Most People Who Start GLP-1 RAs Quit Them Within A Year (Here’s Why)
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Specifically, 54% quit within one year, with that number rising to 72% within two years.
We first wrote about GLP-1 receptor agonists (i.e. semaglutide drugs like Ozempic and Wegovy) a couple of years ago when popularity was just beginning to take off:
However, as we had room only to touch briefly on the side effects and what happens when you stop taking it, you might also want to check out:
What happens when I stop taking a drug like Ozempic or Mounjaro?
…and:
Notwithstanding all this information, there’s a lot of science that has still yet to be done. If you’re a regular 10almonds reader, you’ll be familiar with our research review articles—this one was more of a non-research review, i.e. looking at the great absence of evidence in certain areas, and the many cases of research simply not asking the right questions, for example:
❝Of the four studies that actually looked at the macros (unlike most studies), they found that on average, protein intake decreased by 17.1%. Which is a big deal!
It’s an especially big deal, because while protein’s obviously important for everyone, it’s especially important for anyone trying to lose weight, because muscle mass is a major factor in metabolic base rate—which in turn is much important for fat loss/maintenance than exercise, when it comes to how many calories we burn by simply existing.
A reasonable hypothesis, therefore, is that one of the numerous reasons people who quit GLP-1 agonists immediately put fat back on, is because they probably lost muscle mass in amongst their weight loss, meaning that their metabolic base rate will have decreased, meaning that they end up more disposed to put on fat than before.❞
Read in full: Semaglutide’s Surprisingly Unexamined Effects ← there are a lot more (equally concerning) items discussed in this article
Why people quit GLP-1 RAs
There was a large (n=125,474) study of US adults. The average age was about 54 years, and about 65% were female.
From the total data pool (i.e. not narrowing it down by demographic), 54% stopped within a year, and 72% within two years.
The factors most associated with discontinuation were:
- age above 65 years
- not having type 2 diabetes
The main reasons given for discontinuation were:
- High costs: self-explanatory, but it’s worth noting that people who stopped for this reason were more likely to restart later.
- Adverse side effects: the most common ones were nausea, vomiting, diarrhea, constipation, stomach pain, and loss of appetite. Rarer, but more seriously, side effects included: pancreatitis (severe abdominal pain, nausea, vomiting), gallbladder issues (gallstones, cholecystitis), kidney problems, severe allergic reactions (rash, swelling, difficulty breathing), hypoglycemia, especially if taken with insulin or other diabetes medications, changes in vision (worsening diabetic retinopathy), and an increased heart rate.
- Disappointingly little weight loss: the researchers noted that GLP-1 RA results are “heterogenous”, meaning, they differ a lot. For those for whom it didn’t work, quitting was more likely, for obvious reasons. See also: 10 Mistakes To Sabotage Your Ozempic Progress
- Successful weight loss: while it is widely known that if one stops taking GLP-1 RAs, weight regain is the usual next thing to happen, there are a lot of people who go onto GLP-1 RAs with the rationale “I’ll just use this to lose the weight, and then I’ll keep the weight off with my diet and lifestyle”. Which sounds reasonable, but because of the specific mechanisms of actions of GLP-1 RAs, it simply doesn’t work that way (and, as we mentioned above, there are reasons that you may, after stopping taking GLP-1 RAs, be more disposed to put weight on than you were before you started). So, by the best of current science (which admittedly is not amazing when it comes to this topic), it does seem that taking GLP-1 RAs is a lifetime commitment.
You can read the study itself here:
Want to get similar results, without GLP-1 RAs?
Then check out:
5 Ways To Naturally Boost The “Ozempic Effect” ← this is about natural ways of doing similar hormone-hacking to what GLP-1 RAs do
and
Ozempic vs Five Natural Supplements ← this is about metabolism-tweaking supplements
and
Hack Your Hunger ← this is about appetite management
Take care!
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The Natural Facelift – by Sophie Perry
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First, what this book isn’t: it’s mostly not about beauty, and it’s certainly not about ageist ideals of “hiding” aging.
The author herself discusses the privilege that is aging (not everyone gets to do it) and the importance of taking thankful pride in our lived-in bodies.
The title and blurb belie the contents of the book rather. Doubtlessly the publisher felt that extrinsic beauty would sell better than intrinsic wellbeing. As for what it’s actually more about…
Ever splashed your face in cold water to feel better? This book’s about revitalising the complex array of facial muscles (there are anatomical diagrams) and the often-tired and very diverse tissues that cover them, complete with the array of nerve endings very close to your CNS (not to mention the vagus nerve running just behind your jaw), and some of the most important blood vessels of your body, serving your brain.
With all that in mind, this book, full of useful therapeutic techniques, is a very, very far cry from “massage like this and you’ll look like you got photoshopped”.
The style varies, as some parts of explanation of principles, or anatomy, and others are hands-on (literally) guides to the exercises, but it is all very clear and easy to understand/follow.
Bottom line: aspects of conventional beauty may be a side-effect of applying the invigorating exercises described in this book. The real beauty is—literally—more than skin-deep.
Click here to check out The Natural Facelift, and order yours!
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Zucchini & Oatmeal Koftas
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These vegetarian (and with one tweak, vegan) koftas are delicious as a snack, light lunch, or side to a larger meal. Healthwise, they contain the healthiest kind of fiber, as well as omega-3 fatty acids, and beneficial herbs and spices.
You will need
- ¼ cup oatmeal
- 1 large zucchini, grated
- 1 small carrot, grated
- ¼ cup cheese (your preference; vegan is also fine)
- 2 tbsp ground flaxseed
- 2 tbsp nutritional yeast
- ¼ bulb garlic, minced
- 2 tsp black pepper, coarse ground
- ½ tsp MSG or 1 tsp low-sodium salt
- Small handful fresh parsley, chopped
- Extra virgin olive oil, for frying
Method
(we suggest you read everything at least once before doing anything)
1) Soak the flaxseed in 2 oz hot water for at least 5 minutes
2) Combine all of the ingredients except the olive oil (and including the water that the flax has been soaking in) in a big bowl, mixing thoroughly
3) Shape into small balls, patties, or sausage shapes, and fry until the color is golden and the structural integrity is good. If doing patties, you’ll need to gently flip them to cook both sides; otherwise, rolling them to get all sides is fine.
4) Serve! Traditional is with some kind of yogurt dip, but we’re not the boss of you, so enjoy them how you like:
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- The Best Kind Of Fiber For Overall Health? ← it’s β-glucan, as found in oats
- What Omega-3 Fatty Acids Really Do For Us ← as in the flax
- The Many Health Benefits Of Garlic
- Black Pepper’s Impressive Anti-Cancer Arsenal (And More)
- Monosodium Glutamate: Sinless Flavor-Enhancer Or Terrible Health Risk? ← it’s healthier than table salt
Take care!
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Dyslexia Test
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(and it’s mostly not about reading/writing!)
More than just shuffled letters
This video provides a self-test based on the Bangor Dyslexia Test (BDT). The BDT is 94% accurate in identifying dyslexia, and it includes 9 parts, with a mix of questions and tasks. Answering “yes” or struggling with tasks indicates possible dyslexia. Collecting 4+ indicators suggests dyslexia, but of course is not a replacement for official diagnosis.
It’s best to watch the video if you can, but here’s what to expect:
- Left-Right confusion: point your left hand to your right/left shoulder.
- Family history: any family members with dyslexia or struggles with reading/writing?
- Repeating numbers (order): repeat a given sequence of numbers in order.
- Letter confusion (e.g. b/d): do you confuse letters like “b” and “d” beyond age 8?
- Times tables: recite the 6, 7, and 8 times tables.
- Word manipulation: replace the letters in a word to create a new word, e.g. change “slide” (s ⇾ g) to “glide.”
- Repeating numbers (reversed): repeat a given sequence of numbers in reverse order.
- Months in reverse: recite the months of the year in reverse order.
- Subtraction: do you struggle with subtraction, e.g. 44-9 or 55-12?
Writer’s anecdote: I am not dyslexic, and/but I have an impressive level of dyscalculia (the purely numerical equivalent), to the point I’ll sometimes use a calculator to do single-digit calculations, and I am so bad at calculating ages or other differences between dates (I will have to count on my fingers or else run the severe risk of out-by-one errors). I have also been known to make mistakes counting down from 10, which really ruins dramatic tension.
In contrast, the left-right thing is interesting, because when I was first learning Arabic, I had no trouble reading/writing right-to-left, but I initially struggled so much to remember which way the “backspace” key would take me (in Arabic the backspace key backspaces to the right, despite still pointing to the left).
Anyway, for the test itself, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Reading, Better (Reading As A Cognitive Exercise)
Take care!
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Omega-3 Mushroom Spaghetti
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The omega-3 is not the only healthy fat in here; we’re also going to have medium-chain triglycerides, as well as monounsaturates. Add in the ergothioneine from the mushrooms and a stack of polyphenols from, well, most of the ingredients, not to mention the fiber, and this comes together as a very healthy dish. There’s also about 64g protein in the entire recipe, so you do the math for how much that is per serving, depending on how big you want the servings to be.
You will need
- 1lb wholewheat spaghetti (or gluten-free equivalent, such as a legume-based pasta, if avoiding gluten/wheat)
- 12oz mushrooms, sliced (any non-poisonous edible variety)
- ½ cup coconut milk
- ½ onion, finely chopped
- ¼ cup chia seeds
- ¼ bulb garlic, minced (or more, if you like)
- 2 tbsp extra virgin olive oil
- 1 tbsp black pepper, coarse ground
- 1 tbsp lime juice
Method
(we suggest you read everything at least once before doing anything)
1) Cook the spaghetti according to packet instructions, or your own good sense, aiming for al dente. When it’s done, drain it, and lastly rinse it (with cold water), and set it aside.
2) Heat the olive oil in a skillet and add the onion, cooking for 5 minutes
3) Add the garlic, mushrooms, and black pepper, cooking for another 8 minutes.
4) Add the coconut milk, lime juice, and chia seeds, stirring well and cooking for a further two minutes
5) Reheat the spaghetti by passing boiling water through it in a colander (the time it spent cold was good for it; it lowered the glycemic index)
6) Serve, adding the mushroom sauce to the spaghetti:
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- The Magic of Mushrooms: “The Longevity Vitamin” (That’s Not A Vitamin)
- The Many Health Benefits of Garlic
- Black Pepper’s Impressive Anti-Cancer Arsenal (And More)
- If You’re Not Taking Chia, You’re Missing Out
Take care!
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Fiber Fueled – by Dr. Will Bulsiewicz
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
We generally know that for gut health we should eat fiber, but what of the balances of different sorts of fiber?
That’s one of the main things that make this book stand out—fostering diversity in our microbiome by fostering diversity in our diet. Specifically, diversity of fiber-containing foods.
The book is part “science made easy for the lay reader”, and part recipe book. The recipes come with shopping lists and a meal planner, though we would recommend to use those as a guide rather than to try to adhere perfectly to them.
In particular, this reviewer would encourage much more generous use of healthful seasonings… and less reliance on there being leftovers several days later (tasty food gets gone quickly in this house!)
As for the science, the feel of this is more like reading a science-based observational documentary with explanations, than of reading a science textbook. Studies are mentioned in passing, but not dissected in any detail, and the focus is more on getting the key learnings across.
Bottom line: if you’d like to boost not just the amount, but also the diversity, of fiber in your diet, and reap the gut-health rewards, this book is a great guide for that!
Click here to get your copy of “Fiber Fueled” from Amazon today!
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The Real Reason Your Metabolism Slows After 50 (And How To Fix It)
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
It’s not just about menopause:
The other factors
Researchers (cited in the video) found that menopause itself didn’t significantly reduce metabolic rate in the women studied; instead, differences in metabolism are mainly explained by differences in fat-free mass, which is largely muscle mass.
Note: the basal metabolic rate (BMR) is the energy your body uses at rest for essential functions like breathing, circulation, and organ function; if BMR falls while calorie intake stays the same, excess energy is more likely to be stored as fat.
The study, at a glance:
- Design: the researchers compared 21 premenopausal, 21 perimenopausal, and 21 postmenopausal women with stable body weight, low exercise levels, no medications including HRT, and BMIs between 18.5 and 35.
- Metrics: the study assessed body composition with DEXA scans, activity levels with wearable tracking devices, and metabolism through respiratory quotient measurements taken at rest and after a standardized 500-calorie meal.
- Results: there were no significant differences between the groups in calories burned at rest, calories burned after eating, or whether the body preferentially burned carbohydrates or fat.
However! Those women with more fat-free mass burned more calories both at rest and after meals, suggesting muscle mass was far more important than menopausal status in determining metabolic rate.
Aside from the obvious “exercise for muscle mass”, two important things that often get missed are:
- getting the right amount of protein spread over the course of the day (don’t cram it all into one meal; your body can’t use more than 20–30g at a time anyway)
- getting good sleep; in particular, deep sleep was highlighted as important for muscle repair and growth, making menopause-related sleep disruption another indirect factor affecting body composition
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
The Diet That Reduces Postmenopausal Weight Gain, Hot Flashes, & More
Take care!
Don’t Forget…
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Learn to Age Gracefully
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