A New Tool For Bone Regeneration
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When it comes to rebuilding bones, one of the tools in the orthopedic surgeon’s toolbox is bone grafts. This involves, to oversimplify it a bit, gluing particles of bone to where bone needs rebuilding. However, this comes with problems, most notably:
- that the bone tissue and the adhesive “glue” need to be prepared separately and mixed in situ, which is fiddly, to say the least
- that the resultant mixture mixed in situ will usually be unevenly mixed, resulting in weak bonding and degradation over time
- having any more of one part or the other in any given site means that bone regeneration and adhesion become a “pick one” matter, when both are critically needed
You may be wondering: why can’t they mix them before putting them in?
And the answer is: because then either the glue will set the bone prematurely (and now we have a clump of bone outside of the body which is not what we wanted), or else the glue will have issues with setting in situ, and now we have bone tissue running down the inside of someone’s leg and setting somewhere else, which is also not what we want.
These kinds of problems may seem a little more “arts and crafts” than “orthopedic surgery”, but they are the kind of nitty-gritty real-life real challenges that actually get in the way of healing patients’ bones.
The new solution
Biomaterial research scientists have developed an injectable hydrogel (containing all the necessary ingredients* that uses light to achieve cross-linking of bone particles and mineralization without any of the above being necessary. In again oversimplified terms: they inject the hydrogel where it’s needed, and then irradiate the site with harmless visible light which instantly sets it in place. As to how the light gets in there: it’s just very shiny, like candling an egg to see inside, or like how you can still approximately see bright light even with your eyes closed.
*alginate (natural polysaccharide derived from brown algae), RGD peptide-containing mussel** adhesive protein, calcium ions, phosphonodiols, and a photoinitiator.
**unclear whether this would trigger a shellfish allergy. Probably kosher per “פיקוח נפש” and Talmud Yoma 85b, but we are a health science newsletter, not Talmudic scholars, so please talk to your Rabbi. Probably halal per Qur’an 5:4 and failing that, the same principle as previously mentioned, expressed in Qur’an 5:3 and 6:119, but once again, your humble writer here is no Mufti, so please talk to your Imam. As for if you are vegetarian or vegan, then that is for you to decide whether to take a “medications with animal ingredients are unfortunate but necessary” stance, as most do. This vegan writer would (she’d grumble about it, though, and at least try to find an acceptable alternative first).
Back to the more general practicalities…
How it works, in less oversimplified terms:
❝The coacervate-based formulation, which is immiscible in water, ensures that the hydrogel retains its shape and position after injection into the body. Upon visible light irradiation, cross-linking occurs, and amorphous calcium phosphate, which functions as a bone graft material, is simultaneously formed. This eliminates the need for separate bone grafts or adhesives, enabling the hydrogel to provide both bone regeneration and adhesion.❞
“That’s great, but I was hoping for something I can do right now, ideally at home”
If getting glued back together was not on your bucket list, that’s understandable. There’s still a lot you can do for bone density; here’s a quick overview:
- Get it checked. Yes, this first, if you haven’t already! You want a basis for comparison later. Book a bone density scan. See for example this case study with bone density scans at each end: 21% Stronger Bones in a Year at 62? Yes, It’s Possible (No Calcium Supplements Needed!)
- Enjoy a diet rich in calcium and vitamin D yes, but be aware that you can have too much of a good thing, and doing so will result in more harm than good, including (paradoxically) for your bones. See: Vitamin D + Calcium: Too Much Of A Good Thing?
- Enjoy a diet rich is phosphorus, potassium, and magnesium, which things are also necessary for bone health, and in which people are much more likely to be deficient (especially magnesium). If you’re going to supplement, then there are very big difference in the efficacy of different kinds of magnesium supplement (brace yourself; the cheapest and most common kind barely does anything at all). See: Which Magnesium? (And: When?)
- Enjoy a diet rich in high quality protein—collagen is very useful, but if you want a plant-based approach, don’t worry, our body can and will make it for yourself if you give it a hand—and vitamin C to help its absorption, as well as glycine if you’re going the no-animals route. See: Collagen For Bones: We Are Such Stuff As Fish Are Made Of and: The Sweet Truth About Glycine: Making Your Collagen Work Better
- Consider medication, if your bone density is already lower than what it should be. There are meds to stop further deterioration, and different meds to encourage your body to rebuild bone. However, there are downsides to each of them: Which Osteoporosis Medication, If Any, Is Right For You?
- While we’re on the topic of medications, consider bioidentical HRT if you are female and not otherwise producing your own estrogen and progesterone in adequate quantities to maintain your skeletal integrity: HRT: A Tale Of Two Approaches
- Look after your gut too! So much starts there: Is Your Gut Leading You Into Osteoporosis? Bacterioides Vulgatus & Bone Health
- Lastly, exercise, but exercise right, because with insufficient resistance exercise your bones will not “think” they need to remain strong, and with the wrong kind of resistance exercise, you could break/compress your bones if they are already weak, so check out: Osteoporosis & Exercises: Which To Do (And Which To Avoid)
Too much information?
If that was too much information all at once, then we recommend this as your one-stop article:
The Bare-Bones Truth About Osteoporosis
Want more information?
We are but a humble newsletter and can only include so much per day, but we highly recommend this book we reviewed a little while back, which goes into everything in a lot more detail than we can here:
Enjoy!
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Do you taste words or hear colours? Here’s the neuroscience behind synaesthesia
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Have you ever tasted a word, or seen colours while listening to music?
If you have, you may be among the 1% to 4% of people who have a fascinating trait known as synaesthesia.
Synaesthesia is a neurological phenomenon where the activation of one sense, such as hearing, triggers the activation of another usually unrelated sense, such as sight. This means people with synaesthesia often experience additional sensations compared to the rest of us.
We’ve devoted a lot of time to understanding this rare phenomenon. While there’s much more to unpack, what we do know shows we don’t all perceive the world in the same way.
Vitally Gariev/Unsplash What is synaesthesia?
People with synaesthesia are known as synaesthetes. Research suggests synaesthesia may be more common among women, although this could reflect sampling biases, and may be influenced by genetics.
There are many different types of synaesthesia. Some people have auditory-visual synaesthesia, meaning they see colours when they hear sounds. Others see colours when they read, hear or think about letters or numbers. This is known as grapheme-colour synaesthesia. Another example is mirror-touch synaesthesia, where a person feels sensations on their own body when they see another person being touched.
All of us naturally combine information from different senses. For instance, when you watch someone speak, your brain blends what you see and hear to understand them better. In synaesthesia these links are a bit different – a sound might, for example, trigger a visual experience – but may still depend on the same mechanisms.
People with synaesthesia don’t have any control over how their senses collide. Instead, these are spontaneous, vivid experiences that usually stay the same over time. For example, today a person with grapheme-colour synaesthesia may perceive the letter “A” as being red. And they’ll most likely see it as being the same shade even years later.
It’s worth noting synaesthesia is not an illness or disorder. And it doesn’t cause harm or impairment, although some people may find their synaesthesia overwhelming at times. For example, if they feel pain every time they see someone else in pain, going to the movies can be quite disturbing. However, on the whole it does not seem to interfere with daily life. In fact, many people don’t realise they have synaesthesia because it’s simply how they perceive the world.
What causes it?
We don’t yet know exactly what causes synaesthesia. But scientists have come up with two main theories.
1. Synaesthetes have more connections in their brain
According to this view, known as the cross-activation theory, people with synaesthesia have more connections between different parts of their brain. This could happen because their brain hasn’t gotten rid of unused connections between brain cells. This process, known as synaptic pruning, helps the brain work more efficiently and is part of normal development.
Under this theory, a person with grapheme-colour synaesthesia for example, would have the region that recognises letters directly linked to the part that processes colour. So when they see a letter, they perceive it with a colour.
2. Synaesthetes have slightly different activity in their brain
The other main theory is that people with synaesthesia have the same neural connections as non-synaesthetes, but certain pathways might be stronger or more active. Synaesthesia does seem to build on mechanisms we all have. For example, when you see a picture of a grey banana, you know bananas are usually yellow. We even see patterns of brain activity that reflect this. Grapheme-colour synaesthetes might also do this with letters so that when they see black letters, their brain activates specific colours.
Simply put, the debate about what causes synaesthesia comes down to whether synaesthetes have a different brain structure or just use their brains in an alternative way.
Does it make you more creative?
You might’ve heard artists such as Kandinsky or musicians such as Lorde describe their synaesthesia-like experiences. And there is some evidence to suggest synaesthesia is more common among people in creative fields.
One large survey of Australian synaesthetes found roughly 24% had creative occupations, such as being an artist, musician, architect or graphic designer. This is compared to the less than 2% of people in the general population who have these jobs. This gap is striking, even though we don’t understand what’s behind it. One reason may be synaesthetes link ideas and sensations in unusual ways, helping them think more creatively. Research suggests people with certain kinds of synaesthesia may form stronger memories or have more vivid imaginations, but only to a limited extent.
Synaesthesia is a powerful window into how our brains make sense of the world. It reminds us perception is not a fixed, one-size-fits-all process. Rather, it’s something the brain actively builds in ways that are often more varied, and far richer, than we might expect.
Sophie Smit, Postdoctoral Research Associate in Cognitive Neuroscience, University of Sydney and Anina Rich, Associate Professor and Head of Synaesthesia Research Group, Macquarie University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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What’s So Special About Alpha-Lipoic Acid?
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The Access-All-Areas Antioxidant
Alpha-Lipoic Acid (ALA) is one of the most bioavailable antioxidants in existence. A bold claim, but most antioxidants are only water-soluble or fat-soluble, whereas ALA is both. This has far-reaching implications—and we mean that literally, because its “go everywhere” status means that it can access (and operate in) all living cells of the human body.
We make it inside our body, and we can also get it in our diet, or take it as a supplement.
What foods contain it?
The richest food sources are:
- For the meat-eaters: organ meats
- For everyone: broccoli, tomatoes, & spinach
However, supplements are more efficient at delivering it, by several orders of magnitude:
Read more: Lipoic acid – biological activity and therapeutic potential
What are its benefits?
Most of its benefits are the usual benefits you would expect from any antioxidant, just, more of it. In particular, reduced inflammation and slowed skin aging are common reasons that people take ALA as a supplement.
Does it really reduce inflammation?
Yes, it does. This one’s not at all controversial, as this systematic review of studies shows:
(C-reactive protein is a marker of inflammation)
Does it really reduce skin aging?
Again yes—which again is not surprising for such a potent antioxidant; remember that oxidative stress is one of the main agonists of cellular aging:
As a special feature, ALA shows particular strength against sun-related skin aging, because of how it protects against UV radiation and increases levels of gluthianone, which also helps:
- Photochemical stability of lipoic acid and its impact on skin ageing
- Modern approach to topical treatment of aging skin
Where can I get some?
We don’t sell it, but here for your convenience is an example product on Amazon
Enjoy!
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Vaginal Probiotics: What Does The Science Say?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝Is there any merit to vaginal probiotics?❞
What a fun question! First let’s break it down, as this could mean two different things:
- Probiotics, which you consume, using your mouth, which are marketed as benefiting vaginal health
- Probiotics taken as a vaginal pessary/suppository, to act directly there
The former has limited evidence for it, but generally speaking, improving one’s gut health improves all other areas of health, so it’s not surprising if it helps this too.
See for example:
Some notes:
- candidal vaginitis means a yeast infection causing vaginal inflammation
- bacterial vaginosis means a vaginal bacterial imbalance (generally also featuring vaginal inflammation, though it can be asymptomatic)
In the latter case, the “imbalance” in question is usually a shortage of Lactobacillus sp. (that is to say, the diverse species of the Lactobacillus genus) resulting in an overgrowth of other kinds of bacteria, which in turn results in changing the vaginal microbiome to make it warmer and more acidic than it should be.
While a healthy vagina shouldn’t smell of roses, it shouldn’t smell fishy either; if it does, that’s a sign of bacterial vaginosis.
What it’s supposed to be like: slightly bitter (acidic) yet at the same time slightly salty, distinctly umami, along with a cocktail of personal pheromones (and if menstruating or otherwise* vaginally bleeding, then of course add: iron/”metallic”). The pheromones will also reflect any hormonal changes, but should never make anything smell bad, just different.
*e.g. due to PCOS, fibroids, etc. Note that in the case of PCOS, it may also smell a little different (if it does, then usually: a little more musky, and in extreme cases it may also be approaching sweet-and-salty rather than bitter-and-salty), due to often different hormone levels. Again: it still shouldn’t smell bad, though, just different.
In the above-linked study, taking more live Lactobacillus acidophilus (in yogurt, eating it, with their mouths) improved levels of L. acidophilus in the vagina. While the study authors concluded “this ingestion of yogurt may have reduced episodes of bacterial vaginosis”, which is rather a weak claim, it can be argued that it merely improving the levels of L. acidophilus in the vagina was already a win.
That was a small (n=42, and only 7 followed through to completion) and old (1996) study, and it bears mentioning that most of the studies into this seem to be small and old, but conclude similarly with weakly positive statements.
However, it does make a difference what kind of Lactobacillus is used, for example in this next study…
- L. fermentum RC-14 worked well (90% success rate)
- L. rhamnosus GR-1 worked somewhat (40% success rate)
- L. rhamnosus GG did not work (0% success rate)
So, diversity is key, and getting a wide range of Lactobacillus sp. seems to be a safe bet.
Short version: enjoying probiotics as part of your diet probably improves vaginal health, just like it improves pretty much everything else.
See also: Make Friends With Your Gut (You Can Thank Us Later)
You would think that this would mean that taking probiotics as a vaginal pessary/suppository would be even better, but the results are weaker, as in this study, which produced temporary improvements in about half the study group, with only 3 out of 28 being free of bacterial vaginosis the next month:
Treatment of bacterial vaginosis with lactobacilli
This study got better results, with a 61% success rate:
Important note
Do note that this last category, involving topical treatments (i.e., manually introducing Lactobacillus sp. to the vagina) were all in cases of pre-existing bacterial vaginosis, not as a prophylactic and/or general health-improving thing.
If your vagina seems happy right now, then do not mess with its happy bacterial balance!
And at all times (regardless of whether it seems happy right now or not): do not douche (it does not need it and will not benefit from it; the vagina is self-cleaning*) as this will wash out many of your Lactobacilli and will do absolutely nothing against any Candida there (C. albicans being a rooted fungus, whereas Lactobacillus is a sausage-shaped bacterium with many tiny appendages but no actual ability to stay put), so Candida will flourish in the Lactobacillus’s absence.
*by the vagina, we are referring to the vaginal canal. The vulva—the outside part consisting of the two pairs of labia, the glans clitoris, and clitoral hood—are not self-cleaning, and should just be washed gently per your normal bath/shower routine; that’s perfectly fine and good.
And definitely don’t put any “cleansing” toiletries inside the vagina (or any toiletries at all, for that matter), even if they are sold and marketed for that purpose; they will not help and they will harm.
Also, due to their neighborliness, messing up the microbiome inside the vagina is a common way to also get Candida inside the urethra:
How To Avoid Urinary Tract Infections (UTIs)
One other option
Finally, unless you have a “very good friend” you have a pressing urge to swap germs with, you might want to leave this one to the scientists, but we share this paper just for interest:
Lastly…
Going back to oral supplementation, if you’d like to try that then check out this for further notes on what, why, how, etc:
How Much Difference Do Probiotic Supplements Make To Health?
Take care!
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How to Fall Back Asleep After Waking Up in the Middle of the Night
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Dr. Michael Bruce, the Sleep Doctor, addresses a common concern: waking up in the middle of the night and struggling to fall back asleep.
Understanding the Wake-Up
Firstly, why are we waking up during the night?
Waking up between 2 AM and 3 AM is said to be normal, and linked to your core body temperature. As your body core temperature drops, to trigger melatonin release, and then rises again, you get into a lighter stage of sleep. This lighter stage of sleep makes you more prone to waking up.
Note, there are also some medical conditions (such as sleep apnea) that can cause you to wake up during the night.
But, what can we do about it? Aside from constantly shifting sleeping position (Should I be sleeping on my back? On my left? Right?)
Avoid the Clock
The first step is to resist the urge to check the time. It’s easy to be tempted to have a look at the clock, however, doing so can increase anxiety, making it harder to fall back asleep. As Dr. Bruce says, sleep is like love—the less you chase it, the more it comes.
It may be useful to point your alarm clock (if you still have one of those) the opposite direction to your bed.
Embracing Non-Sleep Deep Rest (NSDR)
Whilst this may not help you fall back asleep, it’s worth pointing out that just lying quietly in the dark without moving still offers rejuvenation. This revujenating stage is called Non-Sleep Deep Rest (otherwise known as NSDR)
If you’re not familiar with NSDR, check out our overview of Andrew Huberman’s opinions on NSDR here.
So, you can reassure yourself that whilst you may not be asleep, you are still resting.
Keep Your Heart Rate Down
To fall back asleep, it’s best if your heart rate is below 60 bpm. So, Dr. Bruce advises avoiding void getting up unnecessarily, as moving around can elevate your heart rate.
On a similar vain, he introduces the 4-7-8 breathing technique, which is designed to lower your heart rate. The technique is simple:
- Breathe in for 4 seconds.
- Hold for 7 seconds.
- Exhale for 8 seconds.
Repeat this cycle gently to calm your body and mind.
As per any of our Video Breakdowns, we only try to capture the most important pieces of information in text; the rest can be garnered from the video itself:
Wishing you a thorough night’s rest!
Do you know any other good videos on sleep? Send them to us via email!
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Pregnant women can now get a free RSV shot. What other vaccines do you need when you’re expecting?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
From today, February 3, pregnant women in Australia will be eligible for a free RSV vaccine under the National Immunisation Program.
This vaccine is designed to protect young infants from severe RSV (respiratory syncytial virus). It does so by generating the production of antibodies against RSV in the mother, which then travel across the placenta to the baby.
While the RSV vaccine is a new addition to the National Immunisation Program, it’s one of three vaccines provided free for pregnant women under the program, alongside ones for influenza and whooping cough. Each offers important protection for newborn babies.
voronaman/Shutterstock The RSV vaccine
RSV is the most common cause of lower respiratory infections (bronchiolitis and pneumonia) in infants. It’s estimated that of every 100 infants born in Australia each year, at least two will be hospitalised with RSV by six months of age.
RSV infection is most common roughly between March and August in the southern hemisphere, but infection can occur year-round, especially in tropical areas.
The vaccine works by conferring passive immunity (from the mother) as opposed to active immunity (the baby’s own immune response). By the time the baby is born, their antibodies are sufficient to protect them during the first months of life when they are most vulnerable to severe RSV disease.
The RSV vaccine registered for use in pregnant women in Australia, Abrysvo, has been used since 2023 in the Americas and Europe. Real-world experience there shows it’s working well.
For example, over the 2024 RSV season in Argentina, it was found to prevent 72.7% of lower respiratory tract infections caused by RSV and requiring hospitalisation in infants aged 0–3 months, and 68% among those aged 0–6 months. This research noted three deaths from RSV, all in infants whose mothers did not receive the RSV vaccine during pregnancy.
This was similar to protection seen in a large multinational clinical trial that compared babies born to mothers who received this RSV vaccine with babies born to mothers who received a placebo. This study found the vaccine prevented 82.4% of severe cases of RSV in infants aged under three months, and 70% under six months, and that the vaccine was safe.
Vaccinating mothers during pregnancy protects the newborn baby. StoryTime Studio/Shutterstock In addition to the maternal vaccine, nirsevimab, a long-acting monoclonal antibody, provides effective protection against severe RSV disease. It’s delivered to the baby by an intramuscular injection, usually in the thigh.
Nirsevimab is recommended for babies born to women who did not receive an RSV vaccine during pregnancy, or who are born within two weeks of their mother having received the shot (most likely if they’re born prematurely). It may also be recommended for babies who are at higher risk of RSV due to a medical condition, even if their mother was vaccinated.
Nirsevimab is not funded under the National Immunisation Program, but is covered under various state and territory-based programs for infants of mothers who fall into the above categories.
But now we have a safe and effective RSV vaccine for pregnancy, all pregnant women should be encouraged to receive it as the first line of prevention. This will maximise the number of babies protected during their first months of life.
Flu and whooping cough
It’s also important pregnant women continue to receive flu and whooping cough vaccines in 2025. Like the RSV vaccine, these protect infants by passing antibodies from mother to baby.
There has been a large whooping cough outbreak in Australia in recent months, including a death of a two-month-old infant in Queensland in November 2024.
The whooping cough vaccine, given in combination with diphtheria and tetanus, prevents more than 90% of whooping cough cases in babies too young to receive their first whooping cough vaccine dose.
Similarly, influenza can be deadly in young babies, and maternal flu vaccination substantially reduces hospital visits associated with influenza for babies under six months. Flu can also be serious for pregnant women, so the vaccine offers important protection for the mother as well.
COVID vaccines are safe in pregnancy, but unless a woman is otherwise eligible, they’re not routinely recommended. You can discuss this with your health-care provider.
When and where can you get vaccinated?
Pregnant women can receive these vaccines during antenatal visits through their GP or in a specialised antenatal clinic.
The flu vaccine is recommended at any time during pregnancy, the whooping cough vaccine from 20 weeks (ideally before 32 weeks), and the RSV vaccine from 28 weeks (before 36 weeks).
It’s safe to receive multiple vaccinations at the same clinic visit.
The RSV vaccine is now available for pregnant women under the National Immunisation Program. Olga Rolenko/Shutterstock We know vaccination rates have declined in a variety of groups since the pandemic, and there’s evidence emerging that suggests this trend has occurred in pregnant women too.
A recent preprint (a study yet to be peer-reviewed) found a decrease of nearly ten percentage points in flu vaccine coverage among pregnant women in New South Wales, from 58.8% in 2020 to 49.1% in 2022. The research showed a smaller drop of 1.4 percentage points for whooping cough, from 79% in 2020 to 77.6% in 2022.
It’s important to work to improve vaccination rates during pregnancy to give babies the best protection in their first months of life.
We know pregnant women would like to receive information about new and routine maternal vaccines early in pregnancy. In particular, many pregnant women want to understand how vaccines are tested for safety, and their effectiveness, which was evident during COVID.
GPs and midwives are trusted sources of information on vaccines in pregnancy. There’s also information available online on Sharing Knowledge About Immunisation, a collaboration led by the National Centre for Immunisation Research and Surveillance.
Archana Koirala, Paediatrician and Infectious Diseases Specialist, University of Sydney; Bianca Middleton, Senior Research Fellow, Menzies School of Health Research; Margie Danchin, Professor of Paediatrics and vaccinologist, Royal Childrens Hospital, University of Melbourne and Murdoch Childrens Research Institute (MCRI); Associate Dean International, University of Melbourne, Murdoch Children’s Research Institute; Peter McIntyre, Professor in Women’s and Children’s Health, University of Otago, and Rebecca Doyle, Adjunct Research Fellow, School of Nursing, Midwifery and Social Work, The University of Queensland
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Are Processed Foods Really Addictive?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
No question/request too big or small 😎
❝Is it true that processed foods are addictive, or is it just a craving that can be overcome with a little more willpower?❞
Short answer: yes and yes
Longer answer:
The two are very closely related, since the mechanisms of cravings and the mechanisms of addiction share some overlaps, usually in reward processing in the brain (e.g. dopamine metabolism), and/or sometimes to do with opioid receptors. There is also in both cases (often, but not always) the issue of tolerance/desensitization and thus a need for more of the same thing to get the same biochemical result as one enjoyed previously from a lower amount, and/or (in some cases) that the effects will be increasingly short-lived.
Ultra-processed foods (UPFs) have a well-earned bad reputation. And yet, most of us still consume at least some, and many people meet the criteria for ultra-processed food addiction.
Now, some UPFs are healthy in moderation. See for example: Not all ultra-processed foods are bad for your health, whatever you might have heard
But we said the bad reputation was well-deserved, and that was true. Most UPFs have a single goal, and that goal isn’t to enrich your health (it’s to increase the company’s profit margin).
They generally do this by:
- Reducing the costs of production by using more shelf-stable ingredients
- Reducing loss of products at the retail stage (many ultra-processed products can be sold tomorrow or next week or next month, while raspberries need to be sold by half past four at the latest, for example, or else they must be heavily reduced in price, and then often thrown out)
- Increasing sales by including high amounts of ingredients that trigger addiction mechanisms (e.g. sugar, salt, fat—which yes, we need all of those things in moderation, but these foods often contain megadoses)
That latter one answers your question; to learn more about the biochemistry and neurochemistry of it, see for example: Diet, Drugs, and Dopamine – by Dr. David Kessler
Or if you’re not up for reading a whole book, then perhaps our main feature: The Not-So-Sweet Science Of Sugar Addiction ← this is really just about sugar, but similar mechanisms exist for fat, and to a lesser degree, salt.
Where the science stands
This one’s not controversial. Let’s pick out some spotlight studies…
❝Highly processed foods (HPFs) can meet the criteria to be labeled as addictive substances using the standards set for tobacco products. The addictive potential of HPFs may be a key factor contributing to the high public health costs associated with a food environment dominated by cheap, accessible and heavily marketed HPFs.❞
~ Dr. Ashley Gearhardt & Dr. Alexandra DiFeliceantonio
❝Ultra-processed food addiction appears to be prevalent among older adults in the United States, particularly among women who were in adolescence and early adulthood when the nutrient quality of the US food supply worsened. Addictive patterns of UPF intake appear to be associated with poorer physical health, mental health, and social well-being.❞
~ Dr. Lucy Loch et al.
Source: Ultra-processed food addiction in a nationally representative sample of older adults in the USA
❝That certain foods can trigger addictive behavior consistent with substance-use disorders (SUDs) is accepted by many addiction scientists and supported by evidence of neurobiological overlap with the brain circuits and molecular targets implicated in ‘classical’ drug addictions❞
~ Dr. Erica LaFata et al.
Source: Now is the time to recognize and respond to addiction to ultra-processed foods
Want to improve your own dietary habits?
First, it’s good to be well-informed. Reading 10almonds is a great start! Of course, we can’t cover every product in your local supermarket though, so check out this:
How Processed Is The Food You Buy, Really? ← includes a huge, free database!
If you prefer a short hit-list, then here you go: Top 10 Unhealthy Foods: How Many Do You Eat?
And if you know which UPFs you want to cut out, but knowing isn’t the problem, then here’s our main feature on how to do that: When It’s More Than “Just” Cravings: How To Beat Food Addictions!
Want to learn more?
You might like this book we reviewed a little while back:
Ultra-Processed People: The Science Behind The Food That Isn’t Food – by Dr. Chris van Tulleken
…and/or as a next step,
Unprocess Your Life: Break Free From Ultra-Processed Foods For Good – by Rob Hobson ← Rob Hobson is not a doctor, but he is a nutritionist with half the alphabet after his name (BSc, PGDip, MSc, AFN, SENR) and decades of experience in the field.
Take care!
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