What Your Hormones Mean For Weight Gain/Loss

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Kait Ann-Michelle describes herself as an “exercise scientist”, so what does that mean?

It means: she has an MS in exercise science, and an MA in clinical psychology.

With this mind, here’s what she has to say about hormones, weight gain/loss, and more:

What she wants us to know

Things to bear in mind over a certain age include:

  • That “certain age” is about 35. If that seems a lifetime ago to you, in a way it could well be, if your hormones were very different then. In popular culture, menopause is often played as a joke, and the bar for having passed it is usually set quite high. But since the hormonal changes themselves begin nearer 35, that’s where to start examining things.
    • A lot of online advice is woefully inappropriate for women over that age. Which is quite an injustice, as the 25–35 age range is such a tiny slice of life, yet it seems 80–90% of everything is aimed at it and tailored for it.
  • Estrogen gets talked about a lot, but there are many hormones involved in perimenopausal symptoms, as one thing affects another, and before you know it, estrogen, progesterone, and even non-sex hormones like cortisol, insulin, thyroid hormones, and melatonin can be entirely out from where they should be. And the longer this goes on, the more pronounced and deep-rooted the effects.
    • That goes for weight too, especially given the cortisol, insulin, and thyroid imbalances.
  • It’s not just a case of “one hormone affects another”, either. Yes, it’s that too, but for example if you have a mood swing due to low estrogen, which creates a stressful situation that ups your cortisol, then you don’t sleep so well, then the next day you are more tired so you skip the exercise you planned, and then and then and then… In short, lifestyle factors matter a lot too; they affect, and are affected by, our hormones.
    • All of this does tend to lead to weight gain if mismanaged.
  • She advises advises taking up HRT once it becomes appropriate (which for most women means around menopause—though other conditions can make HRT indicated earlier or in some cases not at all), and/but also focusing a lot on “lifestyle medicine”, that is to say, diet and exercise, good sleep, stress management, and so forth.
    • All of this does tend to lead to weight loss/maintenance if managed correctly.
  • She doesn’t recommend guesswork when it comes to hormones, though, and rather recommends getting regularly tested for: thyroid panel, estradiol, progesterone, DHEAS, testosterone, CBC, lipid panel, CMP, and hemoglobin A1c, as well as, ideally, “nice-to-have lab values” of cortisol, IGF1, vitamin D3, homocysteine, B12, SHBG, FSH, LH, iron, ferritin, and CRP.
    • That’s a lot of tests, so note, they’re in relative order of importance.

She notes that your doctor probably won’t want to do all those and will probably try to talk you out of them, so be prepared to advocate for yourself, as comprehensive lab work gives a full picture that the bare minimum does not.

For more details on all of these, enjoy:

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  • Asparagus vs Peas – Which is Healthier?
    Our Verdict When comparing asparagus to peas, we picked the peas. Why? Both have their merits! But… In terms of macros, peas have more than 2x the fiber, carbs, and protein, winning this first round easily. In the category of vitamins, asparagus has more of vitamins B5, E, and K, while peas have more of…

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  • How Long COVID May Actually Be Twice The Problem Previously Believed

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    Long COVID is no picnic. See for example: How To Triple Your Chances Of Getting The “Razorblade Throat” COVID Variant Or Long COVID

    And for that matter, here’s an interesting guest article: Can you die from long COVID? The answer is not so simple

    Actually, the answer is quite simple:

    • In practical terms, it’s “yes”.
    • In pedantic terms, it’s much like how technically nobody dies of AIDS (one gets AIDS, one’s immune system flatlines, and then one dies of pneumonia, or flu, or a cold, or something like that).
      • So, on the books, people aren’t directly dying of long COVID, they’re dying of other things because they have long COVID which has compromised their ability to deal with the other things.

    See also: falling doesn’t kill anyone!

    What kills people is other events that transpire after falling (i.e., starting from when you stop falling).

    With that in mind, onto the main topic for today…

    At a certain point in the COVID pandemic, various governments stopped tracking cases. If we were to be cynical, we might hypothesize that it was because the numbers were making them look bad.

    However, scientists have still done their best to keep track, and that goes for long COVID, too:

    Long COVID, wide effects

    Researchers (Dr. Jiazi Tian et al.) analyzed electronic health records from 457,950 adults with COVID across 58 US hospitals, and used a “precision phenotyping” system to identify long COVID cases that were missed by standard diagnostic coding.

    Bad news: they found that 16.28% of COVID patients developed post-acute sequelae of SARS-CoV-2 infection (“PASC”, more commonly called long COVID), or in other words, about 1 in 6 people.

    Why this matters: tracking has largely relied on inadequate coding, which previously identified fewer than 7% of patients. This latest study therefore strongly suggests* that the true burden of long COVID may be more than double commonly reported estimates.

    *In practical terms, it outright indicates this. But we will use the language the researchers used when describing their conclusions, and scientists are cautious sorts who say such things as “mounting evidence suggests that water may be wet; further research is warranted”.

    To take it further, and look at the knock-on effects and what this means for the individual with long COVID: among the 74,560 identified long COVID cases, 66,587 people (89.31%) developed at least one chronic condition requiring ongoing management.

    A lot of this has previously flown under the radar, because while many people have been receiving medical care for new symptoms and diseases after COVID infection, those conditions are often recorded separately, rather than being recognized and recorded as part of long COVID. As a result, health systems and policymakers have tended to underestimate the scale of the problem.

    Further, and perhaps even more concerningly, the study also found that long COVID prevalence has continued to increase over time rather than declining. This has thus been presented as evidence of an accumulating burden of chronic illness, rather than a temporary legacy of the early pandemic.

    You can read the paper itself, here: Long COVID Persistence and Surveillance Gaps Across 58 US Hospitals

    Want to learn more?

    Check out:

    What Can Be Done About Long COVID? ← scientists have found a possible cure, a procedure known as epipharyngeal abrasive therapy, which as enjoyable as it sounds, and is not yet proven to cure it completely (although to give it its due, the science so far really is promising)

    Take care!

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  • The Origin of Everyday Moods – by Dr. Robert Thayer

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    First of all, what does this title mean by “everyday moods”? By this the author is referring to the kinds of moods we have just as a matter of the general wear-and-tear of everyday life—not the kind that come from major mood disorders and/or serious trauma.

    The latter kinds of mood take less explaining, in any case. Dr. Thayer, therefore, spends his time on the less obvious ones—which in turn are the ones that affect most of the most, every day.

    Critical to Dr. Thayer’s approach is the mapping of moods by four main quadrants:

    1. High energy, high tension
    2. High energy, low tension
    3. Low energy, high tension
    4. Low energy, low tension

    …though this can be further divided into 25 sectors, if we rate each variable on a scale of 0–4. But for the first treatment, it suffices to look at whether energy and tension are high or low, respectively, and which we’d like to have more or less of.

    Then (here be science) how to go about achieving that in the most efficient, evidence-based ways. So, it’s not just a theoretical book; it has great practical value too.

    The style of the book is accessible, and walks a fine line between pop-science and hard science, which makes it a great book for laypersons and academics alike.

    Bottom line: if you’d like the cheat codes to improve your moods and lessen the impact of bad ones, this is the book for you.

    Click here to check out The Origin of Everyday Moods, and manage yours!

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  • Black Beans vs Pinto Beans – Which is Healthier?

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    Our Verdict

    When comparing black beans to pinto beans, we picked the pinto beans.

    Why?

    Both of these beans won all their previous comparisons, so it’s no surprise that this one was very close. Despite their different appearance, taste, and texture, their nutritional profiles are almost identical:

    In terms of macros, pinto beans have a tiny bit more protein, carbs, and fiber. So, a nominal win for pinto beans, but again, the difference is very slight.

    When it comes to vitamins, black beans have more of vitamins A, B1, B3, and B5, while pinto beans have more of vitamins B2, B6, B9, C, E, and K. Superficially, again this is nominally a win for pinto beans, but in most cases the differences are so slight as to be potentially the product of decimal place rounding.

    In the category of minerals, black beans have more calcium, copper, iron, and phosphorus, while pinto beans have more magnesium, manganese, selenium, and zinc. That’s a 4:4 tie, but the only one with a meaningful margin of difference is selenium (of which pinto beans have 4x more), so we’re calling this one a very modest win for pinto beans.

    All in all, adding these up makes for a “if we really are pressed to choose” win for pinto beans, but honestly, enjoy either in accordance with your preference (this writer prefers black beans!), or better yet, both.

    Want to learn more?

    You might like to read:

    What’s Your Plant Diversity Score?

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  • Why do some young people use Xanax recreationally? What are the risks?

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    Anecdotal reports from some professionals have prompted concerns about young people using prescription benzodiazepines such as Xanax for recreational use.

    Border force detections of these drugs have almost doubled in the past five years, further fuelling the worry.

    So why do young people use them, and how do the harms differ to those used as prescribed by a doctor?

    Dragana Gordic/Shutterstock

    What are benzodiazepines?

    You might know this large group of drugs by their trade names. Valium (diazepam), Xanax (alprazolam), Normison (temazepam) and Rohypnol (flunitrazepam) are just a few examples. Sometimes they’re referred to as minor tranquillisers or, colloquially, as “benzos”.

    They increase the neurotransmitter gamma aminobutyric acid (GABA). GABA reduces activity in the brain, producing feelings of relaxation and sedation.

    Unwanted side effects include drowsiness, dizziness and problems with coordination.

    Benzodiazepines used to be widely prescribed for long-term management of anxiety and insomnia. They are still prescribed for these conditions, but less commonly, and are also sometimes used as part of the treatment for cancer, epilepsy and alcohol withdrawal.

    Long-term use can lead to tolerance: when the effect wears off over time. So you need to use more over time to get the same effect. This can lead to dependence: when your body becomes reliant on the drug. There is a very high risk of dependence with these drugs.

    When you stop taking benzodiazepines, you may experience withdrawal symptoms. For those who are dependent, the withdrawal can be long and difficult, lasting for several months or more.

    So now they are only recommended for a few weeks at most for specific short-term conditions.

    How do people get them? And how does it make them feel?

    Benzodiazepines for non-medical use are typically either diverted from legitimate prescriptions or purchased from illicit drug markets including online.

    Some illegally obtained benzodiazepines look like prescription medicines but are counterfeit pills that may contain fentanyl, nitazenes (both synthetic opioids) or other potent substances which can significantly increase the risk of accidental overdose and death.

    When used recreationally, benzodiazepines are usually taken at higher doses than those typically prescribed, so there are even greater risks.

    The effect young people are looking for in using these drugs is a feeling of profound relaxation, reduced inhibition, euphoria and a feeling of detachment from one’s surroundings. Others use them to enhance social experiences or manage the “comedown” from stimulant drugs like MDMA.

    There are risks associated with using at these levels, including memory loss, impaired judgement, and risky behaviour, like unsafe sex or driving.

    Some people report doing things they would not normally do when affected by high doses of benzodiazepines. There are cases of people committing crimes they can’t remember.

    When taken at higher doses or combined with other depressant drugs such as alcohol or opioids, they can also cause respiratory depression, which prevents your lungs from getting enough oxygen. In extreme cases, it can lead to unconsciousness and even death.

    Using a high dose also increases risk of tolerance and dependence.

    Is recreational use growing?

    The data we have about non-prescribed benzodiazepine use among young people is patchy and difficult to interpret.

    The National Drug Strategy Household Survey 2022–23 estimates around 0.5% of 14 to 17 year olds and and 3% of 18 to 24 year olds have used a benzodiazepine for non medical purposes at least once in the past year.

    The Australian Secondary Schools Survey 2022–23 reports that 11% of secondary school students they surveyed had used benzodiazepines in the past year. However they note this figure may include a sizeable proportion of students who have been prescribed benzodiazepines but have inadvertently reported using them recreationally.

    In both surveys, use has remained fairly stable for the past two decades. So only a small percentage of young people have used benzodiazepines without a prescription and it doesn’t seem to be increasing significantly.

    Reports of more young people using benzodiazepines recreationally might just reflect greater comfort among young people in talking about drugs and drug problems, which is a positive thing.

    Prescribing of benzodiazepines to adolescents or young adults has also declined since 2012.

    What can you do to reduce the risks?

    To reduce the risk of problems, including dependence, benzodiazepines should be used for the shortest duration possible at the lowest effective dose.

    Benzodiazepines should not be taken with other medicines without speaking to a doctor or pharmacist.

    You should not drink alcohol or take illicit drugs at the same time as using benzodiazepines.

    Person takes Xanax out of pack
    Benzodiazepines shouldn’t be taken with other medicines, without the go-ahead from your doctor or pharmacist. Cloudy Design/Shutterstock

    Counterfeit benzodiazepines are increasingly being detected in the community. They are more dangerous than pharmaceutical benzodiazepines because there is no quality control and they may contain unexpected and dangerous substances.

    Drug checking services can help people identify what is in substances they intend to take. It also gives them an opportunity to speak to a health professional before they use. People often discard their drugs after they find out what they contain and speak to someone about drug harms.

    If people are using benzodiazepines without a prescription to self manage stress, anxiety or insomnia, this may indicate a more serious underlying condition. Psychological therapies such as cognitive behaviour therapy, including mindfulness-based approaches, are very effective in addressing these symptoms and are more effective long term solutions.

    Lifestyle modifications – such as improving exercise, diet and sleep – can also be helpful.

    There are also other medications with a much lower risk of dependence that can be used to treat anxiety and insomnia.

    If you or someone you know needs help with benzodiazepine use, Reconnexions can help. It’s a counselling and support service for people who use benzodiazepines.

    Alternatively, CounsellingOnline is a good place to get information and referral for treatment of benzodiazepine dependence. Or speak to your GP. The Sleep Health Foundation has some great resources if you are having trouble with sleep.

    Nicole Lee, Adjunct Professor at the National Drug Research Institute (Melbourne based), Curtin University and Suzanne Nielsen, Professor and Deputy Director, Monash Addiction Research Centre, Monash University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Can Reflexology Shoes Improve Your Focus?

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    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    No question/request too big or small 😎

    ❝What about shoes with insoles for reflexology, like the new ones with neuroscience claims. Are they legit?❞

    First, a disclaimer-laden answer: probably by “legit” you mean “do they work to improve brain function?”, but it’s hard to uncouple “legit” from “legitimate” in the litigious sense. So, we will say, we are but a humble health science publication, and cannot comment on the legality of any company’s products or claims.

    We can comment on more concrete scientific questions though, such as: does the evidence support claims that such shoes improve brain function?

    In which case, the answer is: no

    What you have to bear in mind is how a lot of companies will make claims that are technically true (for legal reasons) but functionally meaningless (in any practical sense that most readers would read it).

    For example, let’s look at one such example that’s been making headlines lately, perhaps it’s even what you saw. It’s Nike’s new “neuroscience-based footwear”, which they describe with such statements as:

    Nike is launching a new type of shoe designed to help athletes lock in their mindset pre- and post-competition.

    The Mind 001 and Mind 002 are the first neuroscience-based footwear from Nike that tap into the mind-body connection by activating sensory receptors in the feet.

    Nike is introducing its first neuroscience-based footwear: two mind-altering silhouettes designed to help athletes lock in their mindset before and after competition. Scientifically shown to activate key sensory areas of the brain via underfoot stimulation, the Nike Mind 001 mule and Mind 002 sneaker deepen an athlete’s awareness, helping ground them in their bodies and bring them back to the present moment.

    Source: Nike Debuts its First Neuroscience-Based Footwear to Help Athletes Feel Calm, Focused and Present

    These sound like strong claims, but let’s break it down a little:

    designed to help athletes lock in their mindset pre- and post-competition

    When this writer was small, she designed a pair of shoes to help her walk on water (there were shoe-sized pieces of wood attached under them, on the basis that wood floats).

    Were they designed to help our intrepid writer to walk on water? Yes, they were. That was literally what they were designed to do.

    Did they actually enable her to walk on water? No, they did not.

    So, always watch out for such phrases as “designed to”, “intended to”, “aimed at helping”, and so forth.

    Now, as for…

    Scientifically shown to activate key sensory areas of the brain via underfoot stimulation

    That’s a fair claim! But it’s also not what it might seem like. The reality is, anything that you can experience will activate key sensory areas in the brain. If it didn’t, then you wouldn’t experience it, because how could you, if it didn’t activate the relevant sensory areas in your brain?

    And so on, with various other true claims.

    Can they help anything?

    Yes! Shoes are very relevant things for our health.

    For example, shoes with “zero-drop”, i.e. with no incline/decline, and the inside sole of the foot is parallel to the floor (so, not like the featured image for this article, which are by no means high heels, but you can see the heel is raised more than the toes, and there’s a gradient between the two, as is common in most “flat” shoes that aren’t really flat), support good foot health for most people, and foot health is indeed the foundation of a lot of other good health, much like if your car tires are bad, the rest of your car won’t stay in good condition for long.

    We wrote about the zero-drop issue here: Steps For Keeping Your Feet A Healthy Foundation

    …which is consistent with such science as: Foot strike patterns and collision forces in habitually barefoot versus shod runners

    However, some other things are less evidence-based, for example:

    Are Grounding Mats Grounded In Good Science?

    …and:

    Reflexology: What The Science Says

    Want to learn more?

    You might also like:

    The Foot Book – by Dr. Todd Brennan & Dr. Leslie Johnston

    Take care!

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  • Xylitol: Cavity Fighter Or Gut Disruptor?

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    Dr. Michelle Jorgensen explains:

    The dose makes the poison

    Xylitol is a natural sugar alcohol found in fruits and vegetables, and can also be synthesized in a lab. It neutralizes acids in the mouth, thus helping to prevent cavities.

    Concerns about gut microbiome disruption become relevant only when xylitol is consumed in large amounts. The amount used in tooth powder and mouthwash is very small, and most of it is not swallowed (only about 10%, in the case of normal use).

    To match harmful levels found in animal studies, you’d need to consume about 13 jars of tooth powder per day. So don’t do that.

    For more on all of this, enjoy:

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    Want to learn more?

    You might also like:

    Xylitol vs Erythritol – Which is Healthier? ← the answer is xylitol, but this does discuss a concern not mentioned here, which is xylitol’s pro-thrombotic effect.

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