Blood-Brain Barrier Breach Blamed For Brain-Fog

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Move Over, Leaky Gut. Now It’s A Leaky Brain.

…which is not a headline that promises good news, and indeed, the only good news about this currently is “now we know another thing that’s happening, and thus can work towards a treatment for it”.

Back in February (most popular media outlets did not rush to publish this, as it rather goes against the narrative of “remember when COVID was a thing?” as though the numbers haven’t risen since the state of emergency was declared over), a team of Irish researchers made a discovery:

❝For the first time, we have been able to show that leaky blood vessels in the human brain, in tandem with a hyperactive immune system may be the key drivers of brain fog associated with long covid❞

~ Dr. Matthew Campbell (one of the researchers)

Let’s break that down a little, borrowing some context from the paper itself:

  • the leaky blood vessels are breaching the blood-brain-barrier
    • that’s a big deal, because that barrier is our only filter between our brain and Things That Definitely Should Not Go In The Brain™
  • a hyperactive immune system can also be described as chronic inflammation
    • in this case, that includes chronic neuroinflammation which, yes, is also a major driver of dementia

You may be wondering what COVID has to do with this, and well:

  • these blood-brain-barrier breaches were very significantly associated (in lay terms: correlated, but correlated is only really used as an absolute in write-ups) with either acute COVID infection, or Long Covid.
  • checking this in vitro, exposure of brain endothelial cells to serum from patients with Long Covid induced the same expression of inflammatory markers.

How important is this?

As another researcher (not to mention: professor of neurology and head of the school of medicine at Trinity) put it:

❝The findings will now likely change the landscape of how we understand and treat post-viral neurological conditions.

It also confirms that the neurological symptoms of long covid are measurable with real and demonstrable metabolic and vascular changes in the brain.❞

~ Dr. Colin Doherty (see mini-bio above)

You can read a pop-science article about this here:

Irish researchers discover underlying cause of “brain fog” linked with long covid

…and you can read the paper in full here:

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Want to stay safe?

Beyond the obvious “get protected when offered boosters/updates” (see also: The Truth About Vaccines), other good practices include the same things most people were doing when the pandemic was big news, especially avoiding enclosed densely-populated places, washing hands frequently, and looking after your immune system. For that latter, see also:

Beyond Supplements: The Real Immune-Boosters!

Take care!

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  • Dial Down Your Pain

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    This is Dr. Christiane Wolf. Is than an MD or a PhD, you ask? The answer is: yes (it is both; the latter being in psychosomatic medicine).

    She also teaches Mindfulness-Based Stress Reduction, which as you may recall is pretty much the most well-evidenced* form of meditation there is, in terms of benefits:

    No-Frills, Evidence-Based Mindfulness

    *which is not to claim it is necessarily the best (although it also could be); rather, this means that it is the form of meditation that’s accumulated the most scientific backing in total. If another equal or better form of meditation enjoyed less scientific scrutiny, then there could an alternative out there languishing with only two and a half scientific papers to its name. However, we at 10almonds are not research scientists, and thus can only comment on the body of evidence that has been published.

    In any case, today is going to be about pain.

    What does she want us to know?

    Your mind does matter

    It’s easy to think that anything you can do with your mind is going to be quite small comfort when your nerves feel like they’re on fire.

    However, Dr. Wolf makes the case for pain consisting of three components:

    • the physical sensation(s)
    • the emotions we have about those
    • the meaning we give to such (or “the story” that we use to describe it)

    To clarify, let’s give an example:

    • the physical sensations of burning, searing, and occasionally stabbing pains in the lower back
    • the emotions of anguish, anger, despair, self-pity
    • the story of “this pain has ruined my life, is making it unbearable, will almost certainly continue, and may get worse”

    We are not going to tell you to throw any of those out of the window for now (and, would that you could throw the first line out, of course).

    The first thing Dr. Wolf wants us to do to make this more manageable is to break it down.

    Because presently, all three of those things are lumped together in a single box labelled “pain”.

    If each of those items is at a “10” on the scale of pain, then this is 10×10×10=1000.

    If our pain is at 1000/10, that’s a lot. We want to leave the pain in the box, not look at it, and try to distract ourselves. That is one possible strategy, by the way, and it’s not always bad when it comes to giving oneself a short-term reprieve. We balanced it against meditation, here:

    Managing Chronic Pain (Realistically)

    However, back to the box analogy, if we open that box and take out each of those items to examine them, then even without changing anything, even with them all still at 10, they can each be managed for what they are individually, so it’s now 10+10+10=30.

    If our pain is at 30/10, that’s still a lot, but it’s a lot more manageable than 1000/10.

    On rating pain, by the way, see:

    Get The Right Help For Your Pain

    Dealing with the separate parts

    It would be nice, of course, for each of those separate parts to not be at 10.

    With regard to the physical side of pain, this is not Dr. Wolf’s specialty, but we have some good resources here at 10almonds:

    When it comes to emotions associated with pain, Dr. Wolf (who incidentally is a Buddhist and also a teacher of same, and runs meditation retreats for such), recommends (of course) mindfulness, and what in Dialectical Behavior Therapy (DBT) is called “radical acceptance” (in Buddhism, it may be referred to as being at one with things). We’ve written about this here:

    “Hello, Emotions”: Radical Acceptance In CBT & DBT

    Once again, the aim here is still not to throw the (often perfectly valid) emotions out of the window (unless you want to), but rather, to neutrally note and acknowledge the emotions as they arrive, á la “Hello, despair. Depression, my old foe, we meet again. Hello again, resentment.” …and so on.

    The reason this helps is because emotions, much like the physical sensations of pain, are first and foremost messengers, and sometimes (as in the case of chronic pain) they get broken and keep delivering the message beyond necessity. Acknowledging the message helps your brain (and all that is attached to it) realize “ok, this message has been delivered now; we can chill about it a little”.

    Having done that, if you can reasonably tweak any of the emotions (for example, perhaps that self-pity we mentioned could be turned into self-compassion, which is more useful), that’s great. If not, at least you know what’s on the battlefield now.

    When we examine the story of our pain, lastly, Dr. Wolf invites us to look at how one of the biggest drivers of distress under pain is the uncertainty of how long the pain will last, whether it will get worse, whether what we are doing will make it worse, and so forth. See for example:

    How long does back pain last? And how can learning about pain increase the chance of recovery?

    And of course, many things we do specifically in response to pain can indeed make our pain worse, and spread:

    How To Stop Pain Spreading

    Dr. Wolf’s perspective says:

    1. Life involves pain
    2. Pain invariably has a cause
    3. What has a cause, can have an end
    4. We just need to go through that process

    This may seem like small comfort when we are in the middle of the pain, but if we’ve broken it down into parts with Dr. Wolf’s “box method”, and dealt with the first two parts (the sensations and the emotions) as well as reasonably possible, then we can tackle the third one (the story) a little more easily than we could if we were trying to come at it with no preparation.

    What used to be:

    “This pain has ruined my life, is making it unbearable, will almost certainly continue, and may get worse”

    …can now become:

    “This pain is a big challenge, but since I’m here for it whether I want to be or not, I will suffer as I must, while calmly looking for ways to reduce that suffering as I go.”

    In short: you cannot “think healing thoughts” and expect your pain to go away. But you can do a lot more than you might (if you left it unexamined) expect.

    Want to know more from Dr. Wolf?

    We reviewed a book of hers recently, which you might enjoy:

    Outsmart Your Pain – by Dr. Christiane Wolf

    Take care!

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  • Pistachios vs Almonds – Which is Healthier?

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    Our Verdict

    When comparing pistachios to almonds, we picked the almonds.

    Why?

    It was very close! And those who’ve been following our “This or That” comparisons might be aware that pistachios and almonds have both been winning their respective comparisons with other nuts so far, so today we put them head-to-head.

    In terms of macros, almonds have a little more protein and a little more fiber—as well as slightly more fat, though the fats are healthy. Pistachios, meanwhile, are higher in carbs. A moderate win for almonds on the macro front.

    When it comes to vitamins, pistachios have more of vitamins A, B1, and B6, while almonds have more of vitamins B2, B3, and E. We could claim a slight victory for pistachios, based on the larger margins, or else a slight victory for almonds, based on vitamin E being a more common nutritional deficiency than vitamin A, and therefore the more useful vitamin to have more of. We’re going to call this category a tie.

    In the category of minerals, almonds lead with more calcium, magnesium, manganese, and zinc, while pistachios boast more copper, potassium, and selenium, though the margins are more modest for pistachios. A moderate win for almonds on minerals, therefore.

    Adding up the sections gives a win for almonds, but of course, do enjoy both, because both are excellent in their own right.

    Want to learn more?

    You might like to read:

    Take care!

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  • Mango vs Pineapple – Which is Healthier?

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    Our Verdict

    When comparing mango to pineapple, we picked the pineapple.

    Why?

    It was close! Both of these tropical fruits have almost identical macros, and when it comes to vitamins and minerals, mango has slightly more vitamins while pineapple has slightly more minerals, so that balances out too. Their glycemic loads are 11 and 13 respectively, so: very low, and very similar.

    See also: Which Sugars Are Healthier, And Which Are Just The Same?

    In terms of what sets them apart:

    Mango has a lot of vitamin A, to the point that it can interfere with blood-thinners if you take those.

    Pineapple has bromelain, an enzyme with unique anti-inflammatory properties that we must devote a Research Review Monday to one of these days, because there’s a lot to say, but the short version is, it’s very powerful.

    Since bromelain is found only in pineapples, whereas vitamin A is easy to find in abundance in many foods, we went with the pineapple.

    Enjoy!

    Share This Post

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  • Workout Advice For Busy People

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Hampton at Hybrid Calisthenics always has very sound advice in his uplifting videos, and this one’s no exception:

    Key tips for optimizing workouts without burning out

    “We all have the same 24 hours” is a folly when in fact, some of us have more responsibilities and/or other impediments to getting things done (e.g. disabilities).

    A quick word on disabilities first: sometimes people are quick to point out Paralympian athletes, and “if they can do it, so can you!” and forget that these people are in the top percentile of the top percentile of the top percentile of human performance. If you wouldn’t disparagingly say “if Simone Biles/Hussein Bolt/Michael Phelps can do it, so can you”, then don’t for Paralympians either 😉

    Now, as for Hampton’s advice, he recommends:

    Enjoy short, intense workouts:

    • You can get effective results in under 30 minutes (or even just a few minutes per day) with compound exercises (e.g., squats, pull-ups).
    • Focus on full-body movements also saves time!
    • Push closer to failure when possible to maximize efficiency. It’s the last rep where most of the strength gains are made! Same deal with cardiovascular fitness, too. Nevertheless, do take safety into account in both cases, of course.

    Time your rest periods:

    • Resting for 2–3 minutes between sets ensures optimal recovery.
    • Avoid getting distracted during rest by setting a timer to stay focused.
    • 10almonds tip: use this time to practice a mindfulness meditation. That will greatly reduce the chance of you becoming distracted.

    Remember holistic fitness:

    • Fitness isn’t just about exercise; diet, sleep, and stress management are equally important for your fitness as much as for the rest of your health.
    • Better sleep and reduced stress will help you exercise more consistently and avoid junk food.

    Address burnout:

    • If feeling too exhausted to apply these tips, focus on getting better rest and reducing stress first.
    • Taking a short break to reset can help in the long run.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Take care!

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  • Easing Lower Back Pain

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Lower back pain often originates from an unexpected culprit: your pelvis. Similar to how your psoas can contribute to lower back pain, when your pelvis tilts forward due to tight hip flexors, it can misalign your spine, leading to discomfort and pain. As WeShape shows us in the below video, one simple stretch can help realign your pelvis and significantly ease lower back pain.

    Why Your Pelvis Matters

    Sitting for long periods causes your hip flexors to shorten, leading to an anterior pelvic tilt. This forward tilt puts pressure on your spine and SI joint, causing pain and discomfort in the lower back. To help resolve this, you can work on correcting your pelvic alignment, helping to significantly reduce this pressure and alleviate related pain. And no, this doesn’t require any spinal cord stimulation.

    Easy Variations for All

    A lot of you recognise the stretch in this video; it’s quite a well-known kneeling stretch. But, unlike other guides, WeShape also provides a fantastic variation for those who aren’t mobile enough for the kneeling variation

    So, if you can’t comfortably get down on the ground, WeShape outlines a brilliant standing variation. So, regardless of your mobility, there’s an option for you!

    See both variations here:

    Excited to reduce your lower back pain? We hope so! Let us know if you have any tips that you’d like to share with us.

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  • The Doctor’s Kitchen – by Dr. Rupy Aujla

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve featured Dr. Aujla before as an expert-of-the-week, and now it’s time to review a book by him. What’s his deal, and what should you expect?

    Dr. Aujla first outlines the case for food as medicine. Not just “eat nutritionally balanced meals”, but literally, “here are the medicinal properties of these plants”. Think of some of the herbs and spices we’ve featured in our Monday Research Reviews, and add in medicinal properties of cancer-fighting cruciferous vegetables, bananas with dopamine and dopamine precursors, berries full of polyphenols, hemp seeds that fight cognitive decline, and so forth.

    Most of the book is given over to recipes. They’re plant-centric, but mostly not vegan. They’re consistent with the Mediterranean diet, but mostly Indian. They’re economically mindful (favoring cheap ingredients where reasonable) while giving a nod to where an extra dollar will elevate the meal. They don’t give calorie values etc—this is a feature not a bug, as Dr. Aujla is of the “positive dieting” camp that advocates for us to “count colors, not calories”. Which, we have to admit, makes for very stress-free cooking, too.

    Dr. Aujla is himself an Indian Brit, by the way, which gives him two intersecting factors for having a taste for spices. If you don’t share that taste, just go easier on the pepper etc.

    As for the medicinal properties we mentioned up top? Four pages of references at the back, for any who are curious to look up the science of them. We at 10almonds do love references!

    Bottom line: if you like tasty food and you’re looking for a one-stop, well-rounded, food-as-medicine cookbook, this one is a top-tier choice.

    Click here to check out The Doctor’s Kitchen, and satisfy your taste buds—along with the rest of yoru body!

    Don’t Forget…

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