
Saffron For The Brain (& More)
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Saffron For The Brain (& More)
In yesterday’s edition of 10almonds, one of the items in the “health news from around the world” section was:
Clinical trial finds herbal medicine Sailuotong effective for brain health in older people
But, what is it?
❝SaiLuoTong (SLT) is a modern compound Chinese herbal medicine preparation in capsule form containing standardized extracts of Panax ginseng, Ginkgo biloba, and Crocus sativus L❞
We’ve written previously about ginseng and ginkgo biloba:
So, what’s this about Crocus sativus L.?
That is the plant better known as saffron. And, for all its wide availability (your local supermarket probably has at least a tiny amount in the spice section), there’s a reason we don’t see much of it:
❝Saffron blooms only once a year and should be collected within a very short duration. It is picked during 3–4 weeks in October-November. The method for the cultivation of saffron contributes greatly to its high price. According to some reports, this species is a sterile triploid and so does not produce fertile seeds. Germination can take 1–6 months at 18°C. It takes 3 years for plants to flower from seed.❞
Source: Crocus sativus L.: A comprehensive review
That’s fascinating, but what does it do for us?
Well, in the words of El Midaoui et al. (2022):
❝In the frame of a double-blind-placebo-controlled study, 30 mg per day supplementation with saffron for 16 weeks resulted in improved cognitive function in patients suffering from mild to moderate Alzheimer’s disease.
Moreover, the follow-up of this study in which the authors evaluated the effects of saffron (30 mg/day) for 22 weeks showed that saffron was as effective as donepezil in the treatment of mild-to-moderate Alzheimer’s disease❞
Read the full review: Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases
Not just that, but it also has powerful antioxidant and anti-inflammatory properties beyond the brain (though the brain is where research has been most focused, due to its neuroprotective effects).
(this, too, is a full research review in its own right; we’re getting a lot of “bang for buck” on papers today)
And more?
Yes, and more. Lots more. To bullet-pointify even just the abstract from another research review:
- Saffron has been suggested to be effective in the treatment of a wide range of disorders including coronary artery diseases, hypertension, stomach disorders, dysmenorrhea and learning and memory impairments.
- In addition, different studies have indicated that saffron has anti-inflammatory, anti-atherosclerotic, antigenotoxic and cytotoxic activities. (This is all good; the cytotoxic activities are about killing cancer cells)
- Antitussive effects of stigmas and petals of C. sativus and its components, safranal and crocin have also been demonstrated.
- The anticonvulsant and anti-Alzheimer properties of saffron extract were shown in human and animal studies.
- The efficacy of C. sativus in the treatment of mild to moderate depression was also reported in clinical trial.
- Administration of C. sativus and its constituents increased glutamate and dopamine levels in the brain in a dose-dependent manner.
- It also interacts with the opioid system to reduce withdrawal syndrome.
- C. sativus and its components can be considered as promising agents in the treatment of nervous system disorders.
For more details on any of those items, see:
The effects of Crocus sativus (saffron) and its constituents on nervous system: a review
Is it safe?
The effective dose is 30mg/kg and the LD50 is more than 20g/kg, so yes, it’s very safe. Given the price of it, this also means that if you’re the size of this writer (a little over 70kg, or a little over 150lbs) to poison yourself effectively you’d need to consume about 1.4kg of saffron at a time, which would cost well over $6,000.
Where can I get it?
Your local supermarket probably has a tiny amount in the spice section, or you can get better prices buying it in “bulk” online. Here’s an example product on Amazon, for your convenience
Enjoy!
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What’s the difference between food poisoning and gastro? A gut expert explains
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If you’ve got a dodgy tummy, diarrhoea and have been vomiting, it’s easy to blame a “tummy bug” or “off food”.
But which is it? Gastro or food poisoning?
What’s the difference anyway?
Andrey_Popov/Shutterstock What’s gastroenteritis?
Gastroenteritis, or gastro for short, is a gut infection caused by a virus, bacterium or other microbe.
The gut is teeming with cells including healthy microbes and the cells lining the gut. But when viruses, bacteria and other microbes start to invade your gut, they colonise, build up in large numbers and eventually cause the cells lining the gut to inflame. The “-itis” at the end of gastroenteritis means inflammation.
Gastroenteritis is extremely common. In Australia there are an estimated 17.2 million cases a year.
So where do these gastro-causing microbes come from? Eating contaminated food is often the source.
However you can acquire these microbes in other ways. For example, if you touch a surface where someone sick from viral gastroenteritis had vomited on, that virus could transfer to your hands. And if your hands touched your mouth, you in turn could contract viral gastroenteritis.
What’s food poisoning?
Food poisoning refers to getting sick from eating food contaminated with chemicals, microbes or toxins.
For example if you ate food contaminated with insecticides or methyl alcohol (methanol) that would count as food poisoning. If you ate puffer fish or poisonous mushrooms that would count too. But food poisoning doesn’t include the effects of eating a food you’re allergic to.
The vast majority of food poisonings are as a result of food contaminated by microbes and their toxins. When you eat or drink them it’s like a missile strike. The toxins in particular can rapidly cause inflammation and damage the lining of the gut.
To add to the confusion, food poisoning is often referred to as foodborne gastroenteritis.
Food poisoning (or foodborne gastroenteritis) is also common in Australia. It accounts for about one-third of all cases of gastroenteritis or an estimated 5.4 million cases every year.
How can we tell the two apart?
Both gastroenteritis and food poisoning have symptoms such as diarrhoea, vomiting, nausea, abdominal cramps, fever and headaches. But these symptoms can come on in different ways.
Viral gastroenteritis, such as with norovirus, usually causes symptoms 24–48 hours after exposure, which can last for one to two days.
But food poisoning after eating microbial toxins can come on very quickly. For example, toxins from the bacterium Staphylococcus aureus can cause symptoms within 30 minutes of eating contaminated food, such as undercooked meat. Fortunately, symptoms usually get better within 24 hours.
Symptoms don’t always come on so quickly in all cases of bacterial food poisoning. For example, it can take as long as 70 days between exposure to Listeria and symptoms occurring, although, on average it’s about three weeks. This long incubation period can make it difficult to work out if a particular food is responsible for someone getting sick.
As a general guide food poisoning occurs quite quickly (within hours of eating contaminated food) while gastroenteritis can take a day or more after eating to get sick. But there is no hard and fast rule.
It can take weeks from eating soft cheese contaminated with Listeria before you have symptoms. In Green/Shutterstock How do I prevent them?
The same precautions when handling food apply to preventing both gastroenteritis and food poisoning. These steps not only lower your risk of being affected in the first place, they lower your risk of you infecting others.
Wash your hands thoroughly with soap and water before preparing food. Use separate cutting boards and utensils for raw and cooked foods to help avoid cross-contamination. Cook food thoroughly and store it at safe temperatures.
Gastroenteritis can involve transmission of microbes through means other than food, for instance, via poo on your hands if you don’t wash your hands after using the toilet or after changing a child’s nappy. So wash your hands afterwards.
To prevent others from becoming sick, make sure you quickly disinfect contaminated surfaces thoroughly after someone vomits or has diarrhoea. First, put on gloves and wash surfaces with hot water and a detergent. Then disinfect using household bleach containing 0.1% hypochlorite.
How can I get better?
Treating both gastroenteritis and food poisoning focuses on preventing dehydration and relieving symptoms.
To avoid dehydration, drink plenty of fluids. For moderate or severe cases, you can buy commercial oral rehydration solution from a pharmacy.
You can also make your own oral rehydration solution by adding 6 teaspoons of sugar, ½ teaspoon of salt and ½ teaspoon of sodium bicarbonate to a litre of water. You can splash in some cordial for taste.
If symptoms are severe or persist you should see your GP or go to the emergency department.
Vincent Ho, Associate Professor and Clinical Academic Gastroenterologist, Western Sydney University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Five Advance Warnings of Multiple Sclerosis
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Five Advance Warnings of Multiple Sclerosis
First things first, a quick check-in with regard to how much you know about multiple sclerosis (MS):
- Do you know what causes it?
- Do you know how it happens?
- Do you know how it can be fixed?
If your answer to the above questions is “no”, then take solace in the fact that modern science doesn’t know either.
What we do know is that it’s an autoimmune condition, and that it results in the degradation of myelin, the “insulator” of nerves, in the central nervous system.
- How exactly this is brought about remains unclear, though there are several leading hypotheses including autoimmune attack of myelin itself, or disruption to the production of myelin.
- Treatments look to reduce/mitigate inflammation, and/or treat other symptoms (which are many and various) on an as-needed basis.
If you’re wondering about the prognosis after diagnosis, the scientific consensus on that is also “we don’t know”:
Read: Personalized medicine in multiple sclerosis: hope or reality?
this paper, like every other one we considered putting in that spot, concludes with basically begging for research to be done to identify biomarkers in a useful fashion that could help classify many distinct forms of MS, rather than the current “you have MS, but who knows what that will mean for you personally because it’s so varied” approach.
The Five Advance Warning Signs
Something we do know! First, we’ll quote directly the researchers’ conclusion:
❝We identified 5 health conditions associated with subsequent MS diagnosis, which may be considered not only prodromal but also early-stage symptoms.
However, these health conditions overlap with prodrome of two other autoimmune diseases, hence they lack specificity to MS.❞
So, these things are a warning, five alarm bells, but not necessarily diagnostic criteria.
Without further ado, the five things are:
- depression
- sexual disorders
- constipation
- cystitis
- urinary tract infections
❝This association was sufficiently robust at the statistical level for us to state that these are early clinical warning signs, probably related to damage to the nervous system, in patients who will later be diagnosed with multiple sclerosis.
The overrepresentation of these symptoms persisted and even increased over the five years after diagnosis.❞
Read the paper for yourself:
Hot off the press! Published only yesterday!
Want to know more about MS?
Here’s a very comprehensive guide:
National clinical guideline for diagnosis and management of multiple sclerosis
Take care!
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Protein Immune Support Salad
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How to get enough protein from a salad, without adding meat? Cashews and chickpeas have you more than covered! Along with the leafy greens and an impressive array of minor ingredients full of healthy phytochemicals, this one’s good for your muscles, bones, skin, immune health, and more.
You will need
- 1½ cups raw cashews (if allergic, omit; the chickpeas and coconut will still carry the dish for protein and healthy fats)
- 2 cans (2x 14oz) chickpeas, drained
- 1½ lbs baby spinach leaves
- 2 large onions, finely chopped
- 3 oz goji berries
- ½ bulb garlic, finely chopped
- 2 tbsp dessicated coconut
- 1 tbsp dried cumin
- 1 tbsp nutritional yeast
- 2 tsp chili flakes
- 1 tsp black pepper, coarse ground
- ½ tsp MSG, or 1 tsp low-sodium salt
- Extra virgin olive oil, for cooking
Method
(we suggest you read everything at least once before doing anything)
1) Heat a little oil in a pan; add the onions and cook for about 3 minutes.
2) Add the garlic and cook for a further 2 minutes.
3) Add the spinach, and cook until it wilts.
4) Add the remaining ingredients except the coconut, and cook for another three minutes.
5) Heat another pan (dry); add the coconut and toast for 1–2 minutes, until lightly golden. Add it to the main pan.
6) Serve hot as a main, or an attention-grabbing side:
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- Cashew Nuts vs Coconut – Which is Healthier?
- What Matters Most For Your Heart?
- Beyond Supplements: The Real Immune-Boosters!
- Goji Berries: Which Benefits Do They Really Have?
- Our Top 5 Spices: How Much Is Enough For Benefits?
Take care!
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Healing Spices – by Dr. Bharat Aggarwal & Debora Yost
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This is exactly what the subtitle promises it to be, and more. It’s actually herbs and spices, but definitely mostly spices, and includes the kinds found in even the smallest supermarket, to some you might not have heard of, and might need to order online.
We are treated to an explanation of the health-giving properties of each (and any potential contraindications), as well as the culinary properties, many tables of what goes with what and how and why, and even recipes to use them in. For the more adventurous, there’s even advice on how to grow, prepare, and store each of them.
An extra benefit is that everything is cross-linked such that you can look things up by spice or by health condition or by flavor profile, and find what you need and what’ll go with it.
The style is simple and informational, clearly laid-out in encyclopedic form.
Bottom line: this book should be in your kitchen (or related nearby kitchen-book-place).
Click here to check out Healing Spices, and advance your culinary repertoire!
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Inaccurate and misogynistic: why we need to make the term ‘hysterectomy’ history
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Have you had a tonsillectomy (your tonsils taken out), appendectomy (your appendix removed) or lumpectomy (removal of a lump from your breast)? The suffix “ectomy” denotes surgical removal of the named body part, so these terms give us a clear idea of what the procedure entails.
So why is the removal of the uterus called a hysterectomy and not a uterectomy?
The name hysterectomy is rooted in a mental health condition – “hysteria” – that was once believed to affect women. But we now know this condition doesn’t exist.
Continuing to call this significant operation a hysterectomy both perpetuates misogyny and hampers people’s understanding of what it is.
Panuwat Dangsungnoen/Getty Images From the defunct condition ‘hysteria’
Hysteria was a psychiatric condition first formally defined in the 5th century BCE. It had many symptoms, including excessive emotion, irritability, anxiety, breathlessness and fainting.
But hysteria was only diagnosed in women. Male physicians at the time claimed these symptoms were caused by a “wandering womb”. They believed the womb (uterus) moved around the body looking for sperm and disrupted other organs.
Because the uterus was blamed for hysteria, the treatment was to remove it. This procedure was called a hysterectomy. Sadly, many women had their healthy uterus unnecessarily removed and most died.
The word “hysteria” did originally came from the ancient Greek word for uterus, “hystera”. But the modern Greek word for uterus is “mitra”, which is where words such as “endometrium” come from.
Hysteria was only removed as an official medical diagnosis in 1980. It was finally recognised it does not exist and is sexist.
“Hysterectomy” should also be removed from medical terminology because it continues to link the uterus to hysteria.
Common but confusing
About one in three Australian women will have their uterus removed. A hysterectomy is one of the most common surgeries worldwide. It’s used to treat conditions including:
- abnormal uterine bleeding (heavy bleeding)
- uterine fibroids (benign tumours)
- uterine prolapse (when the uterus protrudes down into the vagina)
- adenomyosis (when the inner layer of the uterus grows into the muscle layer)
- cancer.
However, in a survey colleagues and I did of almost 500 Australian adults, which is yet to be published in a peer-reviewed journal, one in five people thought hysterectomy meant removal of the ovaries, not the uterus.
It’s true some hysterectomies for cancer do also remove the ovaries. A hysterectomy or partial hysterectomy is the removal of only the uterus, a total hysterectomy removes the uterus and cervix, while a radical hysterectomy usually removes the uterus, cervix, uterine tubes and ovaries.
There are important differences between these hysterectomies, so they should be named to clearly indicate the nature of the surgery.
Research has shown ambiguous terminology such as “hysterectomy” is associated with low patient understanding of the procedure and the female anatomy involved.
There are different types of hysterectomies, and the label can be confusing. Olena Yakobchuk/Shutterstock Uterectomy should be used for removal of the uterus, in combination with the medical terms for removal of the cervix, uterine tubes and ovaries as needed. For example, a uterectomy plus cervicectomy would refer to the removal of the uterus and the cervix.
This could help patients understand what is (and isn’t) being removed from their bodies and increase clarity for the wider public.
Other female body parts and procedures have male names
There are many eponyms (something named after a person) in anatomy and medicine, such as the Achilles tendon and Parkinson’s disease. They are almost exclusively the names of white men.
Eponyms for female anatomy and procedures include the Fallopian tubes, Pouch of Douglas, and Pap smear.
The anatomical term for Fallopian tubes is uterine tubes. “Uterine” indicates these are attached to the uterus, which reinforces their important role in fertility.
The Pouch of Douglas is the space between the rectum and uterus. Using the anatomical name (rectouterine pouch) is important, because this a common site for endometriosis and can explain any associated bowel symptoms.
Pap smear gives no indication of its location or function. The new cervical screening test is named exactly that, which clarifies it samples cells of the cervix. This helps people understand this tests for risk of cervical cancer.
Language matters in medicine and health care
Language in medicine impacts patient care and health. It needs to be accurate and clear, not include words associated with bias or discrimination, and not disempower a person.
For these reasons, the International Federation of Associations of Anatomists recommends removing eponyms from scientific and medical communication.
Meanwhile, experts have rightly argued it’s time to rename the hysterectomy to uterectomy.
A hysterectomy is an emotional procedure with not only physical but also psychological effects. Not directly referring to the uterus perpetuates the historical disregard of female reproductive anatomy and functions. Removing the link to hysteria and renaming hysterectomy to uterectomy would be a simple but symbolic change.
Educators, medical doctors and science communicators will play an important role in using the term uterectomy instead of hysterectomy. Ultimately, the World Health Organization should make official changes in the International Classification of Health Interventions.
In line with increasing awareness and discussions around female reproductive health and medical misogyny, now is the time to improve terminology. We must ensure the names of body parts and medical procedures reflect the relevant anatomy.
Theresa Larkin, Associate Professor of Medical Sciences, University of Wollongong
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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What You Should Have Been Told About The Menopause Beforehand
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What You Should Have Been Told About Menopause Beforehand
This is Dr. Jen Gunter. She’s a gynecologist, specializing in chronic pain and vulvovaginal disorders. She’s also a woman on a mission to demystify things that popular culture, especially in the US, would rather not talk about.
When was the last time you remember the menopause being referenced in a movie or TV show? If you can think of one at all, was it just played for laughs?
And of course, the human body can be funny, so that’s not necessarily the problem, but it sure would be nice if that weren’t all that there is!
So, what does Dr. Gunter want us to know?
It’s a time of changes, not an end
The name “menopause” is misleading. It’s not a “pause”, and those menses aren’t coming back.
And yet, to call it a “menostop” would be differently misleading, because there’s a lot more going on than a simple cessation of menstruation.
Estrogen levels will drop a lot, testosterone levels may rise slightly, mood and sleep and appetite and sex drive will probably be affected (progesterone can improve all these things!) and
not to mention butwe’re going to mention: vaginal atrophy, which is very normal and very treatable with a topical estrogen cream. Untreated menopause can also bring a whole lot of increased health risks (for example, heart disease, osteoporosis, and, counterintuitively given the lower estrogen levels, breast cancer).However, with a little awareness and appropriate management, all these things can usually be navigated with minimal adverse health outcomes.
Dr Gunter, for this reason, refers to it interchangeably as “the menopausal transition”. She describes it as being less like a cliff edge we fall off, and more like a bridge we cross.
Bridges can be dangerous to cross! But they can also get us safely where we’re going.
Ok, so how do we manage those things?
Dr. Gunter is a big fan of evidence-based medicine, so we’ll not be seeing any yonic crystals or jade eggs. Or “goop”.
See also: Meet Goop’s Number One Enemy
For most people, she recommends Menopausal Hormone Therapy (MHT), which falls under the more general category of Hormone Replacement Therapy (HRT).
This is the most well-evidenced, science-based way to avoid most of the risks associated with menopause.
Nevertheless, there are scare-stories out there, ranging from painful recommencement of bleeding, to (once again) increased risk of breast cancer. However, most of these are either misunderstandings, or unrelated to menopause and MHT, and are rather signs of other problems that should not be ignored.
To get a good grounding in this, you might want to read her Hormone Therapy Guide, freely available as a standalone section on her website. This series of posts is dedicated to hormone therapy. It starts with some basics and builds on that knowledge with each post:
Dr. Gunter’s Guide To The Hormone Menoverse
What about natural therapies?
There are some non-hormonal things that work, but these are mostly things that:
- give a statistically significant reduction in symptoms
- give the same statistically significant reduction in symptoms as placebo
As Dr. Gunter puts it:
❝While most of the studies of prescription medications for hot flashes have an appropriate placebo arm, this is rarely the case with so-called alternative therapies.
In fact, the studies here are almost always low quality, so it’s often not possible to conclude much.
Many reviews that look at these studies often end with a line that goes something like, “Randomized trials with a placebo arm, a low risk of bias, and adequate sample sizes are urgently needed.”
You should interpret this kind of conclusion as the polite way of saying, “We need studies that aren’t BS to say something constructive.”❞
However, if it works, it works, whatever its mechanism. It’s just good, when making medical decisions, to do so with the full facts!
For that matter, even Dr. Gunter acknowledges that while MHT can be lifechanging (in a positive way) for many, it’s not for everyone:
Informed Decisions: When Menopause Hormone Therapy Isn’t Recommended
Want to know more?
Dr. Gunter also has an assortment of books available, including The Menopause Manifesto (which we’ve reviewed previously), and some others that we haven’t, such as “Blood” and “The Vagina Bible”.
Enjoy!
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