
Laughing Gas vs Depression
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Depression is no laughing matter, but one possible therapy just might be.
Before we get to that though, let’s be serious for a moment, and mention that if you found this in a search because you’re struggling with depression, then treatments of various kinds are well-worth pursuing, but here’s what will help you right now today this very moment:
- The Mental Health First-Aid That You’ll Hopefully Never Need ← no, we’re not going to ask you to name 5 things you can see and all that. That’s more to do with anxiety and disassociative disorders in any case. But what this article does have, is a lot of genuinely practical advice that actually works, and yes, even when your motivation is through the floor.
- How To Stay Alive (When You Really Don’t Want To) ← this one’s about as serious as it can get, and we mean it.
If, on the other hand, you’re in a much better mental state and just want to know how laughing gas works vs depression, then…
Can we just say N₂O to depression?
Researchers (Dr. Kiranpreet Gill et al.) examined data from hundreds of participants with major depressive disorder and/or treatment-resistant depression, taking single 25-50% nitrous oxide (N₂O) inhalation sessions, delivered for 20–60 minutes.
Here’s what Dr. Gill and her team found, in numbers:
❝Pooled results from three trials administering 50% N2O in a single session showed significant reductions in depressive symptoms at 2 h (pooled MD −2.74, 95% Confidence Interval (CI): −4.72 to −0.76; p = 0.007) and 24 h (MD −3.32, 95% CI: −5.09 to −1.55; p < 0.0001), but not at 1 week post-inhalation (MD −1.52; 95% CI: −4.07 to 1.03; p = 0.24). AEs were mild and transient, with 25% N2O generally being better tolerated. Evidence mapping showed that most trials are early-phase and focused on short-term outcomes in adults with MDD and TRD.❞
MD = Mean Difference
AE = Adverse Event
MDD = Major Depressive Disorder
TRD = Treatment-Resistant Depression
What they found, in few words: most patients experienced meaningful mood improvements within hours, some reaching remission by 24 hours. Which is a lot faster than most antidepressants! However, effects typically faded by one week later, albeit there were some outliers who enjoyed benefits for longer—including indefinitely, so far as observations have shown so far.
As one might expect, higher doses (50%) were more effective, while lower doses (25%) caused fewer adverse effects (e.g. nausea, dizziness, and headaches)
You might be wondering: would 100% be even more effective? And, technically yes, but only briefly, because then you would die of asphyxiation, because we need O₂ to live, and N₂O doesn’t have that, and 100% N₂O means 0% O₂.
As for how it works: you might think it has to do with making you laugh, but no! N₂O blocks NMDA receptors, modulates glutamate signalling, influences the default mode network, and affects dopamine and opioid pathways, offering a similar rapid-acting mechanism to ketamine, but with a much better safety profile.
You can read the paper in full, here: Nitrous oxide for the treatment of depression: a systematic review and meta-analysis ← including a diagram of a neuron showing how it works!
Want to learn more?
We’ve written quite a bit about ways to fight depression; here are a select few:
- Considering drugs? See: Antidepressants: Personalization Is Key!
- Not that kind of drugs? See: Here’s Why You Want To Know About Mushrooms and Depression
- Prefer nutraceuticals? See: 12 Foods That Fight Depression & Anxiety
- Want to get technological? See: Does This New Machine Cure Depression?
- Or just psychological? See: Behavioral Activation Against Depression & Anxiety
Take care!
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Are Collagen Molecules Too Big To Be Absorbed?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝I read your article about collagen, but I heard collagen molecules are too large to be absorbed, so supplementing with collagen is basically useless, have I been misled?❞
Great question! And the answer is… Nuanced.
Firstly let’s note: absorbed where? The gut (oral supplementation), or the skin (topical application)?
You said “supplementing”, so probably you’re thinking about the gut; we’ll give good attention to that, but for the sake of being methodical, let’s briefly talk about the skin and products with topical collagen that’s applied externally:
Yes, collagen molecules are absolutely huge and cannot be absorbed by the skin. Not only that, but the epidermis (the outer part of your skin) is not where collagen synthesis happens, so this is a bit like trying to fix a structural problem in your house by flinging mud at it from the outside. The mud may have the same minerals that are needed, but it’s just going to sit on the outside of your house until it gets washed off.
So it is with topical collagen creams, masks, etc. They can give a brief “filler” effect at best, but they’re not doing anything for your actual skin and will just get washed off when you wash.
Now, about hydrolysed collagen peptides
This term means that the huge collagen molecules have been broken down into little bits. These now are are small enough to get absorbed.
When it comes to topical treatments, there is currently no good science that we could find to show that they actually help, though, perhaps because while they’re small enough to get absorbed, most aren’t. We can’t know for sure yet though, as studies that do exists are usually not only funded by the beauty company making the tropical product, but also, tiny and often methodologically weak.
Here’s an example; it’s a tiny (n=22) study, funded by the beauty company whose product is being tested, with no control group, the main outcomes were subjective satisfaction, skin roughness measurement (that would be affected by anything physically smoothing over the top of the skin), and then more technical measures that while cited as improvements, have numbers that look like:
❝Furthermore, the skin surface elasticity (total recovery/total elongation; gross elasticity (R2)) increased from 0.81 ± 0.03 to 0.83 ± 0.03❞
Read in full: Effect of a Topical Collagen Tripeptide on Antiaging and Inhibition of Glycation of the Skin: A Pilot Study
Perhaps better, more conclusive studies will be conducted and their results will vindicate the use of topical collagen treatments, but the current state of science is, if being honest about things, “we don’t know”.
About that “subjective satisfaction” thing though—it’s worth noting that that there are no known adverse side effects (beyond rare adverse reactions, usually to some other ingredient), so if you have a topical collagen treatment that you enjoy using, don’t let us stop you.
Now, about the gut
Collagen molecules are, once again, far too large to be absorbed by the gut, too. Hydrolyzed collagen peptides are, once again, the answer.
And this time, not only are they small enough to be absorbed, but also, there is a lot of science to indicate that it really does meaningfully improve bone density, alleviate symptoms of arthritis, and so forth.
And as for its benefits for the skin from the inside, it’s hard to know whether it’s getting there or not, but what we can know is that collagen synthesis is increased systemwide in people who take hydrolysed collagen peptide supplements in the recommended dosage range of 5–20g/day, and that many measurable signs of skin aging are meaningfully reversed (much more so than the paltry numbers in the topical treatment study we linked above):
This is what we wrote about in the article you read, which for convenience we’ll link again here: We Are Such Stuff As Fish Are Made Of ← we also link to where you can get good quality hydrolyzed collagen peptides.
Vegan/Vegetarian?
At present, only animals make collagen. We say “at present” not because it’s likely that plants or fungi are likely to start doing it soon, but rather, because lab-made stuff is often around the corner.
For now, however, all sources of collagen are from animals.
So, what to do if vegan/vegetarian?
The best thing to do is to simply do like those animals did, and include in your diet plenty of the ingredients required for your body to make collagen internally.
As for what they are, check out: The Best Foods For Collagen Production
Enjoy!
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Brussels Sprouts vs Kale – Which is Healthier?
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Our Verdict
When comparing Brussels sprouts to kale, we picked the kale.
Why?
In today’s battle of Brassica oleracea vs Brassica oleracea (these two plants today are the same species, just a different cultivar), there’s a clear winner when all’s said and done:
In terms of macros, there’s really nothing between them, so this round’s a tie. However…
In the category of vitamins, Brussels sprouts have more of vitamins B1 and B5, while kale has more of vitamins A, B2, B3, B6, B7, B9, C, E, and K, winning easily.
Looking at minerals next, Brussels sprouts have more selenium, while kale has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, winning this round too.
In other considerations, both are abundant sources of polyphenols, but kale has more, especially kaempferol and quercetin, winning kale its third round in a row.
Adding up the sections makes for a clear overall win for kale, but by all means enjoy either or both, as diversity is best, and Brussels sprouts really are a superfood too; they just don’t look it when standing next to kale!
Want to learn more?
You might like:
- The Best Foods for Clear, Healthy Skin
- What Does Kaempferol Do, Anyway?
- Fight Inflammation & Protect Your Brain, With Quercetin
Enjoy!
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Unprocessed – by Kimberly Wilson
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First, what this is not: hundreds of pages to say “eat less processed food”. That is, of course, also advisable (and indeed, is advised in the book too), but there’s a lot more going on here too.
Though not a doctor, the author is a psychologist who brings a lot of data to the table, especially when it comes to the neurophysiology at hand, what forgotten micronutrients many people are lacking, and what trends in society worsen these deficiencies in the population at large.
If you only care about the broadest of take-away advice, it is: eat a diet that’s mostly minimally processed plants and some oily fish, watch out for certain deficiencies in particular, and increase dietary intake of them where necessary (with taking supplements as a respectable next-best remedy).
On which note, a point of criticism is that there’s some incorrect information about veganism and brain health; she mentions that DHA is only found in fish (in fact, fish get it from algae, which has it, and is the basis of many vegan omega-3 supplements), and the B12 is found only in animals (also found in yeast, which is not an animal, as well as various bacteria in soil, and farm animals get their B12 from supplements these days anyway, so it is arguable that we could keep things simpler by just cutting out the middlecow).
However, the strength of this book really is in the delivery of understanding about why certain things matter. If you’re told “such-and-such is good for the brain”, you’ll up your intake for 1–60 days, depending on whether you bought a supermarket item or ordered a batch of supplements. And then you’ll forget, until 6–12 months later, and you’ll do it again. On the other hand, if you understand how something is good or bad for the brain, what it does (for good or ill) on a cellular level, the chemistry and neurophysiology at hand, you’ll make new habits for life.
The style is middle-range pop-science; by this we mean there are tables of data and some long words that are difficult to pronounce, but also it’s not just hard science throughout—there’s (as one might expect from an author who is a psychologist) a lot about the psychology and sociology of why many people make poor dietary decisions, and the things governments often do (or omit doing) that affect this adversely—and how we can avoid those traps as individuals (unless we be incarcerated or such).
As an aside, the author is British, so governmental examples are mostly UK-based, but it doesn’t take a lot to mentally measure that against what the governments of, for example, the US or Canada do the same or differently.
Bottom line: there’s a lot of great information about brain health here; the strongest parts are whether the author stays within her field (psychology encompasses such diverse topics as neurophysiology and aspects of sociology, but not microbiology, for example). If you want to learn about the physiology of brain health and enjoy quite a sociopolitical ride along the way, this one’s a good one for that.
Click here to check out Unprocessed, and make the best choices for you!
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Reinventing Your Life – by Dr. Jeffrey Young & Dr. Janet Klosko
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This book is quite unlike any other broadly-CBT-focused books we’ve reviewed before. How so, you may wonder?
Rather than focusing on automatic negative thoughts and cognitive distortions with a small-lens focus on an immediate problem, this one zooms out rather and tackles the cause rather than the symptom.
The authors outline eleven “lifetraps” that we can get stuck in:
- Abandonment
- Mistrust & abuse
- Vulnerability
- Dependence
- Emptional deprivation
- Social exclusion
- Defectiveness
- Failure
- Subjugation
- Unrelenting standards
- Entitlement
They then borrow from other areas of psychology, to examine where these things came from, and how they can be addressed, such that we can escape from them.
The style of the book is very reader-friendly pop-psychology, with illustrative (and perhaps apocryphal, but no less useful for it if so) case studies.
The authors then go on to give step-by-step instructions for dealing with each of the 11 lifetraps, per 6 unmet needs we probably had that got us into them, and per 3 likely ways we tried to cope with this using maladaptive coping mechanisms that got us into the lifetrap(s) we ended up in.
Bottom line: if you feel there’s something in your life that’s difficult to escape from (we cannot outrun ourselves, after all, and bring our problems with us), this book could well contain the key that you need to get out of that cycle.
Click here to check out “Reinventing Your Life” and break free from any lifetrap(s) of your own!
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Body Language (In The Real World)
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Forget What You Think You Know About Body Language
…unless it’s about a specific person whose habits and mannerisms you know intimately, in which case, you probably have enough personal data stored up to actually recognize patterns à la “when my spouse does this, then…”, and probably do know what’s going on.
For everyone else… our body language can be as unique as our idiolect
What’s an idiolect? It’s any one given person’s way of speaking/writing, in their natural state (i.e. without having to adjust their style for some reason, for example in a public-facing role at work, where style often becomes much narrower and more consciously-chosen).
Extreme example first
To give an extreme example of how non-verbal communication can be very different than a person thinks, there’s an anecdote floating around the web of someone whose non-verbal autistic kid would, when he liked someone who was visiting the house, hide their shoes when they were about to leave, to cause them to stay longer. Then one day some relative visited and when she suggested that she “should be going sometime soon”, he hurried to bring her her shoes. She left, happy that the kid liked her (he did not).
The above misunderstanding happened because the visitor had the previous life experience of “a person who brings me things is being helpful, and if they do it of their own free will, it’s because they like me”.
In other words…
Generalizations are often sound… In general
…which does not help us when dealing with individuals, which as it turns out, everyone is.
Clenched fists = tense and angry… Except when it’s just what’s comfortable for someone, or they have circulation issues, or this, or that, or the other.
Pacing = agitated… Except when it’s just someone who finds the body in motion more comfortable
Relaxed arms and hands = at ease and unthreatening… Unless it’s a practitioner of various martial arts for whom that is their default ready-for-action state.
Folded arms = closed-off, cold, distant… Or it was just somewhere to put one’s hands.
Lack of eye contact = deceitful, hiding something… Unless it’s actually for any one of a wide number of reasons, which brings us to our next section:
A liar’s “tells”
Again, if you know someone intimately and know what signs are associated with deceit in them, then great, that’s a thing you know. But for people in general…
A lot of what is repeated about “how to know if someone is lying” has seeped into public consciousness from “what police use to justify their belief that someone is lying”.
This is why many of the traditional “this person is lying” signs are based around behaviors that show up when in fact “this person is afraid, under pressure, and talking to an authority figure who has the power to ruin their life”:
Research on Non-verbal Signs of Lies and Deceit: A Blind Alley
But what about eye-accessing cues? They have science to them, right?
For any unfamiliar: this is about the theory that when we are accessing different parts of our mind (such as memory or creativity, thus truthfulness or lying), our eyes move one way or another according to what faculty we’re accessing.
Does it work? No
But, if you carefully calibrate it for a specific person, such as by asking them questions along the lines of “describe your front door” or “describe your ideal holiday”, to see which ways they look for recall or creativity… Then also no:
The Eyes Don’t Have It: Lie Detection and Neuro-Linguistic Programming
How can we know what non-verbal communication means, then?
With strangers? We can’t, simply. It’s on us to be open-minded, with a healthy balance of optimism and wariness.
With people we know? We can build up a picture over time, learn the person’s patterns. Best of all, we can ask them. In the moment, and in general.
For more on optimizing interpersonal communication, check out:
Save Time With Better Communication
…and the flipside of that:
The Problem With Active Listening (And How To Do It Better)
Take care!
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The Whole-Body Approach to Osteoporosis – by Keith McCormick
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You probably already know to get enough calcium and vitamin D, and do some resistance training. What does this book offer beyond that advice?
It’s pretty comprehensive, as it turns out. It covers the above, plus the wide range of medications available, what supplements help or harm or just don’t have enough evidence either way yet, things like that.
Amongst the most important offerings are the signs and symptoms that can help monitor your bone health (things you can do at home! Like examinations of your fingernails, hair, skin, tongue, and so forth, that will reveal information about your internal biochemical make-up), as well as what lab tests to ask for. Which is important, as osteoporosis is one of those things whereby we often don’t learn something is wrong until it’s too late.
The author is a chiropractor, which doesn’t always have a reputation as the most robustly science-based of physical therapy options, but he…
- doesn’t talk about chiropractic
- did confer with a flock of experts (osteopaths, nutritionists, etc) to inform/check his work
- does refer consistently to good science, and explains it well
- includes 16 pages of academic references, and yes, they are very reputable publications
Bottom line: this one really does give what the subtitle promises: a whole body approach to avoiding (or reversing) osteoporosis.
Click here to check out The Whole Body Approach To Osteoporosis; sooner is better than later!
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