
The Surprising Food Compound That Fixes Leaky Gut
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First, what is leaky gut?
It’s when the barrier between the gut and the rest of the body gets punctured, and things that should definitely stay in the gut escape into the rest of the body.
You may be wondering: how does the gut get punctured and is this only a risk if someone’s stabbing or shooting us?
And the answer is: most often, the gut gets punctured from the inside, either by fungus (usually C. albicans) putting its roots through the intestinal walls, or by other adverse microbiome changes that result in a reduction in mucus and other components of gut’s selective barrier layer that usually allows nutrients to pass through while keeping unpleasantries contained.
You can read more about that, here: Making Friends With Your Gut (You Can Thank Us Later)
And more specifically, for the implications and extra considerations pertaining to this, you might want to check out:
- The Alzheimer’s Gut-Brain Connection—Caught On X-Ray!
- Spicy Foods & Your Gut ← it’s probably not what you might expect!
- Minimize The Harm Of Antibiotics
So, what’s this about a nutrient, or indeed an antinutrient, that can fix it?
Mighty phytic acid to the rescue!
We’ve written before about phytic acid, usually in the context of it being an antinutrient, that is to say, it reduces the absorption of some nutrients, especially certain minerals.
See for example its mentions in the following articles of ours:
- Brown Rice Protein: Strengths & Weaknesses
- Make Your Vegetables Work Better Nutritionally
- Sprout Your Seeds, Grains, Beans, Etc
…in which cases, usually we’re talking about soaking, cooking, and so forth to reduce the phytic acid content and resultant phytates.
A quick note before we continue: in nutrition science, phytic acid and phytates are closely related and in some contexts can even be interchangeable (them both being considered functionally the same antinutrient), but just to clarify…
- Phytic acid: the molecule itself, also known to its friends as inositol hexakisphosphate (InsP6), which plants use to store phosphorus, especially in seeds, grains, legumes, nuts, and seeds.
- Phytates: the salts formed when phytic acid binds to minerals such as calcium, magnesium, iron, zinc, or potassium. In foods and in the digestive tract, phytic acid mostly exists in these mineral-bound forms.
So for example:
- Phytic acid + calcium → calcium phytate
- Phytic acid + zinc → zinc phytate
- Phytic acid + iron → iron phytate
…and lo and behold, those are the minerals it stopped you from absorbing in those cases!
Now, researchers (Dr. Sujan Chatterjee et al.) have discovered that phytic acid also helps maintain the integrity of the intestinal barrier; when this pathway was disrupted in experimental models, the gut barrier became more permeable, and phytic acid supplementation restored much of the lost function.
Why/how this happens: Dr. Chatterjee and her teem found that phytic acid activates HDAC3, a protein that regulates genes involved in maintaining the gut lining; when HDAC3 activity falls, genes that can damage the intestinal barrier become more active, increasing intestinal permeability and inflammation.
So, in other words, a necessary part of a system was taken out, so the system stopped working properly!
This study also suggests that sometimes it’s one of the enzymes that’s lacking, and that restoring for example HDAC3 activity, if that be lacking, can help protect or repair the intestinal barrier.
You can read this paper in full, here: Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function
And you can read about what foods have often-high phytic acid contents when unprocessed (it’s a lot of edible grains, legumes, and nuts), here: Phytic Acid and Whole Grains for Health Controversy
…which may also explain why almonds improve gut barrier health, as we discussed here: What 47 Almonds Can Do For your Gut, Heart, Skin, & more
Want to learn more?
Do consider this very good book that we reviewed:
Heal Your Gut, Save Your Brain – by Dr. Partha Nandi
Enjoy!
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Apple vs Papaya – Which is Healthier?
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Our Verdict
When comparing apple to papaya, we picked the papaya.
Why?
Both do have their merits, but ultimately, it wasn’t close:
In terms of macros, apples have more fiber and carbs, while papaya has more protein. Since the protein is negligible and the fiber difference is greatest, this means a marginal win for apples here.
In the category of vitamins, apples are not higher in any vitamin, while papayas have more of vitamins A, B1, B3, B5, B7, B9, C, E, and K, for a total win in this round.
Looking at minerals, apples have the tiniest bit more phosphorus (so close that simply using slightly different soil could swing it), while papayas have more calcium, copper, iron, magnesium, manganese, potassium, selenium, and zinc, winning easily.
Adding up the sections makes for an overall win for papaya, but by all means enjoy either or both, as diversity is good, and apple’s fiber content is great!
Want to learn more?
You might like:
What Do The Different Kinds Of Fiber Do? 30 Foods That Rank Highest
Enjoy!
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Worried about feeding your baby solid foods? Here’s what you should know
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When you have a baby, mealtimes can be messy and stressful.
If you’re a new parent you may be unsure what, when, and how to feed your little one. And you may also worry about choking, particularly when it’s time to start feeding your baby solid foods.
For babies starting solids at the recommended age of six months, it’s important to offer foods in a variety of different ways. Purees can be a helpful starting point, but they shouldn’t be the only texture a baby experiences.
Research suggests not waiting too long to introduce lumpy or textured foods. Infants who start eating lumps at 10 months or later were more likely to develop feeding difficulties and become selective eaters.
So if you’re a parent, where do you start? And what other foods are good to try?
Jamie Grill/Getty Why texture matters
Mealtimes are crucial for a child’s development because they’re an opportunity to explore different textures and develop oral motor skills.
Imagine you’re eating a piece of toast. This involves performing a range of movements including holding, biting, chewing and swallowing. All of these actions require different muscles to work together, and only improve through practice. But that practice is only effective if it involves real food, as opposed to non-edible teething toys and isolated oral exercises like jaw opening and closing or cheek puffing.
When starting solid foods, many parents rely on purees and pouches as convenient ways to feed their babies. There’s nothing wrong with puree in itself. Many of our favourite foods resemble purees. Think of buttery mashed potato, yogurt, ricotta and applesauce.
The problem arises when purees and pouches become the only texture parents offer their babies, particularly early on. Babies who only eat pureed foods have less opportunity to develop the skills needed for eating and drinking. And research suggests children who frequently eat pouched foods are more likely to become fussy eaters.
So there’s nothing inherently bad about pureed foods. But feeding your baby varied foods gives them more opportunity to develop crucial oral motor skills.
Does it matter how I feed my baby?
There are various ways to start giving your baby solid foods.
One common approach is “baby-led weaning”. That’s where parents encourage their baby to feed themselves, rather than fully spoon-feeding them. This can encourage your baby to be more independent and explore food on their own. But it may also make mealtimes messier and more time-consuming for parents. And it can also feel daunting for parents who are concerned about choking.
However, one 2016 study found babies who feed themselves are no more likely to choke than babies who are spoon-fed. Foods which are suitable for baby-led weaning include strips of omelette, ripe avocado wedges or well-cooked corn on the cob. However, the researchers emphasised the importance of preparing foods appropriately and using risk minimisation strategies. These include avoiding high-risk foods such as popcorn, cutting round foods such as grapes and cherry tomatoes, and supervising babies whenever they eat.
An ‘in-between’ option for feeding is to offer your baby purees, while giving them a degree of independence. For example, you may pre-load a spoon for your baby to bring to their own mouth. You can also pair purees with larger foods, say a broccoli floret dipped in hummus. These combinations will help your baby develop eating skills while you become more confident with feeding your baby.
No matter what feeding approach you take, infant first aid training is a must for parents and carers. And if your child was born premature, has a developmental delay or has specific nutrition requirements, it’s best to speak to a paediatrician before giving them solid foods.
When you have a picky eater
Even if your baby transitions well to solid foods, toddlerhood can bring a new set of challenges.
Toddlers tend to be selective about what foods they do or don’t eat. They may also become more cautious around unfamiliar foods. These are both normal parts of a child’s development.
But problems can arise when parents pressure toddlers to eat food they don’t want to eat or when they aren’t hungry. Even small gestures, such as using a “spoon as aeroplane” or asking them to take “one more bite” in front of the TV or tablet, can put pressure on children. As a result your child may eat that next mouthful but, over time, they may develop a negative relationship with food and mealtimes.
As parents and carers, our role is to offer food at predictable times and in positive mealtime environments. Some ways to do that include:
- trusting they’ll eat as much as they need
- eating shared meals when possible
- modelling enjoyment of different foods during shared meals
- offering new foods alongside familiar favourites
- giving children multiple opportunities to see and try new foods, even if they don’t eat them the first time.
Unfortunately, babies and toddlers won’t love every meal you make them. But in time they’ll come to learn about, and even enjoy, a world of different textures and tastes.
Lillian Krikheli, Lecturer in Speech Pathology, La Trobe University and Samantha Turner, Lecturer in Speech Pathology, La Trobe University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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3 signs your diet is causing too much muscle loss – and what to do about it
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When trying to lose weight, it’s natural to want to see quick results. So when the number on the scales drops rapidly, it seems like we’re on the right track.
But as with many things related to weight loss, there’s a flip side: rapid weight loss can result in a significant loss of muscle mass, as well as fat.
So how you can tell if you’re losing too much muscle and what can you do to prevent it?
EvMedvedeva/Shutterstock Why does muscle mass matter?
Muscle is an important factor in determining our metabolic rate: how much energy we burn at rest. This is determined by how much muscle and fat we have. Muscle is more metabolically active than fat, meaning it burns more calories.
When we diet to lose weight, we create a calorie deficit, where our bodies don’t get enough energy from the food we eat to meet our energy needs. Our bodies start breaking down our fat and muscle tissue for fuel.
A decrease in calorie-burning muscle mass slows our metabolism. This quickly slows the rate at which we lose weight and impacts our ability to maintain our weight long term.
How to tell you’re losing too much muscle
Unfortunately, measuring changes in muscle mass is not easy.
The most accurate tool is an enhanced form of X-ray called a dual-energy X-ray absorptiometry (DXA) scan. The scan is primarily used in medicine and research to capture data on weight, body fat, muscle mass and bone density.
But while DEXA is becoming more readily available at weight-loss clinics and gyms, it’s not cheap.
There are also many “smart” scales available for at home use that promise to provide an accurate reading of muscle mass percentage.
Some scales promise to tell us our muscle mass. Lee Charlie/Shutterstock However, the accuracy of these scales is questionable. Researchers found the scales tested massively over- or under-estimated fat and muscle mass.
Fortunately, there are three free but scientifically backed signs you may be losing too much muscle mass when you’re dieting.
1. You’re losing much more weight than expected each week
Losing a lot of weight rapidly is one of the early signs that your diet is too extreme and you’re losing too much muscle.
Rapid weight loss (of more than 1 kilogram per week) results in greater muscle mass loss than slow weight loss.
Slow weight loss better preserves muscle mass and often has the added benefit of greater fat mass loss.
One study compared people in the obese weight category who followed either a very low-calorie diet (500 calories per day) for five weeks or a low-calorie diet (1,250 calories per day) for 12 weeks. While both groups lost similar amounts of weight, participants following the very low-calorie diet (500 calories per day) for five weeks lost significantly more muscle mass.
2. You’re feeling tired and things feel more difficult
It sounds obvious, but feeling tired, sluggish and finding it hard to complete physical activities, such as working out or doing jobs around the house, is another strong signal you’re losing muscle.
Research shows a decrease in muscle mass may negatively impact your body’s physical performance.
3. You’re feeling moody
Mood swings and feeling anxious, stressed or depressed may also be signs you’re losing muscle mass.
Research on muscle loss due to ageing suggests low levels of muscle mass can negatively impact mental health and mood. This seems to stem from the relationship between low muscle mass and proteins called neurotrophins, which help regulate mood and feelings of wellbeing.
So how you can do to maintain muscle during weight loss?
Fortunately, there are also three actions you can take to maintain muscle mass when you’re following a calorie-restricted diet to lose weight.
1. Incorporate strength training into your exercise plan
While a broad exercise program is important to support overall weight loss, strength-building exercises are a surefire way to help prevent the loss of muscle mass. A meta-analysis of studies of older people with obesity found resistance training was able to prevent almost 100% of muscle loss from calorie restriction.
Relying on diet alone to lose weight will reduce muscle along with body fat, slowing your metabolism. So it’s essential to make sure you’ve incorporated sufficient and appropriate exercise into your weight-loss plan to hold onto your muscle mass stores.
Strength-building exercises help you retain muscle. BearFotos/Shutterstock But you don’t need to hit the gym. Exercises using body weight – such as push-ups, pull-ups, planks and air squats – are just as effective as lifting weights and using strength-building equipment.
Encouragingly, moderate-volume resistance training (three sets of ten repetitions for eight exercises) can be as effective as high-volume training (five sets of ten repetitions for eight exercises) for maintaining muscle when you’re following a calorie-restricted diet.
2. Eat more protein
Foods high in protein play an essential role in building and maintaining muscle mass, but research also shows these foods help prevent muscle loss when you’re following a calorie-restricted diet.
But this doesn’t mean just eating foods with protein. Meals need to be balanced and include a source of protein, wholegrain carb and healthy fat to meet our dietary needs. For example, eggs on wholegrain toast with avocado.
3. Slow your weight loss plan down
When we change our diet to lose weight, we take our body out of its comfort zone and trigger its survival response. It then counteracts weight loss, triggering several physiological responses to defend our body weight and “survive” starvation.
Our body’s survival mechanisms want us to regain lost weight to ensure we survive the next period of famine (dieting). Research shows that more than half of the weight lost by participants is regained within two years, and more than 80% of lost weight is regained within five years.
However, a slow and steady, stepped approach to weight loss, prevents our bodies from activating defence mechanisms to defend our weight when we try to lose weight.
Ultimately, losing weight long-term comes down to making gradual changes to your lifestyle to ensure you form habits that last a lifetime.
At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can register here to express your interest.
Nick Fuller, Charles Perkins Centre Research Program Leader, University of Sydney
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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I’m So Effing Tired – by Dr. Amy Shah
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It’s easy sometimes to feel like we know more or less what we should be doing… If only we had the energy to get going!
- We know we want a better diet… But we don’t have the time/energy to cook so will go for the quickest option even when it’s not the best?
- We know we should exercise… But feel we just need to crash out on the couch for a bit first?
- We would dearly love to get better sleep… But our responsibilities aren’t facilitating that?
…and so on. Happily, Dr. Amy Shah is here with ways to cut through the Gordian Knot that is this otherwise self-perpetuating cycle of exhaustion.
Most of the book is based around tackling what Dr. Shah calls “the energy trifecta“:
- Hormone levels
- Immune system
- Gut health
You’ll note (perhaps with relief) that none of these things require an initial investment of energy that you don’t have… She’s not asking you to hit the gym at 5am, or magically bludgeon your sleep schedule into its proper place, say.
Instead, what she gives is practical, actionable, easy changes that don’t require much effort, to gently slide us back into the fast lane of actually having energy to do stuff!
In short: if you’ve ever felt like you’d like to implement a lot of very common “best practice” lifestyle advice, but just haven’t had the energy to get going, there’s more value in this handbook than in a thousand motivational pep talks.
Click here to check out “I’m So Effing Tired” and get on a better track of life!
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Magic mushrooms may one day treat anorexia, but not just yet
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Anorexia nervosa is a severe mental health disorder where people fear weight gain. Those with the disorder have distorted body image and hold rigid beliefs their body is too big. They typically manage this through restricted eating, leading to the serious medical consequences of malnutrition.
Anorexia has one of the highest death rates of any mental illness. Yet there are currently no effective drug treatments and the outcomes of psychotherapy (talk therapy) are poor. So we’re desperately in need of new and improved treatments.
Psilocybin, commonly known as magic mushrooms, is one such novel treatment. But while it shows early promise, you won’t see it used in clinical practice just yet – more research is needed to test if it’s safe and effective.
Ground Picture/Shutterstock What does treatment involve?
The treatment involves the patient taking a dose of psilocybin in a safe environment, which is usually a specifically set up clinic. The patient undergoes preparation therapy before the dosing session and integration therapy after.
Psilocybin, extracted from mushrooms, is a psychedelic, which means it can produce altered thinking, sense of time and emotions, and can often result in hallucinations. It also has the potential to shift patients out of their rigid thinking patterns.
Psilocybin is not administered alone but instead with combined structured psychotherapy sessions to help the patient make sense of their experiences and the changes to their thinking. This is an important part of the treatment.
What does the research show?
Research has shown improved effects of psilocybin-assisted psychotherapy after one or two dosing sessions, a couple of weeks apart. Most research to date has targeted depression.
Psilocybin has been found to increase cognitive flexibility – our ability to adjust our thinking patterns according to changing environments or demands. This is one of the ways researchers believe psilocybin might improve symptoms for conditions such as depression and alcohol use disorder, which are marked by rigid thinking styles.
People with anorexia similarly struggle with rigid thinking patterns. So researchers and clinicians have recently turned their attention to anorexia.
In 2023, a small pilot study of ten women with anorexia was published in the journal Nature Medicine. It showed psilocybin-assisted psychotherapy (with 25mg of psilocybin) was safe and acceptable. There were no significant side effects and participants reported having valuable experiences.
Although the trial was not a formal efficacy trial, 40% of the patients did have significant drops in their eating disorder behaviour.
However, the trial only had one dosing session and no long-term follow up, so further research is needed.
Researchers are still working out dosages and frequency. 24K-Production/Shutterstock A recent animal study using rats examined whether rigid thinking could be improved in rats when given psilocybin. After the psilocybin, rats gained weight and had more flexible thinking (using a reversal learning task).
These positive changes were related to the serotonin neurotransmitter system, which regulates mood, behaviour and satiety (feeling full).
Brain imaging studies in humans show serotonin disturbances in people with anorexia. Psilocybin-assisted psychotherapy is showing promise at modifying the serotonin disturbances and cognitive inflexibility that have been shown to be problematic in anorexia.
Research with animals can provide unique insights into the brain which can sometimes not be investigated in living humans. But animal models can never truly mimic human behaviour and the complex nature of chronic mental health conditions.
What’s next for research?
Further clinical trials in humans are very much needed – and are underway from a research team at the University of Sydney and ours at Swinburne.
Our trial will involve an initial 5mg dose followed by two subsequent doses of 25mg, several weeks apart. An initial low dose aims to help participants prepare for what is likely to be a new and somewhat unpredictable experience.
Our trial will examine the usefulness of providing psychotherapy that directly addresses body image disturbance. We are also investigating if including a family member or close friend in the treatment increases support for their loved one.
We’re investigating whether including a family member or close friend in treatment could help. Shutterstock Data from other mental health conditions has suggested that not everyone sees benefits, with some people having bad trips and a deterioration in their mental health. So this treatment won’t be for everyone. It’s important to work out who is most likely to respond and under what conditions.
New trials and those underway will be critical in understanding whether psilocybin-assisted psychotherapy is a safe and effective treatment for anorexia, and the optimal conditions to improve the patient’s response. But we are some way off from seeing this treatment in the clinic. One of the big issues being the cost of this intervention and how this will be funded.
Susan Rossell, Director Clinical Trials and Professor Cognitive Neuropsychiatry Centre for Mental Health and Brain Sciences, Swinburne University of Technology and Claire Finkelstein, Clinical Psychologist and PhD candidate, Swinburne University of Technology
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Inverse Vaccines for Autoimmune Diseases
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Inverse Vaccines for Autoimmune Diseases
This is Dr. Jeffrey Hubbell. He’s a molecular engineer, with a focus on immunotherapy, immune response, autoimmune diseases, and growth factor variants.
He’s held 88 patents, and was the recipient of the Society for Biomaterials’ Founders Award for his “long-term, landmark contributions to the discipline of biomaterials”, amongst other awards and honours that would make our article too long if we included them all.
And, his latest research has been about developing…
Inverse Vaccines
You may be thinking: “you mean diseases; he’s engineering diseases?”
And no, it’s not that. Here’s how it works:
Normally in the case of vaccine, it’s something to tell the body “hey, if you see something that looks like this, you should kill it on sight” and the body goes “ok, preparing countermeasures according to these specifications; thanks for the heads-up”
In the case of an inverse vaccine, it’s the inverse. It’s something to tell the body “hey, this thing you seem to think is a threat, it’s actually not, and you should leave it alone”.
Why this matters for people with autoimmune diseases
Normally, autoimmune diseases are treated in one or more of the following ways:
- Dampen the entire immune system (bad for immunity against actual diseases, obviously, and is part of why many immunocompromised people have suffered and died disproportionately from COVID, for example)
- Give up and find a workaround (a good example of this is Type 1 Diabetes, and just giving up on the pancreas not being constantly at war with itself, and living on exogenous insulin instead)
Neither of those are great.
What inverse vaccines do is offer a way to flag the attacked-in-error items as acceptable things to have in the body. Those might be things that are in our body by default, as in the case of many autoimmune diseases, or they may even be external items that should be allowed but aren’t, as in the case of gluten, in the context of Celiac disease.
The latest research is not yet accessible for free, alas, but you can read the abstract here:
Or if you prefer a more accessible pop-science approach, here’s a great explanatory article:
“Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases
Where can we get such inverse vaccines?
❝There are no clinically approved inverse vaccines yet, but we’re incredibly excited about moving this technology forward❞
~ Dr. Jeffrey Hubbell
But! Lest you be disappointed, you can get in line already, in the case of the Celiac disease inverse vaccine, if you’d like to be part of their clinical trial:
Click here to see if you are eligible to be part of their clinical trial
If you’re not up for that, or if your autoimmune disease is something else (most of the rest of their research is presently focusing on Multiple Sclerosis and Type 1 Diabetes), then:
- The phase 1 MS trial is currently active, estimated completion in summer 2024.
- They are in the process of submitting an investigational new drug (IND) application for Type 1 Diabetes
- This is the first step to starting clinical safety and efficacy trials
…so, watch this space!
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