The Pills That Reduce Alcohol Consumption

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Alcohol is, of course, unhealthy. Not even the famous “small glass of red” is recommended:

Can We Drink To Good Health? ← this was mostly about the purported heart health benefits, and the answer to the question is: no, we cannot, and as WHO has declared, “the only safe amount of alcohol is zero”)

See also: How Much Alcohol Does It Take To Increase Cancer Risk? ← the answer is “any” (although, the risk is dose-dependent, so if not abstaining completely, less is still better than more)

A lot of why people think that moderate drinking is healthy, that widespread popular belief stems from flawed associative studies that compared the following two categories of people:

  • non-drinkers, including many former heavy drinkers who stopped because they realized the harm they were doing to themselves
  • light drinkers, who have been able to continue drinking because of their otherwise good health

In other words, they looked at now-teetotal former alcoholics whose health was ruined by drinking and concluded “aha, non-drinkers have bad health; clearly some drinking is best”.

You can read more about this and how that flawed research was later disproven once the confounding variables were removed, here: Are You Making This Alcohol Mistake?

Drugs to the rescue!

“Take drugs to reduce the consumption of alcohol (another drug)” may seem like odd advice, but we’re not talking narcotics here.

Although! The drugs in question are active on the dopamine system, so yes, it is actually rather relevant. In other words, they reduce alcohol cravings (and thus, alcohol consumption), by improving dopamine signalling, which means people are less likely to reach for a bottle to self-medicate in order to try to get certain parts of the brain to light up.

Here some readers may be thinking “but I’m not trying to self-medicate; I just like enjoying the drink”, and if that’s you, then well, consider double-checking, for example:

The Alcohol Experiment – by Annie Grace ← it’s a 30-day no-alcohol challenge. If it’s not a dependency, you can do it no problem, right? Compare how willing you are (or not) to do this challenge, compared to, say, abstaining from some other thing that you frequently enjoy but isn’t addictive.

For example, this writer drinks, on average, 6 cups of spearmint tea per day. I love it. But it’s not addictive, and if challenged to skip it, I wouldn’t be counting the days or having to plan coping strategies.

So, with the knowledge in mind that alcohol is indeed addictive and does hijack dopamine circuitry (and more), a team of researchers (Dr. Andrea de Bejczy et al.) investigated the combination of two existing medications (varenicline, for smoking cessation, and bupropion, an antidepressant that works on the dopamine system) in treating alcohol use disorder.

The study

It was respectably large (n=384) 13-week randomized controlled trial, with adults aged 25–70 years with moderate-to-severe alcohol use disorder. About two thirds of the participants were male, the rest were female.

As for how effective it was: compared to placebo, the combination of both drugs reduced a blood alcohol biomarker (B-PEth) by about 39% and the percentage of self-reported heavy drinking days by about 31%.

It’s worthy of note also that actually varenicline achieved this reduction when tested alone, too; adding buproprion didn’t increase the effectiveness but did decrease the side effects:

❝Nausea is a well-known and troublesome side effect of treatment with varenicline. It was surprising but very encouraging to see that nausea decreased when bupropion was added. The fact that the combination treatment is more tolerable for patients increases the chances that they will complete the full course of treatment❞

~ Dr. Andrea de Bejczy

You can read the paper in full, here: Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial

And if you’d prefer a drug-free approach, check out: Rethinking Drinking: How To Reduce Or Quit Alcohol

Worried you’ve already done too much harm?

It’s never too early to quit drinking, but it’s also never too late:

What Happens To Your Body When You Stop Drinking Alcohol ← for a detailed timeline which parts of your body recover when

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  • Demystifying C-Reactive Protein (CRP)!

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    Most people over a certain age who are at least somewhat invested in their health know that c-reactive protein (CRP) is a blood biomarker that’s considered an indicator of cardiovascular health (or: illness, as the case may be), but often know little more than that.

    So, what is it and what does it mean?

    Oh, CRP

    CRP is produced by the liver in response to immune activation from infections, tissue damage, autoimmune disease, obesity, and diabetes.

    As for what its actual job is (because the body does produce it for reasons other than for its usefulness as a biomarker in blood tests),

    ❝Similar to immunoglobulin (Ig)G, it activates complement, binds to Fc receptors and acts as an opsonin for various pathogens. Interaction of CRP with Fc receptors leads to the generation of proinflammatory cytokines that enhance the inflammatory response. Unlike IgG, which specifically recognizes distinct antigenic epitopes, CRP recognizes altered self and foreign molecules based on pattern recognition. Thus, CRP is though to act as a surveillance molecule for altered self and certain pathogens. This recognition provides early defense and leads to a proinflammatory signal and activation of the humoural, adaptive immune system.❞

    Source: Function of C-reactive protein

    Translating that from sciencese: CRP acts like a first-responder version of an antibody. Like IgG antibodies, it can activate the complement* system, latch onto immune cell receptors, and tag microbes so they are easier for immune cells to destroy. When CRP binds to these receptors, it also triggers the release of inflammatory signals that dial up the immune response.

    The key difference is how it recognizes threats: antibodies such as IgG are very specific—they are custom-made to recognize one precise target and nothing else. CRP, in contrast, looks for broad patterns that signal damage or danger, whether from invading microbes or the body’s own altered cells. Thus, CRP acts as an immune surveillance sensor, providing early warning and kick-starting inflammation and the wider adaptive immune response. Which, in the case of an actual infection or similar, is a good thing.

    *You may be wondering what, in turn, the complement system is and what activating it means. In simple terms, it starts off as a bunch of proteins circulating in your blood in an inactive form. When CRP (or an antibody) binds to a microbe or a damaged cell, it can activate this cascade, which then joints the fight and also does the latching on and tagging that we mentioned, by:

    • directly damaging microbes: in some cases, complement proteins punch holes in bacterial membranes, leading to their death.
    • tagging the target for destruction: complement proteins typically coat the surface of the microbe or damaged cell, making it easier for immune cells to recognize and engulf it.
    • dialling up inflammation: small complement fragments act like chemical alarms, attracting immune cells and increasing local inflammation.

    Again, if there’s actually a genuine threat to respond to, these are all good things for it to be doing.

    CRP as a biomarker

    CRP is a very useful biomarker of low-grade inflammation, and evidence from decades of research shows it predicts heart attacks and strokes better than LDL cholesterol and lipoprotein(a), and at least as well as blood pressure: Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women

    Same goes for when we look at mortality: C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

    For this reason, the American College of Cardiology recommended universal CRP screening alongside cholesterol testing to improve cardiovascular risk assessment. You can read that in full, here:

    Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology

    You may be wondering about numbers: CRP under 1 mg/dL indicates low inflammation and lower risk, while CRP above 3 mg/dL signals higher inflammation and higher risk.

    How likely is it that you are at risk? Well, about 52% of Americans have elevated CRP, so that’s not a promising figure to start with. Now, 10almonds readers are doubtlessly healthier than the average American as a general demographic, but still, it’s worth bearing in mind and not assuming that it could only apply to other people.

    And as for how to improve your numbers? Same deal as most heart health advice that we give here: enjoy a plants-forward (if not entirely plant-based) diet, especially making sure to get a lot of fiber and as many different sources of polyphenols as is reasonable. Get good sleep, do exercise often, and don’t smoke or drink.

    About the dietary aspects specifically, see:

    Want to learn more?

    If you’d like a comprehensive guide to reducing your heart disease risk, no matter your starting point, then you might like to consider:

    Dr. Dean Ornish’s Program For Reversing Heart Disease – by Dr. Dean Ornish

    Take care!

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  • Parents find Health Star Ratings confusing and unhelpful. We need a better food labelling system

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    Food labels are intended to support healthy choices. But not all labelling schemes are equal.

    Australia currently uses a voluntary Health Star Rating system. Food manufacturers can choose to add a star label to their packaging to indicate how it compares to other similar products. Or they can choose not to show a star rating on a product at all.

    The Australian government is now considering making it mandatory.

    But our new research on parenting and food in Australia found the Health Star Ratings are often confusing, misunderstood and have little credibility among shoppers.

    If Health Stars are mandated, the system will also need a major overhaul to be trusted and useful for shoppers.

    Gustavo Fring/Pexels

    How do Health Star Ratings work?

    The government set up the front-of-pack Health Star Rating system in 2014 in collaboration with the food industry, public health and consumer groups.

    Product ratings range from (bad) ½ to (good) 5 stars.

    Calories, saturated fat, sugars and sodium decrease the rating. Fibre, protein, and the content of fruit, vegetables, nuts and legumes increase it.

    The good and bad offset each other. This means companies can strategically formulate products to boost the rating and mask unhealthy ingredients.

    Processing and additives – such as sweeteners, colouring, emulsifiers, preservatives and artificial flavourings – are not part of the calculation.

    Previous research has found the ratings can incentivise ultra-processed foods over minimally and unprocessed foods, and misrepresent healthfulness. Some researchers have also suggested practical ways to modify the rating algorithm to account for processing.

    The Health Star Rating’s own consumer research found 74% of consumers do not understand that the rating cannot be used to compare dissimilar products.

    What parents told us

    In our interviews with 34 parents in Australia, participants often described the Health Star Ratings as “misleading”, “not helpful” and “on the wrong product”. One participant called it the “fake health star rating”.

    They gave many examples:

    Like you might buy 100% orange juice or fruit juice and it might have only half a star health star rating, but then you can buy like a box of processed muesli bars and it will have five stars. – Mother of three high school aged children, urban WA

    Coco Pops or Nutrigrain have three and a half star rating, and what exactly does that mean? – Mother of one primary school aged child, urban WA

    Participants wondered if the Health Stars were something companies paid for, a “marketing thing”.

    Positivity bias

    Part of the problem with the Health Stars is the positivity bias of the symbol. As one participant put it, “All stars are good. Right?”

    Another noted their children comment on the stars, saying “but look Mum, it’s five stars.”

    However, parents were not convinced:

    A lot of packaged stuff is rated as five stars. I’m like yeah, well, don’t know about that. It’s still packaged. – Mother of two primary school aged children, urban NSW

    Participants thought discretionary foods should not have any stars. As one participant said:

    The other day, we saw a mud cake and it has a two out of five star health rating. How can that be a two out of five star?… Like there should not even be a star available for this. – Mother of pre-school aged child, urban NSW

    Burden on parents

    Parents often disregarded the rating. For example:

    This particular thing, you know, had all sorts of additives, had actually had a much higher rating than something that actually didn’t have any additives… what I ended up buying was rated slightly lower. – Mother of two primary school aged children, rural Victoria

    Instead participants used ingredients lists, apps such as Yuka, and “hours of internet research” to guide healthier choices.

    But there was a sense of frustration that the burden was on them. Participants said:

    I feel like food labels are extremely deceptive and by producers, purposely confusing. – Mother of one primary school aged child, urban SA

    It has to be government driven because companies won’t change unless they’re forced to by the government. – Father of two primary school aged children, urban Tasmania

    We need a food labelling system that works

    Still, the parents we spoke to think a front-of-pack system is valuable. As one participant explained:

    I do think if I had a better system for that, that would get a lot of use. – Mother of two primary school aged children, urban NSW

    Parents repeatedly stated a desire for transparency over food, for information they can trust and food policies that prioritise consumer health.

    As one mother put it, the “multi-billion dollar” food industry will not do this on their own, and “that’s where the government needs to step in.”

    If Health Stars are mandatory, how could labelling be overhauled?

    Chile, Mexico, Brazil and other countries, including Canada from 2026, are now using “stop-sign” warnings to steer consumers away from the least healthy products. Large Black Octagons alert consumers to high sugar, sodium and saturated fats, and ultra-processing.

    New Canadian food labelling system
    Starting in 2026, a new front-of-package symbol will be required on many Canadian foods and drinks that are high in saturated fat, sugars or salt. Canada.ca/en/health

    Evidence shows these warning labels have improved nutrition and public health in other countries and could be an option for Australia.

    We need to mandate a fit-for-purpose food labelling system that supports healthy eating. Governments should centre the voices of consumers in these and other national food policies to ensure they work as intended.

    Juliet Bennett, Postdoctoral Research Fellow, University of Sydney; Alex Broom, Professor of Sociology & Director, Sydney Centre for Healthy Societies, University of Sydney, and David Raubenheimer, Leonard P. Ullman Chair in Nutritional Ecology, Nutrition Theme Leader Charles Perkins Centre, Chair Sydney Food and Nutrition Network, University of Sydney

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Is Fast Food Really All That Bad?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Yes, yes it is. However, most people misunderstand the nature of its badness, which is what causes problems. The biggest problem is not the acute effects of one afternoon’s burger and fries; the biggest problem is the gradual slide into regularly eating junk food, and the long-term effects of that habit as our body changes to accommodate it (of which, people tend to focus on subcutaneous fat gain as it’s usually the most visible, but that’s really the least of our problems).

    Cumulative effects

    There are, of course, immediate negative effects too, and they’re not without cause for concern. Because of the composition of most junk food, it will almost by definition result in immediate blood sugar spikes, rising insulin levels, and a feeling of fatigue not long afterwards.

    • Within a week of regularly consuming junk food, gut bacteria will change, resulting in moderate cravings, as well as a tendency towards depression and anxiety. Mood swings are likely, as are the gastrointestinal woes associated with any gut microbiota change.
    • Within two weeks, those effects will be greater, the cravings will increase, energy levels will plummet, and likely skin issues may start to show up (our skin mostly works on a 3-week replacement cycle; some things can show up in the skin more quickly or slowly than that, though).
    • Within three weeks, the rest of our blood metrics (e.g. beyond blood sugar imbalances) will start to stray from safe zones. Increased LDL, decreased HDL, and the beginnings of higher cardiovascular disease risk and diabetes risk.
    • Within a month, we will likely see the onset of non-alcoholic fatty liver disease, and chronic inflammation sets in, raising the risk of a lot of other diseases, especially immune disorders and cancer.

    If that seems drastic, along the lines of “eat junk food for a month and get cancer”, well, it’s an elevated risk, not a scheduled diagnosis, but the body is constantly rebuilding itself, for better or for worse, and if we sabotage its efforts by consuming a poor diet, then it will be for worse.

    The good news is: this works both ways, and we can get our body back on track in fairly short order too, by enjoying a healthier diet; our body will be thrilled to start repairing itself. And of course, all these effects, good and bad, are proportional to how well or badly we eat. There’s a difference between doing a “Supersize Me” month-long 100% junk food diet, and “merely” getting a junk food breakfast each day and eating healthily later.

    In short, if your diet is only moderately bad, then you will only be moderately unwell.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Take care!

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  • Cashews vs Peanuts – Which is Healthier?

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    Our Verdict

    When comparing cashews to peanuts, we picked the peanuts.

    Why?

    Another one for “that which is more expensive is not necessarily the healthier”! Although, certainly both are good:

    In terms of macros, cashews have about 2x the carbs while peanuts have a little more (healthy!) fat and more than 2x the fiber, meaning that peanuts also enjoy the lower glycemic index. All in all, a fair win for peanuts here.

    When it comes to vitamins, cashews have more of vitamins B6 and K, while peanuts have a lot more of vitamins B1, B2, B3, B5, B7, B9, and E. Another easy win for peanuts.

    In the category of minerals; cashews have more copper, iron, magnesium, phosphorus, and selenium, while peanuts have more calcium, manganese, and potassium. A win for cashews, this time.

    Adding up the sections makes for an overall win for peanuts, but (assuming you are not allergic) enjoy either or both! In fact, enjoying both is best; diversity is good.

    Want to learn more?

    You might like to read:

    Why You Should Diversify Your Nuts!

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  • These Signs Often Mean These Nutrient Deficiencies (Do You Have Any?)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    These are not a necessary “if this then this” equation, but rather a “if this, then probably this”, and it’s a cue to try upping that thing in your diet, and if that doesn’t quickly fix it, get some tests done:

    • White bumps on the skin: vitamin A, omega 3
    • Craving sour foods: vitamin C
    • Restless leg syndrome: iron, magnesium
    • Cracked lips: vitamin B2
    • Tingling hands and feet: vitamin B12
    • Easy bruising: vitamin K and vitamin C
    • Canker sores: vitamin B9 (folate), vitamin B12, iron
    • Brittle or misshapen nails: vitamin B7 (biotin)
    • Craving salty foods: sodium, potassium
    • Prematurely gray hair: copper, vitamin B9 (folate), vitamin B12
    • Dandruff: omega 3, zinc, vitamin B6
    • Craving ice: iron

    Dr. LeGrand Peterson has more to say about these though, as well as a visual guide to symptoms, so do check out the video:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to know more?

    You might like this previous main feature about supplements vs nutrients from food

    Do We Need Supplements, And Do They Work?

    Enjoy!

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  • Tasty Tabbouleh with Tahini

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    Tabbouleh is a salad, but it’s not “just a salad”. It’s a special kind of salad that’s as exciting for the tastebuds as it is healthy for the body and brain. Its core ingredients have been traditional for about a dozen generations, and seasonings are always a personal matter (not to mention that Lebanese tabbouleh-makers centuries ago might not have used miso and nooch, as we will today), but the overall feel of the Gestalt of tabbouleh seasonings remains the same, and this recipe is true to that.

    You will need

    For the tabbouleh:

    • 1 cup bulgur wheat
    • 1 cup plum tomatoes, chopped
    • 1 cucumber, peeled and chopped (add the peel to a jug of water and put it in the fridge; this will be refreshing cucumber water later!)
    • 1 cup chickpeas, cooked without salt
    • 1/2 cup parsley, chopped
    • 1/2 cup mint, chopped
    • 2 spring onions, finely chopped
    • 2oz fresh lemon juice
    • 1 tsp white miso paste
    • 1 tsp garlic powder
    • 1 tsp ground cumin
    • 1 tsp ground celery seeds
    • 1 tsp ground nigella seeds
    • 1 tsp ground black pepper
    • 1 tsp MSG, or 1/2 tsp low sodium salt (you can find it in supermarkets, the sodium chloride is cut with potassium chloride to make it have less sodium and more potassium)
    • 1 tbsp nutritional yeast (nooch), ground (it comes in flakes; you will have to grind it in a spice grinder or with a pestle and mortar)

    For the tahini sauce:

    • 3 garlic cloves, crushed
    • 3 tbsp tahini
    • 1 tbsp fresh lemon juice
    • 1 tbsp white miso paste
    • 1 tsp ground cumin

    To serve:

    • A generous helping of leafy greens; we recommend collard greens, but whatever works for you is good; just remember that dark green is best. Consider cavolo nero, or even kale if that’s your thing, but to be honest this writer doesn’t love kale
    • 1 tsp coarsely ground nigella seeds
    • Balsamic vinegar, ideally aged balsamic vinegar (this is thicker and sweeter, but unlike most balsamic vinegar reductions, doesn’t have added sugar).

    Method

    (we suggest you read everything at least once before doing anything)

    1) Rinse the bulgur wheat and then soak it in warm water. There is no need to boil it; the warm water is enough to soften it and you don’t need to cook it (bulgur wheat has already been parboiled before it got to you).

    2) While you wait, take a small bowl and mix the rest of the ingredients from the tabbouleh section (so, the lemon juice, miso paste, and all those ground spices and MSG/salt and ground nutritional yeast); you’re making a dressing out of all the ingredients here.

    3) When the bulgur wheat is soft (expect it to take under 15 minutes), drain it and put it in a big bowl. Add the tomatoes, cucumber, chickpeas, parsley, mint, and spring onions. This now technically qualifies as tabbouleh already, but we’re not done.

    4) Add the dressing to the tabbouleh and mix thoroughly but gently (you don’t want to squash the tomatoes, cucumber, etc). Leave it be for at least 15 minutes while the flavors blend.

    5) Take the “For the tahini sauce” ingredients (all of them) and blend them with 4 oz water, until smooth. You’re going to want to drizzle this sauce, so if the consistency is too thick for drizzling, add a little more water and/or lemon juice (per your preference), 1 tbsp at a time.

    6) Roughly chop the leafy greens and put them in a bowl big enough for the tabbouleh to join them there. The greens will serve as a bed for the tabbouleh itself.

    7) Drizzle the tahini over the tabbouleh, and drizzle a little of the aged balsamic vinegar too.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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