Cordyceps: Friend Or Foe?

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Cordyceps: friend or foe?

Cordyceps is a famously frightening fungus. It’s the one responsible for “zombie ants” and other zombie creatures, and it’s the basis for the existential threat to humanity in the TV show The Last of Us.

It’s a parasitic fungus that controls the central and peripheral nervous systems of its host, slowly replacing the host’s body, as well as growing distinctive spines that erupt out of the host’s body. Taking over motor functions, it compels the host to do two main things, which are to eat more food, and climb to a position that will be good to release spores from.

Fortunately, none of that matters to humans. Cordyceps does not (unlike in the TV show) affect humans that way.

What does Cordyceps do in humans?

Cordyceps (in various strains) is enjoyed as a health supplement, based on a long history of use in Traditional Chinese Medicine, and nowadays it’s coming under a scientific spotlight too.

The main health claims for it are:

  • Against inflammation
  • Against aging
  • Against cancer
  • For blood sugar management
  • For heart health
  • For exercise performance

Sounds great! What does the science say?

There’s a lot more science for the first three (which are all closely related to each other, and often overlapping in mechanism and effect).

So let’s take a look:

Against inflammation

The science looks promising for this, but studies so far have either been in vitro (cell cultures in petri dishes), or else murine in vivo (mouse studies), for example:

In summary: we can see that it has anti-inflammatory properties for mice and in the lab; we’d love to see the results of studies done on humans, though. Also, while it has anti-inflammatory properties, it performed less well than commonly-prescribed anti-inflammatory drugs, for example:

❝C. militaris can modulate airway inflammation in asthma, but it is less effective than prednisolone or montelukast.❞

Source: Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model

Against aging

Because examining the anti-aging effects of a substance requires measuring lifespans and repeating the experiment, anti-aging studies do not tend to be done on humans, because they would take lifetimes to perform. To this end, it’s inconvenient, but not a criticism of Cordyceps, that studies have been either mouse studies (short lifespan, mammals like us) or fruit fly studies (very short lifespan, genetically surprisingly similar to us).

The studies have had positive results, with typical lifespan extensions of 15–20%:

Against cancer

Once again, the studies here have been in vitro, or murine in vivo. They do look good though:

In vitro (human cell cultures in a lab):

In vivo (mouse studies):

Summary of these is: Cordyceps quite reliably inhibits tumor growth in vitro (human cell cultures) and in vivo (mouse studies). However, trials in human cancer patients are so far conspicuous by their absence.

For blood sugar management

Cordyceps appears to mimic the action of insulin, without triggering insulin sensitivity. For example:

The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats

There were some other rat/mouse studies with similar results. No studies in humans yet.

For heart health

Cordyceps contains adenosine. You may remember that caffeine owes part of its stimulant effect to blocking adenosine, the hormone that makes us feel sleepy. So in this way, Cordyceps partially does the opposite of what caffeine does, and may be useful against arrhythmia:

Cardiovascular protection of Cordyceps sinensis act partially via adenosine receptors

For exercise performance

A small (30 elderly participants) study found that Cordyceps supplementation improved VO2 max by 7% over the course of six weeks:

Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers

However, another small study (22 young athletes) failed to reproduce those results:

Cordyceps Sinensis supplementation does not improve endurance exercise performance

In summary…

Cordyceps almost certainly has anti-inflammation, anti-aging, and anti-cancer benefits.

Cordyceps may have other benefits too, but the evidence is thinner on the ground for those, so far.

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  • Ending Aging – by Dr. Aubrey de Grey

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    We know about how to slow aging. We know about diet, exercise, sleep, intermittent fasting, and other lifestyle tweaks to make. But how much can we turn back the clock, according to science?

    Dr. Aubrey de Grey’s foundational principle is simple: the body is a biological machine, and aging is fundamentally an engineering problem.

    He then outlines the key parts to that problem: the princple ways in which cells (and DNA) get damaged, and what we need to do about that in each case. Car tires get damaged over time; our approach is to replace them within a certain period of time so that they don’t blow out. In the body, it’s a bit similar with cells so that we don’t get cancer, for example.

    The book goes into detail regards each of the seven main ways we accumulate this damage, and highlights avenues of research looking to prevent it, and in at least some cases, the measures already available to so.

    Bottom line: if you want a hard science overview of actual rejuvenation research in biogerontology, this is a book that presents that comprehensively, without assuming prior knowledge.

    Click here to check out Ending Aging and never stop learning!

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  • Mango vs Papaya – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing mango to papaya, we picked the mango.

    Why?

    Both are great! But there are some things to set them apart:

    In terms of macros, this one’s not so big of a difference. They are equal in fiber, while mango has more protein and slightly more carbs. They are both low glycemic index, so we’ll call this one a tie, or the slenderest nominal win for papaya.

    When it comes to vitamins, mango has more of vitamins A, B1, B3, B5, B7, B9, E, K, and choline, while papaya has more vitamin C. However, a cup of mango already gives the RDA of vitamin C, so at this point, it’s not even really much of a bonus that papaya has more. In any case, a clear and overwhelming win in the vitamins category for mango.

    As for minerals, this one’s closer; mango has more copper, manganese, phosphorus, and zinc, while papaya has more calcium, iron, and magnesium. Still, a 4:3 win for mango.

    Adding these up makes for a clear win for mango. However, one extra thing to bear in mind about both:

    Both of these fruits interact with warfarin and many other anticoagulants. So if you’re taking those, you might want to skip these, or at least consult with your doctor/pharmacist for input on your personal situation.

    Aside from that; enjoy both; diversity is good! But mango is the more nutritionally dense, and thus the winner here.

    Want to learn more?

    You might like to read:

    5 Ways To Make Your Smoothie Blood Sugar Friendly (Avoid the Spike!)

    Take care!

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  • Intermittent Fasting In Women

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    ❝Does intermittent fasting differ for women, and if so, how?❞

    For the sake of layout, we’ve put a shortened version of this question here, but the actual wording was as below, and merits sharing in full for context

    Went down a rabbit hole on your site and now can’t remember how I got to the “Fasting Without Crashing” article on intermittent fasting so responding to this email lol, but was curious what you find/know about fasting for women specifically? It’s tough for me to sift through and find legitimate studies done on the results of fasting in women, knowing that our bodies are significantly different from men. This came up when discussing with my sister about how I’ve been enjoying fasting 1-2 days/week. She said she wanted more reliable sources of info that that’s good, since she’s read more about how temporary starvation can lead to long-term weight gain due to our bodies feeling the need to store fat. I’ve also read about that, but also that fasting enables more focused autophagy in our bodies, which helps with long-term staving off of diseases/ailments. Curious to know what you all think!

    ~ 10almonds subscriber

    So, first of all, great question! Thanks for asking it

    Next up, isn’t it strange? Books come in the format:

    • [title]
    • [title, for women]

    You would not think women are a little over half of the world’s population!

    Anyway, there has been some research done on the difference of intermittent fasting in women, but not much.

    For example, here’s a study that looked at 1–2 days/week IF, in other words, exactly what you’ve been doing. And, they did have an equal number of men and women in the study… And then didn’t write down whether this made a difference or not! They recorded a lot of data, but neglected to note down who got what per sex:

    Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women

    Here’s a more helpful study, that looked at just women, and concluded:

    ❝In conclusion, intermittent fasting could be a nutritional strategy to decrease fat mass and increase jumping performance.

    However, longer duration programs would be necessary to determine whether other parameters of muscle performance could be positively affected by IF. ❞

    ~ Dr. Martínez-Rodríguez et al.

    Read in full: Effect of High-Intensity Interval Training and Intermittent Fasting on Body Composition and Physical Performance in Active Women

    Those were “active women”; another study looked at just women who were overweight or obese (we realize that “active women” and “obese or overweight women” is a Venn diagram with some overlap, but still, the different focus is interesting), and concluded:

    ❝IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk.❞

    ~ Dr. Michelle Harvie et al.

    Read in full: The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomised trial in young overweight women

    As for your sister’s specific concern about yo-yoing, we couldn’t find studies for this yet, but anecdotally and based on books on Intermittent Fasting, this is not usually an issue people find with IF. This is assumed to be for exactly the reason you mention, the increased cellular apoptosis and autophagy—increasing cellular turnover is very much the opposite of storing fat!

    You might, by the way, like Dr. Mindy Pelz’s “Fast Like A Girl”, which we reviewed previously

    Take care!

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  • Moringa Oleifera Against CVD, Diabetes, Alzheimer’s & Arsenic?
  • Mango vs Papaya – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing mango to papaya, we picked the mango.

    Why?

    Both are great! But there are some things to set them apart:

    In terms of macros, this one’s not so big of a difference. They are equal in fiber, while mango has more protein and slightly more carbs. They are both low glycemic index, so we’ll call this one a tie, or the slenderest nominal win for papaya.

    When it comes to vitamins, mango has more of vitamins A, B1, B3, B5, B7, B9, E, K, and choline, while papaya has more vitamin C. However, a cup of mango already gives the RDA of vitamin C, so at this point, it’s not even really much of a bonus that papaya has more. In any case, a clear and overwhelming win in the vitamins category for mango.

    As for minerals, this one’s closer; mango has more copper, manganese, phosphorus, and zinc, while papaya has more calcium, iron, and magnesium. Still, a 4:3 win for mango.

    Adding these up makes for a clear win for mango. However, one extra thing to bear in mind about both:

    Both of these fruits interact with warfarin and many other anticoagulants. So if you’re taking those, you might want to skip these, or at least consult with your doctor/pharmacist for input on your personal situation.

    Aside from that; enjoy both; diversity is good! But mango is the more nutritionally dense, and thus the winner here.

    Want to learn more?

    You might like to read:

    5 Ways To Make Your Smoothie Blood Sugar Friendly (Avoid the Spike!)

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    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

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  • Artichoke vs Cabbage – Which is Healthier?

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    Our Verdict

    When comparing artichoke to cabbage, we picked the artichoke.

    Why?

    Looking at the macros first of all, artichoke has more than 2x the protein; it also has nearly 2x the carbs, but to more than counterbalance that, it has more than 2x the fiber. An easy win for artichoke in the macros category.

    In the category of vitamins, both are very respectable; artichoke has more of vitamins B1, B2, B3, B5, B9, E, and choline, while cabbage has more of vitamins A, C, and K. Superficially, that’s a 7:3 win for artichoke, but the margins of difference for artichoke’s vitamins are very small (meaning cabbage is hot on its heels for those vitamins), whereas cabbage’s A, C, and K are with big margins of difference (3–7x more), and arguably those vitamins are higher priority in the sense that B-vitamins of various kinds are found in most foods, whereas A, C, and K aren’t, and while E isn’t either, artichoke had a tiny margin of difference for that. All in all, we’re calling this category a tie, as an equally fair argument could be made for either vegetable here.

    When it comes to minerals, there’s a much clearer winner: artichoke has a lot more copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, while cabbage has a tiny bit more selenium. The two vegetables are equal on calcium.

    Adding up two clear artichoke wins and a tie, makes for an overall clear win for artichoke. Of course, enjoy both though; diversity is almost always best of all!

    Want to learn more?

    You might like to read:

    What’s Your Plant Diversity Score?

    Take care!

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  • Hate salad or veggies? Just keep eating them. Here’s how our tastebuds adapt to what we eat

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Do you hate salad? It’s OK if you do, there are plenty of foods in the world, and lots of different ways to prepare them.

    But given almost all of us don’t eat enough vegetables, even though most of us (81%) know eating more vegetables is a simple way to improve our health, you might want to try.

    If this idea makes you miserable, fear not, with time and a little effort you can make friends with salad.

    Why don’t I like salads?

    It’s an unfortunate quirk of evolution that vegetables are so good for us but they aren’t all immediately tasty to all of us. We have evolved to enjoy the sweet or umami (savoury) taste of higher energy foods, because starvation is a more immediate risk than long-term health.

    Vegetables aren’t particularly high energy but they are jam-packed with dietary fibre, vitamins and minerals, and health-promoting compounds called bioactives.

    Those bioactives are part of the reason vegetables taste bitter. Plant bioactives, also called phytonutrients, are made by plants to protect themselves against environmental stress and predators. The very things that make plant foods bitter, are the things that make them good for us.

    Unfortunately, bitter taste evolved to protect us from poisons, and possibly from over-eating one single plant food. So in a way, plant foods can taste like poison.

    For some of us, this bitter sensing is particularly acute, and for others it isn’t so bad. This is partly due to our genes. Humans have at least 25 different receptors that detect bitterness, and we each have our own genetic combinations. So some people really, really taste some bitter compounds while others can barely detect them.

    This means we don’t all have the same starting point when it comes to interacting with salads and veggies. So be patient with yourself. But the steps toward learning to like salads and veggies are the same regardless of your starting point.

    It takes time

    We can train our tastes because our genes and our receptors aren’t the end of the story. Repeat exposures to bitter foods can help us adapt over time. Repeat exposures help our brain learn that bitter vegetables aren’t posions.

    And as we change what we eat, the enzymes and other proteins in our saliva change too. This changes how different compounds in food are broken down and detected by our taste buds. How exactly this works isn’t clear, but it’s similar to other behavioural cognitive training.

    Add masking ingredients

    The good news is we can use lots of great strategies to mask the bitterness of vegetables, and this positively reinforces our taste training.

    Salt and fat can reduce the perception of bitterness, so adding seasoning and dressing can help make salads taste better instantly. You are probably thinking, “but don’t we need to reduce our salt and fat intake?” – yes, but you will get more nutritional bang-for-buck by reducing those in discretionary foods like cakes, biscuits, chips and desserts, not by trying to avoid them with your vegetables.

    Adding heat with chillies or pepper can also help by acting as a decoy to the bitterness. Adding fruits to salads adds sweetness and juiciness, this can help improve the overall flavour and texture balance, increasing enjoyment.

    Pairing foods you are learning to like with foods you already like can also help.

    The options for salads are almost endless, if you don’t like the standard garden salad you were raised on, that’s OK, keep experimenting.

    Experimenting with texture (for example chopping vegetables smaller or chunkier) can also help in finding your salad loves.

    Challenge your biases

    Challenging your biases can also help the salad situation. A phenomenon called the “unhealthy-tasty intuition” makes us assume tasty foods aren’t good for us, and that healthy foods will taste bad. Shaking that assumption off can help you enjoy your vegetables more.

    When researchers labelled vegetables with taste-focused labels, priming subjects for an enjoyable taste, they were more likely to enjoy them compared to when they were told how healthy they were.

    The bottom line

    Vegetables are good for us, but we need to be patient and kind with ourselves when we start trying to eat more.

    Try working with biology and brain, and not against them.

    And hold back from judging yourself or other people if they don’t like the salads you do. We are all on a different point of our taste-training journey.The Conversation

    Emma Beckett, Senior Lecturer (Food Science and Human Nutrition), School of Environmental and Life Sciences, University of Newcastle

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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