Too Much Or Too Little Testosterone?

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One Man’s Saw Palmetto Is Another Woman’s Serenoa Repens…

Today we’re going to look at saw palmetto. So, first:

What is it?

Saw palmetto is a type of palm native to the southeastern United States. Its scientific name is “Serenoa repens”, so if that name appears in studies we cite, it’s the same thing. By whichever name, it’s widely enjoyed as a herbal supplement.

Why do people take it?

Here’s where it gets interesting, because people take it for some completely opposite reasons…

Indeed, searching for it on the Internet will cause Google to suggest “…for men” and “…for women” as the top suggestions.

That’s because it works on testosterone, and testosterone can be a bit of a double-edged sword, so some people want to increase or decrease certain testosterone-related effects on their body.

And it works for both! Here be science:

  • Testosterone (henceforth, “T”) is produced in the human body.
    • Yes, all human bodies, to some extent.
  • An enzyme called 5-alpha-reductase converts T in to DHT (dihydrogen testosterone)
  • DHT is a much more potent androgen (masculinizing agent) than T alone, such that its effects are often unwanted, including:
    • Enlarged prostate (if you have one)
    • Hair loss (especially in men)
    • New facial hair growth (usually unwanted by women)
      • Women are more likely to get this due to PCOS and/or the menopause

To avoid those effects, you really want less of your T to be converted into DHT.

Saw palmetto is a 5α-reductase inhibitor, so if you take it, you’ll have less DHT, and you’ll consequently lose less hair, have fewer prostate problems, etc.

Read: Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

^The above study showed that saw palmetto extract performed comparably to finasteride. Finasteride is the world’s main go-to prescription drug for treating enlarged prostate and/or hair loss.

See also: Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia

Hair today… Growing tomorrow!

So, what was that about increasing T levels?

Men usually suffer declining T levels as they get older, with a marked drop around the age of 45. With lower T comes lower energy, lower mood, lower libido, erectile dysfunction, etc.

Guess what… It’s T that’s needed for those things, not DHT. So if you block the conversion of T to DHT, you’ll have higher blood serum T levels, higher energy, higher mood, higher libido, and all that.

Read: Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis

(the above assumes you have testicles, without which, your T levels will certainly not increase)

Saw Palmetto Against Enlarged Prostate?

With higher DHT levels in mid-late life, prostate enlargement (benign prostatic hyperlasia) can become a problem for many men. The size of that problem ranges from urinary inconvenience (common, when the prostate presses against the bladder) to prostate cancer (less common, much more serious). Saw palmetto, like other 5α-reductase inhibitors such as finasteride, may be used to prevent or treat this.

Wondering how safe/reliable it is? We found a very high-quality fifteen-year longitudinal observational study of the use of saw palmetto, and it found:

❝The 15 years’ study results suggest that taking S. repens plant extract continuously at a daily dose of 320 mg is an effective and safe way to prevent the progression of benign prostatic hyperplasia.❞

Read: 15 years’ survey of safety and efficacy of Serenoa repens extract in benign prostatic hyperplasia patients with risk of progression

Want a second opinion? We also found a 10-year study (by different researchers with different people taking it), which reached the same conclusion:

❝The results of study showed the absence of progression, both on subjective criteria (IPSS, and QoL scores), and objective criteria (prostate volume, the rate of urination, residual urine volume). Furthermore, patients had no undesirable effects directly related to the use of this drug.❞

  • IPSS = International Prostate Symptom Score
  • QoL = Quality of Life

Read: The results of the 10-year study of efficacy and safety of Serenoa repens extract in patients at risk of progression of benign prostatic hyperplasia

But wait a minute; I, a man over the age of 45 with potentially declining T levels but a fabulous beard, remember that you said just a minute ago that saw palmetto is used by women to avoid having facial hair; I don’t want to lose mine!

You won’t. Once your facial hair follicles were fully developed and activated during puberty, they’ll carry on doing what they do for life. That’s no longer regulated by hormones once they’re up and running.

The use of saw palmetto can only be used to limit facial hair if caught early—so it’s more useful at the onset of menopause, for those who have (or will have) such, or else upon the arrival of PCOS symptoms or hirsuitism from some other cause.

Take The Test!

Do you have a prostate, and would like to know your IPSS score, and what that means for your prostate health?

Take The Test Here!

(takes 1 minute, no need to pee or go probing for anything)

Bottom Line on Saw Palmetto

  • It blocks the conversion of T into DHT
  • It will increase blood serum T levels, thus boosting mood, energy, libido, etc in men (who typically have more T, but whose T levels decline with age)
  • It will decrease DHT levels, thus limiting hair loss (especially in men) and later-life new facial hair growth (especially in women).
  • It can be used to prevent or treat prostate enlargement
  • Bonus: it’s a potent antioxidant and thus reduces general inflammation (in everyone)

Want To Try Saw Palmetto?

We don’t sell it (or anything else), but for your convenience…

Click here to check out saw palmetto on Amazon!

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  • What Menopause Does To The Heart

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    World Menopause Day: Menopause & Cardiovascular Disease Risk

    Today, the 18th of October, is World Menopause Day.

    The theme for this year is cardiovascular disease (CVD), and if your first reaction is to wonder what that has to do with the menopause, then this is the reason why it’s being featured. Much of the menopause and its effects are shrouded in mystery; not because of a lack of science (though sometimes a bit of that too), but rather, because it is popularly considered an unimportant, semi-taboo topic.

    So, let’s be the change we want to see, and try to fix that!

    What does CVD have to do with the menopause?

    To quote Dr. Anjana Nair:

    ❝The metabolic and clinical factors secondary to menopause, such as dyslipidemia, insulin resistance, fat redistribution and systemic hypertension, contribute to the accelerated risk for cardiovascular aging and disease.

    Atherosclerosis appears to be the end result of the interaction between cardiovascular risk factors and their accentuation during the perimenopausal period.

    The increased cardiovascular risk in menopause stems from the exaggerated effects of changing physiology on the cardiovascular system.❞

    Source: Cardiovascular Changes in Menopause

    See also: Menopause-associated risk of cardiovascular disease

    Can we do anything about it?

    Yes, we can! Here be science:

    This (in few words: get your hormone levels checked, and consider HRT if appropriate) is consistent with the advice from gynecologist Dr. Jen Gunter, whom we featured back in August:

    What You Should Have Been Told About The Menopause Beforehand

    What about lifestyle changes?

    We definitely can do some good things; here’s what the science has to say:

    For a full low-down on all of these:

    Revealing the evidence-based lifestyle solutions to managing your menopause symptoms

    Want to know more?

    You can get the International Menopause Society’s free downloadable booklet here:

    Menopause & Cardiovascular Disease: What Women Need To Know

    You may also like our previous main feature:

    What Does “Balance Your Hormones” Even Mean?

    Take care!

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  • Elderberries vs Gooseberries – Which is Healthier?

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    Our Verdict

    When comparing elderberries to gooseberries, we picked the elderberries.

    Why?

    These are both berries more likely found in your garden or local wood than in the supermarket, but if you have convenient access to them, they’re great options for eating!

    In terms of macros, elderberry has nearly 2x the carbs and/but also nearly 2x the fiber, which in glycemic index terms, mostly cancels out (although: elderberry has the slightly lower glycemic index of the two)

    In the category of vitamins, both are great but elderberries are winning with more of vitamins A, B1, B2, B3, B6, and C, while gooseberries have more vitamin B5.

    When it comes to minerals, elderberries again lead with more calcium, iron, phosphorus, and potassium, while gooseberries have more magnesium.

    There is an extra category today, which is “extra medicinal properties”, and elderberries have extra immune-boosting qualities, whereas gooseberries—while being as polyphenol-laden as one usually expects berries to be—do not confer the same kind of benefit in this regard.

    You can check out the information about elderberry’s extra properties in the links section below; meanwhile, if you’re choosing between these berries, that’s the clear winner in every category today!

    Want to learn more?

    You might like to read:

    Take care!

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  • Peaceful Kitchen – by Catherine Perez

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The author, a keen cook and Registered Dietician with a Master’s in same, covers the basics of the science of nutrition as relevant to her recipes, but first and foremost this is not a science textbook—it’s a cookbook, and its pages contain more love for the art than citations for the (perfectly respectable) science.

    Mexican and Dominican cuisine are the main influences in this book, but there are dishes from around the world too.

    The recipes themselves are… Comparable in difficulty to the things we often feature in our recipes section here at 10almonds. They’re probably not winning any restaurants Michelin stars, but they’re not exactly student survival recipes either. They’re made from mostly non-obscure whole foods, nutritionally-dense ingredients at that, with minimal processed foods involved.

    That said, she does take a “add, don’t subtract” approach to nutrition, i.e. focussing more on adding in diversity of plants than on “don’t eat this; don’t eat that” mandates.

    If there’s any criticism to be levelled at the book, it’s that in most cases we’d multiply the spices severalfold, but that’s not a big problem as readers can always judge that individually; she’s given the basic information of which spices in which proportions, which is the key knowledge.

    Bottom line: if you’re looking to expand your plant-based cooking repertoire, this one is a fine choice.

    Click here to check out Peaceful Kitchen, and try some new things!

    Share This Post

Related Posts

  • Licorice, Digestion, & Hormones
  • Needle Pain Is a Big Problem for Kids. One California Doctor Has a Plan.

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Almost all new parents go through it: the distress of hearing their child scream at the doctor’s office. They endure the emotional torture of having to hold their child down as the clinician sticks them with one vaccine after another.

    “The first shots he got, I probably cried more than he did,” said Remy Anthes, who was pushing her 6-month-old son, Dorian, back and forth in his stroller in Oakland, California.

    “The look in her eyes, it’s hard to take,” said Jill Lovitt, recalling how her infant daughter Jenna reacted to some recent vaccines. “Like, ‘What are you letting them do to me? Why?’”

    Some children remember the needle pain and quickly start to internalize the fear. That’s the fear Julia Cramer witnessed when her 3-year-old daughter, Maya, had to get blood drawn for an allergy test at age 2.

    “After that, she had a fear of blue gloves,” Cramer said. “I went to the grocery store and she saw someone wearing blue gloves, stocking the vegetables, and she started freaking out and crying.”

    Pain management research suggests that needle pokes may be children’s biggest source of pain in the health care system. The problem isn’t confined to childhood vaccinations either. Studies looking at sources of pediatric pain have included children who are being treated for serious illness, have undergone heart surgeries or bone marrow transplants, or have landed in the emergency room.

    “This is so bad that many children and many parents decide not to continue the treatment,” said Stefan Friedrichsdorf, a specialist at the University of California-San Francisco’s Stad Center for Pediatric Pain, speaking at the End Well conference in Los Angeles in November.

    The distress of needle pain can follow children as they grow and interfere with important preventive care. It is estimated that a quarter of all adults have a fear of needles that began in childhood. Sixteen percent of adults refuse flu vaccinations because of a fear of needles.

    Friedrichsdorf said it doesn’t have to be this bad. “This is not rocket science,” he said.

    He outlined simple steps that clinicians and parents can follow:

    • Apply an over-the-counter lidocaine, which is a numbing cream, 30 minutes before a shot.
    • Breastfeed babies, or give them a pacifier dipped in sugar water, to comfort them while they’re getting a shot.
    • Use distractions like teddy bears, pinwheels, or bubbles to divert attention away from the needle.
    • Don’t pin kids down on an exam table. Parents should hold children in their laps instead.

    At Children’s Minnesota, Friedrichsdorf practiced the “Children’s Comfort Promise.” Now he and other health care providers are rolling out these new protocols for children at UCSF Benioff Children’s Hospitals in San Francisco and Oakland. He’s calling it the “Ouchless Jab Challenge.”

    If a child at UCSF needs to get poked for a blood draw, a vaccine, or an IV treatment, Friedrichsdorf promises, the clinicians will do everything possible to follow these pain management steps.

    “Every child, every time,” he said.

    It seems unlikely that the ouchless effort will make a dent in vaccine hesitancy and refusal driven by the anti-vaccine movement, since the beliefs that drive it are often rooted in conspiracies and deeply held. But that isn’t necessarily Friedrichsdorf’s goal. He hopes that making routine health care less painful can help sway parents who may be hesitant to get their children vaccinated because of how hard it is to see them in pain. In turn, children who grow into adults without a fear of needles might be more likely to get preventive care, including their yearly flu shot.

    In general, the onus will likely be on parents to take a leading role in demanding these measures at medical centers, Friedrichsdorf said, because the tolerance and acceptance of children’s pain is so entrenched among clinicians.

    Diane Meier, a palliative care specialist at Mount Sinai, agrees. She said this tolerance is a major problem, stemming from how doctors are usually trained.

    “We are taught to see pain as an unfortunate, but inevitable side effect of good treatment,” Meier said. “We learn to repress that feeling of distress at the pain we are causing because otherwise we can’t do our jobs.”

    During her medical training, Meier had to hold children down for procedures, which she described as torture for them and for her. It drove her out of pediatrics. She went into geriatrics instead and later helped lead the modern movement to promote palliative care in medicine, which became an accredited specialty in the United States only in 2006.

    Meier said she thinks the campaign to reduce needle pain and anxiety should be applied to everyone, not just to children.

    “People with dementia have no idea why human beings are approaching them to stick needles in them,” she said. And the experience can be painful and distressing.

    Friedrichsdorf’s techniques would likely work with dementia patients, too, she said. Numbing cream, distraction, something sweet in the mouth, and perhaps music from the patient’s youth that they remember and can sing along to.

    “It’s worthy of study and it’s worthy of serious attention,” Meier said.

    This article is from a partnership that includes KQED, NPR, and KFF Health News.

    KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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    Subscribe to KFF Health News’ free Morning Briefing.

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  • Fiber Fueled – by Dr. Will Bulsiewicz

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    We generally know that for gut health we should eat fiber, but what of the balances of different sorts of fiber?

    That’s one of the main things that make this book stand out—fostering diversity in our microbiome by fostering diversity in our diet. Specifically, diversity of fiber-containing foods.

    The book is part “science made easy for the lay reader”, and part recipe book. The recipes come with shopping lists and a meal planner, though we would recommend to use those as a guide rather than to try to adhere perfectly to them.

    In particular, this reviewer would encourage much more generous use of healthful seasonings… and less reliance on there being leftovers several days later (tasty food gets gone quickly in this house!)

    As for the science, the feel of this is more like reading a science-based observational documentary with explanations, than of reading a science textbook. Studies are mentioned in passing, but not dissected in any detail, and the focus is more on getting the key learnings across.

    Bottom line: if you’d like to boost not just the amount, but also the diversity, of fiber in your diet, and reap the gut-health rewards, this book is a great guide for that!

    Click here to get your copy of “Fiber Fueled” from Amazon today!

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  • Anise vs Diabetes & Menopause

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    What A Daily Gram Of Anise Can Do

    Anise, specifically the seed of the plant, also called aniseed, is enjoyed for its licorice taste—as well as its medicinal properties.

    Let’s see how well the science lives up to the folk medicine…

    What medicinal properties does it claim?

    The main contenders are:

    • Reduces menopause symptoms
    • Reduces blood sugar levels
    • Reduces inflammation

    Does it reduce menopause symptoms?

    At least some of them! Including hot flashes and bone density loss. This seems to be due to the estrogenic-like activity of anethole, the active compound in anise that gives it these effects:

    Estrogenic activity of isolated compounds and essential oils of Pimpinella species

    1g of anise/day yielded a huge reduction in frequency and severity of hot flashes, compared to placebo*:

    *you may be wondering what the placebo is for 1g of a substance that has a very distinctive taste. The researchers used capsules, with 3x330g as the dose, either anise seed or potato starch.

    ❝In the experimental group, the frequency and severity of hot flashes before the treatment were 4.21% and 56.21% and, after that, were 1.06% and 14.44% at the end of the fourth week respectively. No change was found in the frequency and severity of hot flashes in the control group. The frequency and severity of hot flashes was decreased during 4 weeks of follow up period. P. anisum is effective on the frequency and severity of hot flashes in postmenopausal women. ❞

    See for yourself: The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes

    As for bone mineral density, we couldn’t find a good study for anise, but we did find this one for fennel, which is a plant of the same family and also with the primary active compound anethole:

    The Prophylactic Effect of Fennel Essential Oil on Experimental Osteoporosis

    That was a rat study, though, so we’d like to see studies done with humans.

    Summary on this one: it clearly helps against hot flashes (per the very convincing human study we listed above); it probably helps against bone mineral density loss.

    Does it reduce blood sugar levels?

    This one got a flurry of attention all so recently, on account of this research review:

    Review on Anti-diabetic Research on Two Important Spices: Trachyspermum ammi and Pimpinella anisum

    If you read this (and we do recommend reading it! It has a lot more information than we can squeeze in here!) one of the most interesting things about the in vivo anti-diabetic activity of anise was that while it did lower the fasting blood glucose levels, that wasn’t the only effect:

    ❝Over a course of 60 days, study participants were administered seed powders (5 g/d), which resulted in significant antioxidant, anti-diabetic, and hypolipidemic effects.

    Notably, significant reductions in fasting blood glucose levels were observed. This intervention also elicited alterations in the lipid profile, LPO, lipoprotein levels, and the high-density lipoprotein (HDL) level.

    Moreover, the serum levels of essential antioxidants, such as beta carotene, vitamin C, vitamin A, and vitamin E, which are typically decreased in diabetic patients, underwent a reversal.❞

    That’s just one of the studies cited in that review (the comments lightly edited here for brevity), but it stands out, and you can read that study in its entirety (it’s well worth reading).

    Rajeshwari et al, bless them, added a “tl;dr” at the top of their already concise abstract; their “tl;dr” reads:

    ❝Both the seeds significantly influenced almost all the parameters without any detrimental effects by virtue of a number of phytochemicals, vitamins and minerals present in the seeds having therapeutic effects.❞

    Full text: Comparison of aniseeds and coriander seeds for antidiabetic, hypolipidemic and antioxidant activities

    Shortest answer: yes, yes it does

    Does it fight inflammation?

    This one’s quick and simple enough: yes it does; it’s full of antioxidants which thus also have an anti-inflammatory effect:

    Review of Pharmacological Properties and Chemical Constituents of Pimpinella anisum

    …which can also be used an essential oil, applied topically, to fight both pain and the inflammation that causes it—at least in rats and mice:

    ❝Indomethacin and etodolac were treated reference drugs for the anti-inflammatory activity. Aspirin and morphine hydrochloride were treated reference drugs for the analgesic activity. The results showed that fixed oil of P. anisum has an anti-inflammatory action more than etodolac and this effect was as strong as indomethacin. P. anisum induces analgesic effect comparable to that of 100 mg/kg Aspirin and 10 mg/kg morphine at 30 th min. of the study❞

    Summary of this section:

    • Aniseeds are a potent source of antioxidants, which fight inflammation.
    • Anise essential oil is probably also useful as a topical anti-inflammatory and analgesic agent, but we’d like to see human tests to know for sure.

    Is it safe?

    For most people, enjoyed in moderation (e.g., within the dosage parameters described in the above studies), anise is safe. However:

    Where to get it?

    As ever, we don’t sell it (or anything else), but for your convenience, you can buy the seeds in bulk on Amazon, or in case you prefer it, here’s an example of it available as an essential oil.

    Enjoy!

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