Do We Need Supplements, And Do They Work?

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Does our diet need a little help?

We asked you for your take on supplements, and got the above-illustrated, below-described set of results.

  • The largest minority of respondents (a little over a third) voted for “I just take something very specific”
  • The next most respondents voted for “I take so many supplements; every little helps!”
  • Almost as many voted for “I just take a vitamin or two / a multivitamin”
  • Fewest, about 8%, voted for “I get everything I need from my diet”

But what does the science say?

Food is less nutritious now than it used to be: True or False?

True or False depending on how you measure it.

An apple today and an apple from a hundred years ago are likely to contain the same amounts of micronutrients per apple, but a lower percentage of micronutrients per 100g of apple.

The reason for this is that apples (and many other food products; apples are just an arbitrary example) have been selectively bred (and in some cases, modified) for size, and because the soil mineral density has remained the same, the micronutrients per apple have not increased commensurate to the increase in carbohydrate weight and/or water weight. Thus, the resultant percentage will be lower, despite the quantity remaining the same.

We’re going to share some science on this, and/but would like to forewarn readers that the language of this paper is a bit biased, as it looks to “debunk” claims of nutritional values dropping while skimming over “yes, they really have dropped percentage-wise” in favor of “but look, the discrete mass values are still the same, so that’s just a mathematical illusion”.

The reality is, it’s no more a mathematical illusion than is the converse standpoint of saying the nutritional value is the same, despite the per-100g values dropping. After all, sometimes we eat an apple as-is; sometimes we buy a bag of frozen chopped fruit. That 500g bag of chopped fruit is going to contain less copper (for example) than one from decades past.

Here’s the paper, and you’ll see what we mean:

Mineral nutrient composition of vegetables, fruits and grains: The context of reports of apparent historical declines

Supplements aren’t absorbed properly and thus are a waste of money: True or False?

True or False depending on the supplement (and your body, and the rest of your diet)

Many people are suffering from dietary deficiencies of vitamins and minerals, that could be easily correctable by supplementation:

However, as this study by Dr. Fang Fang Zhang shows, a lot of vitamin and mineral supplementation does not appear to have much of an effect on actual health outcomes, vis-à-vis specific diseases. She looks at:

  • Cardiovascular disease
  • Cancer
  • Type 2 diabetes
  • Osteoporosis

Her key take-aways from this study were:

  • Randomised trial evidence does not support use of vitamin, mineral, and fish oil supplements to reduce the risk of non-communicable diseases
  • People using supplements tend to be older, female, and have higher education, income, and healthier lifestyles than people who do not use them
  • Use of supplements appreciably reduces the prevalence of inadequate intake for most nutrients but also increases the prevalence of excess intake for some nutrients
  • Further research is needed to assess the long term effects of supplements on the health of the general population and in individuals with specific nutritional needs, including those from low and middle income countries

Read her damning report: Health effects of vitamin and mineral supplements

On the other hand…

This is almost entirely about blanket vitamin-and-mineral supplementation. With regard to fish oil supplementation, many commercial fish oil supplements break down in the stomach rather than the intestines, and don’t get absorbed well. Additionally, many people take them in forms that aren’t pleasant, and thus result in low adherence (i.e., they nominally take them, but in fact they just sit on the kitchen counter for a year).

One thing we can conclude from this is that it’s good to check the science for any given supplement before taking it, and know what it will and won’t help for. Our “Monday Research Review” editions of 10almonds do this a lot, although we tend to focus on herbal supplements rather than vitamins and minerals.

We can get everything we need from our diet: True or False?

Contingently True (but here be caveats)

In principle, if we eat the recommended guideline amounts of various macro- and micro-nutrients, we will indeed get all that we are generally considered to need. Obviously.

However, this may come with:

  • Make sure to get enough protein… Without too much meat, and also without too much carbohydrate, such as from most plant sources of protein
  • Make sure to get enough carbohydrates… But only the right kinds, and not too much, nor at the wrong time, and without eating things in the wrong order
  • Make sure to get enough healthy fats… Without too much of the unhealthy fats that often exist in the same foods
  • Make sure to get the right amount of vitamins and minerals… We hope you have your calculators out to get the delicate balance of calcium, magnesium, potassium, phosphorus, and vitamin D right.

That last one’s a real pain, by the way. Too much or too little of one or another and the whole set start causing problems, and several of them interact with several others, and/or compete for resources, and/or are needed for the others to do their job.

And, that’s hard enough to balance when you’re taking supplements with the mg/µg amount written on them, never mind when you’re juggling cabbages and sardines.

On the topic of those sardines, don’t forget to carefully balance your omega-3, -6, and -9, and even within omega-3, balancing ALA, EPA, and DHA, and we hope you’re juggling those HDL and LDL levels too.

So, when it comes to getting everything we need from our diet, for most of us (who aren’t living in food deserts and/or experiencing food poverty, or having a medical condition that restricts our diet), the biggest task is not “getting enough”, it’s “getting enough of the right things without simultaneously overdoing it on the others”.

With supplements, it’s a lot easier to control what we’re putting in our bodies.

And of course, unless our diet includes things that usually can’t be bought in supermarkets, we’re not going to get the benefits of taking, as a supplement, such things as:

Etc.

So, there definitely are supplements with strong science-backed benefits, that probably can’t be found on your plate!

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  • Artichoke vs Pumpkin – Which is Healthier?

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    Our Verdict

    When comparing artichoke to pumpkin, we picked the artichoke.

    Why?

    It wasn’t close!

    In terms of macros, artichoke has 11x the fiber, slightly more carbs, and more than 3x the protein, winning easily in this category.

    In the category of vitamins, artichoke has more of vitamins B1, B3, B5, B6, B7, B9, C, and K, while pumpkin has more of vitamins A, B2, and E, giving artichoke an 8:3 victory here.

    Looking at minerals, artichoke has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, while pumpkin has more selenium, meaning an 8:1 victory for artichoke in this round.

    In other considerations, artichoke has more polyphenols by far, thus winning one more round.

    Adding up the sections makes for a clear overall win for artichoke, but by all means enjoy either or both, as diversity is good!

    Want to learn more?

    You might like:

    What Do The Different Kinds Of Fiber Do? 30 Foods That Rank Highest

    Enjoy!

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  • GLP-1 Oral Meds: Any Drawbacks?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    First introduced as a diabetes medication, GLP-1 drugs quickly took hold for off-label use as weight loss aids, even when the science was still very young.

    Here’s one of our first articles on that, back in the day: Semaglutide’s Surprisingly Big Research Gap

    As for that popularity? Check out: 1 in 5 US Women Aged 50–64 Has Used GLP-1 RAs: What We’ve Learned

    Spoiler, one of the things we’ve learned is: Most People Who Start GLP-1 RAs Quit Them Within A Year (Here’s Why)

    One of the main things in their favor is, of course, that (for most people, anyway), they work (except when they don’t: Why Intermittent Fasting (& GLP-1 Drugs!) Might Not Work For You).

    In other words, a rocky road with pros and cons. But today, let’s talk about the question many have been asking:

    Does it come in a pill?

    Most people don’t love injections, and GLP-1 drugs being injection-only for these past years has not been simply because the drug companies like to be annoying.

    In fact, there are often technical challenges with making a drug work by different routes of administration, for example:

    • Skincare products are usually not best taken rectally
    • It’s hard to make a gut-repair drug that can be taken as a transdermal skin cream
    • And so on

    For this reason, subcutaneous injections have worked as a way of delivering drugs to agonize GLP-1 receptors, in ways it’s been hard to do with a pill that has to get past stomach acid and your gut barrier, before getting into your bloodstream.

    However! Most recently, researchers (Dr. Vanita Aroda et al.) tested elecoglipron, a once-daily oral GLP-1 receptor agonist for type 2 diabetes, in a sizeable trial involving 406 participants across 9 countries.

    Unlike most GLP-1 drugs, elecoglipron is a non-peptide tablet taken once daily with no food or fluid restrictions, making treatment much more convenient.

    In numbers:

    • Before starting: the average participant was 58.4 years old, weighed 99.8 kg, had a BMI of 34.9 kg/m², and started with an HbA1c of 7.9%.
    • Blood sugar results: after 26 weeks, HbA1c fell by 0.91 to 1.88 percentage points depending on dose, compared with a 0.15 percentage-point reduction in the placebo group.
    • HbA1c results: up to 89.6% of participants receiving elecoglipron reached an HbA1c of 7% or below, compared with 24.9% of those receiving placebo.
    • Weight loss results: up to 72.3% of participants taking elecoglipron lost at least 5% of their body weight, compared with 20.2% in the placebo group.
    • Side effects: adverse events occurred in 63% to 87% of participants across the elecoglipron groups versus 63% with placebo, with the most common being nausea, constipation, diarrhoea, and vomiting. This sounds bad, and by itself it is, but it’s worth noting that the drug’s safety and tolerability were generally consistent with other GLP-1 receptor agonists. So in other words, in terms of adverse effects it’s very comparable to Ozempic, Wegovy, Mounjaro, and all the others of that ilk.

    In other words: it works! Very comparable to other GLP-1 RAs. Same drug-related drawbacks, just without the needles.

    You can find the paper itself, here: Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicentre, phase 2b, randomised, placebo-controlled trial

    Want to learn more?

    You might also like this book that we reviewed a little while back:

    Magic Pill: The Extraordinary Benefits and Disturbing Risks of the New Weight-Loss Drugs – by Johann Hari

    Take care!

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  • Ashwagandha: The Root of All Even-Mindedness?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Ashwagandha: The Root Of All Even-Mindedness?

    In the past few years, Ashwagandha root has been enjoying popular use in consumer products ranging from specialist nootropic supplement stacks, to supermarket teas and hot chocolates.

    This herb is considered to have a calming effect, but the science goes a lot deeper than that. Let’s take a look!

    Last summer, a systematic review was conducted, that asked the question:

    Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress?

    They broadly found the answer was “yes”, although they mentioned in the first line of their abstract, without showing, that it was partially in response to contradictory evidence previously. We (10almonds) were not able to find any contradictory evidence, and their own full article had been made inaccessible to the public, so we couldn’t double-check theirs.

    We promptly did our own research review, and we found many studies this year supporting Ashwaghanda’s use for the management of anxiety and stress, amongst other benefits.

    First, know: Ashwagandha’s scientific name is “Withania somnifera”, so if you see that (or a derivative of it) mentioned in a paper or extract, it’s the same thing.

    Onto the benefits…

    A study from the same summer investigated “the efficacy of Withania somnifera supplementation on adults’ cognition and mood”, and declared that:

    “in conclusion, Ashwagandha supplementation may improve the physiological, cognitive, and psychological effects of stress.”

    We notice the legalistic “may improve”, but the data itself seems more compelling than that, because the study showed that it in fact “did improve” those things. Specifically, Ashwagandha out-performed placebo in most things they measured, and most (statistically) significantly, reduced cortisol output measurably. Cortisol, for any unfamiliar, is “the stress hormone”.

    Another study that looked into its anti-stress properties is this one:

    Ashwagandha Modulates Stress, Sleep Dynamics, and Mental Clarity

    This study showed that Ashwagandha significantly outperformed placebo in many ways, including:

    • sleep quality
    • cognitive function
    • energy, and
    • perceptions of stress management.

    Ashwagandha is popular among students, because it alleviates stress while also promising benefits to memory, attention, and thinking. So, this study on students caught our eye:

    The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial

    Their findings demonstrated that Ashwagandha increased college students’ perceived well-being through supporting sustained energy, heightened mental clarity, and enhanced sleep quality.

    That was about perceived well-being and based on self-reports, though

    So: what about hard science?

    A later study (in September) found supplementation with 400 mg of Ashwagandha improved executive function, helped sustain attention, and increased short-term/working memory.

    Read the study: Effects of Acute Ashwagandha Ingestion on Cognitive Function

    ❝But aside from the benefits regarding stress, anxiety, sleep quality, cognitive function, energy levels, attention, executive function, and memory, what has Ashwagandha ever done for us?

    Well, there have been studies investigating its worth against depression, like this one:

    Can Traditional Treatment Such as Ashwagandha Be Beneficial in Treating Depression?

    Their broad answer: Ashwagandha works against depression, but they don’t know how it works.

    They did add: “Studies also show that ashwagandha may bolster the immune system, increase stamina, fight inflammation and infection, combat tumors*, reduce stress, revive the libido, protect the liver and soothe jangled nerves.

    That’s quite a lot, including a lot of physical benefits we’ve not explored in this research review which was more about Ashwagandha’s use as a nootropic!

    We’ve been focusing on the more mainstream, well-studied benefits, but for any interested in Ashwagandha’s anti-cancer potential, here’s an example:

    Evaluating anticancer properties of [Ashwagandha Extract]-a potent phytochemical

    In summary:

    There is a huge weight of evidence (of which we’ve barely skimmed the surface here in this newsletter, but there’s only so much we can include, so we try to whittle it down to the highest quality most recent most relevant research) to indicate that Ashwagandha is effective…

    • Against stress
    • Against anxiety
    • Against depression
    • For sleep quality
    • For memory (working, short-term, and long-term)
    • For mental clarity
    • For attention
    • For stamina
    • For energy levels
    • For libido
    • For immune response
    • Against inflammation
    • Against cancer
    • And more*

    *(seriously, this is not hyperbole… We didn’t even look at its liver-protective functions, for instance)

    Bottom line:

    You’d probably like some Ashwagandha now, right? We know we would.

    We don’t sell it (or anything else, for that matter), but happily the Internet does:

    Try Out Ashwagandha For Yourself Here!

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  • Strengthening Your Knees: How To Get Your First Pistol Squat

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Pistol squats are a great strengthening/mobility exercise, but they’re hard at first, because they require ankle mobility, hip mobility, and strength, all at once.

    But that doesn’t mean they can’t be added one by one:

    Bit by bit…

    In particular, you will need:

    • Ankle dorsiflexion: so your knee can travel forwards and keep your balance; without it, you either get stuck or fall backwards
    • Knee flexion: thigh and calf need to close together, requiring quad flexibility
    • Hip flexion: your torso and thigh need to fold together, requiring glute flexibility
    • Lifted leg hip flexion: hamstring flexibility and hip flexor strength keep the leg extended in front
    • Internal hip rotation: crucial but rarely discussed; it keeps your pelvis level, balance aligned, and knee tracking over toes
    • Strength: throughout, but especially your quads and glutes must be strong in a stretched position, since muscles are weaker when lengthened

    You can add these things one-by-one by progressing as follows:

    1. Deep bodyweight squats
    2. Kickstand box squats
    3. Eccentric-only box squats
    4. Shrimp squats
    5. Single-leg box squats
    6. Hand-assisted pistol squats
    7. Band-assisted pistol squats
    8. Full pistol squats

    As for how to do each of those, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    The Secret To Better Squats: Foot, Knee, & Ankle Mobility

    Take care!

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  • Black Bean Hummus Panini

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    A recipe for a sandwich? Try it once, and you’ll see why. Welcome to your new favorite!

    You will need

    Method

    (we suggest you read everything at least once before doing anything)

    1) Grill the eggplant slices until soft.

    2) Spread hummus generously on one side of both slices of bread.

    2) Add the black beans on top of one slice (the hummus will help them stay in place), followed by the sun-dried tomatoes and then the eggplant. Top with the other slice of bread, hummus-side down.

    3) Coat (carefully, please) the inside of the panini press (both interior sides) with olive oil. If you don’t have sprayable oil, using a sheet of kitchen roll to apply the oil is a good way to do it without making a mess.

    4) Grill the assembled sandwich, until the bread starts to brown and the insides are warm; this should take about 4 minutes.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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  • Anticancer: A New Way Of Life – by Dr. David Servan-Schreiber

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    A cancer survivor himself, Dr. Servan-Schreiber found himself unimpressed with the advice he was given upon diagnosis, and set out to find better. This, he achieved.

    He first provides an introductory overview of cancer, and then devotes most of the book to detailing how to create a “terrain” (the environment of your body and all that you do with/to it) that is hostile to cancer.

    This includes things like diet, of course, but also exercise (the right way!), mindset, and much more. He doesn’t cover much about standard medical treatments, as he assumes the reader will already be advised about those by their oncologist, and in any case, such treatments are constantly changing as new discoveries are made. It’s worth mentioning that while he advocates strongly for complementary medicine, he does also make clear it should be just that—complementary—and not a replacement for regular treatments in cases where such are recommended.

    The style is comprehensible pop-science, written for the lay reader, and yet with copious scientific references—more than 30 pages thereof. But as well as that, it’s a personal account, often revisiting his own cancer journey to illustrate one point or another, be it something that went well for him or badly, there’s always something to learn.

    Bottom line: this book is important for anyone facing cancer, and useful for anyone who simply would like to improve their odds in a more informed fashion. As he notes, “all of us have cancer cells in our bodies, but not all of us will develop cancer”, and it’s good to try to be on the healthiest side of that.

    Click here to check out Anticancer, and live an anticancer life!

    Don’t Forget…

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