Demystifying C-Reactive Protein (CRP)!

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Most people over a certain age who are at least somewhat invested in their health know that c-reactive protein (CRP) is a blood biomarker that’s considered an indicator of cardiovascular health (or: illness, as the case may be), but often know little more than that.

So, what is it and what does it mean?

Oh, CRP

CRP is produced by the liver in response to immune activation from infections, tissue damage, autoimmune disease, obesity, and diabetes.

As for what its actual job is (because the body does produce it for reasons other than for its usefulness as a biomarker in blood tests),

❝Similar to immunoglobulin (Ig)G, it activates complement, binds to Fc receptors and acts as an opsonin for various pathogens. Interaction of CRP with Fc receptors leads to the generation of proinflammatory cytokines that enhance the inflammatory response. Unlike IgG, which specifically recognizes distinct antigenic epitopes, CRP recognizes altered self and foreign molecules based on pattern recognition. Thus, CRP is though to act as a surveillance molecule for altered self and certain pathogens. This recognition provides early defense and leads to a proinflammatory signal and activation of the humoural, adaptive immune system.❞

Source: Function of C-reactive protein

Translating that from sciencese: CRP acts like a first-responder version of an antibody. Like IgG antibodies, it can activate the complement* system, latch onto immune cell receptors, and tag microbes so they are easier for immune cells to destroy. When CRP binds to these receptors, it also triggers the release of inflammatory signals that dial up the immune response.

The key difference is how it recognizes threats: antibodies such as IgG are very specific—they are custom-made to recognize one precise target and nothing else. CRP, in contrast, looks for broad patterns that signal damage or danger, whether from invading microbes or the body’s own altered cells. Thus, CRP acts as an immune surveillance sensor, providing early warning and kick-starting inflammation and the wider adaptive immune response. Which, in the case of an actual infection or similar, is a good thing.

*You may be wondering what, in turn, the complement system is and what activating it means. In simple terms, it starts off as a bunch of proteins circulating in your blood in an inactive form. When CRP (or an antibody) binds to a microbe or a damaged cell, it can activate this cascade, which then joints the fight and also does the latching on and tagging that we mentioned, by:

  • directly damaging microbes: in some cases, complement proteins punch holes in bacterial membranes, leading to their death.
  • tagging the target for destruction: complement proteins typically coat the surface of the microbe or damaged cell, making it easier for immune cells to recognize and engulf it.
  • dialling up inflammation: small complement fragments act like chemical alarms, attracting immune cells and increasing local inflammation.

Again, if there’s actually a genuine threat to respond to, these are all good things for it to be doing.

CRP as a biomarker

CRP is a very useful biomarker of low-grade inflammation, and evidence from decades of research shows it predicts heart attacks and strokes better than LDL cholesterol and lipoprotein(a), and at least as well as blood pressure: Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women

Same goes for when we look at mortality: C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

For this reason, the American College of Cardiology recommended universal CRP screening alongside cholesterol testing to improve cardiovascular risk assessment. You can read that in full, here:

Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology

You may be wondering about numbers: CRP under 1 mg/dL indicates low inflammation and lower risk, while CRP above 3 mg/dL signals higher inflammation and higher risk.

How likely is it that you are at risk? Well, about 52% of Americans have elevated CRP, so that’s not a promising figure to start with. Now, 10almonds readers are doubtlessly healthier than the average American as a general demographic, but still, it’s worth bearing in mind and not assuming that it could only apply to other people.

And as for how to improve your numbers? Same deal as most heart health advice that we give here: enjoy a plants-forward (if not entirely plant-based) diet, especially making sure to get a lot of fiber and as many different sources of polyphenols as is reasonable. Get good sleep, do exercise often, and don’t smoke or drink.

About the dietary aspects specifically, see:

Want to learn more?

If you’d like a comprehensive guide to reducing your heart disease risk, no matter your starting point, then you might like to consider:

Dr. Dean Ornish’s Program For Reversing Heart Disease – by Dr. Dean Ornish

Take care!

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  • Intuitive Eating Might Not Be What You Think

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    In our recent Expert Insights main features, we’ve looked at two fairly opposing schools of thought when it comes to managing what we eat.

    First we looked at:

    What Flexible Dieting Really Means

    …and the notion of doing things imperfectly for greater sustainability, and reducing the cognitive load of dieting by measuring only the things that are necessary.

    And then in opposition to that,

    What Are The “Bright Lines” Of Bright Line Eating?

    …and the notion of doing things perfectly so as to not go astray, and reducing the cognitive load of dieting by having hard-and-fast rules that one does not second-guess or reconsider later when hungry.

    Today we’re going to look at Intuitive Eating, and what it does and doesn’t mean.

    Intuitive Eating does mean paying attention to hunger signals (each way)

    Intuitive Eating means listening to one’s body, and responding to hunger signals, whether those signals are saying “time to eat” or “time to stop”.

    A common recommendation is to “check in” with one’s body several times per meal, reflecting on such questions as:

    • Do I have hunger pangs? Would I seek food now if I weren’t already at the table?
    • If I hadn’t made more food than I’ve already eaten so far, would that have been enough, or would I have to look for something else to eat?
    • Am I craving any of the foods that are still before me? Which one(s)?
    • How much “room” do I feel I still have, really? Am I still in the comfort zone, and/or am I about to pass into having overeaten?
    • Am I eating for pleasure only at this point? (This is not inherently bad, by the way—it’s ok to have a little more just for pleasure! But it is good to note that this is the reason we’re eating, and take it as a cue to slow down and remember to eat mindfully, and enjoy every bite)
    • Have I, in fact, passed the point of pleasure, and I’m just eating because it’s in front of me, or so as to “not be wasteful”?

    See also: Interoception: Improving Our Awareness Of Body Cues

    And for that matter: Mindful Eating: How To Get More Out Of What’s On Your Plate

    Intuitive Eating is not “80:20”

    When it comes to food, the 80:20 rule is the idea of having 80% of one’s diet healthy, and the other 20% “free”, not necessarily unhealthy, but certainly not moderated either.

    Do you know what else the 80:20 food rule is?

    A food rule.

    Intuitive Eating doesn’t do those.

    The problem with food rules is that they can get us into the sorts of problems described in the studies showing how flexible dieting generally works better than rigid dieting.

    Suddenly, what should have been our free-eating 20% becomes “wait, is this still 20%, or have I now eaten so much compared to the healthy food, that I’m at 110% for my overall food consumption today?”

    Then one gets into “Well, I’ve already failed to do 80:20 today, so I’ll try again tomorrow [and binge meanwhile, since today is already written off]”

    See also: Eating Disorders: More Varied (And Prevalent) Than People Think

    It’s not “eat anything, anytime”, either

    Intuitive Eating is about listening to your body, and your brain is also part of your body.

    • If your body is saying “give me sugar”, your brain might add the information “fruit is healthier than candy”.
    • If your body is saying “give me fat”, your brain might add the information “nuts are healthier than fried food”
    • If your body is saying “give me salt”, your brain might add the information “kimchi is healthier than potato chips”

    That doesn’t mean you have to swear off candy, fried food, or potato chips.

    But it does mean that you might try satisfying your craving with the healthier option first, giving yourself permission to have the less healthy option afterwards if you still want it (you probably won’t).

    See also:

    I want to eat healthily. So why do I crave sugar, salt and carbs?

    Want to know more about Intuitive Eating?

    You might like this book that we reviewed previously:

    Intuitive Eating – by Evelyn Tribole and Elyse Resch

    Enjoy!

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  • Spreading Mental Health Awareness

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    Request: more people need to be aware of suicidal tendencies and what they can do to ward them off

    That’s certainly a very important topic! We’ll cover that properly in one of our Psychology Sunday editions. In the meantime, we’ll mention a previous special that we did, that was mostly about handling depression (in oneself or a loved one), and obviously there’s a degree of crossover:

    The Mental Health First-Aid That You’ll Hopefully Never Need

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  • Longevity… Simplified – by Dr. Howard Luks

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    In the spirit of the book itself, we’ll keep this one simple:

    The information in this book will not be new to regular readers of 10almonds, or at least, not if you’ve been with us for a while (because we can only cover so much per day, so long-time readers will have accumulated more knowledge).

    On the other hand, the information is clear, correct, and very much stripped down to the most important basics. Not the very simplest basics, which would be an oversimplification to the point of inutility, but the most important basics.

    To take an example, when it comes to exercise, he doesn’t say “exercise more” but rather that “a complete exercise program has four pillars: aerobic training, resistance training, balance training, and high-intensity interval training (HIIT)”, and then he goes about explaining, in clear and simple terms, how to do those.

    The style is similar when it comes to diet, sleep, and body-part-specific chapters such as about heart health, brain health, and so forth.

    Bottom line: if you’re a long-time 10almonds reader, you probably don’t need this one, but it’d be a great book for someone else who has expressed an interest in getting healthier, as it really is a top-tier “primer” in increasing health and healthspan.

    Click here to check out Longevity… Simplified, and enjoy simplified longevity!

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  • What To Do If Having A Stroke Alone?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small 😎

    ❝Thank you for the video about what to do if you have a heart attack alone, what about what to do if you have a stroke alone?❞

    (for anyone who missed that video, here it is)

    That’s a good question, especially as stroke risk is rising in the industrialized world in general, and the US in particular.

    However, let’s start with the caveat that if you are having a stroke, there’s a good chance you will forget what we are about to say, what with the immediate effects it has on the brain. That said…

    The general advice when it comes to looking after someone else who is experiencing a stroke, is, “don’t”.

    In other words, call emergency services, and don’t do anything else, e.g:

    • don’t give them anything to eat or drink
    • don’t give them any medications
    • don’t let them go to sleep
    • don’t let them talk you out of calling emergency services
    • don’t let them drive themselves to hospital
    • don’t drive them to hospital yourself either*

    *This is for two reasons:

    1. an ambulance crew has skills and resources that you don’t, and can begin treatment en-route, and also,
    2. not all hospitals have appropriate resources to treat stroke, so the ambulance crew will know to drive to one that does, instead of driving to a random hospital and hoping for the best

    So, flipping this for if it’s you having the stroke, and you’re cognizant enough to remember this:

    • do call an ambulance; stay on the line and don’t do anything else unless instructed by the emergency services.

    In order to do that, of course it’s important to recognize the symptoms; you probably know these but just in case, the mnemonic is “FAST”:

    • Face: is there weakness on one side of their face?
    • Arms: if they raise both arms, does one drift downwards?
    • Speech: if they speak, is their speech slurred or otherwise unusual?
    • Time: to call emergency services

    It’s great to not get caught out by surprise, so you might also want to check out:

    6 Signs Of Stroke (One Month In Advance)

    Take care!

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  • Is TikTok right? Are there health benefits to eating sea moss?

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    Sea moss is the latest “superfood” wellness influencers are swearing by. They claim sea moss products – usually in gel form – have multiple health benefits. These include supporting brain and immune function, or protecting against viruses and other microbes.

    But do these health claims stack up? Let’s take a look.

    Plataresca/Shutterstock

    What is sea moss?

    Sea moss is produced using a kind of seaweed – particularly red algae – that grow in various locations all around the world. Three main species are used in sea moss products:

    • Chondrus crispus (known as Irish moss or carrageenan moss)
    • Eucheuma cottonii (sea moss or seabird’s nest)
    • Gracilaria (Irish moss or ogonori).

    Some products also contain the brown algae Fucus vesiculosus (commonly known as bladderwrack, black tang, rockweed, sea grapes, bladder fucus, sea oak, cut weed, dyers fucus, red fucus or rock wrack).

    Most sea moss products are sold as a gel that can be added to recipes, used in smoothies, frozen into ice cubes or eaten on its own. The products also come in capsule form or can be purchased “raw” and used to make your own gels at home.

    A clump of red algae on wet sand and white pebbles.
    Several kinds of red algae are used in commercially-available sea moss products. Nancy Ann Bowe/Shutterstock

    What’s the evidence?

    Sea moss products claim a host of potential health benefits, from supporting immunity, to promoting skin health and enhancing mood and focus, among many others.

    But is there any evidence supporting these claims?

    Recent studies have reviewed the biological properties of the main sea moss species (Chondrus crispus, Eucheuma cottonii, Gracilaria and Fucus vesiculosus).

    They suggest these species may have anti-inflammatory, antioxidant, anticancer, antidiabetic and probiotic properties.

    However, the vast majority of research relating to Chondrus crispus, Gracilaria and Fucus vesiculosus – and all of the research on Eucheuma cottonii – comes from studies done in test tubes or using cell and animal models. We should not assume the health effects seen would be the same in humans.

    In cell and animal studies, researchers usually administer algae in a laboratory and use specific extracts rich in bioactive compounds rather than commercially available sea moss products.

    They also use very different – often relatively larger – amounts compared to what someone would typically consume when they eat sea moss products.

    This means the existing studies can’t tell us about the human body’s processes when eating and digesting sea moss.

    Sea moss may have similar effects in humans. But so far there is very little evidence people who consume sea moss will experience any of the claimed health benefits.

    Nutritional value

    Eating sea moss does not replace the need for a balanced diet, including a variety of fruits and vegetables.

    Chondrus crispus, Eucheuma cottonii and Gracilaria, like many seaweeds, are rich sources of nutrients such as fatty acids, amino acids, vitamin C and minerals. These nutrients are also likely to be present in sea moss, although some may be lost during the preparation of the product (for example, soaking may reduce vitamin C content), and those that remain could be present in relatively low quantities.

    There are claims that sea moss may be harmful for people with thyroid problems. This relates to the relationship between thyroid function and iodine. The algae used to make sea moss are notable sources of iodine and excess iodine intake can contribute to thyroid problems, particularly for people with pre-existing conditions. That is why these products often carry disclaimers related to iodine sensitivity or thyroid health.

    Is it worth it?

    So you may be wondering if it’s worth trying sea moss. Here are a few things to consider before you decide whether to start scooping sea moss into your smoothies.

    A 375mL jar costs around $A25–$30 and lasts about seven to ten days, if you follow the recommended serving suggestion of two tablespoons per day. This makes it a relatively expensive source of nutrients.

    Two glass jars filled with dark pink gel.
    Sea moss is commonly sold as a gel that can be eaten on a kitchen bench. April Sims/Shutterstock

    Sea moss is often hyped for containing 92 different minerals. While there may be 92 minerals present, the amount of minerals in the algae will vary depending on growing location and conditions.

    The efficiency with which minerals from algae can be absorbed and used by the body also varies for different minerals. For example, sodium is absorbed well, while only about 50% of iodine is absorbed.

    But sea moss has also been shown to contain lead, mercury and other heavy metals – as well as radioactive elements (such as radon) that can be harmful to humans. Seaweeds are known for their ability to accumulate minerals from their environment, regardless of whether these are beneficial or harmful for human nutrition. Remember, more doesn’t always mean better.

    What else am I eating?

    While you won’t get a full nutritional breakdown on the jar, it is always wise to check what other ingredients you may be eating. Sea moss products can contain a range of other ingredients, such as lime, monk fruit powder, spirulina and ginger, among many others.

    These ingredients differ between brands and products, so be aware of your needs and always check.

    Despite their health claims, most sea moss products also carry disclaimers indicating that the products are not intended to diagnose, treat, cure or prevent any disease.

    If you have concerns about your health, always speak to a health professional for accurate and personalised medical advice.

    Margaret Murray, Senior Lecturer, Nutrition, Swinburne University of Technology

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Muhammara

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    This is a Levantine dish, Syrian in origin (although Lebanese cuisine uses it plenty too) and popularly enjoyed all the way up to Turkey, down to Egypt, and across to Armenia. And today, perhaps rather further afield! It’s first and foremost a spicy dip/spread, though it can be lengthened into a sauce, and/or made more substantial by adding an extra protein. We’ll give you the basic recipe though, and let you see where it takes you! Healthwise, it’s very nutritionally dense, mostly thanks to the walnuts and red peppers, though spices and olive oil bring their healthy benefits too.

    You will need

    • ½ cup chopped walnuts (ideally: toasted)
    • 3 red peppers, from a jar (jarred over fresh not only improves the consistency, but also makes it extra gut-healthy due to the fermentation bacteria present; if you must use fresh, roast them first)
    • 2 tbsp extra virgin olive oil
    • 1 tbsp pomegranate molasses (you can omit if you don’t like sweetness, but this is traditional)
    • 1 tbsp tomato purée
    • 1 tbsp Aleppo pepper flakes (less, if you don’t like heat) (substitute another hot pepper if necessary)
    • ½ bulb garlic, crushed
    • 2 tsp ground smoked paprika
    • 1 tsp ground cumin
    • ½ tsp MSG or 1 tsp low-sodium salt
    • Juice of 1 lemon
    • Optional: handful of pomegranate seeds
    • Optional: herb garnish, e.g. cilantro or parsley

    Method

    (we suggest you read everything at least once before doing anything)

    1) Add everything except the pomegranate seeds and herbs to a blender, and blend to a smooth consistency.

    2) Add the pomegranate seeds and herbs, as a garnish.

    3) Serve! Can be enjoyed as a dip (perhaps using our Homemade Healthy Flatbreads recipe), or as a spread, or used as a sauce poured over chickpeas or some other bulky protein, to make a more substantial dish.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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