Creatine: Very Different For Young & Old People
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What’s the Deal with Creatine?
Creatine is best-known for its use as a sports supplement. It has a few other uses too, usually in the case of helping to treat (or recover from) specific medical conditions.
What actually is it?
Creatine is an organic compound formed from amino acids (mostly l-arginine and lysine, can be l-methionine, but that’s not too important for our purposes here).
We can take it as a supplement, we can get it in our diet (unless we’re vegan, because plants don’t make it; vertebrates do), and we can synthesize it in our own bodies.
What does it do?
While creatine supplements mostly take the form of creatine monohydrate, in the body it’s mostly stored in our muscle tissue as phosphocreatine, and it helps cells produce adenosine triphosphate, (ATP).
ATP is how energy is kept ready to use by cells, and is cells’ immediate go-to when they need to do something. For this reason, it’s highly instrumental in cell repair and rebuilding—which is why it’s used so much by athletes, especially bodybuilders or other athletes that have a vested interest in gaining muscle mass and enjoying faster recovery times.
See: Creatine use among young athletes
However! For reasons as yet not fully known, it doesn’t seem to have the same beneficial effect after a certain age:
What about the uses outside of sport?
Almost all studies outside of athletic performance have been on animals, despite it being suggested as potentially helpful for many things, including:
- Alzheimer’s disease
- Parkinson’s disease
- Huntington’s disease
- ischemic stroke
- epilepsy
- brain or spinal cord injuries
- motor neuron disease
- memory and brain function in older adults
However, research that’s been done on humans has been scant, if promising:
- A review of creatine supplementation in age-related diseases: more than a supplement for athletes
- Creatine supplementation and cognitive performance in elderly individuals
In short: creatine may reduce symptoms and slow the progression of some neurological diseases, although more research in humans is needed, and words such as “promising”, “potential”, etc are doing a lot of the heavy lifting in those papers we just cited.
Is it safe?
It seems so: Creatine supplementation and health variables: a retrospective study
Nor does it appear to create the sometimes-rumored kidney problems, cramps, or dehydration:
Where can I get it?
You can get it from pretty much any sports nutrition outlet, or you can order online. For example:
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GABA Against Stress/Anxiety
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A Neurotransmitter Less Talked-About
GABA is taken by many people as a supplement, mostly as a mood modifier, though its health claims go beyond the recreational—and also, we’re of the opinion that mental health is also just health, and if it works, it works. We’ll explore some of the claims and science behind them today…
What is GABA?
GABA stands for gamma-aminobutyric acid, and it’s a neurotransmitter. It’s a lot less talked-about than for example dopamine or serotonin, but it’s very important nonetheless.
We make it ourselves inside our body, and we can also get it from our food, or supplement it, and some drugs will also have an effect on its presence and/or activity in our body.
What foods is it found in?
- Animals, obviously (just like in human brains*)
- Fermented foods (many kinds)
- Yeast
- Tea
- Tomatoes
- Mulberries
For more details, see:
γ-Aminobutyric acid found in fermented foods and beverages: current trends
*However, we do not recommend eating human brains, due to the risk of CJD and prion diseases in general.
What claims are made about it and are they true?
For brevity, we’ll give a little spoiler up-front: all the popular claims for it appear to be valid, though there’s definitely room for a lot more human trials (we skipped over a lot of rodent studies today!).
So we’ll just drop some of its main benefits, and human studies to back those.
Reduction of stress and anxiety
GABA decreases task-related stress and anxiety within 30 minutes of being taken, both in subjective measures (i.e., self-reports) and in objective clinical physiological measures:
Cognitive enhancement
It’s not a does-everything nootropic like some, but it does have clear benefits to episodic memory:
❝GABA intake might help to distribute limited attentional resources more efficiently, and can specifically improve the identification and ordering of visual events that occur in close temporal succession❞
One of the things that makes this one important is that it also deals with the often-asked question of “does GABA pass the blood-brain barrier”:
❝The present findings do give further credence to the idea that oral ingestion does allow GABA to reach the brain and exert direct effects on cognition, which in the present case were specific to temporal attention.❞
Read more:
Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention
Potential for more
We take care to give good quality sources, so the following study comes with a big caveat that it has since been retracted. Why was it retracted, you wonder?
It’s about the sample; they cite “30 healthy adults”, but neglected tp mention that this figure was initially 46. What happened to the other 16 participants is unclear, but given that this was challenged and the challenge not answered, it was sufficient for the journal (Nature) to pull the study, in case of deliberate sample bias.
However! Running the numbers in their results section, a probability of 0.03 is very compelling unless the disappearance of 16 subjects was outright fraudulent (which we regrettably cannot know either way).
Here’s the study (so take it with a pinch of salt, considering the above), and taken at face value, it shows how GABA supplementation improves accurate reactions to fast-moving visual and auditory stimuli:
RETRACTED ARTICLE: γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial
…so, hopefully this experiment will be repeated, without disappearing participants!
The sweet spot
You may be wondering how something that slows a person down (having a relaxing effect) can also speed a person up. This has to do with what it is and isn’t affecting; think of it like a “focus mode” on your computer or other device that greys-out everything else a bit so that you can focus on what you’re doing.
It’s in some ways (by different neurochemical pathways, though) a similar effect to the “relaxed alertness” created by l-theanine supplementation.
There’s also a sweet spot whereby GABA is toning some things down just the right amount, without adversely affecting performance in areas we don’t want slowed down. For the science of this, see:
Is it safe?
GABA is “Generally Recognized As Safe”. However:
- you should speak with your pharmacist if you are taking any medications for blood pressure or epilepsy, as GABA supplementation may cause them to work too well.
- you should absolutely not take GABA with alcohol or opioids as (dose-dependent for all the substances involved, and also depending on your metabolic base rate and other factors) its acute depression of the CNS can mean you relax and slow down too much, and you may find yourself not breathing often enough to sustain life.
Aside from that, it is considered safe up to at least 1g/kg/day*. Given that popular doses are 120–750mg, and most people weigh more than 750g, this is very safe for most people:
United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
Where can I get it?
We don’t sell it, but for your convenience, here’s an example product on Amazon
Enjoy!
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Rewire Your OCD Brain – by Dr. Catherine Pittman & Dr. William Youngs
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OCD is just as misrepresented in popular media as many other disorders, and in this case, it’s typically not “being a neat freak” or needing to alphabetize things, so much as having uncontrollable obsessive intrusive thoughts, and often in response to those, unwanted compulsions. This can come from unchecked spiralling anxiety, and/or PTSD, for example.
What Drs. Pittman & Young offer is an applicable set of solutions, to literally rewire the brain (insofar as synapses can be considered neural wires). Leveraging neuroplasticity to work with us rather than against us, the authors talk us through picking apart the crossed wires, and putting them back in more helpful ways.
This is not, by the way, a book of CBT, though it does touch on that too.
Mostly, the book explains—clearly and simply and sometimes with illustrations—what is going wrong for us neurologically, and how to neurologically change that.
Bottom line: whether you have OCD or suffer from anxiety or just need help dealing with obsessive thoughts, this book can help a lot in, as the title suggests, rewiring that.
Click here to check out Rewire Your OCD Brain, and banish obsessive thoughts!
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Getting Flexible, Starting As An Adult: How Long Does It Really Take?
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Aleks Brzezinska didn’t start stretching until she was 21, and here’s what she found:
We’ll not stretch the truth
A lot of stretching programs will claim “do the splits in 30 days” or similar, and while this may occasionally be true, usually it’ll take longer.
Brzezinska started stretching seriously when she was 21, and made significant flexibility gains between the ages of 21 and 23 with consistent practice. Since then, she’s just maintained her flexibility.
There are facts that affect progress significantly, such as:
- Anatomy: body structure, age, and joint flexibility do influence flexibility; starting younger and/or having hypermobile joints does make it easier.
- Consistency: regular practice (2–3 times a week) is crucial, but avoid overdoing it, especially when sore.
- Lifestyle: weightlifting, running, and similar activities can tighten muscles, making flexibility harder to achieve.
- Hydration: staying hydrated is important for muscle flexibility.
She also recommends incorporating a variety of different stretching types, rather than just one method, for example passive stretching, active stretching, Proprioceptive Neuromuscular Facilitation (PNF) stretching, and mobility work.
For more on each of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Jasmine McDonald’s Ballet Stretching Routine
Take care!
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Morning Routines That Just FLOW
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Morning Routines That Just FLOW
“If the hardest thing you have to do in your day is eat a frog, eat that frog first!”, they say.
And, broadly speaking, it is indeed good to get anything stressful out of the way early, so that we can relax afterwards. But…
- Are we truly best at frog-eating when blurry-eyed and sleepy?
- Is there a spoonful of sugar that could make the medicine go down better?
- What do we need to turn eating the frog into an enjoyable activity?
Flow
“Flow” is a concept brought to public consciousness by psychologist Mihaly Csikszentmihalyi, and it refers to a state in which we feel good about what we’re doing, and just keep doing, at a peak performance level.
Writer’s note: as a writer, for example…
Sometimes I do not want to write, I pace to and fro near my computer, going on side-quests like getting a coffee or gazing out of the window into my garden. But once I get going, suddenly, something magical happens and before I know it, I have to trim my writing down because I’ve written too much. That magical window of effortless productivity was a state of flow.
Good morning!
What is a good morning, to you? Build that into your morning! Set parameters around it so you don’t get carried away timewise and find yourself in the afternoon (unless that would work for you!), but first thing in the morning is the time to light up each part of your brain with appropriate neurotransmitters.
Getting the brain juices flowing
Cortisol
When we wake up, we (unless we have some neurochemical imbalance, such as untreated depression) get a spike of cortisol. Cortisol is much-maligned and feared, and indeed it can be very much deleterious to the health in cases of chronic stress. But a little spike now and again is actually beneficial for us.
Quick Tip: if you want to artificially stimulate (or enhance) a morning cortisol spike, a cold shower is the way to go. Or even just a face-plunge into a bowl of ice-water (put ice in it, give it a couple of minutes to chill the water, then put your face in for a count of 30 seconds, or less if you can’t hold your breath that long).
Serotonin
Serotonin is generally thought of as “the happy chemical”, and it’s stimulated by blue/white light, and also by seeing greenery.
Quick tip: to artificially stimulate (or enhance) a morning serotonin boost, your best friend is sunlight. Even sun through a partly-clouded sky will tend to outperform artificial lighting, including artificial sunlight lighting. Try to get sun between 08:30 and 09:00, if you can. Best of all, do it in your garden or nearby park, as the greenery will be an extra boost!
Dopamine
Generally thought of as “the reward chemical”, but it’s also critical for a lot of kinds of brainwork, including language processing and problem-solving.
Quick Tip: to artificially stimulate* a dopamine surge to get you going, do something that you and/or your body finds rewarding. Examples include:
- Exercise, especially in a vigorous burst
- A good breakfast, a nice coffee, whatever feels right to you
- An app that has motivational bells and whistles, a streak for you to complete, etc
Note: another very enjoyable activity might come to mind that doesn’t even require you getting out of bed. Be aware, however, gentleman-readers in particular, that if you complete that activity, you’ll get a prolactin spike that will wipe out the dopamine you just worked up. So that one’s probably better for a lazy morning of relaxation, than a day when you want to get up and go!
*there’s no “(or enhance)” for this one; you won’t get dopamine from doing nothing, that’s just not how “the reward chemical” works
Flow-building in a stack
When you’ve just woken up and are in a blurry morning haze, that’s not the time to be figuring out “what should I be doing next?”, so instead:
- Work out the things you want to incorporate into your morning routine
- Put them in the order that will be easiest to perform—some things will go a lot better after others!
- Remember to also include things that are simply necessary—morning bathroom ablutions, for example
The goal here is to have a this-and-this-and-this-and-this list of items that you can go through without any deviations, and get in the habit of “after item 1 I automatically do item 2, after which I automatically do item 3, after which…”
Implement this, and your mornings will become practically automated, but in a joyous, life-enhancing way that sets you up in good order for whatever you want/need to do!
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Weight Vests Against Osteoporosis: Do They Really Build Bone?
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Dr. Doug Lucas is a dual board-certified physician specializing in optimizing healthspan and bone health for women experiencing osteoporosis, perimenopause, and menopause. Here, he talks weight vests:
Worth the weight?
Dr. Lucas cites “Wolf’s Law”—bones respond to stress. A weighted vest adds stress, to help build bone density. That said, they may not be suitable for everyone (for example, in cases of severe osteoporosis or a recent vertebral fracture).
He also cites some studies:
- Erlanger Fitness Study (2004): participants with a weighted vest maintained or improved bone density compared to a control group, but there was no group with exercise alone, making it unclear if the vest itself had the biggest impact.
- Newer studies (2016, 2017): showed improved outcomes for groups wearing a weighted vest, but again lacked an exercise-only group for comparison.
- 2012 study: included three groups (control, weighted vest, exercise only). Results showed no significant bone density difference between vest and exercise-only groups, though the vest group showed better balance and motor control.
Dr. Lucas concludes that weighted vests are a useful tool while nevertheless not being a magic bullet for bone health. In other words, they can complement exercise but you will also be fine without. If you do choose to level-up your exercise by using a weight vest, then starting with 5–10% of body weight in a vest is often recommended, but it depends on individual circumstances. If in doubt, start low and build up. Wearing the vest for daily activities can be effective, but improper use (awkward positions or improper impact training) can increase injury risk, so do be careful with that.
For more on all of this, enjoy:
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Want to learn more?
You might also like to read:
- Osteoporosis & Exercises: Which To Do (And Which To Avoid)
- One More Resource Against Osteoporosis!
- The Osteoporosis Breakthrough – by Dr. Doug Lucas ← we reviewed his book a while back!
Take care!
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Black Tea or Green Tea – Which is Healthier?
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Our Verdict
When comparing black tea to green tea, we picked the black tea.
Why?
It was close! Ultimately we picked the black tea as the “best all-rounder”.
Both teas are great for the health, insofar as tea in general is a) a very good way to hydrate (better absorption than plain water) and b) an excellent source of beneficial phytochemicals—mostly antioxidants of various kinds, but there’s a lot in there.
We did a run-down previously of the relative benefits of each of four kinds of tea (black, white, green, red):
Which Tea Is Best, By Science?
Which concluded in its final summary:
Black, white, green, and red teas all have their benefits, and ultimately the best one for you will probably be the one you enjoy drinking, and thus drink more of.
If trying to choose though, we offer the following summary:
- Black tea: best for total beneficial phytochemicals
- White tea:best for your oral health
- Green tea: best for your brain
- ❤️ Red tea: best if you want naturally caffeine-free
Enjoy!
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