Kava vs Anxiety

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Kava, sometimes also called “kava kava” but we’re just going to call it kava once for the sake of brevity, is a heart-shaped herb that bestows the powers of the Black Panther is popularly enjoyed for its anxiolytic (anxiety-reducing) effects. Despite the similarity of the name in many languages, it is unrelated to coffee (except insofar as they are both plants), and its botanical name is Piper methysticum.

Does it work?

Yes! At least in the short-term; more on that later.

Firstly, you may be wondering how it works; it works by its potentiation of GABA receptors in the brain. GABA (or gamma-aminobutyric acid, to give it its full name), as you may recall, is a neurotransmitter that is associated with feelings of calm; we wrote about it here:

GABA Against Stress/Anxiety

So, what does “potentiation of GABA receptors” mean? It means… Scientists don’t for 100% sure know how it works yet, but it does make GABA receptors fire more. It’s possible that to some degree GABA fits the “molecular lock” of the receptors and causes them to say “GABA is here”; it’s also possible that they just make them more sensitive to the real GABA that is there, or there could be another explanation as yet undiscovered. Either way, it means that taking kava has a similar effect to having increased GABA levels in the brain:

Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism

As for how much to use, 20–300mg appears to be an effective dose, and most sources recommend 80–250mg:

Kava as a Clinical Nutrient: Promises and Challenges

This review of clinical trials found that it was more effective than placebo in only 3 of 7 trials; specifically, it was beneficial in the short-term and not in the long-term. For these reasons, the researchers concluded:

❝Kava Kava appears to be a short-term treatment for anxiety, but not a replacement for prolonged anti-anxiety use. Although not witnessed in this review, liver toxicity is especially possible if taken longer than 8 weeks.❞

Source: The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials

Another review of clinical trials found better results over the course of 11 clinical trials, though again, short-term treatment only was considered to be where the “safe and effective” claim can be placed:

❝Compared with placebo, kava extract appears to be an effective symptomatic treatment option for anxiety. The data available from the reviewed studies suggest that kava is relatively safe for short-term treatment (1 to 24 weeks), although more information is required. Further rigorous investigations, particularly into the long-term safety profile of kava are warrant❞

Source: Kava extract for treating anxiety

Is it safe?

Nope! It has been associated with liver damage:

FDA | Consumer Advisory: Kava-Containing Dietary Supplements May be Associated With Severe Liver Injury

The likely main mechanism of toxicity is that it simply monopolizes the liver’s metabolic abilities, meaning that while it’s metabolizing the kava, it’s not metabolizing other things (such as alcohol or other medications), which will then build up, and potentially overwhelm the liver:

Constituents in kava extracts potentially involved in hepatotoxicity: a review

However, traditionally-prepared kava has not had the same effect as modern extracts; at first it seemed the difference was the traditional aqueous extracts vs modern acetonic/ethanolic extracts, but eventually that was found not to be the case, as toxicity occurred with industrial aqueous extracts too. The conclusion so far is that it is about the quality of the source ingredients, and the problems inherent to mass-production:

Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited

Meanwhile, short-term use doesn’t seem to have this problem, if you’re not drinking alcohol or taking medications that affect the liver:

Mechanisms/risk factors – kava-associated hepatotoxicity ← you’ll need to scroll down to 4.2.4 to read about this

Want to try it?

If the potential for hepatotoxicity doesn’t put you off, here’s an example product on Amazon ← we do not recommend it, but we are not the boss of you, and maybe you’re confident about your liver and want to use it only very short-term?

Take care!

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  • Managing [E-word] Dysfunction Reactions

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    It’s Q&A Day at 10almonds!

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    We had several requests pertaining to veganism, meatless mondays, and substitutions in recipes—so we’re going to cover those on a different day!

    As for questions we’re answering today…

    Q: Information on [e-word] dysfunction for those who have negative reactions to [the most common medications]?

    When it comes to that particular issue, one or more of these three factors are often involved:

    • Hormones
    • Circulation
    • Psychology

    The most common drugs (that we can’t name here) work on the circulation side of things—specifically, by increasing the localized blood pressure. The exact mechanism of this drug action is interesting, albeit beyond the scope of a quick answer here today. On the other hand, the way that they work can cause adverse blood-pressure-related side effects for some people; perhaps you’re one of them.

    To take matters into your own hands, so to speak, you can address each of those three things we just mentioned:

    Hormones

    Ask your doctor (or a reputable phlebotomy service) for a hormone test. If your free/serum testosterone levels are low (which becomes increasingly common in men over the age of 45), they may prescribe something—such as testosterone shots—specifically for that.

    This way, it treats the underlying cause, rather than offering a workaround like those common pills whose names we can’t mention here.

    Circulation

    Look after your heart health; eat for your heart health, and exercise regularly!

    Cold showers/baths also work wonders for vascular tone—which is precisely what you need in this matter. By rapidly changing temperatures (such as by turning off the hot water for the last couple of minutes of your shower, or by plunging into a cold bath), your blood vessels will get practice at constricting and maintaining that constriction as necessary.

    Psychology

    [E-word] dysfunction can also have a psychological basis. Unfortunately, this can also then be self-reinforcing, if recalling previous difficulties causes you to get distracted/insecure and lose the moment. One of the best things you can do to get out of this catch-22 situation is to not worry about it in the moment. Depending on what you and your partner(s) like to do in bed, there are plenty of other equally respectable options, so just switch track!

    Having a conversation about this in advance will probably be helpful, so that everyone’s on the same page of the script in that eventuality, and it becomes “no big deal”. Without that conversation, misunderstandings and insecurities could arise for your partner(s) as well as yourself (“aren’t I desirable enough?” etc).

    So, to recap, we recommend:

    • Have your hormones checked
    • Look after your circulation
    • Make the decision to have fun!

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  • How to Vary Breakfast for Digestion?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    ❝Would appreciate your thoughts on how best to promote good digestion. For years, my breakfast has consisted of flaxseeds, sunflower seeds, and almonds – all well ground up – eaten with a generous amount of kefir. This works a treat as far as my digestion is concerned. But I sometimes wonder whether it would be better for my health if I varied or supplemented this breakfast. How might I do this without jeopardising my good digestion?❞

    Sounds like you’re already doing great! Those ingredients are all very nutrient-dense, and grinding them up improves digestion greatly, to the point that you’re getting nutrients your body couldn’t get at otherwise. And the kefir, of course, is a top-tier probiotic.

    Also, you’re getting plenty of protein and healthy fats in with your carbs, which results in the smoothest blood sugar curve.

    As for variety…

    Variety is good in diet, but variety within a theme. Our gut microbiota change according to what we eat, so sudden changes in diet are often met with heavy resistance from our gut.

    • For example, people who take up a 100% plant-based diet overnight often spend the next day in the bathroom, and wonder what happened.
    • Conversely, a long-time vegan who (whether by accident or design) consumes meat or dairy will likely find themself quickly feeling very unwell, because their gut microbiota have no idea what to do with this.

    So, variety yes, but within a theme, and make any changes gradual for the easiest transition.

    All in all, the only obvious suggestion for improvement is to consider adding some berries. These can be fresh, dried, or frozen, and will confer many health benefits (most notably a lot of antioxidant activity).

    Enjoy!

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  • Glucose Revolution – by Jessie Inchauspé

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    While we all know that keeping balanced blood sugars is important for all us (be we diabetic, pre-diabetic, or not at all), it can be a mystifying topic!

    Beyond a generic “sugar is bad”…

    • What does it all mean and how does it all work?
    • Should we go low-carb?
    • What’s the deal with fruit?
    • Carbs or protein for breakfast?
    • Is “quick energy” ever a good thing?
    • How do starches weigh in again?

    It’s all so confusing!

    Happily, Jessie Inchauspé has the incredible trifecta of qualifications to help us: she’s a biochemist, a keen cook, and a great educator. What we mean by this latter is:

    Instead of dry textbook explanations, or “trust me” hand-waives, she explains biochemistry in a clear, simple, digestible (if you’ll pardon the pun) way with very helpful diagrams what things cause (or flatten) blood sugar spikes and how and why. If you read this book, you will understand, without guesswork or gaps, exactly what is happening on a physical level, and why and how her “10 hacks” work.

    Her “10 hacks” are explained so thoroughly that each gets a chapter of its own, but we’ll not keep them a mystery from you meanwhile, they are:

    1. Eat foods in the right order
    2. Add a green starter to your meals
    3. Stop counting calories
    4. Flatten your breakfast curve
    5. Have any type of sugar you like—they’re all the same
    6. Pick dessert over a sweet snack
    7. Reach for the vinegar before you eat
    8. After you eat, move
    9. If you have to snack, go savoury
    10. Put some clothes on your carbs

    She then finishes up with a collection of handy cheat-sheets and some of her own recipes.

    Bottom line: this isn’t just a “how-to” book. It gives the how-to, yes, but it also gives such good explanations that you’ll never be confused again by what’s going on in your glucose-related health.

    Get your copy of Jessie Inchauspé’s #1 international bestseller, “Glucose Revolution”, from Amazon today!

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  • Almond Butter vs Cashew Butter – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing almond butter to cashew butter, we picked the almond.

    Why?

    It’s not just our pro-almonds bias! And of course exact nutritional values may vary depending on the recipe, but we’re using the USDA’s standardized figures which should represent a reasonable average. Specifically, we’re looking at the USDA entries for “[Nut] butter, plain, without salt added”.

    In terms of macros, almond butter takes the lead immediately with nearly 2x the protein and over 3x the fiber. In contrast, cashew butter has 1.5x the carbs, and the two nut butters are approximately equal on fat. An easy win for almond butter so far.

    When it comes to vitamins, almond butter has more of vitamins A, B2, B3, B5, E, and choline, while cashew butter has more of vitamins B1, B6, and K. Thus, a 6:3 win for almond butter.

    In the category of minerals, things are closer, but almond butter has more calcium, magnesium, manganese, phosphorus, and potassium, while cashew butter has more copper, iron, zinc, and selenium. So, a 5:4 win for almond butter.

    In short, these three wins for almond butter add up to one total win for almond butter, unless you have a pressing reason to have different priorities in what you’re looking for in terms of nutrition.

    Enjoy both, of course! Unless you are allergic, in which case, please don’t.

    Want to learn more?

    You might like to read:

    Why You Should Diversify Your Nuts

    Take care!

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  • No, vitamin A does not prevent measles

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    As measles spreads in Texas, New Mexico, and other states, a Texas child died from measles for the first time in the United States since 2015. In a March 2 Fox News editorial, Health and Human Services Secretary Robert F. Kennedy Jr. hinted at the importance of vaccination and stated that good nutrition, including vitamin A, is a “best defense against most chronic and infectious illnesses.”

    However, doctors and public health professionals say that vitamin A is not a replacement for the measles, mumps, and rubella (MMR) vaccine. Vitamin A is sometimes used to treat measles in the hospital—particularly in developing countries where people with poor nutrition tend to be vitamin A deficient. Experts also say that taking vitamin A when your body does not need it can be dangerous. 

    “It’s really important to distinguish prevention and treatment, and measles can be prevented, and it can be prevented one way: through vaccination,” Dr. Preeti Malani, infectious disease physician and professor at the University of Michigan, tells PGN. “The best treatment is to not get measles in the first place.”

    Read on to learn the facts about vitamin A, what it’s used for, its risks, and what you should do to prevent measles. 

    What is vitamin A, and what does it have to do with measles? 

    Vitamin A is a fat-soluble vitamin, which means that it’s stored in the body’s fatty tissue and in the liver, and it’s absorbed with the fat in a person’s diet. Vitamin A helps with our vision, reproduction, growth, and immunity. 

    Vitamin A deficiency can increase the risk of death from measles, among other infections. The World Health Organization recommends it as a supplement along with vaccination for children at risk of vitamin A deficiency in developing countries. 

    However, vitamin A deficiency is rare in the U.S. because most people get enough of it through their diet. (Malani says that’s why research about the use of vitamin A to treat measles is limited in countries like the United States.)

    “Vitamin A deficiency is a major problem in developing nations, particularly those that don’t have access to staple foods that have vitamin A,” says Andrea Love, PhD, a biomedical scientist and founder of the health communication organization Immunologic, to PGN. “The problem is that that’s been kind of extrapolated to high-income countries [like the United States], where vitamin A deficiency is really not a concern.”

    Under Kennedy’s direction, the Centers for Disease Control and Prevention recently updated its guidance to recommend the use of vitamin A to treat severe measles in young children, but specifically in a hospital setting and under a doctor’s supervision.

    Does vitamin A prevent measles?

    No. Vitamin A does not prevent measles. The MMR vaccine is the best way to prevent a measles infection. 

    “Vitamin A is not an alternative to vaccination,” Malani adds. “We have a safe and highly effective vaccine that’s been available for decades—it will protect individuals [and] communities from an outbreak.”

    Are there any risks to taking vitamin A? 

    Yes. If your body doesn’t need extra vitamin A, there are risks. 

    According to the National Institutes of Health, taking too much vitamin A (specifically, the type found in supplements and some medications) can cause nausea, severe headaches, blurred vision, muscle aches, and problems with coordination. In severe cases, it can also lead to coma and death. Taking too much vitamin A while pregnant can cause birth defects. 

    “If you’re already getting sufficient vitamin A from your diet, then when you consume more than what you need, those levels are going to build up in your body, in your fat stores, in your tissues, and you’re going to be at risk of both acute and chronic toxicity,” adds Love. 

    Water-soluble vitamins like vitamin C “get filtered out by your kidneys and you would pee it out, but fat-soluble vitamins [like vitamin A], don’t get processed and excreted as quickly; they start to build up in the body,” she says. 

    What can I do to protect myself from measles? 

    The MMR vaccine is the best way to protect yourself from measles. The CDC recommends children get two doses of the MMR vaccine: the first dose between 12 and 15 months and the second one between 4 and 6 years old. 

    Experts recommend that adults who are not sure about their vaccination or immunity status against measles get at least one dose of the MMR vaccine. Additionally, adults who are at high risk for measles (like health care workers and people who travel internationally) may need two additional doses.

    According to the CDC, you can also get an MMR vaccine within 72 hours of initial exposure to measles, which can give you some protection or make your illness less severe. Additionally, there’s an antibody (a protective protein called immunoglobulin) that a doctor may recommend for high-risk people within six days of being exposed to measles

    For more information, talk to your health care provider.

    This article first appeared on Public Good News and is republished here under a Creative Commons license.

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  • When Did You Last Have a Cognitive Health Check-Up?

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    When Did You Last Have a Cognitive Health Check-Up?

    Regular health check-ups are an important part of a good health regime, especially as we get older. But after you’ve been prodded, probed, sampled and so forth… When did you last have a cognitive health check-up?

    Keeping on top of things

    In our recent Monday Research Review main feature about citicoline, we noted that it has beneficial effects for a lot of measures of cognitive health.

    And that brought us to realize: just how on top of this are we?

    Your writer here today could tell you what her sleep was like on any night in the past year, what her heart rate was like, her weight, and all that. Moods too! There’s an app for that. But cognitive health? My last IQ test was in 2001, and I forget when my last memory test was.

    It’s important to know how we’re doing, or else how to we know if there has been some decline? We’ve talked previously about the benefits of brain-training of various kinds to improve cognition, so in some parts we’ll draw on the same resources today, but this time the focus is on getting quick measurements that we can retest regularly (mark the calendar!)

    Some quick-fire tests

    These tests are all free, quick, and accessible. Some of them will try to upsell you on other (i.e. paid) services; we leave that to your own discretion, but the things we’ll be using today are free.

    Test your verbal memory

    This one’s a random word list generator. It defaults to 12 words, but you can change that if you like. Memorize the words, and then test yourself by seeing how many you can write down from memory. If it gets too easy, crank up the numbers.

    Click here to try it now

    Test your visual memory

    This one’s a series of images; the test is to click to say whether you’ve seen this exact image previously in the series or not.

    Click here to try it now

    Test your IQ

    This one’s intended to be general purpose intelligence; in reality, IQ tests have their flaws too, but it’s not a bad metric to keep track of. Just don’t get too hung up on the outcome, and remember, your only competition is yourself!

    Click here to try it now

    Test your attention / focus

    This writer opened this and this three other attention tests (to get you the best one) before getting distracted, noting the irony, and finally taking the test. Hopefully you can do better!

    Click here to try it now

    Test your creativity

    This one’s a random object generator. Give yourself a set period of time (per your preference, but make a note of the time you allow yourself, so that you can use the same time period when you retest yourself at a later date) in which to list as many different possible uses for the item.

    Click here to try it now

    Test your musical sense

    This one’s a pitch recognition test. So, with the caveat that it is partially testing your hearing as well as your cognition, it’s a good one to take and regularly retest in any case.

    Click here to try it now

    How often should you retest?

    There’s not really any “should” here, but to offer some advice:

    • If you take them too often, you might find you get bored of doing so and stop, essentially burning out.
    • If you don’t take them regularly, you may forget, lose this list of tests, etc.
    • Likely a good “sweet spot” is quarterly or six-monthly, but there’s nothing wrong with testing annually either.

    It’s all about the big picture, after all.

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