The Sugar Alcohol That Reduces BMI!

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Inositol Does-It-Ol’!

First things first, a quick clarification up-front:

Myo-inositol or D-chiro-inositol?

We’re going to be talking about inositol today, which comes in numerous forms, but most importantly:

  • Myo-inositol (myo-Ins)
  • D-chiro-inositol (D-chiro-Ins)

These are both inositol, (a sugar alcohol!) and for our purposes today, the most relevant form is myo-inositol.

The studies we’ll look at today are either:

  • just about myo-inositol, or
  • about myo-inositol in the presence of d-chiro-inositol at a 40:1 ratio.

You have both in your body naturally; wherever supplementation is mentioned, it means supplementing with either:

  • extra myo-inositol (because that’s the one the body more often needs more of), or
  • both, at the 40:1 ratio that we mentioned above (because that’s one way to help balance an imbalanced ratio)

With that in mind…

Inositol against diabetes?

Inositol is known to:

  • decrease insulin resistance
  • increase insulin sensitivity
  • have an important role in cell signaling
  • have an important role in metabolism

The first two things there both mean that inositol is good against diabetes. It’s not “take this and you’re cured”, but:

  • if you’re pre-diabetic it may help you avoid type 2 diabetes
  • if you are diabetic (either type) it can help in the management of your diabetes.

It does this by allowing your body to make better use of insulin (regardless of whether that insulin is from your pancreas or from the pharmacy).

How does it do that? Research is still underway and there’s a lot we don’t know yet, but here’s one way, for example:

❝Evidence showed that inositol phosphates might enhance the browning of white adipocytes and directly improve insulin sensitivity through adipocytes❞

Read: Role of Inositols and Inositol Phosphates in Energy Metabolism

We mentioned its role in metabolism in a bullet-point above, and we didn’t just mean insulin sensitivity! There’s also…

Inositol for thyroid function?

The thyroid is one of the largest endocrine glands in the body, and it controls how quickly the body burns energy, makes proteins, and how sensitive the body should be to other hormones. So, it working correctly or not can have a big impact on everything from your mood to your weight to your energy levels.

How does inositol affect thyroid function?

  • Inositol has an important role in thyroid function and dealing with autoimmune diseases.
  • Inositol is essential to produce H2O2 (yes, really) required for the synthesis of thyroid hormones.
  • Depletion of inositol may lead to the development of some thyroid diseases, such as hypothyroidism.
  • Inositol supplementation seems to help in the management of thyroid diseases.

Read: The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management

Inositol for PCOS?

A systematic review published in the Journal of Gynecological Endocrinology noted:

  • Inositol can restore spontaneous ovarian activity (and consequently fertility) in most patients with PCOS.
  • Myo-inositol is a safe and effective treatment to improve:
    • ovarian function
    • healthy metabolism
    • healthy hormonal balance

While very comprehensive (which is why we included it here), that review’s a little old, so…

Check out this cutting edge (Jan 2023) study whose title says it all:

Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Inositol for fertility?

Just last year, Mendoza et al published that inositol supplementation, together with antioxidants, vitamins, and minerals, could be an optimal strategy to improve female fertility.

This built from Gambiole and Forte’s work, which laid out how inositol is a safe compound for many issues related to fertility and pregnancy. In particular, several clinical trials demonstrated that:

  • inositol can have therapeutic effects in infertile women
  • inositol can also be useful as a preventive treatment during pregnancy
  • inositol could prevent the onset of neural tube defects
  • inositol also reduces the occurrence of gestational diabetes

Due to the safety and efficiency of inositol, it can take the place of many drugs that are contraindicated in pregnancy. Basically: take this, and you’ll need fewer other drugs. Always a win!

Read: Myo-Inositol as a Key Supporter of Fertility and Physiological Gestation

Inositol For Weight Loss

We promised you “this alcohol sugar can reduce your BMI”, and we weren’t making it up!

Zarezadeh et al conducited a very extensive systematic review, and found:

  • Oral inositol supplementation has positive effect on BMI reduction.
  • Inositol in the form of myo-inositol had the strongest effect on BMI reduction.
  • Participants with PCOS and/or who were overweight, experienced the most significant improvement of all.

Want some inositol?

As ever, we don’t sell it (or anything else), but for your convenience, here’s myo-inositol and d-chiro-inositol at a 40:1 ratio, available on Amazon!

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  • Paulina Porizkova (Former Supermodel) Talks Menopause, Aging, & Appearances

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Are supermodels destined to all eventually become “Grizabella the Glamor Cat”, a washed-up shell of their former glory? Is it true that “men grow cold as girls grow old, and we all lose our charms in the end”? And what—if anything—can we do about it?

    Insights from a retired professional

    Paulina Porizkova is 56, and she looks like she’s… 56, maybe? Perhaps a little younger or a bit older depending on the camera and lighting and such.

    It’s usually the case, on glossy magazine covers and YouTube thumbnails, that there’s a 20-year difference between appearance and reality, but not here. Why’s that?

    Porizkova noted that many celebrities of a similar age look younger, and felt bad. But then she noted that they’d all had various cosmetic work done, and looked for images of “real” women in their mid-50s, and didn’t find them.

    Note: we at 10almonds do disagree with one thing here: we say that someone who has had cosmetic work done is no less real for it; it’s a simple matter of personal choice and bodily autonomy. She is, in our opinion, making the same mistake as people make when they say such things as “real people, rather than models”, as though models are not also real people.

    Porizkova found modelling highly lucrative but dehumanizing, and did not enjoy the objectification involved—and she enjoyed even less, when she reached a certain age, negative comments about aging, and people being visibly wrong-footed when meeting her, as they had misconceptions based on past images.

    As a child and younger adult through her modelling career, she felt very much “seen and not heard”, and these days, she realizes she’s more interesting now but feels less seen. Menopause coincided with her marriage ending, and she felt unattractive and ignored by her husband; she questioned her self-worth, and felt very bad about it. Then her husband (they had separated, but had not divorced) died, and she felt even more isolated—but it heightened her sensitivity to life.

    In her pain and longing for recognition, she reached out through her Instagram, crying, and received positive feedback—but still she struggles with expressing needs and feeling worthy.

    And yet, when it comes to looks, she embraces her wrinkles as a form of expression, and values her natural appearance over cosmetic alterations.

    She describes herself as a work in progress—still broken, still needing cleansing and healing, but proud of how far she’s come so far, and optimistic with regard to the future.

    For all this and more in her own words, enjoy:

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    The Many Faces Of Cosmetic Surgery

    Take care!

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  • The Problem With Active Listening

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The problem with active listening

    Listening is an important skill to keep well-trained at any age. It’s important in romantic relationships, parent-child relationships, friendships, and more.

    First, for any unfamiliar or hazy-of-memory: active listening is the practice of listening, actively. The “active” side of this comes in several parts:

    1. Asking helpful questions
    2. Giving feedback to indicate that the answer has been understood
    3. Prompting further information-giving

    This can look like:

    • A: How did you feel when that happened?
    • B: My heart was racing and I felt panicked, it really shocked me
    • A: It really shocked you?
    • B: Yes, because it was so unexpected; I’d never imagined something like this happening
    • A: You’d never expect something like that
    • B: No, I mean, I had no reason to

    And… As a superficial listening technique, it’s not terrible, and it has its place

    But unfortunately, if it’s one’s only listening technique, one will very quickly start sounding like a Furby—that children’s toy from the 90s that allegedly randomly parroted fragments of things that had been said to it. In fact this was a trick of programming, but that’s beyond the scope of this article.

    The point is: the above technique, if used indiscriminately and/or too often, starts to feel like talking to a very basic simulacrum.

    Which is the opposite of feeling like being listened to!

    A better way to listen

    Start off similarly, but better.

    Ask open questions, or otherwise invite sharing of information.

    People can be resistant to stock phrases like “How did that make you feel?”, but this can be got around by simply changing it up, e.g.:

    • “What was your reaction?” ← oblique but often elicits the same information
    • “I’m not sure how I’d feel about that, in your shoes” ← not even a question, but shows active attention much better than the “mmhmm” noises of traditional active listening, and again prompts the same information

    Express understanding… But better

    People have been told “I understand” a lot, and often it’s code for “Stop talking”. So, avoid “I understand”. Instead, try:

    • “I can understand that”
    • “Understandable”
    • “That makes sense”

    Ask clarifying questions… Better

    Sometimes, a clarifying question doesn’t have to have its own point, beyond prompting more sharing, and sometimes, an “open question” can be truly wide open, meaning that vaguer is better, such as:

    • “Oh?”
    • “How so?” ← this is the heavy artillery that can open up a lot

    Know when to STFU

    Something that good therapists (and also military interrogators) know: when to STFU

    If someone is talking, don’t interrupt them. If you do, they might not start again, or might skip what they were going to say.

    Interruption says “I think you’ve said all that needs to be said there”, or else, if the interruption was to ask one of the above questions, it says “you’re not doing a good enough job of talking”, and neither of those sentiments encourage people to share, nor do they make someone feel listened-to!

    Instead, just listen. Passive listening has its place too! When there’s a break, then you can go to one of the above questions/prompts/expressions of understanding, as appropriate.

    Judge not, lest they feel judged

    Reserve judgement until the conversation is over, at the earliest. If asked for your judgement of some aspect, be as reassuring as you can. People feel listened-to when they don’t feel judged.

    If they feel judged, conversely, they can often feel you didn’t listen properly, or else you’d be in agreement with them. So instead, just sit on it for as long as you can.

    Note: that goes for positive judgements too! Sit on it. Expressing a positive judgement too soon can seem that you were simply eager to please, and can suggest insincerity.

    If this seems simple, that’s because it is. But, try it, and see the difference.

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  • Recognize The Early Symptoms Of Parkinson’s Disease

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Parkinson’s disease is a degenerative condition with wide-reaching implications for health. While there is currently no known cure, there are treatments, so knowing about it sooner rather than later is important.

    Spot The Signs

    There are two main kinds of symptoms, motor and non-motor.

    Motor symptoms include:

    • trembling that occurs when muscles are relaxed; often especially visible in the fingers
    • handwriting changes—not just because of the above, but also often getting smaller
    • blank expression, on account of fewer instruction signals getting through to the face
    • frozen gait—especially difficulty starting walking, and a reduced arm swing

    Non-motor symptoms include:

    • loss of sense of smell—complete, or a persistent reduction of
    • sleepwalking, or sleep-talking, or generally acting out dreams while asleep
    • constipation—on an ongoing basis
    • depression/anxiety, especially if there was no prior history of these conditions

    For more detail on each of these, as well as what steps you might want to take, check out what Dr. Luis Zayas has to say:

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    You might also like to read:

    Citicoline vs Parkinson’s (And More)

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  • The Wim Hof Method – by Wim Hof

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    In Wednesday’s main feature, we wrote about the Wim Hof Method, and/but only scratched the surface. Such is the downside of being a super-condensed newsletter! However, it does give us the opportunity to feature the book:

    The Wim Hof Method is definitely loudly trumpeted as “up there” with Atomic Habits or How Not To Die in the category of “life-changing” books. Why?

    Firstly, it’s a very motivational book. Hof is a big proponent of the notion “if you think you can or you think you can’t, you’re right” idea, practises what he preaches, and makes clear he’s not special.

    Secondly, it’s backed up with science. While it’s not a science-heavy book and that’s not the main focus, there are references to studies. Where physiological explanations are given for how certain things work, those explanations are sound. There’s no pseudoscience here, which is especially important for a book of this genre!

    What does the book have that our article didn’t? A good few things:

    • More about Hof’s own background and where it’s taken him. This is generally not a reason people buy books (unless they are biographies), but it’s interesting nonetheless.
    • A lot more advice, data, and information about Cold Therapy and how it can (and, he argues convincingly, should) be built into your life.
    • A lot about breathing exercises that we just didn’t cover at all in our article, but is actually an important part of the Wim Hof Method.
    • More about stepping through the psychological barriers that can hold us back.

    Bottom line: this book offers benefits that stretch into many areas of life, from some simple habits that can be built.

    Pick up your copy of The Wim Hof Method from Amazon today!

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  • Food Expiration Dates Don’t Mean What Most People Think They Mean

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Have you ever wondered why rock salt that formed during the Precambrian era has a label on it saying that it expires next month? To take something more delicate, how about eggs that expire next Thursday; isn’t that oddly specific for something that is surely affected by many variables? What matters, and what doesn’t?

    Covering their assets

    The US in particular wastes huge amounts of food, with 37% of food waste coming from households. Confusion over date labels is a major contributor, accounting for 20% of household food waste. Many people misinterpret these labels, often discarding food that is still safe to eat—which is good for the companies selling the food, because then they get to sell you more.

    Date labels were introduced in the 70s with the “open dating” system to indicate optimal freshness, not safety. These dates are often conservative, set by manufacturers to ensure food is consumed at its best quality and encourage repeat purchases. However, many foods remain safe well past their labeled dates, including shelf-stable items like pasta, rice, and canned goods, as well as frozen foods stored properly.

    Some foods do pose safety risks, especially meat and dairy products, as well as many grain-based foods, all of which which can harbor harmful bacteria. Infant formula labels are strictly regulated for safety. However, most date labels are not linked to health risks, leading to unnecessary waste.

    When it comes down to it, our senses of sight, smell, and taste are more reliable than dates on packaging. Some quick pointers and caveats:

    • If it has changed color in some way that’s not associated with a healthily ripening fruit or vegetable, that’s probably bad
    • If it is moldy, that’s probably bad (but the degree of badness varies from food to food; see the link beneath today’s video for more on that)
    • If a container has developed droplets of water on the inside when it didn’t have those before, that’s probably bad (it means something is respiring, and is thus alive, that probably shouldn’t be)
    • If it smells bad, that’s probably bad—however this is not a good safety test, because a bad smell may often mean you are inhaling mold spores, which are not good for your lungs.
    • If it tastes different than that food usually does, that’s probably bad (especially if it became bitter, pungent, tangy, sour, or cheesy, and does nor normally taste that way).

    Some places have trialled clearer labelling, for example a distinction between “expires” and merely “best before”, but public awareness about the distinction is low. Some places have trialled removing dates entirely, to oblige the consumer to use their own senses instead. This is good for the seller in a different way than household food waste is, because it means the seller will have less in-store waste (because they can still sell something that might previously have been labelled as expired).

    For more on all of this, enjoy:

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    Take care!

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  • Needle Pain Is a Big Problem for Kids. One California Doctor Has a Plan.

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    Almost all new parents go through it: the distress of hearing their child scream at the doctor’s office. They endure the emotional torture of having to hold their child down as the clinician sticks them with one vaccine after another.

    “The first shots he got, I probably cried more than he did,” said Remy Anthes, who was pushing her 6-month-old son, Dorian, back and forth in his stroller in Oakland, California.

    “The look in her eyes, it’s hard to take,” said Jill Lovitt, recalling how her infant daughter Jenna reacted to some recent vaccines. “Like, ‘What are you letting them do to me? Why?’”

    Some children remember the needle pain and quickly start to internalize the fear. That’s the fear Julia Cramer witnessed when her 3-year-old daughter, Maya, had to get blood drawn for an allergy test at age 2.

    “After that, she had a fear of blue gloves,” Cramer said. “I went to the grocery store and she saw someone wearing blue gloves, stocking the vegetables, and she started freaking out and crying.”

    Pain management research suggests that needle pokes may be children’s biggest source of pain in the health care system. The problem isn’t confined to childhood vaccinations either. Studies looking at sources of pediatric pain have included children who are being treated for serious illness, have undergone heart surgeries or bone marrow transplants, or have landed in the emergency room.

    “This is so bad that many children and many parents decide not to continue the treatment,” said Stefan Friedrichsdorf, a specialist at the University of California-San Francisco’s Stad Center for Pediatric Pain, speaking at the End Well conference in Los Angeles in November.

    The distress of needle pain can follow children as they grow and interfere with important preventive care. It is estimated that a quarter of all adults have a fear of needles that began in childhood. Sixteen percent of adults refuse flu vaccinations because of a fear of needles.

    Friedrichsdorf said it doesn’t have to be this bad. “This is not rocket science,” he said.

    He outlined simple steps that clinicians and parents can follow:

    • Apply an over-the-counter lidocaine, which is a numbing cream, 30 minutes before a shot.
    • Breastfeed babies, or give them a pacifier dipped in sugar water, to comfort them while they’re getting a shot.
    • Use distractions like teddy bears, pinwheels, or bubbles to divert attention away from the needle.
    • Don’t pin kids down on an exam table. Parents should hold children in their laps instead.

    At Children’s Minnesota, Friedrichsdorf practiced the “Children’s Comfort Promise.” Now he and other health care providers are rolling out these new protocols for children at UCSF Benioff Children’s Hospitals in San Francisco and Oakland. He’s calling it the “Ouchless Jab Challenge.”

    If a child at UCSF needs to get poked for a blood draw, a vaccine, or an IV treatment, Friedrichsdorf promises, the clinicians will do everything possible to follow these pain management steps.

    “Every child, every time,” he said.

    It seems unlikely that the ouchless effort will make a dent in vaccine hesitancy and refusal driven by the anti-vaccine movement, since the beliefs that drive it are often rooted in conspiracies and deeply held. But that isn’t necessarily Friedrichsdorf’s goal. He hopes that making routine health care less painful can help sway parents who may be hesitant to get their children vaccinated because of how hard it is to see them in pain. In turn, children who grow into adults without a fear of needles might be more likely to get preventive care, including their yearly flu shot.

    In general, the onus will likely be on parents to take a leading role in demanding these measures at medical centers, Friedrichsdorf said, because the tolerance and acceptance of children’s pain is so entrenched among clinicians.

    Diane Meier, a palliative care specialist at Mount Sinai, agrees. She said this tolerance is a major problem, stemming from how doctors are usually trained.

    “We are taught to see pain as an unfortunate, but inevitable side effect of good treatment,” Meier said. “We learn to repress that feeling of distress at the pain we are causing because otherwise we can’t do our jobs.”

    During her medical training, Meier had to hold children down for procedures, which she described as torture for them and for her. It drove her out of pediatrics. She went into geriatrics instead and later helped lead the modern movement to promote palliative care in medicine, which became an accredited specialty in the United States only in 2006.

    Meier said she thinks the campaign to reduce needle pain and anxiety should be applied to everyone, not just to children.

    “People with dementia have no idea why human beings are approaching them to stick needles in them,” she said. And the experience can be painful and distressing.

    Friedrichsdorf’s techniques would likely work with dementia patients, too, she said. Numbing cream, distraction, something sweet in the mouth, and perhaps music from the patient’s youth that they remember and can sing along to.

    “It’s worthy of study and it’s worthy of serious attention,” Meier said.

    This article is from a partnership that includes KQED, NPR, and KFF Health News.

    KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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    KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

    Subscribe to KFF Health News’ free Morning Briefing.

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