Paracetamol pack sizes and availability are changing. Here’s what you need to know

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Changes are coming into effect from February 1 about how paracetamol is sold in Australia.

This mainly affects pack sizes of paracetamol sold outside pharmacies and how paracetamol is accessed in pharmacies.

The changes, announced by Australia’s drug regulator, are in line with moves internationally to reduce the harms of liver toxicity and the risk of overdose.

However, there are no new safety concerns when paracetamol is used as directed. And children’s products are not affected.

Bowonpat Sakaew/Shutterstock

What is paracetamol?

Paracetamol is commonly sold under brand names such as Panadol, Dymadon and Panamax. It’s used to treat mild pain and fever for short periods or can be prescribed for chronic (long-term) pain.

Millions of packs of this cheap and accessible medicine are sold in Australia every year.

Small packs (up to 20 tablets) have been available from supermarkets and other retailers such as petrol stations. Larger packs (up to 100 tablets) are only available from pharmacies.

Paracetamol is relatively safe when used as directed. However, at higher-than-recommended doses, it can cause liver toxicity. In severe cases and when left untreated, this can be lethal.

Why are the rules changing?

In 2022, we wrote about how the Therapeutic Goods Administration (TGA) was considering changes to paracetamol access because of an increase in people going to hospital with paracetamol poisoning.

An expert review it commissioned found there were about 40–50 deaths every year from paracetamol poisoning between 2007 and 2020. Between 2009–10 and 2016–17, hospital admissions for this increased (from 8,617 to 11,697), before reducing in 2019–20 (8,723). Most admissions were due to intentional self-poisonings, and about half of these were among people aged ten to 24.

After the report, the TGA consulted with the public to work out how to prevent paracetamol poisonings.

Options included reducing pack sizes, limiting how many packs could be bought at once, moving larger packs behind the pharmacy counter and restricting access by age.

Responses were mixed. Although responses supported the need to prevent poisonings, there were concerns about how changes might affect:

  • people with chronic pain, especially those in regional areas, where it may be harder to access pharmacies and, therefore, larger packs
  • people on limited incomes, if certain products were made prescription-only.

Although deaths from paracetamol poisoning are tragic and preventable, they are rare considering how much paracetamol Australians use. There is less than one death due to poisoning for every million packs sold.

Because of this, it was important the TGA addressed concerns about poisonings while making sure Australians still had easy access to this essential medicine.

Pharmacist typing at computer behind the counter
If you buy large packs of paracetamol for chronic pain, you’ll need to go to the pharmacy counter. StratfordProductions/Shutterstock

So what’s changing?

The key changes being introduced relate to new rules about the pack sizes that can be sold outside pharmacies, and the location of products sold in pharmacies.

From February 1, packs sold in supermarkets and places other than pharmacies will reduce from a maximum 20 tablets to 16 tablets per pack. These changes bring Australia in line with other countries. These include the United Kingdom, which restricted supermarket packs to 16 tablets in 1998, and saw reductions in poisonings.

In all jurisdictions except Queensland and Western Australia, packs sold in pharmacies larger than 50 tablets will move behind the pharmacy counter and can only be sold under pharmacist supervision. In Queensland and WA, products containing more than 16 tablets will only be available from behind the pharmacy counter and sold under pharmacist supervision.

In all jurisdictions, any packs containing more than 50 tablets will need to be sold in blister packs, rather than bottles.

Several paracetamol products are not affected by these changes. These include children’s products, slow-release formulations (for example, “osteo” products), and products already behind the pharmacy counter or only available via prescription.

What else do I need to know?

These changes have been introduced to reduce the risk of poisonings from people exceeding recommended doses. The overall safety profile of paracetamol has not changed.

Paracetamol is still available from all current locations and there are no plans to make it prescription-only or remove it from supermarkets altogether. Many companies have already been updating their packaging to ensure there are no gaps in supply.

The reduction in pack sizes of paracetamol available in supermarkets means a pack of 16 tablets will now last two days instead of two-and-a-half days if taken at the maximum dose (two tablets, four times a day). Anyone in pain that does not improve after short-term use should speak to their pharmacist or GP.

For people who use paracetamol regularly for chronic pain, it is more cost-effective to continue buying larger packs from pharmacies. As larger packs (50+ tablets) need to be kept out of sight, you will need to ask at the pharmacy counter. Pharmacists know that for many people it’s appropriate to use paracetamol daily for chronic pain.

Natasa Gisev, Clinical pharmacist and Scientia Associate Professor at the National Drug and Alcohol Research Centre, UNSW Sydney and Ria Hopkins, Postdoctoral Research Fellow, National Drug and Alcohol Research Centre, UNSW Sydney

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Reduce Caffeine’s Impact on Kidneys

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    It’s Q&A Day at 10almonds!

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    ❝Avid coffee drinker so very interested in the results Also question Is there something that you could take or eat that would prevent the caffeine from stimulating the kidneys? I tried to drink decaf from morning to night not a good result! Thanks❞

    That is a good question! The simple answer is “no” (but keep reading, because all is not lost)

    There’s no way (that we yet know of) to proof the kidneys against the stimulating effect of caffeine. This is especially relevant because part of caffeine’s stimulating effect is noradrenergic, and that “ren” in the middle there? It’s about the kidneys. This is just because the adrenal gland is situated next to them (actually, it’s pretty much sitting on top of them), hence the name, but it does mean that the kidneys are about the hardest thing in the body to have not effected by caffeine.

    However! The effects of caffeine in general can be softened a little with l-theanine (found in tea, or it can be taken as a supplement). It doesn’t stop it from working, but it makes the curve of the effect a little gentler, and so it can reduce some unwanted side effects.

    You can read more about l-theanine here:

    L-Theanine: What’s The Tea?

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  • Learning to Love Midlife – by Chip Conley

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    While the book is titled about midlife, it could have said: midlife and beyond.

    Some of the benefits discussed in this book really only kick in during one’s 50s, 60s, or 70s, usually. Which, for all but the most optimistic, is generally considered to be stretching beyond what is usually called “midlife”.

    However! Chip Conley makes the argument for midlife being anywhere from one’s early 30s to mid-70s, depending on what (and how) we’re doing in life.

    He talks about (as the subtitle promises) 12 reasons life gets better with age, and those reasons are grouped into 5 categories, thus:

    1. Physical life
    2. Emotional life
    3. Mental life
    4. Vocational life
    5. Spiritual life

    It may surprise some readers that there are physical benefits that come with aging, but we do get two chapters in that category.

    The writing style is very casual, yet with references to science throughout, and a bibliography for such.

    Bottom line: if you’d like to make sure you’re making the most of your midlife and beyond, this a book that offers a lot of guidance on doing so!

    Click here to check out Learning to Love Midlife, and age in style!

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  • Is stress turning my hair grey?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    When we start to go grey depends a lot on genetics.

    Your first grey hairs usually appear anywhere between your twenties and fifties. For men, grey hairs normally start at the temples and sideburns. Women tend to start greying on the hairline, especially at the front.

    The most rapid greying usually happens between ages 50 and 60. But does anything we do speed up the process? And is there anything we can do to slow it down?

    You’ve probably heard that plucking, dyeing and stress can make your hair go grey – and that redheads don’t. Here’s what the science says.

    Oksana Klymenko/Shutterstock

    What gives hair its colour?

    Each strand of hair is produced by a hair follicle, a tunnel-like opening in your skin. Follicles contain two different kinds of stem cells:

    • keratinocytes, which produce keratin, the protein that makes and regenerates hair strands
    • melanocytes, which produce melanin, the pigment that colours your hair and skin.

    There are two main types of melanin that determine hair colour. Eumelanin is a black-brown pigment and pheomelanin is a red-yellow pigment.

    The amount of the different pigments determines hair colour. Black and brown hair has mostly eumelanin, red hair has the most pheomelanin, and blonde hair has just a small amount of both.

    So what makes our hair turn grey?

    As we age, it’s normal for cells to become less active. In the hair follicle, this means stem cells produce less melanin – turning our hair grey – and less keratin, causing hair thinning and loss.

    As less melanin is produced, there is less pigment to give the hair its colour. Grey hair has very little melanin, while white hair has none left.

    Unpigmented hair looks grey, white or silver because light reflects off the keratin, which is pale yellow.

    Grey hair is thicker, coarser and stiffer than hair with pigment. This is because the shape of the hair follicle becomes irregular as the stem cells change with age.

    Interestingly, grey hair also grows faster than pigmented hair, but it uses more energy in the process.

    Can stress turn our hair grey?

    Yes, stress can cause your hair to turn grey. This happens when oxidative stress damages hair follicles and stem cells and stops them producing melanin.

    Oxidative stress is an imbalance of too many damaging free radical chemicals and not enough protective antioxidant chemicals in the body. It can be caused by psychological or emotional stress as well as autoimmune diseases.

    Environmental factors such as exposure to UV and pollution, as well as smoking and some drugs, can also play a role.

    Melanocytes are more susceptible to damage than keratinocytes because of the complex steps in melanin production. This explains why ageing and stress usually cause hair greying before hair loss.

    Scientists have been able to link less pigmented sections of a hair strand to stressful events in a person’s life. In younger people, whose stems cells still produced melanin, colour returned to the hair after the stressful event passed.

    4 popular ideas about grey hair – and what science says

    1. Does plucking a grey hair make more grow back in its place?

    No. When you pluck a hair, you might notice a small bulb at the end that was attached to your scalp. This is the root. It grows from the hair follicle.

    Plucking a hair pulls the root out of the follicle. But the follicle itself is the opening in your skin and can’t be plucked out. Each hair follicle can only grow a single hair.

    It’s possible frequent plucking could make your hair grey earlier, if the cells that produce melanin are damaged or exhausted from too much regrowth.

    2. Can my hair can turn grey overnight?

    Legend says Marie Antoinette’s hair went completely white the night before the French queen faced the guillotine – but this is a myth.

    Painted portrait of Marie Antoinette with elaborate grey hairstyle.
    It is not possible for hair to turn grey overnight, as in the legend about Marie Antoinette. Yann Caradec/Wikimedia, CC BY-NC-SA

    Melanin in hair strands is chemically stable, meaning it can’t transform instantly.

    Acute psychological stress does rapidly deplete melanocyte stem cells in mice. But the effect doesn’t show up immediately. Instead, grey hair becomes visible as the strand grows – at a rate of about 1 cm per month.

    Not all hair is in the growing phase at any one time, meaning it can’t all go grey at the same time.

    3. Will dyeing make my hair go grey faster?

    This depends on the dye.

    Temporary and semi-permanent dyes should not cause early greying because they just coat the hair strand without changing its structure. But permanent products cause a chemical reaction with the hair, using an oxidising agent such as hydrogen peroxide.

    Accumulation of hydrogen peroxide and other hair dye chemicals in the hair follicle can damage melanocytes and keratinocytes, which can cause greying and hair loss.

    4. Is it true redheads don’t go grey?

    People with red hair also lose melanin as they age, but differently to those with black or brown hair.

    This is because the red-yellow and black-brown pigments are chemically different.

    Producing the brown-black pigment eumelanin is more complex and takes more energy, making it more susceptible to damage.

    Producing the red-yellow pigment (pheomelanin) causes less oxidative stress, and is more simple. This means it is easier for stem cells to continue to produce pheomelanin, even as they reduce their activity with ageing.

    With ageing, red hair tends to fade into strawberry blonde and silvery-white. Grey colour is due to less eumelanin activity, so is more common in those with black and brown hair.

    Your genetics determine when you’ll start going grey. But you may be able to avoid premature greying by staying healthy, reducing stress and avoiding smoking, too much alcohol and UV exposure.

    Eating a healthy diet may also help because vitamin B12, copper, iron, calcium and zinc all influence melanin production and hair pigmentation.

    Theresa Larkin, Associate Professor of Medical Sciences, University of Wollongong

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • The Worst Cookware Lurking In Your Kitchen (Toxicologist Explains)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Yvonne Burkart gives us a rundown of the worst offenders, and what to use instead:

    Hot mess

    The very worst offender is non-stick cookware, the kind with materials such as Teflon. These are the most toxic, due to PFAS chemicals.

    Non-stick pans release toxic gases, leach chemicals into food, and release microplastic particles, which can accumulate in the body.

    One that a lot of people don’t think about, in that category, is the humble air-fryer, which often as not has a non-stick cooking “basket”. These she describes as highly toxic, as they combine plastic, non-stick coatings, and high heat, which can release fumes and other potentially dangerous chemicals into the air and food.

    You may be wondering: how bad is it? And the answer is, quite bad. PFAS chemicals are linked to infertility, hypertension in pregnancy, developmental issues in children, cancer, weakened immune systems, hormonal disruption, obesity, and intestinal inflammation.

    Dr. Burkart’s top picks for doing better:

    1. Pure ceramic cookware: top choice for safety, particularly brands like Xtrema, which are tested for heavy metal leaching.
    2. Carbon steel & cast iron: durable and safe; can leach iron in acidic foods (for most people, this is a plus, but some may need to be aware of it)
    3. Stainless steel: lightweight and affordable but can leach nickel and chromium in acidic foods at high temperatures. Use only if nothing better is available.

    And specifically as alternatives to air-fryers: glass convection ovens or stainless steel ovens are safer than conventional air fryers. The old “combination oven” can often be a good choice here.

    For more on all of these, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Take care!

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  • Play reduces stress and lifts wellbeing – and adults benefit as much as children do

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Somewhere along the way to adulthood, time to play fades away. We tend to trade silliness and imagination for seriousness and busyness.

    Yet there is clear evidence that adults benefit from playfulness just as children do.

    Research shows that adults who engage in playful activities tend to cope better with stress, experience more positive emotions, show greater resilience when facing challenges, and report higher levels of life satisfaction.

    Our research with New Zealand families highlights how supporting unstructured play can help adults feel less stressed and more connected, while also normalising playfulness in everyday family life.

    In a world that demands constant busyness, play offers essential qualities we are at risk of losing: spontaneity, togetherness and the freedom to have fun.

    Play in adulthood can look different from play in childhood. It is less about toys or games and more about how we approach everyday experiences.

    Adult play can be physical, social, creative or imaginative. It might involve movement, music, humour, storytelling, problem-solving or simply doing something for the pleasure of it.

    What makes an activity playful is not its form, but the mindset behind it: curiosity, openness and a willingness to engage without a fixed outcome. For adults, play is often woven into hobbies and moments of exploration that sit outside work and obligation.

    Getty Images

    The benefits of play in adult life

    A recent study suggests a potential neurobiological pathway between playfulness and cognitive health in older adults.

    At its core, play provides a space to reset, allowing us to step outside pressure and performance. In doing so, it supports not only stress regulation, but sustains emotional balance and quality of life across adulthood.

    The value of playfulness also goes beyond the individual. Playful engagement in social contexts helps build shared emotional resources, shaping how people interact and cope together over time.

    Playfulness in adults is also associated with higher emotional intelligence, including stronger ability to perceive and manage emotions in social situations. Observational studies further show that adults who engage playfully are more empathetic, reciprocal and positive in their interactions with others, reinforcing social connection and belonging.

    Importantly, play has a unique ability to cut across age boundaries. When adults and children play together, even if unrelated, differences in age, role and status tend to fade, replaced by shared enjoyment and interaction.

    Research suggests these inter-generational play experiences can strengthen relationships, support wellbeing and reduce age-based stereotypes. Play becomes a shared language, bridging age divides that are often reinforced by modern living.

    As our work highlights, unstructured play remains both possible and meaningful in contemporary life, with families reporting benefits for children’s development as well as family cohesion and shared wellbeing. These findings suggest play can function as an ordinary, rather than exceptional, feature of family and community life.

    Making room for play in everyday life

    If play matters across the lifespan, the spaces we inhabit need to support it.

    Yet most public environments continue to treat play as something designed primarily for children. Research in urban design suggests the most effective playful environments for adults are those that don’t announce themselves as playgrounds, but instead embed playful possibilities into everyday settings.

    Features such as oversized steps, stepping stones, interactive seating or winding paths can invite exploration, balance and movement. In some cities, this extends to adult-sized play elements integrated into public space, such as musical swings that turn routine movement into playful interaction.

    Despite these examples, play-oriented design remains the exception rather than the norm, with most public play infrastructure still concentrated in children’s spaces. Designing cities that invite adult play as part of everyday life could be a valuable investment in inclusion, social connection and population wellbeing.

    Environments that support play are not just physical, but social. Just as urban design can invite or discourage playful movement, social norms shape whether play feels acceptable in adult life.

    When play is treated as embarrassing, indulgent or something to apologise for, it quickly disappears. But when playful behaviour is visible and unremarkable, it becomes easier for others to participate.

    Play has long been treated as something separate from adult life, confined to childhood or reserved for rare moments of leisure. Yet the evidence suggests playfulness continues to matter well beyond early development.

    Reframing play as a legitimate part of adult life opens up new ways of thinking about wellbeing across the lifespan.

    Scott Duncan, Professor of Population Health, Auckland University of Technology and Melody Smith, Professor of Health Science, University of Auckland, Waipapa Taumata Rau

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Sweeteners & Your Appetite

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    Sugar is famously not great for the health. See for example: Is Sugar The New Smoking? ← the answer is “no, but it’s still very bad, just not in the same league of badness as smoking”!

    Of course, there are some important circumstantial things to bear in mind, such as:

    From Apples to Bees, and High-Fructose Cs: Which Sugars Are Healthier, And Which Are Just The Same?

    But even without sugar, simply sweetness itself can cause problems: we can build tolerance to sweetness. Many sugar substitutes are many times (in some cases, hundreds of times) sweeter than sugar. This leads to people craving increasingly sweeter foods for the same experiential sweetness level.

    Because of this, the World Health Organization has released a report offering guidance regards the use of sugar-free sweeteners.

    In a nutshell, the guidance is: don’t

    Nevertheless, if you really want to, we previously did a rundown on:

    • Sucrose (metabolic problems)
    • Sucralose (genotoxic)
    • Erythritol (ischemiagenic)
    • Xylitol (gut disruptor)
    • Acesulfame K (gut disruptor)
    • Stevia (strong risk of sweetness tolerance problem)
    • Glycine (beneficial in moderation, sweetness problem though)

    For more details than those one-or-few-word summaries, see: What’s The Healthiest Sweetener?

    We’ve also talked about: The Fascinating Truth About Aspartame, Cancer, & Neurotoxicity

    …which covers how the most popular beliefs about aspartame are myths, and in large part stemming from a single viral hoax chain letter in the 90s!

    But sweeteners really increase your appetite?

    That’s the question that Dr. Sabina Anderson et al. put to the test all so recently, using a mixture of acesulfame K and acesulfame cyclamate (Ace-K/Cyc).

    What they found, in few words:

    • No, there was no increase in food intake: participants didn’t eat more after consuming artificial sweeteners compared with water, even when allowed to eat freely later.
    • No, there was no meaningful effect on hunger overall: hunger, fullness, and satiety were the same between sweeteners and water across all time points during the study.
    • In fact, the participants enjoyed reduced sweet cravings: the sweetened drink lowered the desire to eat something sweet, and this effect persisted even after adjusting for taste differences.

    You may be thinking: what happened to that up top about tolerance spiralling and craving more and more sweet things?!

    And the answer is: that’s in the big picture; this was a 265-minute study, done three times in a row. So, it’s less about what it does in the long term, and more about what it does in the moment.

    Specifically,

    ❝Subjective appetite sensations were measured using visual analogue scales while fasting and nine times during a 250-min postprandial period. During this period, a standardized breakfast (0–10 min) was served and, 2 h later, a test drink containing either Ace-K/Cyc or water (120–130 min) was given. After 265 min, an ad libitum test meal was served.❞

    Read in full: Acute and Prolonged Effects of Sweeteners and Sweetness Enhancers on Postprandial Appetite Sensations, Palatability, and Ad Libitum Energy Intake in Humans: A SWEET Sub-Study (yes, they say “and prolonged”, but when they say “prolonged”, they’re referring to t=265 min, as opposed to immediately after drinking the drink)

    That does mean, of course, that while helpful to know about in the moment, the results may not be extrapolated to the long term.

    It’s also worth noting that the sample size was small (n=26), so in terms of strength of evidence it’s more of an indicative “jumping-off point” for future studies, rather than anything that should necessarily shape policy (including your personal policy) in the meantime.

    One other important limitation is that obviously the results are for acesulfame-K and cyclamate, which means the results cannot necessarily be assumed to apply to all artificial sweeteners.

    In fact, there is some science to the opposite for at least one sweetener, sucralose:

    The Sweetener That Interferes With Hunger/Satiety Signals

    Of course, sucralose is not technically a non-sugar sweetener, as it is chemically a sugar. But in practical terms, sucralose is a sugar in the same way that coffee is a fruit, i.e. it’s true, but for most purposes we can disregard that information as it’s not how we usually use those words in daily parlance.

    Want to learn more?

    This recommendation’s tangential to our main topic today, but it’ll be relevant for a lot of people who use sweeteners as a blood sugar control tool, so:

    Stop Overeating During Low Blood Sugars With Diabetes – by Ginger Vieira

    Take care!

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