GLP-1 Drugs vs Arthritis?

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First introduced as a diabetes medication, GLP-1 drugs quickly took hold for off-label use as weight loss aids, even when the science was still very young.

Here’s one of our first articles on that, back in the day: Semaglutide’s Surprisingly Big Research Gap

As for that popularity? Check out: 1 in 5 US Women Aged 50–64 Has Used GLP-1 RAs: What We’ve Learned

Spoiler, one of the things we’ve learned is: Most People Who Start GLP-1 RAs Quit Them Within A Year (Here’s Why)

One of the main things in their favor is, of course, that (for most people, anyway), they work (except when they don’t: Why Intermittent Fasting (& GLP-1 Drugs!) Might Not Work For You).

In other words, a rocky road with pros and cons. But today, let’s talk about a newly-identified benefit…

Arthritis relief beyond weight loss

It has previously been assumed that GLP-1 drugs help vs arthritis because of weight loss—by the simple mechanism that if you have less weight, then less weight will be stressing your knee joints, for example (knee osteoarthritis being perhaps the most well-studied form of arthritis).

However! Researchers (Dr. Amalie Dyrelund Broksø et al.) detected very small amounts of the hormone GLP-1 in the joint fluid of people with inflammatory arthritis, including rheumatoid arthritis and spondyloarthritis, suggesting that high-dose GLP-1 drugs directly reduce inflammation inside joints.

In particular, GLP-1 levels in joint fluid closely mirrored GLP-1 levels in the bloodstream, suggesting that increasing circulating GLP-1 with medication will indeed also increase how much reaches arthritic joints (something that wouldn’t otherwise be a given).

Nevertheless, while this much is established, what’s not yet tested (and thus not yet proven) is that this apparent cause and effect is indeed cause and effect, and not just a case of a correlation being caused by some third thing:

❝Our findings provide a biological basis for investigating whether GLP-1-based medication may have direct effects in the joints — beyond the known effects on weight and metabolism. However, we have not demonstrated that the treatment works against arthritis. This will require a number of clinical studies❞

~ Dr. Tue Wenzel Kragstrup, one of the researchers involved in this study

The good news, of course, is that if future trials confirm the effect, GLP-1 drugs could then offer a “double benefit” for many arthritis patients by both promoting weight loss and directly reducing inflammation in joints.

You can find this paper itself, here: Detection of GLP-1 and DPP-4 in synovial fluid: implications for therapeutical strategies in arthritis

If you’d like to enjoy at least the anti-inflammatory effects without GLP-1 drugs, then do check out:

And for arthritis care in general, consider:

Want to learn more?

You might also like this book that we reviewed a little while back:

Magic Pill: The Extraordinary Benefits and Disturbing Risks of the New Weight-Loss Drugs – by Johann Hari

Take care!

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  • Brave – by Dr. Margie Warrell

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    Whether it’s the courage to jump out of a plane or the courage to have a difficult conversation, bravery is an important quality that we often don’t go far out of our way to grow. At least, not as adults.

    Rather than viewing bravery as a static attribute—you either have it or you don’t—psychologist Dr. Margie Warrell makes the case for its potential for lifelong development.

    The book is divided into five sections:

    1. Live purposefully
    2. Speak bravely
    3. Work passionately
    4. Dig deep
    5. Dare boldly

    …and each has approximately 10 chapters, each a few pages long, the kind that can easily make this a “chapter-a-day” daily reader.

    As a quick clarification: that “speak bravely” section isn’t about public speaking, but is rather about speaking up when it counts. Life is too short for regrets, and our interactions with others tend to be what matters most in the long-run. It makes a huge difference to our life!

    Dr. Warrell gives us tools to reframe our challenges and tackle them. Rather than just saying “Feel the fear and do it anyway”, she also delivers the how, in all aspects. This is one of the main values the book brings, as well as a sometimes-needed reminder of how and why being brave is something to which we should always aspire… and hold.

    Bottom line: if you’d like to be more brave—in any context—this book can help. We only get one life; might as well live it.

    Click here to check out Brave and give your life a boost!

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  • Sweet Potato vs Pumpkin – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing sweet potato to pumpkin, we picked the sweet potato.

    Why?

    In terms of macros, sweet potato has a lot more fiber, carbs, and protein, winning easily in this category.

    In the category of vitamins, sweet potato has more of vitamins A, B1, B2, B3, B5, B6, B7, C, and K, while pumpkin has (slightly) more of vitamins B9 and E, yielding to sweet potato an 8:2 victory here.

    Looking at minerals next, sweet potato has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, while pumpkin is not higher in any minerals—an open-and-shut case in favor of sweet potato.

    Adding up the sections makes for an overall win for sweet potato, but by all means enjoy either or both, as diversity is good!

    Want to learn more?

    You might like:

    Carb-Strong or Carb-Wrong? Should You Go Light Or Heavy On Carbs?

    Enjoy!

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  • 3 Things Everyone Over 50 Must Do Daily for Healthy Feet

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Will Harlow, the over-50s specialist physio, wants you to be on a good footing:

    Daily steps in the right direction

    The three daily exercises recommended in the video are:

    Exercise 1: Towel Scrunch

    The towel scrunch exercise strengthens the flexor muscles in the feet, improving balance and improving contact with the ground. To do this exercise, sit on a chair with a towel placed on the floor beneath your toes while keeping your heels on the ground. Use only your toes to pull the towel toward your heel, scrunching it up as much as possible. This movement strengthens the arch of the foot and can help alleviate symptoms of flat feet. For best results, practice this exercise for 2–3 minutes once or twice daily. Once you’ve got the hand of doing it sitting, do it while standing.

    Exercise 2: Big Toe Extension

    Big toe extension is an essential exercise for maintaining foot mobility and improving walking kinesthetics by preventing stiffness in the big toe. To do this exercise, keep your foot flat on the floor and try to lift only your big toe while keeping the four other toes firmly pressed down. To be clear, we mean under its own power; not using your hands to help. Many people find this difficult initially, but it’s due to a loss of neural connection rather than muscle strength, so with practice, the ability to isolate the movement improves quite quickly. Perform 10 repetitions in a row, three times per day, for optimal benefits. Once you’ve got the hand of doing it sitting, do it while standing.

    Exercise 3: Calf Stretch

    The calf stretch is an important exercise for maintaining foot health by preventing tight calves, which can contribute to issues like plantar fasciitis and Morton’s neuroma. To do this stretch, place your hands against a wall for support and extend one leg straight behind you while keeping your other heel firmly on the floor. The front knee should be bent while the back leg remains straight, creating a stretch in the calf. Hold this position for 30 seconds (building up to that, if necessary). Since the effectiveness of stretching comes from frequency rather than duration, this stretch should be performed three to four times per day for the best results.

    For more on each of these, plus visual demonstrations, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Steps For Keeping Your Feet A Healthy Foundation ← this one’s about general habits, not exercises

    Take care!

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  • 10 Tips for Better Sleep: Starting In The Morning

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Siobhan Deshauer advises:

    Checklist

    You’ll probably have heard similar advice before (including from us), but it’s always good to do a quick rundown and check which ones you are actually doing, as opposed to merely know you should be doing:

    • Wake up at the same time every day, including weekends, to maintain a consistent sleep schedule and avoid “social jet lag.”
    • Expose yourself to bright light in the morning, either sunlight or light therapy, to regulate your circadian rhythm and melatonin production.
    • Avoid caffeine late in the day to maintain natural sleep pressure, experimenting with a cutoff time based on your sensitivity (e.g. 6–10 hours before bedtime)*.
    • Limit naps to under 30 minutes and take them early in the afternoon to avoid disrupting sleep pressure.
    • Exercise regularly but avoid strenuous activity 2 hours before bed. Optimal exercise time is 4–6 hours before bedtime.
    • Avoid alcohol, as it disrupts sleep quality and may worsen conditions like sleep apnea. If drinking, have your last drink early in the evening—but honestly, it’s better to not drink at all.
    • Establish a wind-down routine 1–2 hours before bed, including dimming lights and engaging in relaxing activities to signal your body to prepare for sleep.
    • Keep your bedroom cool (below 68°F/20°C) and ensure your hands and feet stay warm to aid in natural body temperature regulation.
    • Limit device use before bed. If unavoidable, reduce blue light exposure and avoid mentally stimulating content. Set boundaries, such as placing your phone out of reach.
    • Ensure complete darkness in your sleeping environment using blackout curtains, covering light-emitting devices, or wearing a sleep mask.

    *we imagine she picked 6–10 hours because, depending on whether you have the fast or slow caffeine metabolizer gene, the biological halflife of caffeine in your body will be around 4 or 8 hours (that’s not a range, that’s two distinct and non-overlapping options). However, if we use 4 or 8 hours depending on which gene version we have, then that will mean that 4 or 8 hours later, respectively, we’ll have half the caffeine in us that we did 4 or 8 hours ago (that’s what a halflife means). So for example if you had a double espresso that number of hours before bedtime, then congratulations, you have the caffeine of a single espresso in your body by bedtime. Which, for most people**, is not an ideal nightcap. Hence, adding on a few more hours. Again, earlier is better though, so consider limiting caffeine to the morning only.

    **we say “most people”, because if you have ADHD or a similar condition, your brain’s relationship with caffeine is a bit different, and—paradoxically—stimulants can help you to relax. Do speak with your doctor though, as individual cases vary widely, and it also may make a difference depending on what relevant meds (if any) you’re on, too.

    For more on all of those things, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Take care!

    Don’t Forget…

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  • Mango vs Plum – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing mangos to plums, we picked the mangos.

    Why?

    In terms of macros, mangos have more fiber and carbs for the same (minimal) protein, scoring a first-round win as the “most food per food” option here.

    In the category of vitamins, mangos have a lot more of vitamins A, B2, B3, B5, B9, B7, B9, C, and E, while plums have a little more vitamin K, so that’s an easy 9:1 win for mangos.

    Looking at minerals, mangos have more calcium, copper, magnesium, manganese, potassium, and selenium, while plums have more iron, phosphorus, and zinc, yielding a 6:3 win for mangos here.

    In other considerations, plums do have some anticancer properties that aren’t known of mangos (beyond “fruit is generally a good food to eat vs cancer”), so that is a point in their favor.

    Still, adding up the sections makes for a clear overall win for mangos, but by all means do enjoy either or both, as diversity is best!

    Want to learn more?

    You might like:

    Top 8 Fruits That Prevent & Kill Cancer

    Enjoy!

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  • Shedding Some Obesity Myths

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Let’s shed some obesity myths!

    There are a lot of myths and misconceptions surrounding obesity… And then there are also reactive opposite myths and misconceptions, which can sometimes be just as harmful!

    To tackle them all would take a book, but in classic 10almonds style, we’re going to put a spotlight on some of the ones that might make the biggest difference:

    True or False: Obesity is genetically pre-determined

    False… With caveats.

    Some interesting results have been found from twin studies and adoption studies, showing that genes definitely play some role, but lifestyle is—for most people—the biggest factor:

    In short: genes predispose; they don’t predetermine. But that predisposition alone can make quite a big difference, if it in turn leads to different lifestyle factors.

    But upon seeing those papers centering BMI, let’s consider…

    True or False: BMI is a good, accurate measure of health in the context of bodyweight

    False… Unless you’re a very large group of thin white men of moderate height, which was the demographic the system was built around.

    Bonus information: it was never intended to be used to measure the weight-related health of any individual (not even an individual thin white man of moderate height), but rather, as a tool to look at large-scale demographic trends.

    Basically, as a system, it’s being used in a way it was never made for, and the results of that misappropriation of an epidemiological tool for individual health are predictably unhelpful.

    To do a deep-dive into all the flaws of the BMI system, which are many, we’d need to devote a whole main feature just to that.

    Update: we have now done so!

    Here it is: When BMI Doesn’t Measure Up

    True or False: Obesity does not meaningfully impact more general health

    False… In more ways than one (but there are caveats)

    Obesity is highly correlated with increased risk of all-cause mortality, and weight loss, correspondingly, correlates with a reduced risk. See for example:

    Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis

    So what are the caveats?

    Let’s put it this way: owning a horse is highly correlated with increased healthy longevity. And while owning a horse may come with some exercise and relaxation (both of which are good for the health), it’s probably mostly not the horse itself that conveys the health benefits… it’s that someone who has the resources to look after a horse, probably has the resources to look after their own health too.

    So sometimes there can be a reason for a correlation (it’s not a coincidence!) but the causative factor is partially (or in some cases, entirely) something else.

    So how could this play out with obesity?

    There’s a lot of discrimination in healthcare settings, unfortunately! In this case, it often happens that a thin person goes in with a medical problem and gets treated for that, while a fat person can go in with the same medical problem and be told “you should try losing some weight”.

    Top tip if this happens to you… Ask: “what would you advise/prescribe to a thin person with my same symptoms?”

    Other things may be more systemic, for example:

    When a thin person goes to get their blood pressure taken, and that goes smoothly, while a fat person goes to get their blood pressure taken, and there’s not a blood pressure cuff to fit them, is the problem the size of the person or the size of the cuff? It all depends on perspective, in a world built around thin people.

    That’s a trivial-seeming example, but the same principle has far-reaching (and harmful) implications in healthcare in general, e.g:

    • Surgeons being untrained (and/or unwilling) to operate on fat people
    • Getting a one-size-fits-all dose that was calculated using average weight, and now doesn’t work
    • MRI machines are famously claustrophobia-inducing for thin people; now try not fitting in it in the first place

    …and so forth. So oftentimes, obesity will be correlated with a poor healthcare outcome, where the problem is not actually the obesity itself, but rather the system having been set up with thin people in mind.

    It would be like saying “Having O- blood type results in higher risks when receiving blood transfusions”, while omitting to add “…because we didn’t stock O- blood”.

    True or False: to reduce obesity, just eat less and move more!

    False… Mostly.

    Moving more is almost always good for most people. When it comes to diet, quality is much more important than quantity. But these factors alone are only part of the picture!

    But beyond diet and exercise, there are many other implicated factors in weight gain, weight maintenance, and weight loss, including but not limited to:

    • Disrupted sleep
    • Chronic stress
    • Chronic pain
    • Hormonal imbalances
    • Physical disabilities that preclude a lot of exercise
    • Mental health issues that add (and compound) extra levels of challenge
    • Medications that throw all kinds of spanners into the works with their side effects

    …and even just those first two things, diet and exercise, are not always so correlated to weight as one might think—studies have found that the difference for exercise especially is often marginal:

    Read: Widespread misconceptions about obesity ← academic article in the Journal of the College of Family Physicians of Canada

    Don’t Forget…

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