Citicoline: Better Than Dietary Choline?
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Citicoline: Better Than Dietary Choline?
Citicoline, also known as cytidine diphosphate-choline (or CDP-Choline, to its friends, or cytidine 5′-diphosphocholine if it wants to get fancy) is a dietary supplement that the stomach can metabolize easily for all the brain’s choline needs. What are those needs?
Choline is an essential nutrient. We technically can synthesize it, but only in minute amounts, far less than we need. Choline is a key part of the neurotransmitter acetylcholine, as well as having other functions in other parts of the body.
As for citicoline specifically… it appears to do the job better than dietary sources of choline:
❝Intriguing data, showing that on a molar mass basis citicoline is significantly less toxic than choline, are also analyzed.
It is hypothesized that, compared to choline moiety in other dietary sources such as phosphatidylcholine, choline in citicoline is less prone to conversion to trimethylamine (TMA) and its putative atherogenic N-oxide (TMAO).
Epidemiological studies have suggested that choline supplementation may improve cognitive performance, and for this application citicoline may be safer and more efficacious.❞
Source: Citicoline: A Superior Form of Choline?
Great! What does it do?
What doesn’t it do? When it comes to cognitive function, anyway, citicoline covers a lot of bases.
Short version: it improves just about every way a brain’s healthy functions can be clinically measured. From cognitive improvements in all manner of tests (far beyond just “improves memory” etc; also focus, alertness, verbal fluency, logic, computation, and more), to purely neurological things like curing tinnitus (!), alleviating mobility disorders, and undoing alcohol-related damage.
One of the reasons it’s so wide in its applications, is that it has a knock-on effect to other systems in the brain, including the dopaminergic system.
Long version: Citicoline: pharmacological and clinical review, 2022 update
(if you don’t want to sit down for a long read, we recommend skimming to the charts and figures, which are very elucidating even alone)
Spotlight study in memory
For a quick-reading example of how it helps memory specifically:
Keeping dementia at bay
For many older people looking to improve memory, it’s less a matter of wanting to perform impressive feats of memory, and more a matter of wanting to keep a sharp memory throughout our later years.
Dr. Maria Bonvicini et al. looked into this:
❝We selected seven studies including patients with mild cognitive impairment, Alzheimer’s disease or post-stroke dementia
All the studies showed a positive effect of citicoline on cognitive functions. Six studies could be included in the meta-analysis.
Overall, citicoline improved cognitive status, with pooled standardized mean differences ranging from 0.56 (95% CI: 0.37-0.75) to 1.57 (95% CI: 0.77-2.37) in different sensitivity analyses❞
The researchers concluded “yes”, and yet, called for more studies, and of higher quality. In many such studies, the heterogeneity of the subjects (often, residents of nursing homes) can be as much a problem (unclear whether the results will be applicable to other people in different situations) as it is a strength (fewer confounding variables).
Another team looked at 47 pre-existing reviews, and concluded:
❝The review found that citicoline has been proven to be a useful compound in preventing dementia progression.
Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases.
Its positive impact on learning and cognitive functions among the healthy population is also worth noting.❞
Source: Application of Citicoline in Neurological Disorders: A Systematic Review
The dopamine bonus
Remember how we said that citicoline has a knock-on effect on other systems, including the dopaminergic system? This means that it’s been studied (and found meritorious) for alleviating symptoms of Parkinson’s disease:
❝Patients with Parkinson’s disease who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech.
Citicoline allowed effective reduction of levodopa by up to 50%.
Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy.❞
Source: Citicoline as Adjuvant Therapy in Parkinson’s Disease: A Systematic Review
Where to get it?
We don’t sell it, but here’s an example product on Amazon, for your convenience
Enjoy!
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Small Pleasures – by Ryan Riley
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When Hippocrates said “let food be thy medicine, and let medicine be thy food”, he may or may not have had this book in mind.
In terms of healthiness, this one’s not the very most nutritionist-approved recipe book we’ve ever reviewed. It’s not bad, to be clear!
But the physical health aspect is secondary to the mental health aspects, in this one, as you’ll see. And as we say, “mental health is also just health”.
The book is divided into three sections:
- Comfort—for when you feel at your worst, for when eating is a chore, for when something familiar and reassuring will bring you solace. Here we find flavor and simplicity; pastas, eggs, stews, potato dishes, and the like.
- Restoration—for when your energy needs reawakening. Here we find flavors fresh and tangy, enlivening and bright. Things to make you feel alive.
- Pleasure—while there’s little in the way of health-food here, the author describes the dishes in this section as “a love letter to yourself; they tell you that you’re special as you ready yourself to return to the world”.
And sometimes, just sometimes, we probably all need a little of that.
Bottom line: if you’d like to bring a little more joie de vivre to your cuisine, this book can do that.
Click here to check out Small Pleasures, and rekindle joy in your kitchen!
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What Actually Causes High Cholesterol?
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In 1968, the American Heart Association advised limiting egg consumption to three per week due to cholesterol concerns linked to cardiovascular disease. Which was reasonable based on the evidence available back then, but it didn’t stand the test of time.
Eggs are indeed high in cholesterol, but that doesn’t mean that those who eat them will also be high in cholesterol, because…
It’s not quite what many people think
Some quite dietary pointers to start with:
- Egg yolks are high in cholesterol but have a minimal impact on blood cholesterol.
- Saturated and trans fats (as found in fatty meats or dairy, and some processed foods) have a greater influence on LDL levels than dietary cholesterol.
And on the other hand:
- Unsaturated fats (e.g. from fish, nuts, seeds) have anti-inflammatory benefits
- Fiber-rich foods help lower LDL by affecting fat absorption in the digestive tract
A quick primer on LDL and other kinds of cholesterol:
- VLDL (Very Low-Density Lipoprotein):
- delivers triglycerides and cholesterol to muscle and fat cells for energy
- is converted into LDL after delivery
- LDL (Low-Density Lipoprotein):
- is called “bad cholesterol”, which we call that due to its role in arterial plaque formation
- in excess leads to inflammation, overworked macrophage activity, and artery narrowing
- HDL (High-Density Lipoprotein):
- known as “good cholesterol,” picks up excess LDL and returns it to the liver for excretion
- is anti-inflammatory, in addition to regulating LDL levels
There are other factors too, for example:
- Smoking and drinking increase LDL buildup and cause oxidative damage to lipids in general and the blood vessels through which they travel
- Regular exercise, meanwhile, can lower LDL and raise HDL
- Statins and other medications can help lower LDL and manage cholesterol when lifestyle changes and genetics require additional support—but they often come with serious side effects, and the usefulness varies from person to person.
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Take care!
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How To Unchoke Yourself If You Are Dying Alone
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The first things that most people think of, won’t work. This firefighter advises on how to actually do it:
Steps to take
Zero’th step: he doesn’t mention this, but try coughing first. You might think coughing will be a natural reaction anyway, but that tends only to happen automatically with small partial obstructions, not a complete blockage. Either way, try to cough forcefully to see if it dislodges whatever you’re choking on. If that doesn’t work…
Firstly: don’t rely on calling for help if you’re alone and cannot speak; you’re unlikely to be able to communicate and you will just waste time (when you don’t have time to waste). Even if you call emergency services and they trace your location, chances are that, at most, a cop car will show up some hours later to see what it was about. They will not dispatch an ambulance on the strength of “someone called and said nothing”.
Secondly, it is probable that will not be able to perform an abdominal thrust (also called Heimlich maneuvre in the US) on yourself the way you could on another person, and hitting your chest with your hand will produce insufficient force even if you’re quite strong. Nor are you likely to be able to slap yourself on the back to way you might another person.
Instead, he advises:
- Find a sturdy object: use a chair, table, countertop, or another firm surface that has an edge.
- Use gravity to perform self-Heimlich: position yourself with the edge of the object just below your sternum (he says ribcage, but the visuals show he clearly means the bottom of the sternum, where the diaphragm is, not the lower ribs). Fall onto the object forcefully to create pressure and dislodge the obstruction. This will not be fun.
- If it doesn’t work indoors: move to a visible outdoor location like your yard or a neighbor’s lawn. Falling visibly on the ground will likely alert someone to call for help.
While doing the above, remain as calm as possible, as this will not only increase the length of time you have before passing out, but will also help avoid your throat muscles tightening even more, worsening the choking.
After doing the above, seek medical attention now that you can communicate; you’ve probably broken some ribs and you might have organ damage.
For more on all this plus visual demonstrations, enjoy:
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Want to learn more?
You might also like to read:
How To Survive A Heart Attack When You’re Alone ← very different advice for this scenario!
Take care!
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Indistractable – by Nir Eyal
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Have you ever felt that you could accomplish anything you wanted/needed, if only you didn’t get distracted?
This book lays out a series of psychological interventions for precisely that aim, and it goes a lot beyond the usual “download/delete these apps to help you stop checking social media every 47 seconds”.
Some you’ll have heard of before, some you won’t have, and if even one method works for you, it’ll have been well worth your while reading this book. This reviewer, for example, enjoyed the call to identity-based strength, e.g. adopting an “I am indistractable*” perspective going into tasks. This is akin to the strength of, for example, “I don’t drink” over “I am a recovering alcoholic”.
*the usual spelling of this, by the way, is “undistractable”, but we use the author’s version here for consistency. It’s a great marketing gimmick, as all searches for the word “indistractable” will bring up his book.
Nor is the book just about maximizing productivity to the detriment of everything else; this is not about having a 25 hours per day “grindset”. Rather, it even makes sure to cover such things as focusing on one’s loved ones, for instance.
Bottom line: if you’ve tried blocking out the distractions but still find you can’t focus, this book offers next-level solutions
Click here to check out Indistractible, and become indeed indistractable!
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Barley Malt Flour vs chickpea flour – Which is Healthier?
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Our Verdict
When comparing barley malt flour to chickpea flour, we picked the chickpea.
Why?
First, some notes:
About chickpea flour: this is also called besan flour, gram flour, and garbanzo bean flour; they are all literally the same thing by different names, and are all flour made from ground chickpeas.
About barley malt flour: barley is a true grain, and does contain gluten. We’re not going to factor that into today’s decision, but if you are avoiding gluten, avoid barley. As for “malt”; malting grains means putting them in an environment (with appropriate temperature and humidity) that they can begin germination, and then drying them with hot air to stop the germination process from continuing, so that we still have grains to make flour out of, and not little green sprouting plants. It improves the nutritional qualities and, subjectively, the flavor.
To avoid repetition, we’re just going to write “barley” instead of “barley malt” now, but it’s still malted.
Now, let’s begin:
Looking at the macros first, chickpea flour has 2x the protein and also more fiber, while barley flour has more carbs. An easy win for chickpea flour.
In the category of vitamins, chickpea flour has more of vitamins A, B1, B5, B9, E, and K, while barley flour has more of vitamins B2, B3, B6, and C. A modest 6:4 victory for chickpea flour.
When it comes to minerals, things are much more one-sided; chickpea flour has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, while barley flour has more selenium. An overwhelming win for chickpea flour.
Adding up these three wins for chickpea flour makes for a convincing story in favor of using that where reasonably possible as a flour! It has a slight nutty taste, so you might not want to use it in everything, but it is good for a lot of things.
Want to learn more?
You might like to read:
- Grains: Bread Of Life, Or Cereal Killer?
- Gluten: What’s The Truth?
- Sprout Your Seeds, Grains, Beans, Etc
Take care!
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The Procrastination Cure – by Jeffery Combs
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Why do we procrastinate? It’s not usually because we are lazy, and in fact we can often make ourselves very busy while procrastinating. And at some point, the bad feelings about procrastinating become worse than the experience of actually doing the thing. And still we often procrastinate. So, why?
Jeffery Combs notes that the reasons can vary, but generally fall into six mostly-distinct categories. He calls them:
- The neurotic perfectionist
- The big deal chaser
- The chronic worrier
- The rebellious rebel
- The drama addict
- The angry giver
These may overlap somewhat, but the differences are important when it comes to differences of tackling them.
Giving many illustrative examples, Combs gives the reader all we’ll need to know which category (or categories!) we fall into.
Then, he draws heavily on the work of Dr. Albert Ellis to find ways to change the feelings that we have that are holding us back.
Those feelings might be fear, shame, resentment, overwhelm, or something else entirely, but the tools are in this book.
A particular strength of this book is that it takes an approach that’s essentially Rational Emotive Behavior Therapy (REBT) repackaged for a less clinically-inclined audience (Combs’ own background is in marketing, not pyschology). Thus, for many readers, this will tend to make the ideas more relatable, and the implementations more accessible.
Bottom line: if you’ve been meaning to figure out how to beat your procrastination, but have been putting it off, now’s the time to do it.
Click here to check out The Procrastination Cure sooner rather than later!
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