Advance Warnings Of Multiple Sclerosis (15-Year Timeline!)

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There’s a lot of mystery to multiple sclerosis (MS). We don’t know what causes it. We don’t know how it happens. We don’t know how it can be fixed.

We do know approximately what it is, though; it’s not a “the doctors are half-sure the patient is making it up” thing. In MS, we know it’s an autoimmune condition, and that it degrades the myelination of nerves. We don’t know the mechanism of how the autoimmune condition actually degrades the myelin, but we see specific markers of chronic inflammation and we see myelin withering away, so we’re pretty sure the former leads to the latter somehow.

Another thing we know: we do know what heralds its coming! We wrote about that before, here: Five Advance Warnings of Multiple Sclerosis

If you don’t want to click through, we’ll not keep the 5 signs a secret, they are:

  1. depression
  2. sexual disorders
  3. constipation
  4. cystitis
  5. urinary tract infections

And indeed:

❝This association was sufficiently robust at the statistical level for us to state that these are early clinical warning signs, probably related to damage to the nervous system, in patients who will later be diagnosed with multiple sclerosis. The overrepresentation of these symptoms persisted and even increased over the five years after diagnosis.❞

~ Dr. Céline Louapre

But now there’s more: we have a timeline!

A plucky band of researchers (Dr. Marta Ruiz-Algueró et al.) looked at thousands of patients with (n=2,038) and without (n=10,182) MS, and looked at their medical histories over 25 years prior to the onset of clinical symptoms of MS (e.g., the characteristic demyelination of nerves).

They found some surprisingly clear patterns, and the timeline looks like this:

  • 15 years before: increased visits to general practitioners for fatigue, pain, dizziness, and mental health concerns.
  • 12 years before: increased psychiatrist visits.
  • 8–9 years before: increased visits to neurologists and ophthalmologists (especially: blurry vision, eye pain).
  • 3–5 years before: rise in emergency medicine and radiology visits.
  • 1 year before: peak in physician visits across multiple specialties.

You may be wondering: where are the UTIs, constipation, etc from the other study? The answer is they are in the last few years, and come under the umbrella terms mentioned.

In short, there is a long, complex prodromal period (much longer and more complex than previously known) where early signs, often initially mental health-related, emerge before the disease’s clear neurological symptoms. This is interesting, because prodromal phases are also seen in Parkinson’s disease, which as the researchers suggested, might reflect a similar progression pattern (or it might not—that research is yet to be done).

You can read the paper in full, here: Health Care Use Before Multiple Sclerosis Symptom Onset

So, forewarned is fore-armed, as they say. On which note…

Is there anything that can be done?

Yes! While there is as yet no known cure, it is—per the case study of Dr. Saray Stancic—possible to at least become mostly symptom-free, which is a big win:

Dr. Saray Stancic is another from the ranks of “doctors who got a serious illness and it completely changed how they view the treatment of serious illness”.

In her case, Stancic was diagnosed with multiple sclerosis, and wasn’t impressed with the results from the treatments offered, so (after 8 years of pain, suffering, and many medications, only for her condition to worsen) she set about doing better with an evidence-based lifestyle medicine approach.

After 7 years of her new approach, she would go on to successfully run a marathon and live symptom-free.

All this to say: her approach isn’t a magic quick fix, but it is a serious method for serious results, and after all, while it’d be nice to be magically in perfect health tomorrow, what’s important is being in good health for life, right?❞

You can read all about what she did and how to do it, here: Lifestyle vs Multiple Sclerosis & More ← the “and more” is because the same model can be applied to quite a number of other conditions too 😎

Take care!

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  • Longevity… Simplified – by Dr. Howard Luks

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    In the spirit of the book itself, we’ll keep this one simple:

    The information in this book will not be new to regular readers of 10almonds, or at least, not if you’ve been with us for a while (because we can only cover so much per day, so long-time readers will have accumulated more knowledge).

    On the other hand, the information is clear, correct, and very much stripped down to the most important basics. Not the very simplest basics, which would be an oversimplification to the point of inutility, but the most important basics.

    To take an example, when it comes to exercise, he doesn’t say “exercise more” but rather that “a complete exercise program has four pillars: aerobic training, resistance training, balance training, and high-intensity interval training (HIIT)”, and then he goes about explaining, in clear and simple terms, how to do those.

    The style is similar when it comes to diet, sleep, and body-part-specific chapters such as about heart health, brain health, and so forth.

    Bottom line: if you’re a long-time 10almonds reader, you probably don’t need this one, but it’d be a great book for someone else who has expressed an interest in getting healthier, as it really is a top-tier “primer” in increasing health and healthspan.

    Click here to check out Longevity… Simplified, and enjoy simplified longevity!

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  • Does Quitting Bread For 30 Days Trigger Weight Loss?

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    Here’s what’s going on, physiologically:

    On the rise

    In few words: cutting bread for 30 days can lead to weight loss for some people, but the initial change is often more a matter of reduced water retention and bloating rather than immediate fat loss. In particular, it’s common for people feel lighter within the first week or so because reducing fermentable carbohydrates can decrease gas production and resultant digestive discomfort, especially in those with sensitive guts.

    On which note…

    About wheat components and tolerance: certain compounds in wheat—such as gluten, lectins, and phytates—don’t affect everyone the same way, but in those whose physiologies don’t handle them well, repeated exposure contributes to low-grade inflammation and/or mineral absorption issues, all of which can trigger feelings of sluggishness.

    Speaking of feelings, it’s worth noting that digestion of gluten can produce peptides that mildly interact with opioid receptors, so temporary cravings during the first 1–2 weeks is generally a matter of neurobiological adaptation.

    However, there are some more things to consider, for example: bread is primarily starch that rapidly converts to glucose, triggering insulin release, which means that reducing frequent refined carbohydrate exposure (i.e. most bread) will typically lower fasting insulin and improve blood sugar stability over time.

    This is relevant also to the weight loss issue, because when insulin spikes happen less often, your body can more easily switch between burning glucose and stored fat.

    In short, a 30-day break from bread can function as a short-term self-experiment to observe changes in energy, digestion, cravings, and possibly weight, but long-term metabolic health depends much more on overall dietary patterns than on any single food.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Grains: Bread Of Life, Or Cereal Killer?

    Take care!

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  • Body on Fire – by Dr. Monica Aggarwal and Dr. Jyothi Rao

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    There are times when you do really need a doctor, not a dietician. But there are also times when a doctor will prescribe something for the symptom, leaving the underlying issue untouched. If only there were a way to have the best of both worlds!

    That’s where Drs. Rao and Aggarwal come in. They’re both medical doctors… with a keen interest in nutrition and healthy lifestyle changes to make us less sick such that we have less need to go to the doctor at all.

    Best of all, they understand—while some things are true for everyone—there’s not a one-size-fits all diet or exercise regime or even sleep setup.

    So instead, they take us hand-in-hand (chapter by chapter!) through the various parts of our life (including our diet) that might need tweaking. Each of these changes, if taken up, promise a net improvement that becomes synergistic with the other changes. There’s a degree of biofeedback involved, and listening to your body, to be sure of what’s really best for you, not what merely should be best for you on paper.

    The writing style is accessible while science-heavy. They don’t assume prior knowledge, and/but they sure deliver a lot. The book is more text than images, but there are plenty of medical diagrams, explanations, charts, and the like. You will feed like a medical student! And it’s very much worth studying.

    Bottom line: highly recommendable even if you don’t have inflammation issues, and worth its weight in gold if you do.

    Get your copy of Body on Fire from Amazon today!

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  • Technology: Good Or Bad For Brain Health In Later Life?

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    The word “screentime” isn’t usually associated with anything positive. We all use apps to try to limit it, we all read articles telling us about how it hurts teenagers’ sleep and damages toddlers’ development.

    Now, it could be that the tech isn’t really to blame. This writer certainly remembers staying up late as a child without modern tech to blame! Perhaps you (dear reader) did the same.

    The case against tech

    There are several main potential problems:

    However! We can mitigate each of those:

    • Engage with our technology actively, and thus make it a cognitively stimulating activity; this means doing things that challenge us cognitively. It doesn’t have to mean hard stuff, but it does have to be the kind of thing we couldn’t do while half-asleep.
    • Consciously decide our technology’s access to us. For example, this writer has her phone silenced 100% of the time, and only allows a very few apps to give even silent notifications, and there are set hours when her phone goes completely untouched.
    • Decide what cognitive abilities we don’t care to maintain. You may be thinking “but surely, all our cognitive abilities are important!”, but… Are they? Is it truly critical for you to be able to do mental arithmetic rather than use a calculator? Do you really need to know how to spell “necessary eligibility embarrassment privilege”? Do you really need to know (by heart) your friend’s phone number? And, maybe you do! We all lead different lives, after all. But it may well be that there’s some merit to be found in picking your battles. This writer with dyscalculia (numerical equivalent of dyslexia) will use a calculator to do very simple calculations sometimes, for me it’s better to not waste my time expending a lot of mental energy on simple sums that I might still get wrong, and use that time and energy on more productive things. Perhaps you have a similar area of cognitive function that it makes sense for you to offload.

    The case for tech

    Much more research has been done into how technology use affects developing brains, than on how technology use affects aging brains.

    But “less” is not “none”, so…

    Our technology enables our connection to other people. It’s often viewed as the opposite, “people don’t know how to have a conversation these days; they’re all on their phones”, but before that it was radios, before that, newspapers/magazines; there’s always been something.

    But, phones were originally designed to connect humans to other humans, and that remains their principal function, in various ways.

    See also: Effectiveness of Technology Interventions in Addressing Social Isolation, Connectedness, and Loneliness in Older Adults: Systematic Umbrella Review

    And this is critical, because a lack of social connection is one of the highest predictors of cognitive decline:

    See for example: Late-life social activity and subsequent risk of dementia and mild cognitive impairment

    Plus, even on the less social side of things, technology can also help us to stay independent for longer:

    How can technology support ageing in place in healthy older adults? A systematic review

    …which again, beyond the obvious immediate health-related quality of life differences, has an impact on maintenance of cognitive functions.

    See further: A meta-analysis of technology use and cognitive aging

    Want to learn more?

    Check out:

    How To Make Social Media Work For Your Mental Health

    Take care!

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  • Do You Have Anosognosia?

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    This is Dr. Ian McDonough. He’s a postdoctoral neuroscience research fellow and psychology professor, specializing in episodic memory, aging, and biomarkers of pre-clinical Alzheimer’s disease.

    What does he want us to know?

    As we get older, most of us tend to have fairly accurate perceptions of our financial abilities, and this awareness tends to improve with age and experience—until cognitive decline begins.

    This was brought to light by a study he led, that analyzed 10 years of data from 2,802 older adults (age 65+). Participants rated their perceived ability in tasks like making change and paying bills, then performed actual financial tasks to test their competence.

    Older adults in their 70s were better able to predict their financial performance than younger “older adults”, which the researchers noted was probably because…

    ❝It does seem people get better with time. So, by the time you get to your 70s, as long as you maintain your cognition decently well, you’re able to predict your financial ability slightly better. It’s almost like you do learn as you get more and more experience, especially as you retire, and you’re dealing with Social Security, Medicaid, Medicare and all those types of things that have to do with finances.❞

    ~ Dr. Ian McDonough

    However! Cognitive decline disrupts this accuracy; people with cognitive decline (especially if progressing to dementia) often lose insight into their financial abilities, believing they’re more competent than they are—due to a condition called anosognosia, where one is unaware of one’s own cognitive impairment.

    Which is reasonable, really. The very mental faculties that would normally clue us in to noticing our decline in a certain area, have been hit by the cognitive decline too.

    This becomes a problem, because it then leaves people more vulnerable to suffering financial losses, either by maladministration of their affairs, or by falling prey to scams.

    You can find the paper here: Relationship Between Perceived and Objective Financial Abilities Among Older Adults: Results From the Advanced Cognitive Training for Independent and Vital Elderly Cohort

    What should we do about it?

    According to Dr. McDonough,

    ❝Our research suggests that there is a critical window of time after people begin to experience cognitive decline during which they are still aware of their financial abilities. We believe that this is when people can take action to secure their finances and develop systems to protect themselves from fraud❞

    We wrote about this a little before, in the context of planning around an Alzheimer’s diagnosis: Alzheimer’s: The Bad News And The Good

    We also covered the topic of a “Living Will”, to enact if you are no longer considered able to advocate for yourself, here: Managing Your Mortality: When Planning Is a Matter of Life and Death ← while the title does not herald a cheerful prognosis, we promise we do also talk about living wills and such too!

    This may particularly important in people with Parkinson’s disease, because of The Meds That Impair Decision-Making

    Delegating to others is an obvious (and often reasonable) solution, but it can come with problems, because of such things as:

    However, there are other options! For example:

    Ten-Year Effects of the Advanced Cognitive Training for Independent and Vital Elderly Cognitive Training Trial on Cognition and Everyday Functioning in Older Adults

    Short version: it works! You can read a pop-science rendering of things, here:

    How brain changes may affect financial skills: research by neuroscientist Ian McDonough could lead to interventions that preserve seniors’ financial independence

    Wondering how good your cognitive abilities are, and what that means in terms of dementia risk?

    It’s actually quite identifiable, if one knows what things “count” and what things don’t:

    Is It Dementia? Spot The Signs (Because None Of Us Are Immune)

    Take care!

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  • How a Friend’s Death Turned Colorado Teens Into Anti-Overdose Activists

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    Gavinn McKinney loved Nike shoes, fireworks, and sushi. He was studying Potawatomi, one of the languages of his Native American heritage. He loved holding his niece and smelling her baby smell. On his 15th birthday, the Durango, Colorado, teen spent a cold December afternoon chopping wood to help neighbors who couldn’t afford to heat their homes.

    McKinney almost made it to his 16th birthday. He died of fentanyl poisoning at a friend’s house in December 2021. His friends say it was the first time he tried hard drugs. The memorial service was so packed people had to stand outside the funeral home.

    Now, his peers are trying to cement their friend’s legacy in state law. They recently testified to state lawmakers in support of a bill they helped write to ensure students can carry naloxone with them at all times without fear of discipline or confiscation. School districts tend to have strict medication policies. Without special permission, Colorado students can’t even carry their own emergency medications, such as an inhaler, and they are not allowed to share them with others.

    “We realized we could actually make a change if we put our hearts to it,” said Niko Peterson, a senior at Animas High School in Durango and one of McKinney’s friends who helped write the bill. “Being proactive versus being reactive is going to be the best possible solution.”

    Individual school districts or counties in California, Maryland, and elsewhere have rules expressly allowing high school students to carry naloxone. But Jon Woodruff, managing attorney at the Legislative Analysis and Public Policy Association, said he wasn’t aware of any statewide law such as the one Colorado is considering. Woodruff’s Washington, D.C.-based organization researches and drafts legislation on substance use.

    Naloxone is an opioid antagonist that can halt an overdose. Available over the counter as a nasal spray, it is considered the fire extinguisher of the opioid epidemic, for use in an emergency, but just one tool in a prevention strategy. (People often refer to it as “Narcan,” one of the more recognizable brand names, similar to how tissues, regardless of brand, are often called “Kleenex.”)

    The Biden administration last year backed an ad campaign encouraging young people to carry the emergency medication.

    Most states’ naloxone access laws protect do-gooders, including youth, from liability if they accidentally harm someone while administering naloxone. But without school policies explicitly allowing it, the students’ ability to bring naloxone to class falls into a gray area.

    Ryan Christoff said that in September 2022 fellow staff at Centaurus High School in Lafayette, Colorado, where he worked and which one of his daughters attended at the time, confiscated naloxone from one of her classmates.

    “She didn’t have anything on her other than the Narcan, and they took it away from her,” said Christoff, who had provided the confiscated Narcan to that student and many others after his daughter nearly died from fentanyl poisoning. “We should want every student to carry it.”

    Boulder Valley School District spokesperson Randy Barber said the incident “was a one-off and we’ve done some work since to make sure nurses are aware.” The district now encourages everyone to consider carrying naloxone, he said.

    Community’s Devastation Turns to Action

    In Durango, McKinney’s death hit the community hard. McKinney’s friends and family said he didn’t do hard drugs. The substance he was hooked on was Tapatío hot sauce — he even brought some in his pocket to a Rockies game.

    After McKinney died, people started getting tattoos of the phrase he was known for, which was emblazoned on his favorite sweatshirt: “Love is the cure.” Even a few of his teachers got them. But it was classmates, along with their friends at another high school in town, who turned his loss into a political movement.

    “We’re making things happen on behalf of him,” Peterson said.

    The mortality rate has spiked in recent years, with more than 1,500 other children and teens in the U.S. dying of fentanyl poisoning the same year as McKinney. Most youth who die of overdoses have no known history of taking opioids, and many of them likely thought they were taking prescription opioids like OxyContin or Percocet — not the fake prescription pills that increasingly carry a lethal dose of fentanyl.

    “Most likely the largest group of teens that are dying are really teens that are experimenting, as opposed to teens that have a long-standing opioid use disorder,” said Joseph Friedman, a substance use researcher at UCLA who would like to see schools provide accurate drug education about counterfeit pills, such as with Stanford’s Safety First curriculum.

    Allowing students to carry a low-risk, lifesaving drug with them is in many ways the minimum schools can do, he said.

    “I would argue that what the schools should be doing is identifying high-risk teens and giving them the Narcan to take home with them and teaching them why it matters,” Friedman said.

    Writing in The New England Journal of Medicine, Friedman identified Colorado as a hot spot for high school-aged adolescent overdose deaths, with a mortality rate more than double that of the nation from 2020 to 2022.

    “Increasingly, fentanyl is being sold in pill form, and it’s happening to the largest degree in the West,” said Friedman. “I think that the teen overdose crisis is a direct result of that.”

    If Colorado lawmakers approve the bill, “I think that’s a really important step,” said Ju Nyeong Park, an assistant professor of medicine at Brown University, who leads a research group focused on how to prevent overdoses. “I hope that the Colorado Legislature does and that other states follow as well.”

    Park said comprehensive programs to test drugs for dangerous contaminants, better access to evidence-based treatment for adolescents who develop a substance use disorder, and promotion of harm reduction tools are also important. “For example, there is a national hotline called Never Use Alone that anyone can call anonymously to be supervised remotely in case of an emergency,” she said.

    Taking Matters Into Their Own Hands

    Many Colorado school districts are training staff how to administer naloxone and are stocking it on school grounds through a program that allows them to acquire it from the state at little to no cost. But it was clear to Peterson and other area high schoolers that having naloxone at school isn’t enough, especially in rural places.

    “The teachers who are trained to use Narcan will not be at the parties where the students will be using the drugs,” he said.

    And it isn’t enough to expect teens to keep it at home.

    “It’s not going to be helpful if it’s in somebody’s house 20 minutes outside of town. It’s going to be helpful if it’s in their backpack always,” said Zoe Ramsey, another of McKinney’s friends and a senior at Animas High School.

    “We were informed it was against the rules to carry naloxone, and especially to distribute it,” said Ilias “Leo” Stritikus, who graduated from Durango High School last year.

    But students in the area, and their school administrators, were uncertain: Could students get in trouble for carrying the opioid antagonist in their backpacks, or if they distributed it to friends? And could a school or district be held liable if something went wrong?

    He, along with Ramsey and Peterson, helped form the group Students Against Overdose. Together, they convinced Animas, which is a charter school, and the surrounding school district, to change policies. Now, with parental permission, and after going through training on how to administer it, students may carry naloxone on school grounds.

    Durango School District 9-R spokesperson Karla Sluis said at least 45 students have completed the training.

    School districts in other parts of the nation have also determined it’s important to clarify students’ ability to carry naloxone.

    “We want to be a part of saving lives,” said Smita Malhotra, chief medical director for Los Angeles Unified School District in California.

    Los Angeles County had one of the nation’s highest adolescent overdose death tallies of any U.S. county: From 2020 to 2022, 111 teens ages 14 to 18 died. One of them was a 15-year-old who died in a school bathroom of fentanyl poisoning. Malhotra’s district has since updated its policy on naloxone to permit students to carry and administer it.

    “All students can carry naloxone in our school campuses without facing any discipline,” Malhotra said. She said the district is also doubling down on peer support and hosting educational sessions for families and students.

    Montgomery County Public Schools in Maryland took a similar approach. School staff had to administer naloxone 18 times over the course of a school year, and five students died over the course of about one semester.

    When the district held community forums on the issue, Patricia Kapunan, the district’s medical officer, said, “Students were very vocal about wanting access to naloxone. A student is very unlikely to carry something in their backpack which they think they might get in trouble for.”

    So it, too, clarified its policy. While that was underway, local news reported that high school students found a teen passed out, with purple lips, in the bathroom of a McDonald’s down the street from their school, and used Narcan to revive them. It was during lunch on a school day.

    “We can’t Narcan our way out of the opioid use crisis,” said Kapunan. “But it was critical to do it first. Just like knowing 911.”

    Now, with the support of the district and county health department, students are training other students how to administer naloxone. Jackson Taylor, one of the student trainers, estimated they trained about 200 students over the course of three hours on a recent Saturday.

    “It felt amazing, this footstep toward fixing the issue,” Taylor said.

    Each trainee left with two doses of naloxone.

    This article was produced by KFF Health News, which publishes California Healthline, an editorially independent service of the California Health Care Foundation. 

    KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

    Subscribe to KFF Health News’ free Morning Briefing.

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