What you need to know about xylazine

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Xylazine is a non-opioid tranquilizer designed for veterinary use in animals. The sedative is not approved for use in people, yet it’s becoming more prevalent in the illicit drug supply.

Sometimes called “tranq,” it’s often mixed with other drugs, such as fentanyl, a potent opioid responsible for a growing number of overdose deaths. Last year, the White House Office of National Drug Control Policy declared fentanyl mixed with xylazine an “emerging threat.”

Read on to learn more about xylazine: what happens when people take it, what to do if an overdose is suspected, and how harm reduction tools can prevent overdose deaths.

How are people who use drugs exposed to xylazine?

Studies show people are exposed to xylazine—knowingly or unknowingly—when it’s mixed with other drugs like heroin, cocaine, meth, and, most frequently, fentanyl. When combined with opioids or other drugs, it increases the risk of a drug overdose.

What happens if someone takes xylazine?

Taking xylazine can cause drowsiness, amnesia, slow breathing, slow heart rate, dangerously low blood pressure, wounds that can become infected, and death, especially when taken in combination with other drugs.

Why does xylazine increase the risk of overdose?

Xylazine is a central nervous system depressant, which means that it slows down the body’s heart rate and breathing. It can also enhance the effects of other depressants, such as opioids, which may lead to suffocation.

What are the signs of a xylazine-related overdose?

Xylazine-related overdoses look like opioid overdoses. A person who has overdosed may exhibit a slow pulse, slow breathing, blurry vision, disorientation, drowsiness, confusion, blue skin, and loss of consciousness.

How many people die from xylazine-related overdoses in the U.S.?

Xylazine-related overdose deaths in the U.S. rose from 102 deaths in 2018 to 3,468 deaths in 2021. Most occurred in Delaware, the District of Columbia, Maryland, Pennsylvania, Virginia, and West Virginia. Fentanyl was the most frequently co-occurring drug involved in those deaths.

What should I do if an overdose is suspected?

If you suspect that a person has overdosed on any drug, call 911 and give them naloxone—sometimes sold under the brand name Narcan—a medication that can reverse an opioid overdose. You should also stay with the person who has overdosed until first responders arrive. Most states have Good Samaritan laws, which protect people who have overdosed and those assisting them from certain criminal penalties.

While naloxone cannot reverse the effects of xylazine alone, experts recommend administering naloxone if an overdose is suspected because it’s often mixed with opioids.

You can get naloxone for free from some nonprofit organizations and government-run programs. You can also purchase over-the-counter naloxone at pharmacies, grocery and convenience stores, and other retailers.

Learn how to use naloxone in this short training video from the American Medical Association, or sign up for a free online training.

How can people prevent xylazine-related overdoses?

Harm reduction programs are community programs that prevent drug overdoses, reduce the spread of infectious diseases, and connect people to medical care. These programs provide lifesaving tools like naloxone, as well as fentanyl and xylazine test strips, which can detect the presence of these drugs in a substance and prevent overdoses. Drug test strips can also be ordered online.

However, test strips are considered “drug paraphernalia” in some states and are not legal everywhere. Learn more about state laws around drug checking equipment from the Network for Public Health Law.

Learn more about harm reduction from the CDC.

This article first appeared on Public Good News and is republished here under a Creative Commons license.

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  • Lettuce vs Spinach – Which is Healthier?

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    Our Verdict

    When comparing lettuce to spinach, we picked the spinach.

    Why?

    This one came by request from a reader, who asked: “Which is better… leafy green lettuce or spinach?”

    In terms of macros, spinach has more fiber, carbs, and protein, making it the winner in this round. The ratio of fiber to carbs is also better in spinach, by the way.

    In the category of vitamins, lettuce has more vitamin B3, while spinach has more of vitamins A, B1, B2, B5, B6, B7, B9, C, E, K, and choline. An overwhelming win for spinach.

    Looking at minerals, lettuce is not higher in any minerals, while spinach has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc. Another clear win for spinach.

    When it comes to other considerations, spinach has more polyphenols (especially flavonols), which is a point in spinach’s favor, however it is also high in oxalates, which is not an issue for most people, but if you have certain kidney problems, you’ll want to avoid those.

    Adding up the sections makes for a clear overall win for spinach, unless you need to avoid oxalates, in which case, different leafy greens are in order.

    Want to learn more?

    You might like:

    Make Your Vegetables Work Better Nutritionally ← one of the many things mentioned here (different things to do for different nutrients) is that cooking reduces oxalates, however if we’re comparing to lettuce, probably you wanted it in a leafy salad, not cooked. Still, information is good and useful, of course.

    Enjoy!

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  • What happens if I eat too much protein?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The hype around protein intake doesn’t seem to be going away.

    Social media is full of people urging you to eat more protein, including via supplements such as protein shakes. Food companies have also started highlighting protein content on food packages to promote sales.

    But is all the extra protein giving us any benefit – and can you have too much protein?

    lakshmiprasad S/Getty Images

    Protein’s important – but many eat more than they need

    Eating enough protein is important. It helps form muscle tissue, enzymes and hormones and it plays a role in immune function. It can also give you energy.

    Australia’s healthy eating guidelines, penned by experts and backed by government, recommend we get 15–25% of our daily energy needs from protein.

    The recommended daily intake of protein for adults is 0.84 grams per kilogram of body weight for men and 0.75 grams per kilogram of body weight for women

    This is about 76 grams per day for a 90 kilogram man or 53 grams per day for a 70 kilogram woman. (It’s a bit more if you’re over 70 or a child, though).

    Most Australian adults are already eating plenty of protein.

    Even so, many people still go out of their way to add even more protein to their diet.

    For people working to increase muscle mass through resistance training, such as lifting weights, a protein intake up to 1.6 grams per kilogram of body weight per day (that’s 144 grams a day for a 90 kilogram person) can help with increasing muscle strength and size.

    But research shows there is no additional muscle gain benefit from eating any more than that.

    For most of us, there’s no benefit in consuming protein above the recommended level.

    In fact, having too much protein can cause problems.

    A family eats prawns and poultry at dinner.
    For most of us, there’s no benefit in consuming protein above the recommended level. Photo by Angela Roma/Pexels

    What happens when I eat too much protein?

    Excess protein is not all simply excreted from the body in urine or faeces. It stays in the body and has various effects.

    Protein is a source of energy, so eating more protein means taking in more energy.

    When we consume more energy than we need, our body converts any excess into fatty tissue for storage.

    There are some health conditions where excess protein intake should be avoided. For example, people with chronic kidney disease should closely monitor their protein intake, under the supervision of a dietitian, to avoid damage to the kidneys.

    There is also a condition called protein poisoning, which is where you eat too many proteins without getting enough fats, carbohydrates and other nutrients.

    It’s also known as “rabbit starvation”, a term often linked to early 20th century explorer Vilhjalmur Stefansson, in reference to the fact that those who subsisted on a diet of mainly rabbits (which are famously lean) quickly fell dangerously ill.

    Where you get your protein from matters

    We can get protein in our diets from plant sources (such as beans, lentils, wholegrains) and animal sources (such as eggs, dairy, meat or fish).

    A high intake of protein from animal sources has been associated with an increased risk of premature death among older Australians (especially death from cancer).

    High animal protein intake is also associated with increased risk of type 2 diabetes.

    On the other hand, consuming more plant sources of protein is associated with:

    Many animal sources of protein are also relatively high in fat, particularly saturated fat.

    A high intake of saturated fat contributes to increased risk of chronic diseases such as heart disease. Many Australians already eat more saturated fat than we need.

    Many plant sources of protein, however, are also sources of dietary fibre, which most Australians don’t get enough of.

    Having more dietary fibre helps reduce the risk of chronic diseases (such as heart disease) and supports gut health.

    Striking a balance

    Overall, where you get protein from – and having a balance between animal and plant sources – is more important than simply just trying to add ever more protein to your diet.

    Protein, fats and carbohydrates all work together to keep your body healthy and the engine running smoothly.

    We need all of these macro nutrients, along with vitamins and minerals, in the right proportions to support our health.

    Margaret Murray, Senior Lecturer, Nutrition, Swinburne University of Technology

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • PCOS affects 1 in 8 women worldwide, yet it’s often misunderstood. A name change might help

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Polycystic ovary syndrome (PCOS) affects one in eight women globally. However, this complex hormonal condition is under-researched and often misunderstood.

    This is partly due to its name, which overemphasises “cysts” and the ovaries. In fact, you can have PCOS without cysts.

    It can affect many parts of the body, not just the ovaries, leading to acne, excess body hair, changes in metabolism and even mental health issues.

    Our new research, published today, shows that changing the name would help better reflect the complexity of PCOS and improve awareness about this condition. We surveyed 7,700 health professionals and people with PCOS and found the majority supported a name change.

    LightField Studios/Shutterstock

    What is PCOS?

    PCOS is a chronic condition caused by an imbalance of multiple hormones – the body’s chemical messengers – that circulate through the body.

    Genes and environment play a role. Lifestyle factors, such as diet (especially ultraprocessed foods) and activity, can also lead to weight gain and worsen its severity.

    In PCOS, the “cysts” are actually partially developed eggs that, due to underlying hormonal imbalance, remain dormant. This means they are less likely to be released (ovulation).

    Unlike conventional ovarian cysts, these dormant eggs will generally not grow larger, cause pain, require surgery or burst. Instead, they are slowly reabsorbed over time back into the ovary.

    Having dormant eggs in your ovaries is not, by itself, enough to be diagnosed with PCOS – and you can have PCOS without any dormant eggs.

    So, what’s needed to diagnose PCOS?

    For adults, a diagnosis requires two of three features:

    1) irregular periods (due to limited ovulation)

    2) high levels of certain hormones (androgens), such as testosterone, which is evident either in blood tests or symptoms (excess facial and body hair, acne, and thinning/balding scalp)

    3) excess dormant eggs detected either on an ultrasound or ovarian hormone blood test

    In adolescents, only the first two criteria are needed for a diagnosis. Ovary tests (ultrasound or blood tests) are not recommended until after age 20, as changes in the ovaries are common during normal adolescent development.

    However, these criteria focus heavily on the ovaries and menstrual cycles, neglecting the condition’s broader impacts.

    Widespread health effects

    In fact, hormonal imbalances in PCOS affect multiple systems in the body. This can include:

    metabolism – higher blood pressure and cholesterol, and greater risk of heart disease and diabetes.

    reproductive system – irregular menstrual cycles, reduced fertility and pregnancy complications and increased endometrial cancer risk.

    skin – excess facial/body hair, acne, scalp hair thinning and dark skin patches.

    mental health – anxiety, depression, disordered eating and body image concerns.

    PCOS has also been linked to sleep apnoea (a sleep disorder involving irregular breathing, snoring and fatigue) and inflammatory conditions such as asthma.

    Three smiling women in exercise gear.
    PCOS affects one in eight women globally. Brothers91/Getty

    Widespread confusion

    It’s not uncommon for women with PCOS to see two or three doctors and wait years for a diagnosis. Many types of doctors, including GPs and hormone, skin and fertility specialists, may be involved in care.

    Often, health-care providers focus on reproductive concerns, overlooking other health impacts.

    Common but problematic approaches include not informing women of the diagnosis, telling them not to “worry” about their PCOS until they wish to conceive, providing inadequate information or only addressing the problem in their speciality area, such as infertility.

    This fragmentation creates a troubling paradox. Some are told they’ll face infertility. Yet without proper education they may be unaware they can still occasionally ovulate and may experience unexpected pregnancies.

    Conversely, others planning for families often face unforeseen fertility difficulties that early comprehensive care – such as reproductive life planning, healthy lifestyle and early treatment – could have addressed.

    The case to change the name

    In our new study, we surveyed 3,462 health professionals and 4,246 people with PCOS across six continents.

    We wanted to find out what health-care professionals, doctors and those affected by the condition understood about PCOS, and whether understanding has improved over time.

    We also wanted to understand whether changing the name – for example, to include “endocrine” or “metabolic” – could have a positive impact, given frequent confusion and misdiagnosis.

    Support for a name change was widespread: 86% of women with PCOS and 76% of health professionals said renaming PCOS would better reflect the condition, reduce confusion and likely lead to better outcomes.

    We are now leading an international process to find a consensus on a new name and formally change it in the International Classification of Diseases. This involves engaging widely with health professionals and people with PCOS.

    By reframing PCOS beyond a purely reproductive disorder, a name change can support broader research funding, education and advocacy. It may lead to better recognition and improved diagnosis, care and outcomes for people with PCOS.

    Combating misinformation with evidence

    Accurate information is critical for proper PCOS management. Yet misinformation about the condition – for example, that PCOS can be cured through diet or exacerbated by the oral contraceptive pill – is rife on social media.

    We have also co-designed and developed evidence-based guidelines and free resources for people with PCOS to find out more about the condition, including the free “Ask PCOS” app.

    Renaming PCOS is another key step in improving knowledge about this understudied condition – and care for the 170 million women affected worldwide.

    Helena Teede, Director of Monash Centre for Health Research Implementation, Monash University; Chau Thien Tay (Jillian), Research Fellow, Monash Centre for Health Research and Implementation, Monash University, and Lorna Berry, Consumer Lead, Centre for Research Excellence in Women’s Health in Reproductive Life, Monash University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • 20 Easy Ways To Lose Belly Fat (Things To *Not* Do)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Waist circumference (and hip to waist ratio) has been found to be a much better indicator of metabolic health than BMI. So, while at 10almonds we generally advocate for not worrying too much about one’s BMI, there are good reasons why it can be good to trim up specifically the visceral belly fat. But how?

    What not to do…

    Autumn Bates is a nutritionist, and her tips include nutrition and other lifestyle factors; here are some that we agree with:

    For more, including to learn what she has against peanut butter, enjoy her video:

    Click Here If The Embedded Video Doesn’t Load Automatically

    Want to know more?

    Check out our previous main feature:

    Visceral Belly Fat & How To Lose It

    Take care!

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  • The 5 Love Languages Gone Wrong

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    Levelling up the 5 love languages

    The saying “happy wife; happy life” certainly goes regardless of gender, and if we’re partnered, it’s difficult to thrive in our individual lives if we’re not thriving as a couple. So, with the usual note that mental health is also just health, let’s take a look at getting beyond the basics of a well-known, often clumsily-applied model:

    The 5 love languages

    You’re probably familiar with “the 5 love languages”, as developed by Dr. Gary Chapman. If not, they are:

    1. Acts of Service
    2. Gift-Giving
    3. Physical Touch
    4. Quality Time
    5. Words of Affirmation

    The idea is that we each weight these differently, and problems can arise when a couple are “speaking a different language”.

    So, is this a basic compatibility test?

    It doesn’t have to be!

    We can, if we’re aware of each other’s primary love languages, make an effort to do a thing we wouldn’t necessarily do automatically, to ensure they’re loved the way they need to be.

    But…

    What a lot of people overlook is that we can also have different primary love languages for giving and for receiving. And, missing that can mean that even taking each other’s primarily love languages into account, efforts to make a partner feel loved, or to feel loved oneself, can miss 50% of the time.

    For example, I (your writer here today, hi) could be asked my primary love language and respond without hesitation “Acts of Service!” because that’s my go-to for expressing love.

    I’m the person who’ll run around bringing drinks, do all the housework, and without being indelicate, will tend towards giving in the bedroom. But…

    A partner trying to act on that information to make me feel loved by giving Acts of Service would be doomed to catastrophic failure, because my knee-jerk reaction would be “No, here, let me do that for you!”

    So it’s important for partners to ask each other…

    • Not: “what’s your primary love language?” ❌
    • But: “what’s your primary way of expressing love?” ✅
    • And: “which love language makes you feel most loved?” ✅

    For what it’s worth, I thrive on Words of Affirmation, so thanks again to everyone who leaves kind feedback on our articles! It lets me know I provided a good Act of Service

    So far, so simple, right? You and your partner (or: other person! Because as we’ve just seen, these go for all kinds of dynamics, not just romantic partnerships) need to be aware of each other’s preferred love languages for giving and receiving.

    But…

    There’s another pitfall that many fall into, and that’s assuming that the other person has the same idea about what a given love language means, when there’s more to clarify.

    For example:

    • Acts of Service: is it more important that the service be useful, or that it took effort?
    • Gift-Giving: is it better that a gift be more expensive, or more thoughtful and personal?
    • Physical Touch: what counts here? If we’re shoulder-to-shoulder on the couch, is that physical touch or is something more active needed?
    • Quality Time: does it count if we’re both doing our own thing but together in the same room, comfortable in silence together? Or does it need to be a more active and involved activity together? And is it quality time if we’re at a social event together, or does it need to be just us?
    • Words of Affirmation: what, exactly, do we need to hear? For romantic partners, “I love you” can often be important, but is there something else we need to hear? Perhaps a “because…”, or perhaps a “so much that…”, or perhaps something else entirely? Does it no longer count if we have to put the words in our partner’s mouth, or is that just good two-way communication?

    Bottom line:

    There’s a lot more to this than a “What’s your love language?” click-through quiz, but with a little application and good communication, this model can really resolve a lot of would-be problems that can grow from feeling unappreciated or such. And, the same principles go just the same for friends and others as they do for romantic partners.

    In short, it’s one of the keys to good interpersonal relationships in general—something critical for our overall well-being!

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  • Weak Knees? Four Exercises To Strengthen Every Knee Muscle

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Over-50s specialist physio Will Harlow shows us how:

    The most bang-for-buck:

    We’ll keep it simple; the four exercises are:

    1. Knee extensions while sitting: sit back in a chair, straighten your leg, pull your toes towards you, and strongly contract your thigh while pushing your knee down into the chair, before lowering and repeating.
    2. Hamstring bridge: lie on your back on the floor with your legs resting on a chair or similar elevated surface, press your lower back into the floor, then push through your heels to lift your pelvis by squeezing your hamstrings, before lowering slowly.
    3. Forward lean calf raise: stand about a meter from a wall, lean forwards with your hands on it, then rise onto your toes through a full range before lowering under control, progressing to one leg if reasonable.
    4. sit to stand progression: move from a standard sit-to-stand to a staggered stance, and eventually a single-leg version, leaning your body forwards, and controlling both the lift and the descent.

    For more on all of this plus visual demonstrations, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Take care!

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