Policosanol: A Rival To Statins, Without The Side Effects?
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Policosanol (which can be extracted from various sources, but is mostly made from sugar cane extract) is marketed as lipid-lowering agent for improving cholesterol levels, but its research history has not been without controversy:
2001: it works!
After a lot of research in the 1990s, it came out of the gate strong in 2001, with:
❝Policosanol (5 and 10 mg/day) significantly decreased LDL-cholesterol (17.3% and 26.7%, respectively), total cholesterol (12.9% and 19.5%), as well as the ratios of LDL-cholesterol to high-density lipoprotein (HDL)-cholesterol (17.2% and 26.5%) and total cholesterol to HDL-cholesterol (16.3% and 21.0%) compared with baseline and placebo❞
This, by the way, is comparable in efficacy to the most powerful statins, but without the adverse side effects.
Source: Efficacy and tolerability of policosanol in hypercholesterolemic postmenopausal women
Furthermore, its effects were not limited to postmenopausal women, and additionally, it was found that 20mg/day was sufficient for optimal effects; 40mg worked exactly the same as 20mg:
2006–2010: we do not trust the Cubans!
After it had been marketed and used in much of the world for some years, extra scrutiny was brought upon it, because the initial studies had been performed by the same lab in Cuba, a commercial lab that had tested them for a private interest (i.e., a company selling the supplement):
Heart Beat: Policosanol: A sweet nothing for high cholesterol
And furthermore, US-based labs were unable to replicate the results:
Policosanols as Nutraceuticals: Fact or Fiction
The Cuban researchers countered that the composition of policosanol as produced in their lab was different than the composition of the policosanol as produced in the US labs, because of the purity of the ingredients used in the Cuban lab.
Which, on the face of it, could be true or could just be the claim of a commercial lab with an association with a company selling a product.
Of course, importing Cuban ingredients to test them in the US was not a reasonably accessible option for the US-based labs, because of the US’s embargo of Cuba. In principle it could be done, but unless there is already a huge clear profit incentive, research scientists are usually on their hands and knees begging for grants already, so getting extra funding for specially-important Cuban ingredients was not going to be likely.
2012: never mind, it does work after all!
An American meta-analysis of 4596 patients from 52 eligible studies (from around the world, so many of them not affected by the US’s embargo; some were from within the US using non-Cuban ingredients, though), found:
❝policosanol is more effective than plant sterols and stanols for LDL level reduction and more favorably alters the lipid profile, approaching antilipemic drug efficacy❞
Those last words there, to be clear, mean “yes, the original claim of being on a par with statins is at least more or less true”.
Source: Meta-Analysis of Natural Therapies for Hyperlipidemia: Plant Sterols and Stanols versus Policosanol
2018: also yes, the Cuban kind does get those extra-effective results, even when tested outside of Cuba
A Korean research team verified this; it’s quite straightforward so for brevity we’ll just drop links:
- Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double-Blinded, and Placebo-Controlled Study
- Long-Term Consumption of Cuban Policosanol Lowers Central and Brachial Blood Pressure and Improves Lipid Profile With Enhancement of Lipoprotein Properties in Healthy Korean Participants
Mystery resolved!
Want to try some?
We don’t sell it, but here for your convenience is an example product on Amazon—it’s not the Cuban kind, because the US’s trade embargo makes it difficult for the US to import even things that are theoretically now exempt from the embargo such as food and medicines. In principle they can now be imported, but in practice, the extra regulations added to Cuban imports make it nearly impossible, especially for small sellers.
Still, it’s 40mg/tablet policosanol from sugar cane extract, and 3rd party lab tested, so it’s the next best thing 😎
Enjoy!
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How To Be 7.5x More Likely To Develop Chronic Fatigue Syndrome
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First, what is it?
Many more people have chronic fatigue, which is the symptom of being exhausted all the time, than have chronic fatigue syndrome (CFS) which is the illness of myalgic encephalomyelitis (ME).
This is because fatigue can be a symptom of many, many other conditions, and can be heavily influenced by lifestyle factors too.
A lot of the advice for dealing with chronic fatigue is often the same in both cases, but some will be different, because for example:
- If your fatigue is from some other condition, that condition probably impacts what lifestyle factors you are (and are not) able to change, too
- If your fatigue is from lifestyle factors, that hopefully means you can change those and enjoy less fatigue…
- But if it’s not from lifestyle factors, as in ME/CFS, then advice to “exercise more” etc is not going to help so much.
There are ways to know the difference though:
Check out: Do You Have Chronic Fatigue Syndrome?
The chronic disease pipeline
While it had been strongly suspected that COVID infection could lead to CFS, with long COVID having chronic fatigue as one of its characteristic symptoms, a research team led by Dr. Suzanne Vernon has now established the nature of the relationship.
It was a large (n=13,224) longitudinal observational cohort study of people with no pre-existing ME/CFS, grouped according to their COVID infection status:
- acute infected, enrolled within 30 days of infection or enrolled as uninfected who became infected (n=4,515)
- post-acute infected, enrolled greater than 30 days after infection (n=7,270)
- uninfected (n=1,439).
(to be clear, that last means “never infected”, or else they would be in group 2)
Note: people who had COVID and were hospitalized for it were excluded from the study, so this risk is the risk represented by even just more “moderate” infections.
What they found:
❝The proportion of all RECOVER-Adult participants that met criteria for ME/CFS following SARS-CoV-2 infection was 4.5% (531 of 11,785) compared to 0.6% (9 of 1439) in uninfected participants.❞
There are then different numbers if we look per 100 person-years, as the study also did—in which case, we get a re-modelled increase in risk of 5x instead of 7.5x, but a) that’s still not good b) the “here-and-now” figures of 4.5% vs 0.6% are also relevant.
Read in full: Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study
The killer nobody wants to talk about anymore
Of course, as we all know the pandemic is over, because politicians declared it so, which is very reassuring.
Nevertheless, COVID is currently the still 4th leading cause of death in the US, placing it higher than stroke, Alzheimer’s, diabetes, and others.
See also: Emergency or Not, Covid Is Still Killing People. Here’s What Doctors Advise to Stay Safe
So, while it’s very good to take care of our hearts, brains, blood sugars, and so forth, let’s at the very least continue to keep on top of our vaccinations, avoid enclosed crowded spaces where possible, etc.
And for extra boosts to one’s chances: Why Some People Get Sick More (And How To Not Be One Of Them)
What if I do get (or already have) long COVID and/or ME/CFS?
Well, that is definitely going to suck, but there are still some things that can be done.
Here’s a big one: How To Eat To Beat Chronic Fatigue ← this will not, of course, cure you, but it’s a way of getting maximum nutrition for minimum effort, given that for someone with chronic fatigue, effort is a very finite resource that must be used sparingly
Finally, here are some further resources:
Support For Long COVID & Chronic Fatigue
Take care!
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Ramadan is almost here. 5 tips to boost your wellbeing and energy levels if you’re fasting
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Ramadan is one of the most significant months of the Islamic lunar calendar. It marks the time when the Quran was revealed to Prophet Mohammed (peace be upon him).
Almost 2 billion Muslims worldwide observe this month of prayer and reflection, which includes fasting between two prayers, Fajr at dawn and Maghrib at sunset.
Ramadan is about purifying the mind, body and soul, and practising self-restraint. It’s a time for spiritual growth and dedication to God (or Allah in Arabic). Ramadan also brings people together for meals and celebrations, with a focus on helping those less fortunate.
Depending on where you live, Ramadan can mean going 12 to 19 hours without eating or drinking anything, including water.
Our research shows choosing balanced, nutrient-dense foods and drinks can result in better wellbeing and greater energy levels than following your usual diet during Ramadan.
Here’s what to consider if you’re fasting for Ramadan.
Drazen Zigic/Shutterstock Do you have any health issues?
Healthy Muslims are expected to fast during Ramadan once they have reached puberty.
Frail older adults are exempt from fasting, as are pregnant, breastfeeding and menstruating women. Anyone who cannot participate in fasting can make up for the missed fasting days later.
People with chronic illness or mental health may be exempt if fasting poses a risk to their health. If you suffer from chronic illness, such as diabetes, heart disease or kidney problems, and want to fast, consult your GP first.
Fasting can have severe health consequences for people with certain medical conditions and those who rely on prescription medication. Some medications need to be taken at a specific time (and some with food) to be safe and effective.
If you’re not drinking enough water during Ramadan, your body might also handle some medications differently: they may not work as well or cause side effects.
For people who can safely fast, here are five tips to maintain your wellbeing during Ramadan.
1. Plan ahead
In preparation for Ramadan, stock up on essentials. Plan your meals and hydration in advance, to stay on top of your nutritional intake.
Start reducing your caffeine gradually in the week leading to Ramadan, so your body can adjust. This can help prevent or reduce the fasting headaches that many experience at the beginning of Ramadan.
Move your meals gradually towards Suhoor and Iftar times, so your body gets used to the new mealtimes.
Plan your meals ahead of time. Ground Picture/Shutterstock 2. Stay hydrated
Staying hydrated is important during Ramadan. Women should aim to drink 2.1 litres of water or fluids (such as coconut water, clear soups, broths or herbal teas) each day. Men should aim for 2.6 litres.
Limit the intake of sugary or artificially sweetened drinks and enjoy fresh fruit juice only in moderation. Sugary drinks cause a rapid increase in blood sugar levels. The body responds by releasing insulin, causing a drop in blood sugar, which can leave you feeling fatigued, irritable and hungry.
Increase your hydration by including water-rich foods, such as cucumbers and watermelon, in your diet.
3. Get your nutrients early
Before dawn, have a nutrient-rich, slow-digesting meal, along with plenty of water.
Select healthy nutrient-dense food with proteins and fats from lean meats, fish, chickpeas, tofu, nuts and seeds.
Choose whole grain products, a variety of vegetables and fruits, and fermented foods, such as kimchi and pickles, which can support your digestion.
When you prepare your meals, consider grilling, steaming or air frying instead of deep frying.
Stay away from processed foods such as cakes, ice cream, chips and chocolates, as they often lack essential nutrients and are high in sugar, salt and fat. Processed foods also tend to be low in fibre and protein, which are crucial for maintaining a feeling of fullness.
4. Avoid the temptation to overeat in the evening
At sunset, many Muslims come together with family and friends for the fast-breaking evening meal (Iftar). During these occasions, it may be tempting to overindulge in sweets, salty snacks and fatty dishes.
But overeating can strain the digestive system, cause discomfort and disrupt sleep.
Start with something small. Tekkol/Shutterstock Instead, listen to your body’s signals, control your portions, and eat mindfully – this means slowly and without distractions.
Start with something small, such as a date and a glass of water. You may choose to complete the Maghrib prayer before returning for your main meal and more fluids.
5. Keep moving
Finally, try to include some light exercise into your schedule, to maintain your fitness and muscle mass, and promote sleep.
But avoid heavy workouts, sauna and intensive sports while fasting, as these may increase dehydration, which can increase your risk of feeling faint and falling.
Romy Lauche, Deputy Director (Research), National Centre for Naturopathic Medicine, Southern Cross University; Fatima El-Assaad, Senior Research Fellow, Microbiome Research Centre, UNSW Sydney, and Jessica Bayes, Postdoctoral Research Fellow at the National Centre for Naturopathic Medicine, Southern Cross University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Dancing vs Parkinson’s Depression
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This is a fun study, and the results are/were very predictable, and/but not necessarily something that people might think of in advance. First, let’s look at how some things work:
Parkinson’s disease & depression
Parkinson’s disease is a degenerative neurological disease that, amongst other things, is characterized by low dopamine levels.
For the general signs and symptoms, see: Recognize The Early Symptoms Of Parkinson’s Disease
Dopamine is the neurotransmitter responsible for feelings of reward, is involved in our language faculties and the capacity to form plans (even simple plans such as “make a cup of coffee”) as well as being critical for motor functions.
See also: Neurotransmitter Cheatsheet ← for demystifying some of “what does what” for commonly-conflated chemicals
You can see, therefore, why Parkinson’s disease will often have depression as a comorbidity—there may be influencing social factors as well (many Parkinson’s disease sufferers are quite socially isolated, which certainly does not help), but a clear neurochemical factor that we can point to is “a person with low dopamine levels will feel joyless, bored, and unmotivated”.
Let movement be thy medicine
Parkinson’s disease medications, therefore, tend to involve increasing dopamine levels and/or the brain’s ability to use dopamine.
Antidepressant medications, however, are more commonly focused on serotonin, as serotonin is another neurotransmitter associated with happiness—it’s the one we get when we look at open green spaces with occasional trees and a blue sky ← we get it in other ways too, but for evolutionary reasons, it seems our brains still yearn the most for landscapes that look like the Serengeti, even if we have never even been there personally.
There are other kinds of antidepressants too, and (because depression can have different causes) what works for one person won’t necessarily work for another. See: Antidepressants: Personalization Is Key!
In the case of Parkinson’s disease, because the associated depression is mostly dopamine-related, those green spaces and blue skies and SSRIs won’t help much. But you know what does?
Dance!
A recent (published last month, at time of writing) study by Dr. Karolina Bearss et al. did an interventional study that found that dance classes significantly improved both subjective experience of depression, and objective brain markers of depression, across people with (68%) and without (32%) Parkinson’s disease.
The paper is quite short and it has diagrams, and discusses the longer-term effect as well as the per-session effect:
Dance is thought to have a double-effect, improving both cognitive factors and motor control factors, for obvious reasons, and all related to dopamine response (dancing is an activity we are hardwired to find rewarding*, plus it is exercise which also triggers various chemicals to be made, plus it is social, which also improves many mental health factors).
*You may have heard the expression that “dancing is a vertical expression of a horizontal desire”, and while that may not be true for everyone on an individual level, on a species level it is a very reasonable hypothesis for why we do it and why it is the way it is.
Want to learn more?
We wrote previously about battling depression (of any kind) here:
The Mental Health First-Aid That You’ll Hopefully Never Need
Take care!
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The Pains That Good Posture Now Can Help You Avoid Later
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Dr. Murat Dalkilinç explains:
As a rule…
Posture is the foundation for all body movements and good posture helps the body adapt to stress.
Problems arise when poor posture causes muscles to overwork in ways that are not good for them, becoming tight or inhibited over time. Bad posture can lead to wear and tear on joints, increase accident risk, and make some organs (like the lungs, which feed everything else with the oxygen necessary for normal functioning) less efficient. It’s also of course linked to issues like scoliosis, tension headaches, and back pain, and can even affect emotions and pain sensitivity.
Good posture includes straight alignment of vertebrae when viewed from the front/back, and three natural curves in a (very!) gentle S-shape when viewed from the side. Proper posture allows for efficient movement, reduces fatigue, and minimizes muscle strain. For sitting posture, the neck should be vertical, shoulders relaxed, arms close to the body, and knees at a right angle with feet flat.
But really, one should avoid sitting, to whatever extent is reasonably possible. Standing is better than sitting; walking is better than standing. Movement is crucial, as being stationary for extended periods, even with good posture, is not good for our body.
Advices given include: adjust your environment, use ergonomic aids, wear supportive shoes, and keep moving. Regular movement and exercise keep muscles strong to support the body.
For more on all this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Beyond Just Good Posture: 6 Ways To Look After Your Back
Take care!
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The Age of Scientific Wellness – by Dr. Leroy Hood & Dr. Nathan Price
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We don’t usually do an author bio beyond mentioning their professional background, but in this case it’s worth mentioning that the first-listed author, Dr. Leroy Hood, is the one who invented the automated gene sequencing technology that made the Human Genome Project possible. In terms of awards, he’s won everything short of a Nobel Prize, and that’s probably less a snub and more a matter of how there isn’t a Nobel Prize for Engineering—his field is molecular biotechnology, but what he solved was an engineering problem.
In this book, the authors set out to make the case that “find it and fix it” medicine has done a respectable job of getting us where we are, but what we need now is P4 medicine:
- Predict
- Prevent
- Personalize
- Participate
The idea is that with adequate data (genomic, phenomic, and digital), we can predict the course of health sufficiently well to interrupt the process of disease at its actual (previously unseen) starting point, instead of waiting for symptoms to show up, thus preventing it proactively. The personalization is because this will not be a “one size fits all” approach, since our physiologies are different, our markers of health and disease will be somewhat too. And the participatory aspect? That’s because the only way to get enough data to do this for an entire population is with—more or less—an entire population’s involvement.
This is what happens when, for example, your fitness tracker asks if it can share anonymized health metrics for research purposes and you allow it—you are becoming part of the science (a noble and worthy act!).
You may be wondering whether this book has health advice, or is more about the big picture. And, the answer is both. It’s mostly about the big picture but it does have a lot of (data-driven!) health advice too, especially towards the end.
The style is largely narrative, talking the reader through the progresses (and setbacks) that have marked the path so far, and projecting the next part of the journey, in the hope that we can avoid being part of a generation born just too late to take advantage of this revolutionary approach to health.
Bottom line: this isn’t a very light read, but it is a worthwhile one, and it’ll surely inspire you to increase the extent to which you are proactive about your health!
Click here to check out The Age Of Scientific Wellness, and be part of it!
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7 Ways To Boost Mitochondrial Health To Fight Disease
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Fatigue and a general lack of energy can be symptoms of many things, and for most of them, looking after our mitochondrial health can at least help, if not outright fix the issue.
The Seven Ways
Dr. Jonas Kuene suggests that we…
- Enjoy a good diet: especially, limiting simple sugars, reducing overall carbohydrate intake, and swapping seed oils for healthier oils like avocado oil and olive oil.
- Take supplements: including coenzyme Q10, alpha-lipoic acid, and vitamins
- Decrease exposure to toxins: limit alcohol consumption (10almonds tip: limit it to zero if you can), avoid foods that are likely high in heavy metals or pesticides, and check you’re not being overmedicated (there can be a bit of a “meds creep” over time if left unchecked, so it’s good to periodically do a meds review in case something is no longer needed)
- Practice intermittent fasting: Dr. Kuene suggests a modest 16–18 hours fast per week; doing so daily is generally considered good advice, for those for whom this is a reasonable option
- Build muscle: exercise in general is good for mitochondria, but body composition itself counts for a lot too
- Sleep: aiming for 7–9 hours, and if that’s not possible at night, add a nap during the day to make up the lost time
- Get near-infrared radiation: from the sun, and/or made-for-purpose IR health devices.
For more info on these (including the referenced science), enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
- Coenzyme Q10 From Foods & Supplements
- How To Reduce Or Quit Alcohol
- Intermittent Fasting: What’s the truth?
- Build Muscle (Healthily!)
- Red Light, Go!
Take care!
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Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!
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