The Mental Health First-Aid That You’ll Hopefully Never Need

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Take Your Mental Health As Seriously As General Health!

Sometimes, health and productivity means excelling—sometimes, it means avoiding illness and unproductivity. Both are essential, and today we’re going to tackle some foundational stuff. If you don’t need it right now, great; we suggest to read it for when and if you do. But how likely is it that you will?

  • One in four of us are affected by serious mental health issues in any given year.
  • One in five of us have suicidal thoughts at some point in our lifetime.
  • One in six of us are affected to at least some extent by the most commonly-reported mental health issues, anxiety and depression, in any given week.

…and that’s just what’s reported, of course. These stats are from a UK-based source but can be considered indicative generally. Jokes aside, the UK is not a special case and is not measurably worse for people’s mental health than, say, the US or Canada.

While this is not an inherently cheery topic, we think it’s an important one.

Depression, which we’re going to focus on today, is very very much a killer to both health and productivity, after all.

Speaking of being a killer, suicidality is a very important adjacent topic that we won’t be focusing on in this article; for that, see: How To Stay Alive (When You Really Don’t Want To)

For now, we’ll speak on depression itself:

One of the most commonly-used measures of depression is known by the snappy name of “PHQ9”. It stands for “Patient Health Questionnaire Nine”, and you can take it anonymously online for free (without signing up for anything; it’s right there on the page already):

Take The PHQ9 Test Here! (under 2 minutes, immediate results)

There’s a chance you took that test and your score was, well, depressing. There’s also a chance you’re doing just peachy, or maybe somewhere in between. PHQ9 scores can fluctuate over time (because they focus on the past two weeks, and also rely on self-reports in the moment), so you might want to bookmark it to test again periodically. It can be interesting to track over time.

In the event that you’re struggling (or: in case one day you find yourself struggling, or want to be able to support a loved one who is struggling), some top tips that are useful:

Accept that it’s a medical condition like any other

Which means some important things:

  • You/they are not lazy or otherwise being a bad person by being depressed
  • You/they will probably get better at some point, especially if help is available
  • You/they cannot, however, “just snap out of it”; illness doesn’t work that way
  • Medication might help (it also might not)

Do what you can, how you can, when you can

Everyone knows the advice to exercise as a remedy for depression, and indeed, exercise helps many. Unfortunately, it’s not always that easy.

Did you ever see the 80s kids’ movie “The Neverending Story”? There’s a scene in which the young hero Atreyu must traverse the “Swamp of Sadness”, and while he has a magical talisman that protects him, his beloved horse Artax is not so lucky; he slows down, and eventually stops still, sinking slowly into the swamp. Atreyu pulls at him and begs him to keep going, but—despite being many times bigger and stronger than Atreyu, the horse just sinks into the swamp, literally drowning in despair.

See the scene: The Neverending Story movie clip – Artax and the Swamp of Sadness (1984)

Wow, they really don’t make kids’ movies like they used to, do they?

But, depression is very much like that, and advice “exercise to feel less depressed!” falls short of actually being helpful, when one is too depressed to do it.

If you’re in the position of supporting someone who’s depressed, the best tool in your toolbox will be not “here’s why you should do this” (they don’t care; not because they’re an uncaring person by nature, but because they are physiologically impeded from caring about themself at this time), but rather:

“please do this with me”

The reason this has a better chance of working is because the depressed person will in all likelihood be unable to care enough to raise and/or maintain an objection, and while they can’t remember why they should care about themself, they’re more likely to remember that they should care about you, and so will go with your want/need more easily than with their own. It’s not a magic bullet, but it’s worth a shot.

What if I’m the depressed person, though?

Honestly, the same, if there’s someone around you that you do care about; do what you can to look after you, for them, if that means you can find some extra motivation.

But I’m all alone… what now?

Firstly, you don’t have to be alone. There are free services that you can access, for example:

…which varyingly offer advice, free phone services, webchats, and the like.

But also, there are ways you can look after yourself a little bit; do the things you’d advise someone else to do, even if you’re sure they won’t work:

  • Take a little walk around the block
  • Put the lights on when you’re not sleeping
  • For that matter, get out of bed when you’re not sleeping. Literally lie on the floor if necessary, but change your location.
  • Change your bedding, or at least your clothes
  • If changing the bedding is too much, change just the pillowcase
  • If changing your clothes is too much, change just one item of clothing
  • Drink some water; it won’t magically cure you, but you’ll be in slightly better order
  • On the topic of water, splash some on your face, if showering/bathing is too much right now
  • Do something creative (that’s not self-harm). You may scoff at the notion of “art therapy” helping, but this is a way to get at least some of the lights on in areas of your brain that are a little dark right now. Worst case scenario is it’ll be a distraction from your problems, so give it a try.
  • Find a connection to community—whatever that means to you—even if you don’t feel you can join it right now. Discover that there are people out there who would welcome you if you were able to go join them. Maybe one day you will!
  • Hiding from the world? That’s probably not healthy, but while you’re hiding, take the time to read those books (write those books, if you’re so inclined), learn that new language, take up chess, take up baking, whatever. If you can find something that means anything to you, go with that for now, ride that wave. Motivation’s hard to come by during depression and you might let many things slide; you might as well get something out of this period if you can.

If you’re not depressed right now but you know you’re predisposed to such / can slip that way?

Write yourself instructions now. Copy the above list if you like.

Most of all: have a “things to do when I don’t feel like doing anything” list.

If you only take one piece of advice from today’s newsletter, let that one be it!

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  • Guava vs Lime – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing guava to lime, we picked the guava.

    Why?

    Not a contentious one today:

    In terms of macros, guava has nearly 2x the fiber, more than 4x the protein, and slightly more carbs, winning this round.

    In the category of vitamins, guava has a lot more of vitamins A, B1, B2, B3, B5, B6, B7, B9, C, E, K, and choline, while limes are not higher in any vitamins. You might be wondering about the difference in vitamin C, for which limes are famous, and the answer is that guavas have about 7x more vitamin C than limes. In any case, a clear win for guava on all counts.

    Looking at minerals, guavas have more copper, magnesium, manganese, phosphorus, potassium, selenium, and zinc, while limes have more calcium and iron. Another win for guavas.

    In other considerations, guavas are also higher in polyphenols, so that’s another point scored there.

    Adding up the sections makes for a complete win for guavas, but by all means enjoy either or both; diversity is good!

    Want to learn more?

    You might like:

    Why You’re Probably Not Getting Enough Fiber (And How To Fix It)

    Enjoy!

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  • The Popular Longevity Compound That Gives You Cancer?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Aging and cancer are deeply interconnected.

    To oversimplify (because otherwise each bullet point would be the size of a large library):

    • Cellular aging is in large part a matter of DNA damage, copying errors, errors beyond copied forwards, exacerbating the problem
      • That latter item, by the way, is one of the reasons why sometimes a lot of aging seems to arrive all at once in a burst; it’s because once a DNA copying error is made, it gets copied forwards and proliferated rapidly. On which note…
    • Cancer is in large part a matter of DNA damage that specifically made the cell line accidentally immortal (sounds good, is very bad), and then it gets copied forwards and proliferated
      • Which can kill you, because you’re only supposed to have so many cells there (they’re supposed to die at approximately the same rate that they’re made, and instead they’ve stopped dying and they’re proliferating exponentially) so what you end up with is exponentially increasingly many cells that are still using the resources from the still-working cells around them, and/but doing nothing but growing an ever-increasing tumorous mass that, depending on where it is, might kill you directly (by pressure against an organ, especially if it’s the brain) if the systemic exhaustion and/or indirect organ failure doesn’t get you first.

    The good news is that this means that many things that are anti-aging are also anticancer.

    The bad news is that this isn’t always so!

    Polyamines: for better or for worse, in sickness or in health?

    We’ve written about polyamines before, and their role in healthy longevity, for example: Spermidine For Longevity

    And, for that matter: Spermine vs Alzheimer’s & Parkinson’s!

    However, scientists (Dr. Keiko Kashiwagi et al.) have investigated why these longevity-inducing compounds are also consistently elevated in cancer cells (remember, cancer cells are terribly long-lived, being in fact biologically immortal!).

    Firstly, we need to understand what polyamines do in healthy cells: polyamines act as “geroprotectors” by stimulating autophagy*, the cellular recycling process, primarily through activation of a specific protein (known to its friends by the snappy name of “eIF5A1”), which supports mitochondrial function and healthy aging.

    *We wrote about this here: Fisetin: The Anti-Aging Assassin ← so-called because it works by killing the aging cells that need to die sooner rather than later if aging is not to be exacerbated by copying their mistakes forwards

    What Dr. Kashiwagi and her team found, using high-resolution proteomics across more than 6,700* proteins in human cancer cell lines, was that polyamines first and foremost boost glycolysis—rapid glucose breakdown for energy—rather than mitochondrial respiration. In other words, reinforcing a metabolic pattern typical of cancer cells.

    *The paper says “>6,700”, and links to a database. Wanting to know the precise number to tell you, we went to look at the database. It took a long time to download, and well, it’s an Excel spreadsheet with 60 columns and 96,294 rows. We’re keen to go the extra mile at 10almonds, but even we have our limits, so we will tell you the number is somewhere between 6,700 and 96,294. It’s a lot.

    Back to the concepts rather than the numbers: this difference (favoring glycolysis vs mitochondrial respiration) becomes a problem, because… Well, you remember our dear friend eIF5A1?

    It has a sneaky sibling, eIF5A2.

    Now, while eIF5A1 supports autophagy and mitochondrial health in normal cells, this closely-related eIF5A2 protein—sharing 84% of its amino acid sequence—is selectively increased in cancer cells and, as an encore, drives tumor-promoting gene expression.

    You can read the paper itself, here: Polyamines stimulate the protein synthesis of the translation initiation factor eIF5A2, participating in mRNA decoding, distinct from eIF5A1

    So, what does this mean, in practical terms?

    The researchers suggest that targeting eIF5A2 or its interaction with ribosomes could provide a selective cancer therapy strategy, potentially blocking tumor growth without disrupting the beneficial eIF5A1-mediated effects linked to healthy aging.

    But that’s not very useful on an individual level.

    Instead, what we might do is draw from conclusions about the use of other senolytics—compounds that increase autophagy and thus improve healthy longevity by killing “zombie cells” that otherwise were overdue for dying.

    For example, in this: The Drug & Supplement Combo That Reverses Aging

    In this case, the researchers found that the senolytic compounds were best taken not daily, but rather once every two weeks.

    Why? So that the body’s normal tumor-suppression systems can be working most of the time, and the senolytic does a clearing-out of old cells once every two weeks, which is a one- or two-day purge, not long enough for any cancer to get a foothold before the normal tumor-suppression systems come back online.

    Want to learn more?

    You might enjoy:

    Fasting Cancer – by Dr. Valter Longo

    Take care!

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  • The Living Kitchen – by Tamara Green and Sarah Grossman

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    For the most part, this is a very respectable book of recipes; plants-forward though not entirely plant-based (which from a cancer perspective is fine; poultry and fish are cancer-neutral, and fermented dairy may even be protective).

    They do focus on including a lot of phytonutrient-rich foods (mostly: colorful plants), which indeed have a lot of anticancer potency between them.

    It was an interesting choice to include some beef, since red meat is well-established as a carcinogen. The authors advise that it should be grass-fed, and this is a definite health improvement over the alternative, but still not great.

    In a similar vein they recommend “sustainably farmed fish”. Not a known carcinogen, by the way (though watch out for antibiotics which are very high in farmed fish), but do you see the problem? Paying attention to sustainability is great; truly laudable. However, it won’t actually make any difference to the health impact on the consumer. Farmed fish is full of antibiotics, whether deemed sustainable or not.

    The front cover shows a soup; the recipes in the book are a wide variety of different dishes, of which soups are just one category. There is a juices section, which not only was probably superfluous, but also is not amazing for the metabolism (and thus, not great in the context of cancer). On a more positive note though, the “mains” section is divided into “omnivore mains” and “vegetarian mains”, with equal attention given to both (20 pages each), so the recipes list isn’t entirely padded with juices and sauces and things (though yes, that also).

    Bottom line: from an anticancer perspective, this one’s a bit of a mixed bag, but mostly good ones.

    Click here to check out The Living Kitchen, and add to your culinary repertoire!

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Related Posts

  • Basil vs Cilantro – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing basil to cilantro, we picked the cilantro.

    Why?

    Both have their strong merits, but there can be only one winner when all’s said and done:

    First, you may be thinking: these are just herbs; we don’t eat enough of these for the nutritional values to be relevant!

    And to this we say: there’s nothing stopping you :p Herbs are full of flavor and goodness and there is really no reason to deny yourself. On this note, check out the sabzi khordan (traditional Levantine herb platter), linked below. You’ll start thinking about herbs in new ways, and you can thank us later!

    So, onwards to the comparisons…

    In terms of macros, the only relevant distinguishing factor is that cilantro has nearly 2x the fiber, so that’s a win in this category of cilantro.

    In the category of vitamins, basil has more of vitamins B6, B7, B9, and K, while cilantro has more of vitamins A, B1, B2, B3, B5, C, and E, winning this round too.

    Looking at minerals, however, basil has more calcium, copper, iron, magnesium, manganese, phosphorus, and zinc, while cilantro has more potassium and selenium, yielding an 8:1 win to basil in this category.

    In other considerations, both are equally good sources of polyphenols, so that’s a tie in this round.

    Adding up the sections makes for a clear overall win for cilantro, but by all means do enjoy either or both, as diversity is best!

    Want to learn more?

    You might like:

    Enjoy!

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  • Serotonin vs Dopamine (Know The Differences)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Of the various neurotransmitters that people confuse with each other, serotonin and dopamine are the two highest on the list (with oxytocin coming third as people often attribute its effects to serotonin). But, for all they are both “happiness molecules”, serotonin and dopamine are quite different, and are even opposites in some ways:

    More than just happiness

    Let’s break it down:

    Similarities:

    • Both are neurotransmitters, neuromodulators, and monoamines.
    • Both impact cognition, mood, energy, behavior, memory, and learning.
    • Both influence social behavior, though in different ways.

    Differences (settle in; there are many):

    • Chemical structure:
      • Dopamine: catecholamine (derived from phenylalanine and tyrosine)
      • Serotonin: indoleamine (derived from tryptophan)
    • Derivatives:
      • Dopamine → noradrenaline and adrenaline (stress and alertness)
      • Serotonin → melatonin (sleep and circadian rhythm)
    • Effects on mental state:
      • Dopamine: drives action, motivation, and impulsivity.
      • Serotonin: promotes calmness, behavioral inhibition, and cooperation.
    • Role in memory and learning:
      • Dopamine: key in attention and working memory
      • Serotonin: crucial for hippocampus activation and long-term memory

    Symptoms of imbalance:

    • Low dopamine:
      • Loss of motivation, focus, emotion, and activity
      • Linked to Parkinson’s disease and ADHD
    • Low serotonin:
      • Sadness, irritability, poor sleep, and digestive issues
      • Linked to PTSD, anxiety, and OCD
    • High dopamine:
      • Excessive drive, impulsivity, addictions, psychosis
    • High serotonin:
      • Nervousness, nausea, and in extreme cases, serotonin syndrome (which can be fatal)

    Brain networks:

    • Dopamine: four pathways controlling movement, attention, executive function, and hormones.
    • Serotonin: widely distributed across the cortex, partially overlapping with dopamine systems.

    Speed of production:

    • Dopamine: can spike and deplete quickly; fatigues faster with overuse.
    • Serotonin: more stable, releasing steadily over longer periods.

    Illustrative examples:

    • Coffee boosts dopamine but loses its effect with repeated use.
    • Sunlight helps maintain serotonin levels over time.

    If you remember nothing else, remember this:

    • Dopamine: action, motivation, and alertness.
    • Serotonin: contentment, happiness, and calmness.

    For more on all of the above, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Neurotransmitter Cheatsheet

    Take care!

    Don’t Forget…

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  • Complete Guide To Fasting – By Dr. Jason Fung

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    When it comes to intermittent fasting, the plethora of options can be daunting at first, as can such questions as what fluids are ok to take vs what will break the fast, what to expect in terms of your first fasting experience, and how not to accidentally self-sabotage.

    Practised well, intermittent fasting can be a very freeing experience, and not at all uncomfortable. Practised badly, it can be absolutely miserable, and this is one of those things where knowledge makes the difference.

    Dr. Fung (yes, the same Dr. Fung we’ve featured before as an expert on metabolic health) shares this knowledge over the course of 304 pages, with lots of scientific information and insider tips. He covers the different kinds of fasting, how each of them work and what they do for the body and brain, hunger/satiety hacks, lots of “frequently asked questions”, and even a range of recipes to help smooth your journey along its way.

    The style is very well-written pop-science; it’s engaging and straightforward without skimping on science at all.

    Bottom line: if you’re thinking of trying intermittent fasting but aren’t sure where/how to best get started, this book can set you off on the right foot and keep you on the right track thereafter.

    Click here to check out The Complete Guide to Fasting, and enjoy the process as well as the results!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

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