
Ways To Boost Brain-Derived Neurotrophic Factor (BDNF)
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝You said that exercise is a good way to boost BDNF, are there any supplements you’d recommend?❞
Exercise is indeed a great way, and is generally considered the best way! Indeed, it’ll even work in the absence of eating anything, as in this study which found:
- Prolonged (90 min) light cycling exercise increased plasma- and serum-derived BDNF irrespective of being fed or fasted and seemed to be independent of changes in cerebral shear stress.
- Six minutes of high-intensity cycling intervals increased every metric of circulating BDNF by 4 to 5 times more than prolonged low-intensity cycling; the increase in plasma-derived BDNF was correlated with a 6-fold increase in circulating lactate irrespective of feeding or fasting.
- Compared to 1 day of fasting with or without prolonged light exercise, high-intensity exercise is a much more efficient means to increase BDNF in circulation.
Read in full: Fasting for 20 h does not affect exercise-induced increases in circulating BDNF in humans ← according to the research, a 7-minute HIIT session is excellent for this!
If you’re wondering whether your body is truly up to high-intensity exercise, the answer is almost certainly yes, if you go about it with due care and attention. We wrote about this here: How To Do HIIT (Without Wrecking Your Body)
Drugs are technically possible, but hard to get hold of
As for supplements/drugs, the only thing not related to food that we know of is Noopept:
The original novel nootropic and neuroprotective agent noopept
…which was readily available if you knew that right people in Russia 15–20 years ago, but is almost certainly not available at your local drugstore, and availability online is scarce, difficult, and risky (gray market / black market sites).
Food for thought
In terms of food, there are many options, which also means supplements derived from those foods. In order to make BDNF, your brain is best when well-nourished with:
- Polyphenols, especially flavonoids (see also: Are You Getting The Right Kinds Of Flavonoids?)
- DHA, the most brain-ready form of omega-3 (See also: What Omega-3 Fatty Acids Really Do For Us)
- Caffeine, which if you get from coffee or green tea, comes with many polyphenols too (See also: The Bitter Truth About Coffee (or is it?))
Learn more: Effects of nutritional interventions on BDNF concentrations in humans: a systematic review
With regard to omega-3 in particular:
❝The effects were larger when supplements were used for longer than 10 weeks, doses under 1500mg/day, and adults older than 50 years.❞
Adaptogens allow your brain to increase BDNF levels
You can also help your brain to produce BDNF by supplementing with adaptogens, that is to say, compounds that help your body to better manage stress, thus reducing cortisol levels, which otherwise interfere with BDNF production.
If you’d like a BDNF-optimized stack of such adaptogens in one supplement, here’s an example product on Amazon 😎
Can you take BDNF directly?
You may be wondering if you can get BDNF directly, by simply consuming it as part of your diet. And, technically you can, but we don’t recommend it, because eating human brains carries a risk of CJD and other assorted prion diseases.
So, it’s better to simply enjoy the foods that allow your own brain to make it.
Take care!
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Visceral Fat: Why It Matters & How To Improve It
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Dr. Ruth Machin demystifies it:
At the core of things
Visceral fat is fat stored deep inside your abdominal cavity, underneath your abdominal wall muscles, surrounding your organs. As such, it’s different from subcutaneous fat (under your skin, the fat you can squish from the outside), and belongs to the broader category of ectopic fat (ectopic = “out of place”).
While it’s fine for your organs to have a little padding, the problem with excess visceral fat is that it secretes pro-inflammatory adipokines that drive insulin resistance, raise the risk of type 2 diabetes, promote hypertension, contribute to heart disease, and generally bring about (or exacerbate) metabolic syndrome in general.
Although overall weight gain in midlife comes mostly from age and reduced activity, not menopause itself, menopause is a factor—because declining estrogen levels result in the body shifting fat storage from hips and thighs, towards your midsection, increasing visceral fat.
How to measure visceral fat: it cannot be seen externally; waist-to-height ratio is a better guide than BMI; thresholds above 0.5 signal increased risk; imaging such as MRI is required for accurate measurement in research.
Still, if you have a smart scale, it’ll do a decent estimate for you as part of its body composition test, based on conductivity. Just remember, it’s not accurate, so in that case, worry less about the actual numbers, and more about the trends (e.g. whether the visceral fat score is going up or down over time or remaining the same).
Some notes from Dr. Machin on dietary considerations:
- Diet quality for reducing visceral fat: research shows that a mild (!) calorie deficit combined with avoiding saturated fats but enjoying low-GI carbohydrates (i.e: get plenty of fiber with your carbs) reduces visceral fat.
- Whole-food approaches that work: both low-carb and higher carb diets with unprocessed foods reduce visceral fat; avoiding added sugars and refined carbohydrates improves insulin resistance and abdominal fat patterns. No surprises here.
- Why the Mediterranean diet is effective: it promotes whole grains, beans, legumes, olive oil, fish, fruit, vegetables, and nuts; it supports cardiovascular health and reduces visceral fat more effectively than low-fat or low-carb diets in the long term.
- Extra benefits from polyphenols: the green Mediterranean diet, enriched with walnuts, green tea, and other polyphenol-dense foods, produced larger visceral fat reductions than the standard Mediterranean diet in clinical trials.
- Foods rich in polyphenols to include: dark berries, green and black tea, nuts with skins (e.g. almonds!), extra virgin olive oil, cocoa, ground flaxseed, red onions, dark green vegetables, and soy; these all improve waist circumference and metabolic markers.
- Overall eating guidance: enjoy unprocessed whole foods, keep added sugars low, avoid sugary drinks especially, replace refined carbohydrates with whole grains, and aim for a diet you can maintain for decades rather than weeks.
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Visceral Belly Fat & How To Lose It
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Why are people on TikTok talking about going for a ‘fart walk’? A gastroenterologist weighs in
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“Fart walks” have become a cultural phenomenon, after a woman named Mairlyn Smith posted online a now-viral video about how she and her husband go on walks about 60 minutes after dinner and release their gas.
Smith, known on TikTok as @mairlynthequeenoffibre and @mairlynsmith on Instagram, has since appeared on myriad TV and press interviews extolling the benefits of a fart walk. Countless TikTok and Instagram users and have now shared their own experiences of feeling better after taking up the #fartwalk habit.
So what’s the evidence behind the fart walk? And what’s the best way to do it?
CandyBox Images/Shutterstock Exercise can help get the gas out
We know exercise can help relieve bloating by getting gas moving and out of our bodies.
Researchers from Barcelona, Spain in 2006 asked eight patients complaining of bloating, seven of whom had irritable bowel syndrome, to avoid “gassy” foods such as beans for two days and to fast for eight hours before their study.
Each patient was asked to sit in an armchair, in order to avoid any effects of body position on the movement of gas. Gas was pumped directly into their small bowel via a thin plastic tube that went down their mouth, and the gas expelled from the body was collected into a bag via a tube placed in the rectum. This way, the researchers could determine how much gas was retained in the gut.
The patients were then asked to pedal on a modified exercise bike while remaining seated in their armchairs.
The researchers found that much less gas was retained in the patients’ gut when they exercised. They determined exercise probably helped the movement and release of intestinal gas.
Walking may have another bonus; it may trigger a nerve reflex that helps propel foods and gas contents through the gut.
Walking can also increase internal abdominal pressure as you use your abdominal muscles to stay upright and balance as you walk. This pressure on the colon helps to push intestinal gas out.
Proper fart walk technique
One study from Iran studied the effects of walking in 94 individuals with bloating.
They asked participants to carry out ten to 15 minutes of slow walking (about 1,000 steps) after eating lunch and dinner. They filled out gut symptom questionnaires before starting the program and again at the end of the four week program.
The researchers found walking after meals resulted in improvements to gut symptoms such as belching, farting, bloating and abdominal discomfort.
Now for the crucial part: in the Iranian study, there was a particular way in which participants were advised to walk. They were asked to clasp hands together behind their back and to flex their neck forward.
The clasped hands posture leads to more internal abdominal pressure and therefore more gentle squeezing out of gas from the colon. The flexed neck posture decreases the swallowing of air during walking.
This therefore is the proper fart walk technique, based on science.
Could walking with your hands behind your back yield better or more farts? candy candy/Shutterstock What about constipation?
A fart walk can help with constipation.
One study involved middle aged inactive patients with chronic constipation, who did a 12 week program of brisk walking at least 30 minutes a day – combined with 11 minutes of strength and flexibility exercises.
This program, the researchers found, improved constipation symptoms through reduced straining, less hard stools and more complete evacuation.
It also appears that the more you walk the better the benefits for gut symptoms.
In patients with irritable bowel syndrome, one study increasing the daily step count to 9,500 steps from 4,000 steps led to a 50% reduction in the severity of their symptoms.
And just 30 minutes of a fart walk has been shown to improve blood sugar levels after eating.
Walking after eating can help keep your blood sugar levels under control. IndianFaces/Shutterstock What if I can’t get outside the house?
If getting outside the house after dinner is impossible, could you try walking slowly on a treadmill or around the house for 1,000 steps?
If not, perhaps you could borrow an idea from the Barcelona research: sit back in an armchair and pedal using a modified exercise bike. Any type of exercise is better than none.
Whatever you do, don’t be a couch potato! Research has found more leisure screen time is linked to a greater risk of developing gut diseases.
We also know physical inactivity during leisure time and eating irregular meals are linked to a higher risk of abdominal pain, bloating and altered bowel motions.
Try the fart walk today
It may not be for everyone but this simple physical activity does have good evidence behind it. A fart walk can improve common symptoms such as bloating, abdominal discomfort and constipation.
It can even help lower blood sugar levels after eating.
Will you be trying a fart walk today?
Vincent Ho, Associate Professor and clinical academic gastroenterologist, Western Sydney University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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The Abs-Brain Axis
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You’ve heard of the gut-brain axis, but now there’s also this!
Quick note: if you in fact haven’t heard of the gut-brain axis, then here you go:
- The Brain-Gut Highway: A Two-Way Street
- The Vagus Nerve (And How You Can Make Use Of It)
- The Gut Bacteria That Improve Your General Decision-Making In Life
Whence such considerations as: Heal Your Gut, Save Your Brain – by Dr. Partha Nandi
So, what’s the new news?
Abs-olute brain benefits
This time, it has more to do with brain-cleaning, and how even small body movements—especially abdominal muscle contractions—can gently shift your brain inside your skull, helping cerebrospinal fluid circulate and clear waste.
You might remember the brain-centric part of this general idea from such things as:
- How To Clean Your Brain (Glymphatic Health Primer)
- Take Care Of Your Lymphatic System To Beat Cognitive Decline
- Goodnight, Glymphatic System: How Your Sleep Position Changes Dementia Risk
So, why are abdominal muscles special in this regard?
Per recent research by Dr. Beatrice Ghitti et al., tightening your core increases abdominal pressure, which pushes blood through the vertebral venous plexus—a vein network linking your abdomen, spine, and brain—creating a subtle hydraulic effect that moves your brain slightly. Sounds bad, doesn’t it? Well, it isn’t!
This tiny brain motion was observed to help “rinse” the brain by moving cerebrospinal fluid across brain tissue, to support waste removal and reduce buildup associated with neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and so forth.
We talk often about how “what’s good for your heart is good for your brain”, because of how the circulation is so important for that, and it goes not just for reducing risk factors (see: What’s Your Vascular Dementia Risk?), but also for improving cognitive function, e.g: How Your Exercise Today Gives A Brain Boost Tomorrow
In this case, it’s not just about circulation, however, because brain motion was linked more strongly to movement and abdominal contractions than to breathing or heartbeat, showing how physical activity itself may directly support brain-cleaning processes, in addition to circulatory benefits.
You can read the paper in full, here: Brain motion is driven by mechanical coupling with the abdomen
Want to learn more?
Check out:
Breathing For Pain Relief & Core Strength (How To Reconnect Your Breath & Body) ← this has to do with abdominal control also for, incidentally, brain benefits
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Blood-Brain Barrier Breach Blamed For Brain-Fog
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Move Over, Leaky Gut. Now It’s A Leaky Brain.
…which is not a headline that promises good news, and indeed, the only good news about this currently is “now we know another thing that’s happening, and thus can work towards a treatment for it”.
Back in February (most popular media outlets did not rush to publish this, as it rather goes against the narrative of “remember when COVID was a thing?” as though the numbers haven’t risen since the state of emergency was declared over), a team of Irish researchers made a discovery:
❝For the first time, we have been able to show that leaky blood vessels in the human brain, in tandem with a hyperactive immune system may be the key drivers of brain fog associated with long covid❞
~ Dr. Matthew Campbell (one of the researchers)
Let’s break that down a little, borrowing some context from the paper itself:
- the leaky blood vessels are breaching the blood-brain-barrier
- that’s a big deal, because that barrier is our only filter between our brain and Things That Definitely Should Not Go In The Brain™
- a hyperactive immune system can also be described as chronic inflammation
- in this case, that includes chronic neuroinflammation which, yes, is also a major driver of dementia
You may be wondering what COVID has to do with this, and well:
- these blood-brain-barrier breaches were very significantly associated (in lay terms: correlated, but correlated is only really used as an absolute in write-ups) with either acute COVID infection, or Long Covid.
- checking this in vitro, exposure of brain endothelial cells to serum from patients with Long Covid induced the same expression of inflammatory markers.
How important is this?
As another researcher (not to mention: professor of neurology and head of the school of medicine at Trinity) put it:
❝The findings will now likely change the landscape of how we understand and treat post-viral neurological conditions.
It also confirms that the neurological symptoms of long covid are measurable with real and demonstrable metabolic and vascular changes in the brain.❞
~ Dr. Colin Doherty (see mini-bio above)
You can read a pop-science article about this here:
Irish researchers discover underlying cause of “brain fog” linked with long covid
…and you can read the paper in full here:
Want to stay safe?
Beyond the obvious “get protected when offered boosters/updates” (see also: The Truth About Vaccines), other good practices include the same things most people were doing when the pandemic was big news, especially avoiding enclosed densely-populated places, washing hands frequently, and looking after your immune system. For that latter, see also:
Beyond Supplements: The Real Immune-Boosters!
Take care!
Don’t Forget…
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- the leaky blood vessels are breaching the blood-brain-barrier
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Apple vs Pear – Which is Healthier?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Our Verdict
When comparing apple to pear, we picked the pear.
Why?
Both are great! But there’s a category that puts pears ahead of apples…
Looking at their macros first, pears contain more carbs but also more fiber. Both are low glycemic index foods, though.
In the category of vitamins, things are moderately even: apples contain more of vitamins A, B1, B6, and E, while pears contain more of vitamins B3, B9, K, and choline. That’s a 4:4 split, and the two fruits are about equal in the other vitamins they both contain.
When it comes to minerals, pears contain more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc. A resounding victory for pears, as apples are not higher in any mineral.
In short, if an apple a day keeps the doctor away, a pear should keep the doctor away for about a day and a half, based on the extra nutrients ← this is slightly facetious as medicine doesn’t work like that, but you get the idea: pears simply have more to offer. Apples are still great though! Enjoy both! Diversity is good.
Want to learn more?
You might like to read:
From Apples To Bees, And High-Fructose Cs: Which Sugars Are Healthier, And Which Are Just The Same?
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5 Movements You’ll Wish You’d Known Sooner
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Alisa Szyman, mobility coach, shows us why:
Best for mobility, best against pain
These movements are what’s needed for good mobility (range of motion, flexibility, strength, stability) while also being a top-tier way of combatting pain, due to what they do for the body’s natural functions.
Specifically, the exercises are intended to build on one another, beginning with neck stability, then restoring upper-back rotation, activating your glutes, improving hip control, and finally reducing hamstring and posterior-chain tightness:
- Chin tucks: stand tall, bring your chin slightly forwards, then push it straight back to create a double chin while keeping your head level, and follow with slow shoulder shrugs by lifting your shoulders towards your ears and lowering them under control.
- Quadruped thoracic rotations: start on all fours with one hand on the floor and the other extended to the side, rotate through your upper back to lift the arm towards the ceiling while following it with your eyes, then return to the start position.
- Glute bridges: lie on your back with your knees bent and feet flat, squeeze your glutes before lifting your hips, hold briefly at the top, then lower slowly while keeping the effort in your glutes rather than your lower back.
- Hip CARs (controlled articular rotations): stand or kneel, lift one knee and slowly move your hip through its fullest circular range while keeping your spine and upper body still, then repeat in both directions on each side.
- Sciatic nerve flossing: lie on your back with one knee bent and your foot flat on the floor, raise the other leg towards the ceiling, then gently flex and point your foot or make slow ankle circles, to glide the sciatic nerve through its range of motion.
For more on all of this plus visual demonstrations, enjoy:
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Want to learn more?
You might also like:
Best Mobility Drills For Posture & Pain Relief
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