Awakening Your Ikigai – by Dr. Ken Mogi

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It’s been well-established in supercentenarian studies that one of the key factors beyond diet or exercise or suchlike (important as those things definitely are), is having a purpose to one’s life.

Neuroscientist Dr. Ken Mogi explains in this very easy-to-read book, how we can bring ikigai into our lives.

From noticing the details of the small things in life, to reorienting one’s life around what’s most truly most important to us, Dr. Mogi gives us not just a “this is ikigai” exposé, but rather, a practical and readily applicable how-to guide.

Bottom line: if you’ve so far been putting off ikigai as “I’ll get to that”, the time to start is today.

Click here to check out Awakening Your Ikigai, and actually awaken yours!

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Recommended

  • The Pain-Free Mindset – by Dr. Deepak Ravindran
  • The Good Life – by Robert Waldinger, MD, and Marc Schulz, PhD
    This book is the perfect middle-ground between self-help books and clinical data, offering actionable insights from the 80-year-long Harvard Study of Adult Development.

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  • Dioscorea Villosa: Hormones, Arthritis, & Skin

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    On A Wild Yam Chase?

    We recently came across a supplement blend that had wild yam extract as a minor ingredient. Our plucky (and usually very knowledgable) researcher had never heard of its use before, so she set about doing her thing. This is what she found…

    What health claims are made?

    Wild yam extract (Dioscorea villosa) is traditionally sold and used for:

    • Balancing hormones
    • Combating arthritis
    • Anti-aging effects for the skin

    Does it balance hormones?

    First, as a quick catch-up, we’ll drop a previous article of ours for your convenience:

    What Does “Balance Your Hormones” Even Mean?

    We couldn’t find almost any studies into wild yam extract’s hormone-balancing effects, but we did find one study, and:

    ❝Symptom scores showed a minor effect of both placebo and active treatment on diurnal flushing number and severity and total non-flushing symptom scores, and on nocturnal sweating after placebo, but no statistical difference between placebo and active creams.

    This study suggests that short-term treatment with topical wild yam extract in women suffering from menopausal symptoms is free of side-effects, but appears to have little effect on menopausal symptoms❞

    …which is a very thorough, polite, sciencey way of saying “wow, this does so many different kinds of nothing”

    Source: Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women

    On the one hand, this was a small study (n=23). On the other hand, it was also literally the only study we could find.

    Does it combat arthritis?

    Maybe! We again didn’t find much research into this but we did find two in vitro studies that suggests that diosgenin (which can be derived from wild yam extract) helps:

    And we also found a rodent study that found that wild yam extract specifically helped against “acetic acid-induced writhing and formalin-induced pain“, and put that down to anti-inflammatory properties:

    Read: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

    So, none of these studies tell us much about whether it would be helpful for humans—with or without arthritis, and hopefully without “acetic acid-induced writhing and formalin-induced pain”.

    However, they do suggest that it would be reasonable to test in humans next.

    You might prefer:

    Does it keep skin young?

    Again, research is thin on the ground, but we did find some! A study with wild-yam-derived diosgenin found that it didn’t make anything worse, and otherwise performed a similar role to vitamin A:

    Read: Novel effects of diosgenin on skin aging

    That was on rats with breast cancer though, so its applicability to healthy humans may be tenuous (while in contrast, simply getting vitamin A instead is a known deal).

    Summary

    • Does it balance hormones? It probably does little to nothing in this regard
    • Does it combat arthritis? It probably has anti-inflammatory effects, but we know of no studies in humans. There are much more well-established anti-inflammatories out there.
    • Does it keep the skin young? We know that it performs a role similar to vitamin A for rats with breast cancer, and didn’t make anything worse for them. That’s the extent of what we know.

    Where can I get some?

    In the unlikely event that the above research review has inspired you with an urge to buy wild yam extract, here is an example product for your convenience.

    Some final words…

    If you are surprised that we’re really not making any effort to persuade you of its merits, please know that (outside of the clearly-marked sponsor section, which helps us keep the lights on, so please do visit those) we have no interest in selling you anything. We’re genuinely just here to inform 🙂

    If you are wondering why we ran this article at all if the supplement has negligible merits, it’s because science is science, knowledge is knowledge, and knowing that something has negligible merit can be good knowledge to have!

    Also, running articles like this from time to time helps you to know that when we do sing the praises of something, it’s with good reason

    Take care!

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  • Self-Compassion In A Relationship (Positives & Pitfalls)

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    Practise Self-Compassion In Your Relationship (But Watch Out!)

    Let’s make clear up-front: this is not about “…but not too much”.

    With that in mind…

    Now let’s set the scene: you, a happily-partnered person, have inadvertently erred and upset your partner. They may or may not have already forgiven you, but you are still angry at yourself.

    Likely next steps include all or any of:

    • continuing to apologise and try to explain
    • self-deprecatory diatribes
    • self-flagellation, probably not literally but in the sense of “I don’t deserve…” and acting on that feeling
    • self-removal, because you don’t want to further inflict your bad self on your partner

    As you might guess, these are quite varied in their degree of healthiness:

    • apologising is good, as even is explaining, but once it’s done, it’s done; let it go
    • self-deprecation is pretty much never useful, let alone healthy
    • self-flagellation likewise; it is not only inherently self-destructive, but will likely create an additional problem for your partner too
    • self-removal can be good or bad depending on the manner of that removal: there’s a difference between just going cold and distant on your partner, and saying “I’m sorry; this is my fault not yours, I don’t want to take it out on you, so please give me half an hour by myself to regain my composure, and I will come back with love then if that’s ok with you”

    About that last: mentioning the specific timeframe e.g. “half an hour” is critical, by the way—don’t leave your partner hanging! And then do also follow through on that; come back with love after the half-hour elapses. We suggest mindfulness meditation in the interim (here’s our guide to how), if you’re not sure what to do to get you there.

    To Err Is Human; To Forgive, Healthy (Here’s How To Do It) ← this goes for when the forgiveness in question is for yourself, too—and we do write about that there (and how)!

    This is important, by the way; not forgiving yourself can cause more serious issues down the line:

    Self-blame-selective hyper-connectivity between anterior temporal and subgenual cortices predicts prognosis in major depressive disorder

    If, by the way, you’re hand-wringing over “but was my apology good enough really, or should I…” then here is how to do it. Basically, do this, and then draw a line under it and consider it done:

    The Apology Checklist ← you’ll want to keep a copy of this, perhaps in the notes app on your phone, or a screenshot if you prefer

    (the checklist is at the bottom of that page)

    The catch

    It’s you, you’re the catch 👈👈😎

    Ok, that being said, there is actually a catch in the less cheery sense of the word, and it is:

    “It is important to be compassionate about one’s occasional failings in a relationship” does not mean “It is healthy to be neglectful of one’s partner’s emotional needs; that’s self-care, looking after #1; let them take care of themself too”

    …because that’s simply not being a couple at all.

    Think about it this way: the famous airline advice,

    “Put on your own oxygen mask before helping others with theirs”

    …does not mean “Put on your own oxygen mask and then watch those kids suffocate; it’s everyone for themself”

    So, the same goes in relationships too. And, as ever, we have science for this. There was a recent (2024) study, involving hundreds of heterosexual couples aged 18–73, which looked at two things, each measured with a scaled questionnaire:

    • Subjective levels of self-compassion
    • Subjective levels of relationship satisfaction

    For example, questions included asking participants to rate, from 1–5 depending on how much they felt the statements described them, e.g:

    In my relationship with my partner, I:

    • treat myself kindly when I experience sorrow and suffering.
    • accept my faults and weaknesses.
    • try to see my mistakes as part of human nature.
    • see difficulties as part of every relationship that everyone goes through once.
    • try to get a balanced view of the situation when something unpleasant happens.
    • try to keep my feelings in balance when something upsets me.

    Note: that’s not multiple choice! It’s asking participants to rate each response as applicable or not to them, on a scale of 1–5.

    And…

    ❝Women’s self-compassion was also positively linked with men’s total relationship satisfaction. Thus, men seem to experience overall satisfaction with the relationship when their female partner is self-kind and self-caring in difficult situations.

    Unexpectedly, however, we found that men’s relationship-specific self-compassion was negatively associated with women’s fulfillment.

    Baker and McNulty (2011) reported that, only for men, a Self-Compassion x Conscientiousness interaction explained whether the positive effects of self-compassion on the relationship emerged, but such an interaction was not found for women.

    Highly self-compassionate men who were low in conscientiousness were less motivated than others to remedy interpersonal mistakes in their romantic relationships, and this tendency was in turn related to lower relationship satisfaction❞

    ~ Dr. Astrid Schütz et al. (2024)

    Read in full: Is caring for oneself relevant to happy relationship functioning? Exploring associations between self-compassion and romantic relationship satisfaction in actors and partners

    And if you’d like to read the cited older paper from 2011, here it is:

    Read in full: Self-compassion and relationship maintenance: the moderating roles of conscientiousness and gender

    The take-away here is not: “men should not practice self-compassion”

    (rather, they absolutely should)

    The take-away is: we must each take responsibility for managing our own mood as best we are able; practice self-forgiveness where applicable and forgive our partner where applicable (and communicate that!)…. And then go consciously back to the mutual care on which the relationship is hopefully founded.

    Which doesn’t just mean love-bombing, by the way, it also means listening:

    The Problem With Active Listening (And How To Do Better)

    To close… We say this often, but we mean it every time: take care!

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  • Antihistamines for Runny Nose?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small 😎

    ❝Do you have any articles about using Anti-Histamines? My nose seems to be running a lot. I don’t have a cold or any allergies that I know of. I tried a Nasal spray Astepro, but it doesn’t do much.?❞

    Just for you, we wrote such an article yesterday in response to this question!

    The Astepro that you tried, by the way, is a brand name of the azelastine we mentioned near the end, before we got to talking about systemic corticosteroids such as beclometasone dipropionate—this latter might help you if antihistamines haven’t, and if your doctor advises there’s no contraindication (for most people it is safe for there are exceptions, such as if you are immunocompromised and/or currently fighting some infection).

    You can find more details on all this in yesterday’s article, which in case you missed it, can be found at:

    Antihistamines’ Generation Gap: Are You Ready For Allergy Season?

    Enjoy!

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Related Posts

  • The Pain-Free Mindset – by Dr. Deepak Ravindran
  • Five Advance Warnings of Multiple Sclerosis

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Five Advance Warnings of Multiple Sclerosis

    First things first, a quick check-in with regard to how much you know about multiple sclerosis (MS):

    • Do you know what causes it?
    • Do you know how it happens?
    • Do you know how it can be fixed?

    If your answer to the above questions is “no”, then take solace in the fact that modern science doesn’t know either.

    What we do know is that it’s an autoimmune condition, and that it results in the degradation of myelin, the “insulator” of nerves, in the central nervous system.

    • How exactly this is brought about remains unclear, though there are several leading hypotheses including autoimmune attack of myelin itself, or disruption to the production of myelin.
    • Treatments look to reduce/mitigate inflammation, and/or treat other symptoms (which are many and various) on an as-needed basis.

    If you’re wondering about the prognosis after diagnosis, the scientific consensus on that is also “we don’t know”:

    Read: Personalized medicine in multiple sclerosis: hope or reality?

    this paper, like every other one we considered putting in that spot, concludes with basically begging for research to be done to identify biomarkers in a useful fashion that could help classify many distinct forms of MS, rather than the current “you have MS, but who knows what that will mean for you personally because it’s so varied” approach.

    The Five Advance Warning Signs

    Something we do know! First, we’ll quote directly the researchers’ conclusion:

    ❝We identified 5 health conditions associated with subsequent MS diagnosis, which may be considered not only prodromal but also early-stage symptoms.

    However, these health conditions overlap with prodrome of two other autoimmune diseases, hence they lack specificity to MS.❞

    So, these things are a warning, five alarm bells, but not necessarily diagnostic criteria.

    Without further ado, the five things are:

    1. depression
    2. sexual disorders
    3. constipation
    4. cystitis
    5. urinary tract infections

    ❝This association was sufficiently robust at the statistical level for us to state that these are early clinical warning signs, probably related to damage to the nervous system, in patients who will later be diagnosed with multiple sclerosis.

    The overrepresentation of these symptoms persisted and even increased over the five years after diagnosis.❞

    ~ Dr. Céline Louapre

    Read the paper for yourself:

    Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis

    Hot off the press! Published only yesterday!

    Want to know more about MS?

    Here’s a very comprehensive guide:

    National clinical guideline for diagnosis and management of multiple sclerosis

    Take care!

    Don’t Forget…

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  • The Orchid That Renovates Your Gut (Gently)

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    The Orchid That Renovates Your Gut (Gently)

    Dendrobium officinale is an orchid that’s made its way from Traditional Chinese Medicine into modern science.

    Read: Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale

    To summarize its benefits, we’ll quote from Dr. Paharia’s article featured in our “what’s happening in the health world” section all so recently:

    ❝Gut microbes process Dendriobium officinale polysaccharides (DOPs) in the colon, producing short-chain fatty acids (SCFAs) and oligosaccharides that alter gut microbial composition and improve human health.

    DOPs have been shown to decrease harmful bacteria like E. coli and Staphylococcus while promoting beneficial ones like Bifidobacterium.❞

    Source: The future of functional foods: leveraging Dendrobium officinale for optimal gut health and disease prevention

    We don’t stop at secondary sources, though, so we took a look at the science.

    Dr. Wu et al. found (we’ll quote directly for these bullet points):

    • DOPs have been shown to influence the gut microbiota, such as the abundance of Lactobacillus, Bifidobacterium, Akkermansia, Bacteroides, and Prevotella, and provide different benefits to the host due to structural differences.
    • The dietary intake of DOPs has been shown to improve the composition of the gut microbiome and offers new intervention strategies for metabolic diseases such as obesity and type 2 diabetes as well as inflammatory diseases such as chronic obstructive pulmonary disease and colitis.
    • Compared to drug therapy, intervention with DOPs is not specific and has a longer intervention duration

    Source: Structure, Health Benefits, Mechanisms, and Gut Microbiota of Dendrobium officinale Polysaccharides: A Review

    This is consistent with previous research on Dendrobium officinale, such as last year’s:

    ❝DOP significantly increased benign intestinal microbe proportion (Lactobacillus, etc.), but reduced harmful bacteria (Escherichia shigella) (P < 0.05), and significantly increased butyric acid production (P < 0.05)❞

    Source: Dendrobium officinale Xianhu 2 polysaccharide helps forming a healthy gut microbiota and improving host immune system

    In summary…

    Research so far indicates that this does a lot of good for the gut, in a way that can “kickstart” healthier, self-regulating gut microbiota.

    As to its further prospects, check out:

    Dendrobium as a new natural source of bioactive for the prevention and treatment of digestive tract diseases: a comprehensive review with future perspectives

    Very promising!

    Where can I get it?

    We don’t sell it, but for your convenience here’s an example product on Amazon

    Be warned, it is expensive though!

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  • Creatine’s Brain Benefits Increase With Age

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    Creatine is generally thought of as a body-building supplement, and for most young people, that’s all it is. But with extra years come extra advantages, and creatine starts to confer cognitive benefits. Dr. Brad Stanfield shares the science:

    What the science says

    Although 95% of creatine is stored in muscles, 5% is found in the brain, where it helps produce energy needed for brain processes (and that’s a lot of energy—about 20% of our body’s metabolic base rate is accounted for by our brain).

    In this video, Dr. Stanfield shares studies showing creatine improving memory, especially in older adults—and also in vegetarians/vegans, since creatine is found in meat (just like in our own bodies, which are also made of meat) and not in plants. On the meta-analysis level, a systematic review concluded that creatine supplementation indeed improves memory, with stronger effects observed in older adults.

    Dr. Stanfield also addresses the safety concerns about creatine, which, on balance, are not actually supported by the science (of course, always consult your own doctor to be sure, as your case could vary).

    As for dosage, 5g/day is recommended. For more on all of this plus links to the studies cited, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Creatine: Very Different For Young & Old People

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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