
The Fat That Fuels Alzheimer’s Disease
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This is not about trans fats, or super-processed hydrogenated vegetable oils, or butter.
Although, you might want to check out: Can Saturated Fats Be Healthy? and, for that matter, A Word About Trans-Fatty Acids (TFAs) ← when you click this one, you’ll need to scroll down slightly for the bit about trans fats.
No, it’s about adipose tissue.
The Adipose-Brain Crosstalk
Body fat is blamed for many things, often unfairly.
By this we mean: there are many adverse health conditions that are associated with being in the “obese” category of a BMI scale, but this is very misleading if we don’t look at the actual causes at hand. It would be like saying that since black people die in the US at a higher rate than white people do, blackness itself is to blame, instead of looking at the systemic issues at hand, ranging from higher association with poverty due to generational disprivilege, to receiving lower quality medical care. We wrote previously about Fat’s Real Barriers To Health, shining a similar light on the actual problems at hand, often including such things as:
- medication dosages being tailored to thin people rather than calculated on a per-kg basis and guess what, now it doesn’t work and you might die
- surgeons being untrained and/or unwilling to operate on people unless they lose weight first (often resulting in a denial of essential surgery)
- hospital equipment that was built with smaller sizes in mind, ranging from blood pressure cuffs to MRI machines, resulting again in skipped (or substandard) medical care
You can read more about this kind of thing in: Shedding Some Obesity Myths
So, all that shows how in many cases, fat isn’t the real problem; it’s just a bodily attribute that people either see and decide to hand it problems, or else simply do not care enough to address a need going unmet.
However, this today is not one of those instances.
Researchers (Dr. Li Yang et al.) used a combination of human patient fat samples, mouse models, and lab tests of amyloid clumping, to discover that fat tissue releases extracellular vesicles that can cross the blood–brain barrier and accelerate amyloid-β plaque buildup, a hallmark of Alzheimer’s disease.
Furthermore, the more adipose (fat) tissue you have, the worse this seems to be.
Limitation: the researchers did not distinguish between different types of adipose tissue. We may hypothesize that white adipose tissue will be the worst, yellow adipose tissue not so bad, and we wouldn’t be surprised if brown adipose tissue turned out to be protective. For why we make that latter prediction, see: The BAT-pause! ← the title here refers to the production of highly beneficial brown adipose tissue (BAT) slowing down during the menopause, if we’re not careful—but there are things we can do to convert white adipose tissue to yellow and brown.
You can read the paper in full, here: Decoding adipose–brain crosstalk: Distinct lipid cargo in human adipose-derived extracellular vesicles modulates amyloid aggregation in Alzheimer’s disease
Before you decide on your next weight-loss plan, though, please be aware that over the age of 65, a BMI in the “overweight” category is protective against all-cause mortality
Thus, a potentially sensible plan if you’re already in a weight range you’re happy with (and an adiposity range you’re happy with, for that matter, since of course weight can come from more things than just fat, e.g. water weight, muscle mass), is to use what we talked about in the “BAT-pause” article linked above, to convert adipose tissue into its healthiest form. However, as a caveat, that’s just us doing a 2+2=4 on the evidence, and not a matter of interventional RCTs having been done to confirm the hypothesis. We’d love to see such studies, though, and will definitely keep an eye out for them!
Want to nourish your brain without fueling Alzheimer’s?
Check out:
A New Contender For “Best Diet For Heart & Brain” In Aging
Enjoy!
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Dates vs Grapes – Which is Healthier?
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Our Verdict
When comparing dates to grapes, we picked the dates.
Why?
It’s not close:
In terms of macros, dates have 4x the carbs and/but 8x the fiber, making for the lower glycemic index. Also, for what it’s worth, they have nearly 4x the protein, but probably nobody is eating either of these fruits for the protein. In any case, it’s an easy and clear win for dates in the category of macros.
In the category of vitamins, dates have more of vitamins B2, B3, B5, B6, B9, and choline, while grapes have more of vitamins B1, C, E, and K, making for a 6:4 win for dates.
When it comes to minerals, it’s more one-sided: dates have more calcium, copper, iron, magnesium, phosphorus, potassium, selenium, and zinc, while grapes have more manganese. An easy win for dates here.
Of course, enjoy either or both (diversity is good), but if you’re looking for nutrient density, dates are where it’s at.
Want to learn more?
You might like:
Can We Drink To Good Health? ← while there are polyphenols such as resveratrol in red wine that per se would boost heart health, there’s so little per glass that you may need 100–1000 glasses per day to get the dosage that provides benefits in mouse studies.
If you’re not a mouse, you might even need more than that!
To this end, many people prefer resveratrol supplementation ← link is to an example product on Amazon, but there are plenty more so feel free to shop around 😎
Enjoy!
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Can You Reverse Gray Hair? A Dermatologist Explains
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Betteridge’s Law of Headlines states “any headline that ends in a question mark can be answered by the word no“—it’s not really a universal truth, but it’s true surprisingly often, and, as board certified dermatologist “The Beauty MD” Dr. Sam Ellis explains, it’s true in this case.
But, all is not lost.
Physiological Factors
Hair color is initially determined by genes and gene expression, instructing the body to color it with melanin (brown and black) and/or pheomelanin (blonde and red). If and when the body produces less of those pigments, our hair will go gray.
Factors that affect if/when our hair will go gray include:
- Genetics: primary determinant, essentially a programmed change
- Age: related to the above, but critically, the probability of going gray in any given year increases with age
- Ethnicity: the level of melanin in our skin is an indicator of how long we are likely to maintain melanin in our hair. Black people with the darkest skintones will thus generally go gray last, whereas white people with the lightest skintones will generally go gray first, and so on for a spectrum between the two.
- Medical conditions: immune conditions such as vitiligo, thyroid disease, and pernicious anemia promote an earlier loss of pigmentation
- Stress: oxidative stress, mainly, so factors like smoking will cause earlier graying. But yes, also chronic emotional stress does lead to oxidative stress too. Interestingly, this seems to be more about norepinephrine than cortisol, though.
- Nutrient deficiencies: the body can make a lot of things, but it needs the raw ingredients. Not having the right amounts of important vitamins and minerals will result in a loss of pigmentation (amongst other more serious problems). Vitamins B6, B9, and B12 are talked about in the video, as are iron and zinc. Copper is also needed for some hair colors. Selenium is needed for good hair health in general (but not too much, as an excess of selenium paradoxically causes hair loss), and many related things will stop working properly without adequate magnesium. Hair health will also benefit a lot from plenty of vitamin B7.
So, managing the above factors (where possible; obviously some of the above aren’t things we can influence) will result in maintaining one’s hair pigment for longer. As for texture, by the way, the reason gray hair tends to have a rougher texture is not for the lack of pigment itself, but is due to decreased sebum production. Judicious use of exogenous hair oils (e.g. argan oil, coconut oil, or whatever your preference may be) is a fine way to keep your grays conditioned.
However, once your hair has gone gray, there is no definitive treatment with good evidence for reversing that, at present. Dye it if you want to, or don’t. Many people (including this writer, who has just a couple of streaks of gray herself) find gray hair gives a distinguished look, and such harmless signs of age are a privilege not everyone gets to reach, and thus may be reasonably considered a cause for celebration
For more on all of the above, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
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The Origin of Everyday Moods – by Dr. Robert Thayer
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First of all, what does this title mean by “everyday moods”? By this the author is referring to the kinds of moods we have just as a matter of the general wear-and-tear of everyday life—not the kind that come from major mood disorders and/or serious trauma.
The latter kinds of mood take less explaining, in any case. Dr. Thayer, therefore, spends his time on the less obvious ones—which in turn are the ones that affect most of the most, every day.
Critical to Dr. Thayer’s approach is the mapping of moods by four main quadrants:
- High energy, high tension
- High energy, low tension
- Low energy, high tension
- Low energy, low tension
…though this can be further divided into 25 sectors, if we rate each variable on a scale of 0–4. But for the first treatment, it suffices to look at whether energy and tension are high or low, respectively, and which we’d like to have more or less of.
Then (here be science) how to go about achieving that in the most efficient, evidence-based ways. So, it’s not just a theoretical book; it has great practical value too.
The style of the book is accessible, and walks a fine line between pop-science and hard science, which makes it a great book for laypersons and academics alike.
Bottom line: if you’d like the cheat codes to improve your moods and lessen the impact of bad ones, this is the book for you.
Click here to check out The Origin of Everyday Moods, and manage yours!
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What This Physio Did When He Got Sciatica
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Will Harlow, the over-50s specialist physio, got a taste of his own medicine:
How to bounce back (without bouncing your back)
Sciatica is quite a pain, to say the least, not to mention a considerable inconvenience. And yet, it can strike even very healthy people, but if it does, it’s not the end of the world and there are things to do to fix it.
When it happened to Will Harlow, lessons he quickly learned included:
- his sciatica symptoms were unpredictable and chaotic
- certain slight positions hurt more than larger movements
- spinal compression from heavy loads often worsened symptoms
- exercises or stretches that he knew “should” help actually worsened his symptoms too
- in this latter case, his mistake was that he introduced them too early; he needed to get past the first stage of recovery first!
So, he recommends to learn from his mistakes and stay as active as possible without provoking symptoms, prioritize walking throughout recovery, and/but modify gym training (light loads, focus on good form, keep a neutral spine where reasonably possible) rather than stopping entirely.
Sleep positioning can be a big deal for sciatic (well, in general really, but especially in cases of sciatica), and side sleeping with a pillow between your knees can reduce nerve tension, improve pelvic alignment, and make sleep far more comfortable.
For more on all of this and some specific exercise recommendations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Healing Back Pain – by Dr. John Sarno
Take care!
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Boundary-Setting Beyond “No”
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More Than A “No”
A lot of people struggle with boundary-setting, and it’s not always the way you might think.
The person who “can’t say no” to people probably comes to mind, but the problem is more far-reaching than that, and it’s rooted in not being clear over what a boundary actually is.
For example: “Don’t bring him here again!”
Pretty clear, right?
And while it is indeed clear, it’s not a boundary; it’s a command. Which may or may not be obeyed, and at the end of the day, what right have we to command people in general?
Same goes for less dramatic things like “Don’t talk to me about xyz”, which can still be important or trivial, depending on whether the topic of xyz is deeply traumatizing for you, or mildly annoying, or something else entirely.
Why this becomes a problem
It becomes a problem not because of any lack of clarity about your wishes, but rather, because it opens the floor for a debate. The listener may be given to wonder whether your right to not experience xyz is greater or lesser than their right to do/say/etc xyz.
“My right to swing my fist ends where someone else’s nose begins”
…does not help here, firstly because both sides will believe themself (or nobody) to be the injured party; for the fist-swinger, the other person’s nose made a vicious assault on their freedom. Or secondly, maybe there was some higher principle at stake; a reason why violence was justified. And then ten levels of philosophical debate. We see this a lot when it comes to freedom of expression, and vigorous debate over whether this entails freedom from social consequences of one’s words/actions.
How a good boundary-setting works (if this, then that)
Consider two signs:
- No trespassing!
- Trespassers will be shot!
Superficially, the second just seems like a more violent rendition of the first. But in fact, the second is more informationally useful: it explains what will happen if the boundary is not respected, and allows the reader to make their own informed decision with regard to what to do with that information.
We can employ this method (and can even do so gently, if we so wish and hopefully we mostly do wish to be gentle) when it comes to social and interpersonal boundary-setting:
- If you bring him here again, I will refuse you entrance
- If you bring up that topic again, I will ask you to leave
- If you do that, I will never speak to you again
- If you don’t stop drinking, I will divorce you
This “if-this-then-that” model does the very first thing that any good boundary does: make itself clear.
It doesn’t rely on moral arguments; it doesn’t invite debate. For example in that last case, it doesn’t argue that the partner doesn’t have the right to drink—it simply expresses what the speaker will exercise their own right to do, in that eventuality.
(as an aside, the situation that occurs when one is enmeshed with someone who is dependent on a substance is a complex topic, and if you’re interested in that, check out: Codependency Isn’t What Most People Think)
Back on track: boundary-setting is not about what’s right or good—it’s about nothing more nor less than a clear delineation between what we will and won’t accept, and how we’ll enforce that.
We can also, in particularly personal boundary-setting (such as with sexual boundaries’ oft-claimed “gray areas”), fix an improperly-set boundary that forgot to do the above, e.g:
“How about [proposition]?”
“No thank you” ← casually worded answer; contextually reasonable, and yet not a clear boundary per what we discussed above
“Come on, I think you’d like it”
“I said no. No means no. Ask me again and I will [consequences that are appropriate and actionable]”What’s “appropriate and actionable” may vary a lot from one situation to another, but it’s important that it’s something you can do and are prepared to do and will do if the condition for doing it is met.
Anything less than that is not a boundary—it’s just a request.
Note: this does not require that we have power, by the way. If we have zero power in a situation, well, that definitely sucks, but even then we can still express what is actionable, e.g. “I will never trust you again”.
“Price of entry”
You may have wondered, upon reading “boundary-setting is not about what’s right or good—it’s about nothing more nor less than a clear delineation between what we will and won’t accept, and how we’ll enforce that”, can’t that be used to control and manipulate people, essentially coercing them to do or not do things with the threat of consequences (specifically: bad ones)?
And the answer is: yes, yes it can.
But that’s where the flipside comes into play—the other person gets to set their boundaries, too.
For all of us, if we have any boundaries at all, there is a “price of entry” and all who want to be in our lives, or be close to us, have to decide for themselves whether that price of entry is worth it.
- If a person says “do not talk about topic xyz to me or I will leave”, that is a price of entry for being close to them.
- If you are passionate about talking about topic xyz to the point that you are unwilling to shelve it when in their presence, then that is the price of entry for being close to you.
- If one or more of you is not willing to pay the price of entry, then guess what, you’re just not going to be close.
In cases of forced proximity (e.g. workplaces or families) this is likely to get resolved by the workplace’s own rules (i.e. the price of entry that you agreed to when signing a contract to work there), and if something like that doesn’t exist (such as in families), well, that forced proximity is going to reach a breaking point, and somebody may discover it wasn’t enforceable after all.
See also: Family Estrangement: More Common Than Most People Think
…which also details how to fix it, where possible.
Take care!
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Why Do We Have Pores, And Could We Not?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small
❝Do we really need pores, and why are they bigger on the face?❞
Pores secrete sweat or sebum (there are different kinds of pores for each).
If we didn’t have sweat pores, we’d be unable to sweat, which superficially may seem like a bonus, but it’d make us prone to overheating (like dogs, pigs, and other mammals that cannot sweat).
If we didn’t have sebum pores (usually called hair follicles, which are supplied by a sebaceous gland), we’d be completely hairless, and also unable to supply our skin with natural oils that keep it healthy. So we’d have no hair and very unhappy skin.
Which is ironic, because to believe beauty magazines, we must at all costs minimize our pores (and indeed, interventions like botox* can kill them).
*Let’s give that its full name though:
Suffice it to say, we do not recommend getting injected with neurotoxins unless it is truly necessary to ward off a greater harm. That said, we’re not the boss of you, and the safety profile is better than you might expect: How Safe Is Botox, Really? ← at least in the short term; if people are getting monthly top-ups for many years, the outcomes may be different.
As for being bigger on the face, they need not be, but sebaceous glands are more active and numerous there, being most active and numerous in the face/forehead—which is why oily skin is more likely to appear there than other parts of the body.
If your facial sebaceous glands are too active for your liking…
…there are ways to reduce that, a simple and relatively gentle way (relative, for example, botox) is with retinoids, including retinols or retinoic acids. Here’s some of the science of that; the paper is about treating acne, but the mechanism of action is the same (down-regulating the sebaceous glands’ action):
The potential side-effects, however were noted as:
- Cheilitis
- Desquamation of the skin
- Pruritus
Which, in translation from sciencese, means:
- Chapped lips
- Flaky skin
- Itchiness
Which aren’t necessarily fun, which is why with retinoids are best taken in very small doses at first to see how your skin reacts.
Remember when we said what your skin would be like without pores? This is what would happen, only much worse.
Take care!
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