and anxiety are also often linked to menopause but they’re less menopause-specific than hot flushes and night sweats, as they’re common across the entire adult life span.
The most robust guidelines do not stipulate women must have hot flushes or night sweats to be considered as having perimenopausal or post-menopausal symptoms. They acknowledge that new mood disturbances may be a primary manifestation of menopausal hormonal changes.
The extent to which menopausal hormone changes impact memory, concentration and problem solving (frequently talked about as “brain fog”) is uncertain. Some studies suggest perimenopause may impair verbal memory and resolve as women transition through menopause. But strategic thinking and planning (executive brain function) have not been shown to change.
Who might benefit from hormone therapy?
The Lancet papers suggest menopause hormone therapy alleviates hot flushes and night sweats, but the likelihood of it improving sleep, mood or “brain fog” is limited to those bothered by vasomotor symptoms (hot flushes and night sweats).
In contrast, the highest quality clinical guidelines consistently identify both vasomotor symptoms and mood disturbances associated with menopause as reasons for menopause hormone therapy. In other words, you don’t need to have hot flushes or night sweats to be prescribed menopause hormone therapy.
Often, menopause hormone therapy is prescribed alongside a topical vaginal oestrogen to treat vaginal symptoms (dryness, irritation or urinary frequency).
You don’t need to experience hot flushes and night sweats to take hormone therapy.
Monkey Business Images/ShutterstockHowever, none of these guidelines recommend menopause hormone therapy for cognitive symptoms often talked about as “brain fog”.
Despite musculoskeletal pain being the most common menopausal symptom in some populations, the effectiveness of menopause hormone therapy for this specific symptoms still needs to be studied.
Some guidelines, such as an Australian endorsed guideline, support menopause hormone therapy for the prevention of osteoporosis and fracture, but not for the prevention of any other disease.
What are the risks?
The greatest concerns about menopause hormone therapy have been about breast cancer and an increased risk of a deep vein clot which might cause a lung clot.
Oestrogen-only menopause hormone therapy is consistently considered to cause little or no change in breast cancer risk.
Oestrogen taken with a progestogen, which is required for women who have not had a hysterectomy, has been associated with a small increase in the risk of breast cancer, although any risk appears to vary according to the type of therapy used, the dose and duration of use.
Oestrogen taken orally has also been associated with an increased risk of a deep vein clot, although the risk varies according to the formulation used. This risk is avoided by using estrogen patches or gels prescribed at standard doses
What if I don’t want hormone therapy?
If you can’t or don’t want to take menopause hormone therapy, there are also effective non-hormonal prescription therapies available for troublesome hot flushes and night sweats.
In Australia, most of these options are “off-label”, although the new medication fezolinetant has just been approved in Australia for postmenopausal hot flushes and night sweats, and is expected to be available by mid-year. Fezolinetant, taken as a tablet, acts in the brain to stop the chemical neurokinin 3 triggering an inappropriate body heat response (flush and/or sweat).
Unfortunately, most over-the-counter treatments promoted for menopause are either ineffective or unproven. However, cognitive behaviour therapy and hypnosis may provide symptom relief.
The Australasian Menopause Society has useful menopause fact sheets and a find-a-doctor page. The Practitioner Toolkit for Managing Menopause is also freely available.
Susan Davis, Chair of Women’s Health, Monash University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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The Best 4 Pool Exercises to Strengthen Your Core & Tone Up
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A lot of people don’t love working on their core strength, but exercising in the pool can make it a lot more enjoyable, as well as minimizing risk of injury.
Dr Alyssa Kuhn, arthritis specialist, also advises “being in the water also helps to control for balance and can offload the joints so they aren’t as painful”:
The gentlest exercise
The specific exercises she recommends are:
Wood Chops
Stagger your feet, clasp your hands, and submerge them in the water. Now, move your hands diagonally from one side to the other. This engages your core and balance using water resistance. Perform 10–20 reps per side, exhaling on the hardest part.
Front Kick with Opposite Arm Press
Kick one leg forward while pushing the opposite arm out or overhead—higher kicks increase difficulty by requiring more balance. If balance isn’t sufficient for you yet, hold onto the pool wall if needed. Either way, engage the core to lift the leg. Do 20–30 reps alternating sides.
Wall Push-Ups
Place your hands on the pool wall, shoulder-width apart. Keep feet together and hips slightly tucked for core engagement. Next, move your chest toward the wall and push back while maintaining a straight body—avoid arching your back. Do 10–20 reps.
Arm Circles
Stand with your feet wider than shoulder-width. Clasp your hands, extend your arms, and submerge them in the water. Make large circular motions for resistance training. This can be done with straight or bent arms for different difficulty levels. Do 10–20 circles in each direction.
For more on each of these plus visual demonstrations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Osteoporosis & Exercises: Which To Do (And Which To Avoid)
Take care!
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Are Supplements Worth Taking?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝There seems to be a lot of suggestions to take supplements for every thing, from your head to your toes. I know it’s up to the individual but what are the facts or stats to support taking them versus not?❞
Short answer:
- supplementary vitamins and minerals are probably neither needed nor beneficial for most (more on this later) people, with the exception of vitamin D which most people over a certain age need unless they are white and getting a lot of sun.
- other kinds of supplement can be very beneficial or useless, depending on what they are, of course, and also your own personal physiology.
With regard to vitamins and minerals, in most cases they should be covered by a healthy balanced diet, and the bioavailability is usually better from food anyway (bearing in mind, we say vitamin such-and-such, or name an elemental mineral, but there are usually multiple, often many, forms of each—and supplements will usually use whatever is cheapest to produce and most chemically stable).
However! It is also quite common for food to be grown in whatever way is cheapest and produces the greatest visible yield, rather than for micronutrient coverage.
This goes for most if not all plants, and it goes extra for animals (because of the greater costs and inefficiencies involved in rearing animals).
We wrote about this a while back in a mythbusting edition of 10almonds, covering:
- Food is less nutritious now than it used to be: True or False?
- Supplements aren’t absorbed properly and thus are a waste of money: True or False?
- We can get everything we need from our diet: True or False?
You can read the answers and explanations, and see the science that we presented, here:
Do We Need Supplements, And Do They Work?
You may be wondering: what was that about “most (more on this later) people”?
Sometimes someone will have a nutrient deficiency that can’t be easily remedied with diet. Often this occurs when their body:
- has trouble absorbing that nutrient, or
- does something inconvenient with it that makes a lot of it unusable when it gets it.
…which is why calcium, iron, vitamin B12, and vitamin D are quite common supplements to get prescribed by doctors after a certain age.
Still, it’s best to try getting things from one’s diet first all of all, of course.
Things we can’t (reasonably) get from food
This is another category entirely. There are many supplements that are convenient forms of things readily found in a lot of food, such as vitamins and minerals, or phytochemicals like quercetin, fisetin, and lycopene (to name just a few of very many).
Then there are things not readily found in food, or at least, not in food that’s readily available in supermarkets.
For example, if you go to your local supermarket and ask where the mimosa is, they’ll try to sell you a cocktail mix instead of the roots, bark, or leaves of a tropical tree. It is also unlikely they’ll stock lion’s mane mushroom, or reishi.
If perchance you do get the chance to acquire fresh lion’s mane mushroom, by the way, give it a try! It’s delicious shallow-fried in a little olive oil with black pepper and garlic.
In short, this last category, the things most of us can’t reasonably get from food without going far out of our way, are the kind of thing whereby supplements actually can be helpful.
And yet, still, not every supplement has evidence to support the claims made by its sellers, so it’s good to do your research beforehand. We do that on Mondays, with our “Research Review Monday” editions, of which you can find in our searchable research review archive ← we also review some drugs that can’t be classified as supplements, but mostly, it’s supplements.
Take care!
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Your Vitamins are Obsolete: The Vitamer Revolution – by Dr. Sheldon Zablow
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First, what this is not:a book to tell you “throw out your vitamins and just eat these foods”.
This book focuses mainly on two vitamins in which deficiencies are common especially as we get older: B9 and B12.
So, what does the title mean? It’s not so much that your vitamins are obsolete—that would imply that they were more useful previously, which is not the case. Rather, the most common forms of vitamins B9 and B12 provided in supplements are folic acid and cyanocobalamin, respectively, which as he demonstrates with extensive research to back up his claims, cannot be easily absorbed or used especially well.
About those vitamers: a vitamer is simply a form of a vitamin—most vitamins we need can arrive in a variety of forms. In the case of vitamins B9 and B12, he advocates for ditching vitamers folic acid and cyanocobalamin, cheap as they are, and springing for bioactive vitamers L-methylfolate, methylcobalamin, and adenosylcobalamin.
He also discusses (again, just as well-evidenced as the above things) why we might struggle to get enough from our diet after a certain age. For example, if trying to get these vitamins from meat, 50% of people over 50 cannot manufacture enough stomach acid to break down that protein to release the vitamins.
And as for methyl-B12 vitamers, you might expect you can get those from meat, and technically you can, but they don’t occur in all animals, just in one kind of animal. Specifically, the kind that has the largest brain-to-body ratio. However, eating the meat of this animal can result in protein folding errors in general and Creutzfeldt–Jakob disease in particular, so the author does not recommend eating humans, however nutritionally convenient that would be.
All this means that supplementation after a certain age really can be a sensible way to do it—but do it wisely, and pick the right vitamers.
The style of the book is informationally dense, but very readable even for a layperson provided one starts at the beginning and reads forwards, as otherwise one will find oneself in a mire of terms whose explanations one missed when they were first introduced.
Bottom line: if you are over 50 and/or have any known or suspected issues with vitamins B9 and/or B12, this book becomes very important reading.
Click here to check out Your Vitamins Are Obsolete, and get your body what it needs!
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Scattered Minds – by Dr. Gabor Maté
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This was not the first book that Dr. Maté sat down to write, by far. But it was the first that he actually completed. Guess why.
Writing from a position of both personal and professional experience and understanding, Dr. Maté explores the inaptly-named Attention Deficit Disorder (if anything, there’s often a surplus of attention, just, to anything and everything rather than necessarily what would be most productive in the moment), its etiology, its presentation, and its management.
This is a more enjoyable book than some others by the same author, as while this condition certainly isn’t without its share of woes (often, for example, a cycle of frustration and shame re “why can’t I just do the things; this is ruining my life and it would be so easy if I could just do the things!”), it’s not nearly so bleak as entire books about trauma, addiction, and so forth (worthy as those books also are).
Dr. Maté frames it specifically as a development disorder, and one whereby with work, we can do the development later that (story of an ADHDer’s life) we should have done earlier but didn’t. In terms of practical advice, he includes a program for effecting this change, including as an adult.
The style is easy-reading, in small chapters, with ADHD’d-up readers in mind, giving a strong sense of speeding pleasantly through the book.
Bottom line: when it’s a book by Dr. Gabor Maté, you know it’s going to be good, and this is no exception. Certainly read it if you, anyone you care about, or even anyone you just spend a lot of time around, has ADHD or similar.
Click here to check out Scattered Minds, and unscatter yours!
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The Minerals That Neutralize Viruses (While Being Harmless To Humans)
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Researchers in Estonia and Sweden (it was a joint project, with five researchers from each country) have found a way to use titanium dioxide nanoparticles to neutralize viruses, including COVID & flu.
Titanium dioxide, yes, the common additive to foods, cosmetics, and more (in most cases, added as a non-bleaching whitening agent—simply, titanium dioxide is body-safe, white in color, and very reflective, making it a brilliant, shiny white). Also used in sunscreens, for its excellent safety profile and again, its full-spectrum reflectiveness.
See also: Who Screens The Sunscreens?
How it works
Some viruses, including coronaviruses and influenza viruses, have an outer layer that’s a lipid membrane. The researchers found (by testing against multiple viruses, and by using a control of silicotungstate polyoxymethalate nanoparticles), that the ability of titanium dioxide to bind to phospholipids (and ability that the silicotungstate polyoxymethalate doesn’t have) means that the nanoparticles bind to the virus’s outer case, thus preventing it from effectively entering human cells (which it needs to do in order to infect the host, as this is how viruses replicate themselves).
What this means, in practical terms
While more research will be needed to know whether this can be used in the medicinal sense, it already means that a nanoparticle spray can be used to create virus-neutralizing layers on surfaces and in air filters. This alone could greatly reduce transmission in enclosed spaces such as public transport (ranging from taxis to airplanes), as well as other places where people get packed into a small space.
If you have an air purifier at home, keep an eye out for when improved filters arrive on the market!
See also: What’s Lurking In Your Household Air?
Wait, you said “minerals”; are there more?
It seems so, but we can’t truly say for sure until they’ve been tested. However, the researchers see no reason why other small metal oxides that bind strongly to phospholipids shouldn’t work exactly the same way—which would include iron oxide (yes, as in rust) and aluminum oxide (the coating that automatically forms immediately when aluminum is exposed to oxygen (aluminum is so reactive to oxygen, that it’s almost impossible to get aluminum without an oxidized surface, unless you use something else to coat it, or cut it in an oxygen-free atmosphere and keep it there).
You can read the paper itself here:
Molecular mechanisms behind the anti corona virus activity of small metal oxide nanoparticles
And on a related note (different scientists, different science, similar principle, though, using mineral nanotechnology to kill microbes):
❝Researchers report that laboratory tests of their nanoflower-coated dressings demonstrate antibiotic, anti-inflammatory and biocompatible properties. They say these results show these tannic acid and copper(II) phosphate sprouted nanoflower bandages are promising candidates for treating infections and inflammatory conditions.❞
Read in full: This delicate nanoflower is downright deadly to bacteria
Want to learn more?
Check out:
Move over, COVID and Flu! We Have “Hybrid Viruses” To Contend With Now
Take care!
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