
How Stress Affects Your Body
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Dr. Sharon Bergquist gives us a tour:
Stress, from the inside out
Stress is a natural physical and emotional response to challenges or being overwhelmed. It can be beneficial in short-term situations (e.g. escape from a tiger) but is harmful when prolonged or frequent (e.g. escape the rat-race).
Immediate physiological response: cortisol, adrenaline (epinephrine), and norepinephrine are released by the adrenal glands.
The effects this has (non-exhaustive list; we’re just citing what’s in the video here):
- Cortisol impairs blood vessel function, promoting atherosclerosis.
- Adrenaline increases heart rate and blood pressure, leading to hypertension.
- Stress disrupts the brain-gut connection, causing:
- Digestive issues like irritable bowel syndrome and heartburn.
- Changes in gut bacteria composition, potentially affecting overall health.
- Cortisol increases appetite and cravings for energy-dense “comfort foods”.
- This in turn promotes visceral fat storage, which raises the risk of heart disease and insulin resistance.
- Immune-specific effects:
- Stress hormones initially aid in healing and immune defense.
- Chronic stress weakens immune function (by over-working it constantly), increasing susceptibility to infections and slowing recovery.
- Other systemic effects:
- Chronic stress shortens telomeres, which protect chromosomes. Shortened telomeres accelerate cellular aging.
- Chronic stress can also cause acne, hair loss, sexual dysfunction, headaches, muscle tension, fatigue, irritability, and difficulty concentrating.
So, how to manage this? The video says that viewing stressful situations as controllable challenges, rather than insurmountable threats, leads to better short-term performance and long-term health.
Which would be wonderful, except that usually things are stressful precisely because they are not entirely within the field of our control, and the usual advice is to tend to what we can control, and accept what we can’t.
However… That paradigm still leaves out the very big set of “this might be somewhat within our control or it might not; we really don’t know yet; we can probably impact it but what if we don’t do enough, or take the wrong approach and do the wrong thing? And also we have 17 competing stressors, which ones should we prioritize tending to first, and…” and so on.
To that end, we suggest checking out the “Want to learn more?” link we drop below the video today, as it is about managing stress realistically, in a world that, if we’re honest about it, can sometimes be frankly unmanageable.
Meanwhile, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Heart Health vs Systemic Stress ← this is good in and of itself, and also links to other stress-related resources of ours
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The Neuroscience of You – by Dr. Chantel Prat
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The insides of people are rarely so standardized as one finds in a medical textbook, and that’s just as true of the brain as it is of any other organ—and often more so.
Our brains all look quite different from each other’s. Of course there are similarities; a wobbly mass of white and grey matter with tiny blood vessels running through. The constituent parts are (usually!) all present and correct. But… what is “correct”?
Dr. Chantel Prat takes us on a tour of the anatomical features that we may have grown or shrunken over the course of our life, according to how we’ve used them, or not. She also looks at what’s going on when it comes to the smaller scale—from the neuronal to the neurochemical.
We learn the truth (and myth) when it comes to left- and right-brainedness, and we learn how whether we saw that dress as black and blue or white and gold, depends on our circadian rhythm (and thus whether we have wired ourselves for perceiving colors more or less often under daylight or artificial light). And lots more.
The style throughout is very accessible, for a book that goes beyond most “how the brain works” books.
Bottom line: if you’re interested in the workings of your brain (as opposed to: a standardized Platonic ideal of what a brain might be), then this book will set you on the right track.
Click here to check out The Neuroscience of You, and learn more about what makes you you!
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Best Salt for Neti Pots?
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❓ Q&A With 10almonds Subscribers!
Q: What kind of salt is best for neti pots?
A: Non-iodised salt is usually recommended, but really, any human-safe salt is fine. By this we mean for example:
- Sodium chloride (like most kitchen salts),
- Potassium chloride (as found in “reduced sodium” kitchen salts), or
- Magnesium sulfate (also known as epsom salts).
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How Psychedelics Repair Brain Myelin!
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We’ve written before about myelin (the protective sheath that neurons live in—basically, myelin sheaths do for neurons what telomere caps do for DNA).
Behold: How To Rebuild Your Neurons’ Myelin Sheaths ← this is an article about phosphatidylserine’s role in that process
The health of our myelin is important, because as well as protecting the neurons, the myelin also insulates them—remember that in essence, nerves (made of neurons) are a lot like electrical wires, and they can absolutely be shorted out, misfired, etc, and myelin is a large part of what keeps that from happening (provided everything’s working as it should).
Consequently, demyelination is considered an issue partially responsible for the ill effects of several degenerative diseases, with multiple sclerosis (MS) being high on the list.
So, how do psychedelics help?
Psychedelics, myelin, and you
Regular readers may recall our articles about psychedelics and mental health, such as:
Taking A Trip Through The Evidence On Psychedelics
…and also:
…which has to do with the lasting benefits of a single dose of a psychedelic compound. How lasting, you wonder? Well, there’s nuance to the answer, so you’ll need to read the article for that, but “a surprisingly good while”.
Now, most recently, researchers (Dr. Mehmet Bostancıklıoğlu et al.) found that psychedelics can support long-term PTSD recovery by promoting myelin repair and (with it) reorganization of brain networks.
Why this matters in PTSD: post-traumatic stress disorder involves not just strongly encoded unpleasant memories, but also disrupted timing and coordination across brain circuits, particularly in memory-related regions like the dentate gyrus of the hippocampus. And that’s “how it gets you”, in terms of the brain not really fully accepting that the Bad Thing™ is in the past, and that you are safe now, even if intellectually you know these things. It can sound like psychobabble or (more charitably) therapy talk, and in a way it is that latter, but there’s also some very clear neurology going on here, as this study elucidates.
What Dr. Bostancıklıoğlu and his team found is that low repeated doses of psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) caused changes in oligodendrocytes (the cells that produce myelin) and multi-omic genetic signatures that are consistent with myelin remodeling, which gave the clue that that repairing neuronal insulation (i.e., the myelination) could help stabilize healthier circuit dynamics after psychedelic treatment.
Not liking to leave hypotheses untested, the team did find causation, not just correlation:
- Experimenting on rats, the researchers experimentally damaged myelin, finding that the anxiolytic effects of psilocybin and MDMA disappeared, while improving myelination supported recovery, showing that intact myelin was required for behavioural improvement.
- Next up, they blocked the serotonin 5-HT2A receptors, which prevented both behavioural benefits and myelin-related changes, showing that classic psychedelic receptor pathways are necessary for these structural effects too.
- Lastly, they found that using anisomycin to block fear-memory formation reduced anxiety but did not repair myelin, showing that mere symptom suppression (however potentially beneficial as an end in itself) differs from the true biological recovery that this provides.
In other words, it not only works (which we already somewhat knew, by virtue of studies such as those we talked about in our “Taking A Trip Through The Evidence On Psychedelics” article), but also, we now know how it works too.
Which is useful, because:
- understanding how it works helps us to help it to work better
- understanding how it works will promote more research
- understanding how it works will help improve accessibility*
*because, for example, health insurers find it harder to say no, the more strongly evidence-based a treatment is, and also doctors will be quicker to sign prescriptions for things that are well-understood.
You can read the paper in full, at: MDMA and psilocybin regulate oligodendrocyte-lineage cell numbers and anxiety-like behaviors in a rat model of fear
Want to learn more?
For more comprehensive brain-rebuilding advice, check out:
Building Your Brain At Every Age ← for a more multimodal approach, because after all, why rely on just one thing?
And for more on psychedelics specifically, you might like this book we reviewed a little while back:
Psychedelics and Psychotherapy – Edited by Dr. Tim Read & Maria Papaspyrou
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12 Questions For Better Brain Health
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We usually preface our “Expert Insights” pieces with a nice banner that has a stylish tall cutout that allows us to put a photo of the expert in. Today we’re not doing that, because for today’s camera-shy expert, we could only find one photo, and it’s a small, grainy, square headshot that looks like it was taken some decades ago, and would not fit our template at all. You can see it here, though!
In any case, Dr. Linda Selwa is a neurologist and neurophysiologist with nearly 40 years of professional experience.
The right questions to ask
As a neurologist, she found that one of the problems that results in delayed interventions (and thus, lower efficacy of those interventions) is that people don’t know there’s anything to worry about until a degenerative brain condition has degenerated past a certain point. With that in mind, she bids us ask ourselves the following questions, and discuss them with our primary healthcare providers as appropriate:
- Sleep: Are you able to get sufficient sleep to feel rested?
- Affect, mood and mental health: Do you have concerns about your mood, anxiety, or stress?
- Food, diet and supplements: Do you have concerns about getting enough or healthy enough food, or have any questions about supplements or vitamins?
- Exercise: Do you find ways to fit physical exercise into your life?
- Supportive social interactions: Do you have regular contact with close friends or family, and do you have enough support from people?
- Trauma avoidance: Do you wear seatbelts and helmets, and use car seats for children?
- Blood pressure: Have you had problems with high blood pressure at home or at doctor visits, or do you have any concerns about blood pressure treatment or getting a blood pressure cuff at home?
- Risks, genetic and metabolic factors: Do you have trouble controlling blood sugar or cholesterol? Is there a neurological disease that runs in your family?
- Affordability and adherence: Do you have any trouble with the cost of your medicines?
- Infection: Are you up to date on vaccines, and do you have enough information about those vaccines?
- Negative exposures: Do you smoke, drink more than one to two drinks per day, or use non-prescription drugs? Do you drink well water, or live in an area with known air or water pollution?
- Social and structural determinants of health: Do you have concerns about keeping housing, having transportation, having access to care and medical insurance, or being physically or emotionally safe from harm?
You will note that some of these are well-known (to 10almonds readers, at least!) risk factors for cognitive decline, but others are more about systemic and/or environmental considerations, things that don’t directly pertain to brain health, but can have a big impact on it anyway.
About “concerns”: in the case of those questions that ask “do you have concerns about…?”, and you’re not sure, then yes, you do indeed have concerns.
About “trouble”: as for these kinds of health-related questionnaires in general, if a question asks you “do you have trouble with…?” and your answer is something like “no, because I have a special way of dealing with that problem” then the answer for the purposes of the questionnaire is yes, you do indeed have trouble.
Note that you can “have trouble with” something that you simultaneously “have under control”—just as a person can have no trouble at all with something that they leave very much out of control.
Further explanation on each of the questions
If you’re wondering what is meant by any of these, or what counts, or why the question is even being asked, then we recommend you check out Dr. Selwa et al’s recently-published paper, then all is explained in there, in surprisingly easy-to-read fashion:
Emerging Issues In Neurology: The Neurologist’s Role in Promoting Brain Health
If you scroll past the abstract, introduction, and disclaimers, then you’ll be straight into the tables of information about the above 12 factors.
Want to be even more proactive?
Check out:
How To Reduce Your Alzheimer’s Risk
Take care!
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Can Reflexology Shoes Improve Your Focus?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
No question/request too big or small 😎
❝What about shoes with insoles for reflexology, like the new ones with neuroscience claims. Are they legit?❞
First, a disclaimer-laden answer: probably by “legit” you mean “do they work to improve brain function?”, but it’s hard to uncouple “legit” from “legitimate” in the litigious sense. So, we will say, we are but a humble health science publication, and cannot comment on the legality of any company’s products or claims.
We can comment on more concrete scientific questions though, such as: does the evidence support claims that such shoes improve brain function?
In which case, the answer is: no
What you have to bear in mind is how a lot of companies will make claims that are technically true (for legal reasons) but functionally meaningless (in any practical sense that most readers would read it).
For example, let’s look at one such example that’s been making headlines lately, perhaps it’s even what you saw. It’s Nike’s new “neuroscience-based footwear”, which they describe with such statements as:
Nike is launching a new type of shoe designed to help athletes lock in their mindset pre- and post-competition.
The Mind 001 and Mind 002 are the first neuroscience-based footwear from Nike that tap into the mind-body connection by activating sensory receptors in the feet.
Nike is introducing its first neuroscience-based footwear: two mind-altering silhouettes designed to help athletes lock in their mindset before and after competition. Scientifically shown to activate key sensory areas of the brain via underfoot stimulation, the Nike Mind 001 mule and Mind 002 sneaker deepen an athlete’s awareness, helping ground them in their bodies and bring them back to the present moment.
Source: Nike Debuts its First Neuroscience-Based Footwear to Help Athletes Feel Calm, Focused and Present
These sound like strong claims, but let’s break it down a little:
designed to help athletes lock in their mindset pre- and post-competition
When this writer was small, she designed a pair of shoes to help her walk on water (there were shoe-sized pieces of wood attached under them, on the basis that wood floats).
Were they designed to help our intrepid writer to walk on water? Yes, they were. That was literally what they were designed to do.
Did they actually enable her to walk on water? No, they did not.
So, always watch out for such phrases as “designed to”, “intended to”, “aimed at helping”, and so forth.
Now, as for…
Scientifically shown to activate key sensory areas of the brain via underfoot stimulation
That’s a fair claim! But it’s also not what it might seem like. The reality is, anything that you can experience will activate key sensory areas in the brain. If it didn’t, then you wouldn’t experience it, because how could you, if it didn’t activate the relevant sensory areas in your brain?
And so on, with various other true claims.
Can they help anything?
Yes! Shoes are very relevant things for our health.
For example, shoes with “zero-drop”, i.e. with no incline/decline, and the inside sole of the foot is parallel to the floor (so, not like the featured image for this article, which are by no means high heels, but you can see the heel is raised more than the toes, and there’s a gradient between the two, as is common in most “flat” shoes that aren’t really flat), support good foot health for most people, and foot health is indeed the foundation of a lot of other good health, much like if your car tires are bad, the rest of your car won’t stay in good condition for long.
We wrote about the zero-drop issue here: Steps For Keeping Your Feet A Healthy Foundation
…which is consistent with such science as: Foot strike patterns and collision forces in habitually barefoot versus shod runners
However, some other things are less evidence-based, for example:
Are Grounding Mats Grounded In Good Science?
…and:
Reflexology: What The Science Says
Want to learn more?
You might also like:
The Foot Book – by Dr. Todd Brennan & Dr. Leslie Johnston
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What is frozen shoulder? And will I need surgery?
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Frozen shoulder can make simple tasks – such as lifting your arm, sleeping on your side, getting out of bed, putting on a bra, driving or playing with your kids – painful and challenging.
This condition usually starts with pain suddenly developing in the shoulder and stiffness. Over time, the pain and stiffness get worse. It can drag on for months or even years.
So, what causes frozen shoulder? And can it be treated?
Mikolette/Getty What is frozen shoulder?
This shoulder condition, also known as “adhesive capsulitis”, affects around 8% of men and 10% of women aged 25–64. But it’s more common over 40, especially for people in their 60s.
We don’t fully understand what causes frozen shoulder.
The tissues around the joint become tight, swollen and stiff. But we don’t know exactly why these changes occur and lead to pain and limited movement.
There are usually three stages:
- freezing – pain gradually gets worse and the shoulder becomes stiff, limiting the range of movement
- frozen – stiffness and pain usually peak, but may begin to ease
- thawing – pain and stiffness slowly improve, and movement begins to return.
While health professionals commonly accept it, this staged description suggests frozen shoulder will follow a predictable pattern and always get better on its own. But research suggests this is not always the case.
For example, the “freezing” stage is usually expected to last at least ten weeks. But some people will start to notice improved movement sooner.
Recovery stages will vary from person to person and can take months to years. Some people may not fully recover, even with treatment.
One 2020 study followed up with 215 patients with frozen shoulder. While over 70% of participants said they were happy with improvements in their symptoms, around 40% still had some movement restriction two years after their symptoms began.
Another study from 2008 found over a third of people they surveyed (41%) had ongoing symptoms two to seven years later, including pain and difficulty sleeping.
Who is most at risk?
Certain groups are more likely to develop frozen shoulder:
- women, especially during menopause
- people with diabetes
- older adults
- those with high cholesterol or thyroid problems.
There is some evidence genetics also plays a role, as a family history increases your risk.
But we need more high-quality research to understand what’s behind these risk factors.
For example, people with diabetes are around five times more likely to develop frozen shoulder than those without diabetes – and also have worse pain. This may be linked to diabetes-related changes in the body, such as reduced blood flow to tissues and chemical changes from high blood sugar. But the exact mechanisms are unclear, and research is yet to determine whether controlling blood sugar better could help prevent or slow frozen shoulder.
Similarly, women are 40% more likely to develop frozen shoulder than men, with one theory suggesting hormone fluctuations during menopause are responsible. But there is no clear evidence yet to support this.
How is frozen shoulder treated?
There is mixed evidence about which treatments are effective, including whether over-the-counter pain medication such as Voltaren helps.
Oral steroids
A review of the evidence suggests oral steroids, such as prednisolone, can provide some short-term pain relief and improve shoulder movement, compared to doing nothing or a placebo. But these benefits don’t seem to last beyond six weeks, and the evidence comes from a few small studies. These require a prescription.
Injections
High-quality evidence shows corticosteroid injections can provide short-term relief, compared to doing nothing.
There is also some limited evidence that corticosteroid injections and platelet rich plasma injections can provide better short-term pain relief, compared with over-the-counter pain relief and physiotherapy. However, the studies are small or poorly designed and the effects are small, so the evidence needs to be interpreted with caution.
Physiotherapy
Moderate-quality evidence suggests physiotherapy can help improve shoulder movement. Benefits of physio are greater when combined with a steroid injection, and followed up by doing the exercises at home. More research is needed to understand how well these treatments work in the long term.
What about surgery?
There are two main procedures for frozen shoulder, both done while the patient is unconscious under anaesthetic.
1. Manipulation under anaesthetic
This is a less invasive procedure where the surgeon stretches the shoulder, without cutting into the joint, to help loosen tight tissue that may be causing stiffness.
2. Arthroscopic capsular release
In this type of keyhole surgery, the surgeon cuts tight tissues inside the shoulder joint to try to free up shoulder movement.
Improvements from these procedures are typically small, and evidence suggests the results are not better than non-surgical treatments. For example, one study showed that after one year, patients who’d had surgery had similar improvements to those who’d had physiotherapy and a steroid injection, but no surgery.
These procedures also have several downsides. It’s more expensive than other treatments, carries additional risks, and typically requires weeks (and up to three months) of rehabilitation.
The bottom line
Being physically active and doing exercises can help if you’re experiencing pain and limited movement. But you don’t have to work this out alone. It’s a good idea to get advice on managing pain and how to stay active.
If you suspect you have frozen shoulder, it’s important to see a doctor or physiotherapist so they can rule out other conditions, such as fracture and arthritis.
A health professional can also discuss management – the potential benefits, harms, costs, and how easy it is to access each treatment option.
Fernando Sousa, Research Fellow in Physiotherapy, Monash University; Joshua Zadro, NHMRC Emerging Leader Research Fellow, Sydney Musculoskeletal Health, University of Sydney, and Peter Malliaras, Professor in Physiotherapy, Monash University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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