The Meds That Impair Decision-Making

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Impairment to cognitive function is often comorbid with Parkinson’s disease. That is to say: it’s not a symptom of Parkinson’s, but it often occurs in the same people. This may seem natural: after all, both are strongly associated with aging.

However, recent (last month, at time of writing) research has brought to light a very specific way in which medication for Parkinson’s may impair the ability to make sound decisions.

Obviously, this is a big deal, because it can affect healthcare decisions, financial decisions, and more—greatly impacting quality of life.

See also: Age-related differences in financial decision-making and social influence

(in which older people were found more likely to be influenced by the impulsive financial preferences of others than their younger counterparts, when other factors are controlled for)

As for how this pans out when it comes to Parkinson’s meds…

Pramipexole (PPX)

This drug can, due to an overlap in molecular shape, mimic dopamine in the brains of people who don’t have enough—such as those with Parkinson’s disease. This (as you might expect) helps alleviate Parkinson’s symptoms.

However, researchers found that mice treated with PPX and given a touch-screen based gambling game picked the high-risk, high reward option much more often. In the hopes of winning strawberry milkshake (the reward), they got themselves subjected to a lot of blindingly-bright flashing lights (the risk, to which untreated mice were much more averse, as this is very stressful for a mouse).

You may be wondering: did the mice have Parkinson’s?

The answer: kind of; they had been subjected to injections with 6-hydroxydopamine, which damages dopamine-producing neurons similarly to Parkinson’s.

This result was somewhat surprising, because one would expect that a mouse whose depleted dopamine was being mimicked by a stand-in (thus, doing much of the job of dopamine) would be less swayed by the allure of gambling (a high-dopamine activity), since gambling is typically most attractive to those who are desperate to find a crumb of dopamine somewhere.

They did find out why this happened, by the way, the PPX hyperactivated the external globus pallidus (also called GPe, and notwithstanding the name, this is located deep inside the brain). Chemically inhibiting this area of the brain reduced the risk-taking activity of the mice.

This has important implications for Parkinson’s patients, because:

  • on an individual level, it means this is a side effect of PPX to be aware of
  • on a research-and-development level, it means drugs need to be developed that specifically target the GPe, to avoid/mitigate this side effect.

You can read the study in full here:

Pramipexole Hyperactivates the External Globus Pallidus and Impairs Decision-Making in a Mouse Model of Parkinson’s Disease

Don’t want to get Parkinson’s in the first place?

While nothing is a magic bullet, there are things that can greatly increase or decrease Parkinson’s risk. Here’s a big one, as found recently (last week, at the time of writing):

Air Pollution and Parkinson’s Disease in a Population-Based Study

Also: knowing about its onset sooner rather than later is scary, but beneficial. So, with that in mind…

Recognize The Early Symptoms Of Parkinson’s Disease

Finally, because Parkinson’s disease is theorized to be caused by a dysfunction of alpha-synuclein clearance (much like the dysfunction of beta-amyloid clearance, in the case of Alzheimer’s disease), this means that having a healthy glymphatic system (glial cells doing the same clean-up job as the lymphatic system, but in the brain) is critical:

How To Clean Your Brain (Glymphatic Health Primer)

Take care!

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  • Older, Faster, Stronger – by Margaret Webb

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The author, now in her 60s, made it her mission in her 50s to become the best runner she could. Before that, she’d been a keen runner previously, but let things slip rather in her 40s. But the book’s not about her 40s, it’s about her 50s and onwards, and other female runners in their 50s, 60s, 70s, 80s, and even 90s.

    There’s a lot of this book that’s about people’s individual stories, and those should certainly be enough to prompt almost any reader that “if they can do it, I can”.

    A lot, meanwhile, is about health and exercise science, training methods, and what has worked for various later-life athletes, including the author. So, it’s also partway instruction manual, with plenty of reference to science and medical considerations too.

    Bottom line: sometimes, life throws us challenges. Sometimes, the best response is “Yeah? Bet” and surprise everyone.

    Click here to check out Older, Faster, Stronger, and become all those cool things!

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  • The Keys to Good Mental Wellbeing

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The Nine Keys To Good Mental Wellbeing

    Today’s main feature is a bit “pop psychology”, but it has its underpinnings in actual psychology, and is especially useful if approached from that angle.

    What it’s most popularly enjoyed as:

    • A personality-typing system.
    • People love little quizzes and identifiers and such.

    What it’s actually really useful as:

    • A tool for understanding why people (including ourselves) are the way we are
    • A foundational knowledge for living better ourselves, and helping others too

    This stems from the fairly simple principle, uncontroversial in psychology:

    • We have needs, desires, and aversions
    • We act in a way that tries to get our needs met and avoid suffering
    • Thus: Need/Fear → Motivation → Action

    The Enneagram

    The Enneagram (ἐννέα = “nine” in Ancient Greek) system posits that we each have one fundamental need/fear (from a list of nine) that’s strongest for us. A deep-seated insecurity/longing, that we’ll go to almost any lengths to try to meet. Sometimes, in good ways, sometimes, bad.

    The Nine Basic Fears/Insecurities, And Their Corresponding Needs/Desires:

    1. Fear of being a fundamentally bad, wrong person / Need to be good and correct
    2. Fear of being fundamentally unloveable / Need to be loved
    3. Fear of being fundamentally worthless / Need to be valued
    4. Fear of being like everyone else / Need to be different
    5. Fear of being useless / Need to be useful
    6. Fear of being outcast / Need to have a set place in the group
    7. Fear of missing out / Need to experience things
    8. Fear of being hurt or controlled / Need to be in control
    9. Fear of conflict / Need to be at peace

    Of course, most of us have most of these fears/needs to some extent, though usually one will stand out—especially if we aren’t managing it well. The less healthy our coping mechanisms, the more obvious it is how we’re trying to overcompensate in some fashion. For example:

    1. A person who fears being wrong and so becomes a perfectionist rules-abider to a fault
    2. A person who fears being unloveable, and so exaggerates problems to get pity, as the next best thing
    3. A person who fears being worthless, and so exaggerates their accomplishments in order to be admired and valued
    4. A person who fears being like everyone else, and so descends into a “nobody could ever possibly understand me” black hole of pathos.
    5. A person who fears being useless, so burns themself out trying to be an omnicompetent Leonardo da Vinci without ever actually taking the time to stop and smell the flowers as Leonardo did.
    6. A person who fears being outcast, so becomes clingy, passive-aggressive, and suspicious
    7. A person who fears missing out, so tries to experience all the things all the time, ruining their health with dizzying highs and crushing lows.
    8. A person who fears being hurt or controlled, so becomes aggressive and domineering
    9. A person who fears conflict, so shuts down at the slightest hint of it

    If we have healthier coping mechanisms, these same nine people can look a lot different, but in much more subtle ways because we’re not trying to overcompensate so badly:

    1. A person who lives their life rationally by principles that can be adapted as they learn
    2. A person who loves and is loved, as perhaps the most notable part of their character
    3. A person who sets reasonable goals and accomplishes them, and seeks to uplift others
    4. A person who creates and innovates, enriching their own life and the lives of others
    5. A person who is simply very competent and knowledgeable, without overstretching
    6. A person who is dependable and loyal, and a reliable part of something bigger than themself
    7. A person who is fun to be around and loves trying new things, while also knowing how to relax
    8. A person who develops their leadership skills and is a tower of strength for others
    9. A person who knows how to make peace and does so—by themself, and with others

    By being aware of our own fears/insecurities that may drive our motivations and thus underpin our behaviors, we can usually manage them in a much more mindful fashion. Same goes when it comes to managing interactions with other people, too:

    • Letting the Type 3 know you value them, not their accomplishments or what they can do for you.
    • Appreciating the Type 5’s (varied or specialist) skills and knowledge.
    • Giving love to a Type 2 unprompted, but on your own terms, with your own boundaries.
    • And so on for other types

    Or for yourself…

    • As a Type 8, remembering that you can let go sometimes and let someone else be in charge.
    • As a Type 1, catching yourself holding yourself (or others) to impossible standards, and then easing up on that a little.
    • As a Type 9, remembering to stand up for yourself and others, however gently, but firmly.
    • And so on for other types

    If you’re unsure what to focus on, ask yourself: what’s your worst nightmare or greatest daydream? Then work out what it is about that, that makes it feel so bad or good.

    Then, approach things mindfully. Catch yourself in your unhealthy coping mechanisms, and find healthy ones instead.

    What if I get my type wrong? Or I get someone else’s type wrong?

    Obviously it’s better to get them right for maximum effect, but you can never go too far wrong anyway… because we all have all nine of those qualities in us, it’s just a matter of how strong a factor each is for us. So in the worst case scenario, you’ll make someone feel more secure about something that was only a very minor insecurity for them, for example.

    Or in the case of your own type, you may mistakenly think you’re acing being the world’s healthiest Type 5, until you realize you’re actually a Type 3 who thought learning all those things would make you more worthy (spoiler: those things are great, but you’re worthy already). Again, not the end of the world! No matter what, you’re learning and growing, and that’s good.

    Want to delve further?

    Read: The Nine Enneagram Type Descriptions (Basic, but more detailed descriptions than the above)

    Read: How The Enneagram System Works (More complex. Now we’re getting into the more arcane stuff we didn’t have time for today—wings and lines, triads, health levels, directions of integration and disintegration, and more)

    Like learning from books? Here are our top two picks, depending on your learning style:

    We’d love to offer a quick free test here, but all the tests we could find either require paid registration or are wildly inaccurate, so we’ll not waste your time.

    However, we do also think that working it out for yourself is better, as it means you have a handle on what those ideas, fears, insecurities, desires, needs, really mean to you—that way you can actually use the information!

    We’ll close by repeating our previous advice: If you’re unsure what to focus on, ask yourself: what’s your worst nightmare or greatest daydream? Then work out what it is about those scenarios that make them so bad or good. That’ll help you find your real fears/needs, such that you can work on them.

    Good luck!

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  • Beat Osteoporosis with Exercise – by Dr. Karl Knopf

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    There are a lot of books about beating osteoporosis, and yet when it comes to osteoporosis exercises, it took us some work to find a good one. But, this one’s it!

    A lot of books give general principles and a few sample exercises. This one, in contrast, gives:

    • An overview of osteopenia and osteoporosis, first
    • A brief overview of non-exercise osteoporosis considerations
    • Principles for exercising a) to reduce one’s risk of osteoporosis b) if one has osteoporosis
    • Clear explanations of about 150 exercises that fit both categories

    This last item’s important, because a lot of popular advice is exercises that are only good for one or the other (given that a lot of things that strengthen a healthy person’s bones can break the bones of someone with osteoporosis), so having 150 exercises that are safe and effective in both cases, is a real boon.

    That doesn’t mean you have to do all 150! If you want to, great. But even just picking and choosing and putting together a little program is good.

    Bottom line: if you’d like a comprehensive guide to exercise to keep you strong in the face of osteoporosis, this is a great one.

    Click here to check out Beat Osteoporosis With Exercise, and stay strong!

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    Feel free to browse our articles while you do

    Here are 10 good reasons to give it a try; there are another 10 in the short (3:18) video:

    • Improves blood circulation
    • Improves blood pressure
    • Relaxes the body as a whole
    • Alleviates lower back tension
    • Eases headaches and migraines
    • Reduces knee pain
    • Relieves swelling in feet and ankles
    • Improves lymphatic flow
    • Stretches the hamstrings (and hip flexors, if you do it wide)
    • Helps quiet the mind

    As for the rest…

    Click Here If The Embedded Video Doesn’t Load Automatically

    PS: about that circulation… As a general rule of thumb, anything that slightly confuses the heart (anatomically, not romantically) will tend to have a beneficial effect, in moderation. This goes for being upside-down (as is partly the case here), and also for high-intensity interval training (HIIT):

    How To Do HIIT (Without Wrecking Your Body)

    Take care!

    Don’t Forget…

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  • Heart Smarter for Women – by Dr. Jennifer Mieres

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Mieres takes us through understanding our own heart disease risks as individuals rather than as averages. As the title suggests, she does assume a female readership, so if you are a man and have no female loved ones, this might not be the book for you. But aside from that, she walks us through examining risk in the context of age, other health conditions, lifestyle factors, and so forth—including not turning a blind eye to factors that might intersect, such as for example if a physical condition reduces how much we can exercise, or if there’s some reason we can’t follow the usual gold standard of heart-healthy diet.

    On which note, she does offer dietary advice, including information around recipes, meal-planning, and what things to always have in stock, as well as what things matter the most when it comes to what and how we eat.

    It’s not all lifestyle medicine though; Dr. Mieres gives due attention to many of the medications available for heart health issues—and the pros and cons of these.

    The style of the book is very simple and readable pop-science, without undue jargon, and with a generous glossary. As with many books of this genre, it does rely on (presumably apocryphal) anecdotes, though an interesting choice for this book is that it keeps a standing cast of four recurring characters, each to represent a set of circumstances and illustrate how certain things can go differently for different people, with different things then being needed and/or possible. Hopefully, any given reader will find themself represented at least moderately well somewhere in or between these four characters.

    Bottom line: this is a very informative and accessible book, that demystifies a lot of common confusions around heart health.

    Click here to check out Heart Smarter For Women, and take control of your health!

    Don’t Forget…

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  • Gut Renovation – by Dr. Roshini Raj, with Sheila Buff

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    Unless we actually feel something going on down there, gut health is an oft-neglected part of overall health—which is unfortunate, because invisible as it may often be, it affects so much.

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    She also does some mythbusting along the way, and advises about what things don’t make a huge difference, including what medications don’t have a lot of evidence for their usefulness.

    The style is easy-reading pop-science, with plenty of high-quality medical content.

    Reading between the lines, a lot of the book as it stands was probably written by the co-author, Sheila Buff, who is a professional ghostwriter and specializes in working closely with doctors to produce works that are readable and informative to the layperson while still being full of the doctor’s knowledge and expertise. So a reasonable scenario is that Dr. Raj gave her extensive notes, she took it from there, passed it back to her for medical corrections, and they had a little back and forth until it was done. Whatever their setup, the end result was definitely good!

    Bottom line: if you’d like a guide to gut health that’s practical and easy to read, while being quite comprehensive and certainly a lot more than “eat probiotics and fiber”, then this book is a fine choice.

    Click here to check out Gut Renovation, and renovate yours!

    Don’t Forget…

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