How Serious Are Antidepressant Side Effects?

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It’s Q&A Day at 10almonds!

Have a question or a request? We love to hear from you!

In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

So, no question/request too big or small 😎

❝I have been considering Antidepressants, but am concerned about the side effects including depression (how is that even possible) , suicidal thoughts, and anxiety, I don’t want to make things worse, should I be worred?❞

First of all: we hope things get better for you, whether with meds or not!

Secondly: we’ll quickly draw attention to our standard medical/legal disclaimer; we provide bite-size health science information here, and/but absolutely cannot give medical advice; for that see your own pharmacist or doctor (with the former generally being the better-informed about medication side effects), who will be aware of your personal circumstances.

Thirdly: we’ll now look at the actual topic with which you’ve kindly presented us 🙂

Most antidepressants work by increasing levels of one or more neurotransmitters in the brain, by one or more mechanisms. If that sounds vague, it’s because there’s a lot of antidepressants out there, and they fall into a lot of different categories of drugs.

For an overview, see: Antidepressants: Personalization Is Key! ← which also covers why antidepressants seem to work a lot better for some people than for others

Consequently, because “antidepressants” is really an umbrella term for a lot of different drugs working in a lot of different ways, each of which may or may not help one specific person with their (or your!) specific kind of depression, there are numerous possible outcomes from taking antidepressants, including:

  • nothing discernible happens
  • nothing discernible happens, which is a crushing emotional blow as the person had been really counting on this working, so now they feel even more hopeless and wretched
  • depression lifted, but an excess of one or more neurotransmitters in the brain (from having been boosted by the antidepressants) is now causing a different problem, such as anxiety
  • depression slightly lifted, which means that a person who was previously feeling suicidal but unmotivated to do anything, is now capable of doing things, and thus more likely to act on the urge
  • depression gone and no new problems (yay)

There are also other less obviously brain-related potential side effects, with weight gain being a common one for many antidepressants, but

  • it’s usually not severe
  • it can also be a matter of regaining healthy weight that one lost unhealthily while depressed

For more on that, see: How Much Weight Gain Do Antidepressants Cause?

Back to the potential outcomes of increased suicidality, depression, or anxiety:

With regard to suicidal ideation and thus potential suicidality, in this writer’s experience: key is understanding suicide prevention methods, and consciously choosing to employ them for oneself.

We wrote about that, here: How To Stay Alive (When You Really Don’t Want To)

Perhaps most importantly in this case: understand in advance that you might feel that way, and understand that it’s because depression lies to you, and that you have decided to defy that, live anyway, and come out the other side into depression-free life.

With regard to increased depression: chances are it was just the wrong antidepressant for you. If it’s not working out for you after a few weeks, you might want to consider rolling the dice again on a different class of antidepressant, or else trying a different (i.e. non-medicated) approach. See also: The Mental Health First-Aid That You’ll Hopefully Never Need ← this is about depression-management strategies, whether in yourself or a loved one

With regard to increased anxiety: assuming that your meds indeed eased your depression, while giving you anxiety, then only you can decide for yourself whether that’s worth it. If you are open to the use of Cognitive Behavioral Therapy, then that has much higher success rates with anxiety than depression—because it’s a lot easier to flowchart one’s way through “maybe they didn’t reply to my text because they’re busy, and not because I’m a contemptible idiot and they hate me”, than it is flowchart one’s way out of feeling nothing and feeling like doing nothing. See also: Radical CBT Tools To Try

One tool with a good record against both depression and anxiety is Behavioral Activation, so check out: Behavioral Activation Against Depression & Anxiety

Last but not least….

Here are some traps to not fall into:

5 Self-Care Trends That Are Actually Ruining Your Mental Health

Take care!

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  • Red Cabbage vs Cauliflower – Which is Healthier?

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    Our Verdict

    When comparing red cabbage to cauliflower, we picked the cabbage.

    Why?

    In terms of macros, there’s no meaningful difference between them; they’re both mostly water with just enough fiber to hold them together, a small amount of carbs, and an even more trivial amount of protein. So, a tie on macros.

    Looking at the vitamins, red cabbage has more of vitamins A, B1, B2, B6, C, E, and K, while cauliflower has more of vitamins B3, B5, B9, and choline. So, a 7:4 win for red cabbage.

    In the category of minerals, red cabbage has more calcium, manganese, and iron, while cauliflower has more copper, phosphorus, and potassium. The margins of difference are comparable too, thus, a 3:3 tie on minerals.

    It’s always worth taking a look at polyphenols for plants like these, but in this case, once again, there’s not much to set one above the other. However, it’s good to note also that despite them both being Brassica oleracea (same species, different cultivar), there isn’t much overlap in their polyphenol content, meaning they complement each other very well. In particular, red cabbage is a source of luteolin and quercetin, while cauliflower is a source of gallic acid and caffeic acid, for example.

    Adding up the three ties and the one win for red cabbage, gives the cabbage the victory today—but do enjoy either or both; diversity is good!

    Want to learn more?

    You might like to read:

    21 Most Beneficial Polyphenols & What Foods Have Them

    Enjoy!

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  • Play Bold – by Magnus Penker

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    This book is very different to what you might expect, from the title.

    We often see: “play bold, believe in yourself, the universe rewards action” etc… Instead, this one is more: “play bold, pay attention to the data, use these metrics, learn from what these businesses did and what their results were”, etc.

    We often see: “here’s an anecdote about a historical figure and/or celebrity who made a tremendous bluff and it worked out well so you should too” etc… Instead, this one is more: “see how what we think of as safety is actually anything but! And how by embracing change quickly (or ideally: proactively), we can stay ahead of disaster that may otherwise hit us”.

    Penker’s background is also relevant here. He has decades of experience, having “launched 10 start-ups and acquired, turned around, and sold over 30 SMEs all over Europe”. Importantly, he’s also “still in the game”… So, unlike many authors whose last experience in the industry was in the 1970s and who wonder why people aren’t reaping the same rewards today!

    Penker is the therefore opposite of many who advocate to “play bold” but simply mean “fail fast, fail often”… While quietly relying on their family’s capital and privilege to leave a trail of financial destruction behind them, and simultaneously gloating about their imagined business expertise.

    In short: boldness does not equate to foolhardiness, and foolhardiness does not equate to boldness.

    As for telling the difference? Well, for that we recommend reading the book—It’s a highly instructive one.

    Take The First Bold Step Of Checking Out This Book On Amazon!

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  • Anti-Aging Myths This Dermatologist Wants You To Stop Believing

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dermatologist Dr. Sam Ellis lays all bare:

    Bare-faced lies?

    Obviously, we are hearing from a dermatologist here, so the focus is on skin aging specifically. We may well also not want to age our brain, joints, etc, but that’s not what this one is about.

    So, without further ado, here are the myths she wants to bust:

    • “Medical grade skincare”: the term “medical grade” is a marketing term and does not indicate superior efficacy or better ingredients.
    • “Expensive skincare is more effective”: price does not always correlate with effectiveness; some high-end products justify their cost, but many do not.
    • “More products = better results”: using too many products can reduce effectiveness and cause irritation; a simple routine with sunscreen and a retinoid is key.
    • “Drink more water for better skin”: if you’re dehydrated, then yes, hydrate—but drinking excessive water does not improve skin appearance beyond normal hydration levels.
    • “You don’t need anti-aging products until you see signs of aging”: starting skincare early, especially sun protection, helps maintain youthful skin longer.
    • “Wrinkles are the first signs of aging”: hyperpigmentation and sagging are often more significant early indicators of aging than wrinkles.
    • “Skincare is all you need for anti-aging”: by “skincare” here she means creams, lotions, tonics, etc, and recommends other treatments such as laser treatment and even Botox*.
    • “Non-prescription retinoids are a waste of time”: over-the-counter retinoids like retinol and retinal can still be effective alternatives to prescription retinoids.
    • “You must use retinoids every night”: retinoids are effective even when used a few times per week, depending on individual tolerance.

    *We’re not convinced about the Botox; we’ll have to do a deep-dive research review one of these days!

    For more on each of these, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Retinoids: Retinol vs Retinal vs Retinoic Acid vs..?

    Take care!

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  • The Fiber Fueled Cookbook – by Dr. Will Bulsiewicz

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve previously reviewed Dr. Bulsiewicz’s book “Fiber Fuelled” (which is great), but this one is more than just a cookbook with the previous book in mind. Indeed, this is even a great stand-alone book by itself, since it explains the core principles well enough already, and then adds to it.

    It’s also about a lot more than just “please eat more fiber”, though. It looks at FODMAPs, purine, histamine intolerance, celiac disease, altered gallbladder function, acid reflux, and more.

    He offers a five-part strategy:

    Genesis (what is the etiology of your problem)

    1. Restrict (cut things out to address that first)
    2. Observe (keep a food/symptom diary)
    3. Work things back in (re-add potential triggers one by one, see how it goes)
    4. Train your gut (your microbiome does not exist in a vacuum, and communication is two-way)
    5. Holistic healing (beyond the gut itself, looking at other relevant factors and aiming for synergistic support)

    As for the recipes themselves, there are more than a hundred of them and they are good, so no more “how can I possibly cook [favorite dish] without [removed ingredient]?”

    Bottom line: if you’d like better gut health, this book is a top-tier option for fixing existing complaints, and enjoying plain-sailing henceforth.

    Click here to check out The Fiber Fueled Cookbook; your gut will thank you later!

    Don’t Forget…

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    Learn to Age Gracefully

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  • The Aesthetic Brain – by Dr. Anjan Chatterjee

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Anjan Chatterjee (not to be mistaken for Dr. Rangan Chatterjee, whose books we have also sometimes reviewed before) is a neurologist.

    A lot about aesthetics is easy enough to understand. We like physical features in humans that suggest a healthy mate, and we like lush and/or colorful plants that reassure us that we will have plenty to eat.

    But what about a beautiful building, or a charcoal drawing of some captivatingly eldritch horror? And what, neurologically speaking, is the difference between a bowl of fruit and a painting of a bowl of fruit? And what, if anything, does appreciation of such do for us?

    In this very readable pop-science book, we learn about these things and many more, from the perspective of an experienced neurologist who explains things simply but with plenty of science.

    Bottom line: if you’d like to understand how and why your brain does more things than just process tasks necessary for survival, this book will give you plenty of insight.

    Click here to check out The Aesthetic Brain, and learn more about yours!

    Don’t Forget…

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  • How Effective Is THC Against Chronic Pain?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    No question/request too big or small 😎

    ❝Does cannabis have painkilling properties comparable to opiods or is it just a matter of being high and not thinking about the pain?❞

    Short answer: no

    More useful answer: of course, it’s not really an either/or question—but neither are generally considered to be the case, no.

    We say “generally considered”, because the illegality of cannabis in the US for a long time really hampered science, so there’s a lot of research that’s just being done now for the first time, when in an ideal world we’d be a good number of decades further along now. That’s not to say there was no research in the interim; there was, but…

    • When the substance is illegal, there is a lot less funding to research its properties (since companies can’t sell it)
    • When the substance is illegal and public campaigns are saying it’s dangerous, it’s a lot harder to do big trials with large sample sizes (fewer volunteers, harder to get media to run ads)

    Even now, to get large sample sizes it’s necessary to look at larger reviews of smaller trials, to get the numbers together. Take this one for example:

    ❝25 short-term (1 to 6 months) randomized controlled trials (n = 2303; 64% neuropathic pain) assessed cannabinoids. Oral synthetic/purified high THC-to-CBD (THC only) may slightly reduce and oromucosal, extracted, comparable THC-to-CBD ratio products probably slightly reduce pain severity (pooled differences, −0.78 and −0.54 points, respectively, [0 to 10 scale]), with moderate or large increased dizziness, sedation, and nausea. Among THC-only products, nabilone moderately reduced pain severity but dronabinol did not (pooled differences, −1.59 and −0.23 points, respectively). Low THC-to-CBD interventions may not improve outcomes.❞

    Read in full: Cannabis-Based Products for Chronic Pain: An Updated Systematic Review

    Translating some of that from sciencese:

    • Neuropathic pain is a good one for research, because since the problem is with the nerves themselves, there isn’t also a different causal problem to confound the data
    • High THC ratio products “may slightly reduce pain severity” or “probably slightly reduce pain severity” depending on means of administration.
      • That’s very unimpressive
    • High THC ratio products do, however, offer “moderate or large increased dizziness, sedation, and nausea”
      • That’s not great either
    • Low THC ratio prducts “may not improve outcomes”
      • That is hardly a claim at all
    • THC-only prodcuts may or may not moderately reduce pain severity. Only nabilone achieved this, out of the products they tested.
      • That may arguably be the most worthwhile piece of information to come out of this 2,303-person systematic review

    Is it worth it?

    The science is not exactly a rave review, is it? But the fact is, many people do swear by it. And ultimately, if it works for you, it works for you.

    So, whether or not it’s worth it is a personal, subjective decision for several reasons:

    1. It may work better or worse for you than for the average person.
    2. You may experience more of fewer adverse side effects than the average person.
    3. You may experience those adverse side effects more or less strongly than the average person.
    4. Pain impairs function. THC also impairs function. Only you can decide which function(s) you’d rather have impaired.
    5. You may or may not have other options available, compared to the average person.

    We can offer health information here, but not health advice. Not just for legal reasons, but also because we don’t know your individual circumstances.

    What we can do is say: consider the options, assess the risks, and get what support you can.

    For unravelling some popular confusions with regard to the risks, do see: Cannabis Myths vs Reality

    And for CBD-only considerations: CBD Oil: What Does The Science Say?

    Want to learn more?

    If you’re looking for alternatives, we’ve written quite a bit about pain management, including:

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails: