
Exercising With Less Soreness!
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An Ancient Sports Drink & Healing Potion, Now With Modern Science?
Ginseng has many health benefits, we talked about 8 of them in this previous edition of 10almonds:
โฆbut weโve somehow never yet done a Mondayโs Research Review for it! We must do one, one of these days. For now though, itโs Saturdayโs Life Hacks, and weโre here withโฆ
Speeding up recovery after muscle damage
We talked about this topic before too:
Overdone It? How To Speed Up Recovery After Exercise
โฆwhich gives very good advice (including some supplements that help), but was published before the latest science that weโre going to talk about today:
A team of researchers all so very recently found that ginseng also reduces muscular fatigue and, importantly, hastens recovery of muscle damage caused by exercise.
And thatโs not allโฆ
โIt should also be noted that, by reducing fatigue, taking ginseng on a regular basis may also help reduce the risk of injury, particularly in the case of muscles or ligaments, which can in turn improve athletic performance.โ
This means that it can be taken regularly and prophylactically, as they found:
โtaking ginseng systematically for a long time can mitigate the response of the biological markers, mainly creatine kinase (CK) and interleukin 6 (IL-6), responsible for exercise-induced muscle damage and inflammation.โ
You may be thinking โisnโt creatine good?โ and yes, yes it is:
Creatine: Very Different For Young & Old People
โฆhowever, creatine kinase is not creatine. Creatine kinase (CK) is an enzyme that affects the creatine (to put it in few words, without getting into the fascinating biochemistry of this). Now, itโs necessary for us to have some CK (or else we wouldnโt be able to do what we need to with the creatine), but elevated levels often indicate some sort of problem going on:
Approach to asymptomatic creatine kinase elevation
โฆso ginseng keeping those things balanced is a good thing.
The study
Weโve talked a lot about the findings and what they mean, but if youโd like to read the paper for yourself, you can read it here:
Effect of Ginseng Intake on Muscle Damage Induced by Exercise in Healthy Adults
Where to get ginseng
If youโd like to take ginseng as a supplement, then there are many ways to do so, with the most common being capsules or ginseng tea, which has an interesting and distinctive taste, and is very refreshing. Here are examples on Amazon, for your convenience:
Enjoy!
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Gut-Healthy Tacos
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Full of prebiotics and probiotics, healthy fats, colorful salad boasting vitamins and minerals aplenty, and of course satisfying protein too, these tacos are also boasting generous flavors to keep you coming back for more…
You will need
- 24 sardinesโcanned is fine (if vegetarian/vegan, substitute tempeh and season generously; marinade if you have time)
- 12 small wholewheat tortillas
- 1 14oz/400g can black beans, drained
- 1 ripe avocado, stoned and cut into small chunks
- 1 red onion, thinly sliced
- 1 little gem lettuce, shredded
- 12 cherry tomatoes, halved
- 1 bulb garlic, crushed
- 1 lemon, sliced
- 4 tbsp plain unsweetened yogurt (your choice what kind, but something with a live culture is best)
- 3oz pickled jalapeรฑos, roughly chopped
- 1oz cilantro (or substitute parsley if you have the cilantro-tastes-like-soap gene), finely chopped
- 1 tbsp extra virgin olive oil
- 2 tsp black pepper
- 1 tsp smoked paprika
- Juice of 1 lime
- Optional: Tabasco sauce, or similar hot sauce
Method
(we suggest you read everything at least once before doing anything)
1) Preheat your oven to a low temperature; 200โ or just under 100โ is fine
2) Place the lemon slices on top of the sardines on top of foil on a baking tray; you want the foil to be twice as much as you’d expect to need, because now you’re going to fold it over and make a sort of sealed envelope. You could use a dish with a lid yes, but this way is better because there’s going to be less air inside. Upturn the edges of the envelope slightly so that juices won’t run out, and make sure the foil is imperfectly sealed so a little steam can escape but not much at a time. This will ensure it doesn’t dry out, while also ensuring your house doesn’t smell of fish. Put all this into the oven on a middle shelf.
3) Mix the lime juice with the onion in a bowl, and add the avocado and tomatoes, mixing gently. Add half the cilantro, and set aside.
4) Put the black beans in a sieve and pour boiling water over them to refresh and slightly warm them. Tip them into a bowl and add the olive oil, black pepper, and paprika. Mix thoroughly with a fork, and no need to be gentle this time; in fact, deliberately break the beans a little in this case.
5) Mix the yogurt, jalapeรฑos, garlic, and remaining cilantro in a small bowl.
6) Get the warmed sardines from the oven; discard the lemon slices.
7) Assemble! We recommend the order: tortilla, lettuce, fish (2 per taco), black bean mixture, salad mixture, garlic jalapeรฑo yogurt mixture. You can also add a splash of the hot sauce per your preference, or if catering for more people, let people add their own.
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- We Are Such Stuff As Fish Are Made Of
- Level-Up Your Fiber Intake! (Without Difficulty Or Discomfort)
- Making Friends With Your Gut (You Can Thank Us Later)
- Our Top 5 Spices: How Much Is Enough For Benefits?
- Enjoy Pungent Polyphenols For Your Heart & Brain
Take care!
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Do women really need more sleep than men? A sleep psychologist explains
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If you spend any time in the wellness corners of TikTok or Instagram, youโll see claims women need one to two hours more sleep than men.
But what does the research actually say? And how does this relate to whatโs going on in real life?
As weโll see, who gets to sleep, and for how long, is a complex mix of biology, psychology and societal expectations. It also depends on how you measure sleep.
klebercordeiro/Getty What does the evidence say?
Researchers usually measure sleep in two ways:
- by asking people how much they sleep (known as self-reporting). But people are surprisingly inaccurate at estimating how much sleep they get
- using objective tools, such as research-grade, wearable sleep trackers or the gold-standard polysomnography, which records brain waves, breathing and movement while you sleep during a sleep study in a lab or clinic.
Looking at the objective data, well-conducted studies usually show women sleep about 20 minutes more than men.
One global study of nearly 70,000 people who wore wearable sleep trackers found a consistent, small difference between men and women across age groups. For example, the sleep difference between men and women aged 40โ44 was about 23โ29 minutes.
Another large study using polysomnography found women slept about 19 minutes longer than men. In this study, women also spent more time in deep sleep: about 23% of the night compared to about 14% for men. The study also found only menโs quality of sleep declined with age.
The key caveat to these findings is that our individual sleep needs vary considerably. Women may sleep slightly more on average, just as they are slightly shorter on average. But there is no one-size-fits-all sleep duration, just as there is no universal height.
Suggesting every woman needs 20 extra minutes (let alone two hours) misses the point. Itโs the same as insisting all women should be shorter than all men.
Even though women tend to sleep a little longer and deeper, they consistently report poorer sleep quality. Theyโre also about 40% more likely to be diagnosed with insomnia.
This mismatch between lab findings and the real world is a well-known puzzle in sleep research, and there are many reasons for it.
For instance, many research studies donโt consider mental health problems, medications, alcohol use and hormonal fluctuations. This filters out the very factors that shape sleep in the real world.
This mismatch between the lab and the bedroom also reminds us sleep doesnโt happen in a vacuum. Womenโs sleep is shaped by a complex mix of biological, psychological and social factors, and this complexity is hard to capture in individual studies.
Letโs start with biology
Sleep problems begin to diverge between the sexes around puberty. They spike again during pregnancy, after birth and during perimenopause.
Fluctuating levels of ovarian hormones, particularly oestrogen and progesterone, seem to explain some of these sex differences in sleep.
For example, many girls and women report poorer sleep during the premenstrual phase just before their periods, when oestrogen and progesterone begin to fall.
Perhaps the most well-documented hormonal influence on our sleep is the decline in oestrogen during perimenopause. This is linked to increased sleep disturbances, particularly waking at 3am and struggling to get back to sleep.
Some health conditions also play a part in womenโs sleep health. Thyroid disorders and iron deficiency, for instance, are more common in women and are closely linked to fatigue and disrupted sleep.
How about psychology?
Women are at much higher risk of depression, anxiety and trauma-related disorders. These very often accompany sleep problems and fatigue. Cognitive patterns, such as worry and rumination, are also more common in women and known to affect sleep.
Women are also prescribed antidepressants more often than men, and these medications tend to affect sleep.
Society also plays a role
Caregiving and emotional labour still fall disproportionately on women. Government data released this year suggests Australian women perform an average nine more hours of unpaid care and work each week than men.
While many women manage to put enough time aside for sleep, their opportunities for daytime rest are often scarce. This puts a lot of pressure on sleep to deliver all the restoration women need.
In my work with patients, we often untangle the threads woven into their experience of fatigue. While poor sleep is the obvious culprit, fatigue can also signal something deeper, such as underlying health issues, emotional strain, or too-high expectations of themselves. Sleep is certainly part of the picture, but itโs rarely the whole story.
For instance, rates of iron deficiency (which we know is more common in women and linked to sleep problems) are also higher in the reproductive years. This is just as many women are raising children and grappling with the โjuggleโ and the โmental loadโ.
Women in perimenopause are often navigating full-time work, teenagers, ageing parents and 3am hot flashes. These women may have adequate or even high-quality sleep (according to objective measures), but that doesnโt mean they wake feeling restored.
Most existing research also ignores gender-diverse populations. This limits our understanding of how sleep is shaped not just by biology, but by things such as identity and social context.
So where does this leave us?
While women sleep longer and better in the lab, they face more barriers to feeling rested in everyday life.
So, do women need more sleep than men? On average, yes, a little. But more importantly, women need more support and opportunity to recharge and recover across the day, and at night.
Amelia Scott, Honorary Affiliate and Clinical Psychologist at the Woolcock Institute of Medical Research, and Macquarie University Research Fellow, Macquarie University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Why Keto Fat Loss Doesnโt Work So Well For Women
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We’ve written before about the ketogenic diet:
Ketogenic Diet: Burning Fat Or Burning Out?
…and the answer to the question posed by that title is “both”:
- the one thing that it is generally considered good for (aside from managing refractory epilepsy in children, which is what the diet was originally designed for) is fat loss
- however, this comes at the cost of cumulative health issues, mostly for the heart, which risks thus become more dangerous over time, for example:
โAs obesity rates in the populace keep rising, dietary fads such as the ketogenic diet are gaining traction.
Although they could help with weight loss, this study had a notable observation of severe hypercholesterolemia and increased risk of atherosclerotic cardiovascular disease among the ketogenic diet participants.โ
~ Dr. Shadan Khdher et al.
…although there are other problems too, for example: Is Losing Weight Worth Losing Your Kidney: Keto Diet Resulting in Renal Failure
Nevertheless, let’s take a look at that fat loss for which so many people turn to keto:
Ketogenic diet and sex differences
Like most health science for anything outside of “the bikini zone” (i.e. places covered by a bikini), most research into the ketogenic diet has not taken sex differences into account, and has typically looked at either male participants, or participants of any sex and/but without those sex differences being looked at.
However, “most” is not “all”, and a team of researchers (Dr. Yingying Jiao et al.) did examine those sex differences.
She and her team found that over the same period of time, men lost 11.63% of body weight vs 8.95% for women on identical ketogenic diet protocols.
Grabbing a calculator (100(11.63-8.95)/11.63), we see that that means 23% less weight loss for women.
You can read the paper in full, here: Sex differences in ketogenic diet: are men more likely than women to lose weight?
As to why, it comes down to several factors, but first, let’s do a quick recap of how the ketogenic diet works for fat loss: it’s an extremely low-carb, moderate-protein, high-fat diet that mimics fasting. In response to this, the body shifts from using glucose for energy to using ketones. This promotes fat breakdown, reduces appetite, and maintains blood glucose levels as it goes.
Now, let’s look at the process piece by piece.
In terms of hormone signalling:
- estrogen conserves fat breakdown via ฮฑ-adrenergic receptors
- testosterone accelerates fat breakdown by increasing ฮฒ-adrenergic receptors
In terms of metabolic energy use:
- estrogen promotes the storage fatty acids as triglycerides and use of carbs as energy
- testosterone promotes the oxidization of fatty acids for energy and store carbs
In terms of where body fat is stored (and thus how easy it is for the body to get at it):
- estrogen promotes the storage of fat subcutaneously (harder to mobilize)
- testosterone promotes the storage of fat viscerally (easier to burn)
In short, everything estrogen does in this regard improves our endurance and helps us survive famine.
Which, on an evolutionary level, is fabulous. However, when it comes to trying to use fasting (or, as in the case of keto, a fast-mimicking diet) to lose weight, then it isn’t so helpful.
Our body is just too well-prepared for it and responds to the “famine” (extremely low-carb diet) by going “don’t worry, we’ve got this!” and carefully rationing our body fat to ensure we can survive the winter.
You may be wondering: if all this is about estrogen vs testosterone, then does untreated menopause (and thus much lower estrogen levels) change this?
And the answer is: yes, it does, albeit not completely, because testosterone levels will still not be so high as in men. Thus, in the category of fat loss, the ketogenic diet:
- works well for men,
- works moderately well for women in untreated menopause, and
- works least well for premenopausal women and women on HRT.
(This is all discussed in the above-linked paper too, by the way)
On that latter note (the menopause etc), it’s also worth bearing in mind that an extra concern that typically comes with the menopause anyway, is further compounded in the case of conforming to a ketogenic diet, because even in the short term, keto already increases osteoporosis risk:
โMarkers of bone modeling/remodeling were impaired after short-term low-carbohydrate high-fat diet, and only one marker of resorption recovered after acute carbohydrate restorationโ
~ Dr. Ida Heikura et al.
A Short-Term Ketogenic Diet Impairs Markers of Bone Health in Response to Exercise
If you, dear reader, are a woman and perhaps of a certain age, and all this has prompted you to wonder what dietary balance (especially: ratio of energy from fat to energy from carbs) might be better for you, then this is quite personalizable, so check out:
What Macronutrient Balance Is Right For You?
Want to lose weight, but not on keto?
We’ve got you covered:
How To Lose Weight (Healthily!)
Want to learn more?
For more on sex differences in nutrition (and exercise), with a focus on what’s best with female physiology, you might like this very good book that we reviewed recently:
Enjoy!
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The Teenage Brain โ by Dr. Frances Jensen
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We realize that we probably have more grandparents of teenagers than parents of teenagers here, but most of us have at least some teenage relative(s). Which makes this book interesting.
There are a lot of myths about the teenage brain, and a lot of popular assumptions that usually have some basis in fact but are often misleading.
Dr. Jensen gives us a strong foundational grounding in the neurophysiology of adolescence, from the obvious-but-often-unclear (such as the role of hormones) to less-known things like the teenage brain’s general lack of myelination. Not just “heightened neuroplasticity” but, if you imagine the brain as an electrical machine, then think of myelin as the insulation between the wires. Little wonder some wires may get crossed sometimes!
She also talks about such things as the teenage circadian rhythm’s innate differences, the impact of success and failure on the brain, and harder topics such as addictionโand the adolescent cortisol functions that can lead to teenagers needing to seek something to relax in the first place.
In criticism, we can only say that sometimes the author makes sweeping generalizations without acknowledging such, but that doesn’t detract from what she has to say on the topic of neurophysiology.
Bottom line: if there’s a teenager in your life whose behavior and/or moods are sometimes baffling to you, and whose mysteries you’d like to unravel, this is a great book.
Click here to check out the Teenage Brain, and better understand those around you!
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How To Walk Away From Alzheimer’s
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We have written before avoiding Alzheimer’s in many different ways, for example:
Alzheimerโs Causative Factors To Avoid
…and regular readers will also be aware of our dictum “what’s good for the heart, is good for the brain”, which is because the heart feeds the brain, with oxygen and nutrients, and also ultimately clears away detritus like beta-amyloid (associated with Alzheimerโs).
For much more detail on this, see: Whatโs Your Vascular Dementia Risk? โ includes actual numbers and a risk calculator tool and things like that
So, it’s no surprise of course that exercise is protective against dementia, and as per the above, typically the most important thing here is heart health, so getting regular cardiovascular exercise, such walking, running, or dancing is great. Cycling too. Things like that.
Beyond cardio
First, some background. A previous (2023) study concluded:
โAmong older adults, more time spent in sedentary behaviors was significantly associated with higher incidence of all-cause dementia. Future research is needed to determine whether the association between sedentary behavior and risk of dementia is causal.โ
Source: Sedentary Behavior and Incident Dementia Among Older Adults
We’re not going to go deeply into that paper, because our interest today is about the answer to that call of “future research is needed”, because a team of scientists have now delivered on that.
In terms of how recent this new research is, it was published today (at time of writing), in the Journal of the Alzheimer’s Association.
In it, Dr. Marissa Gogniat et al. examined the relationship between sedentary behavior and cognitive decline and neurodegeneration, in 404 adults aged 50+.
A note on “cognitive decline” and “neurodegeneration”: those two terms are often used interchangeably, because they are usually strongly associated with each other so if one goes up or down then so does the other, but technically:
- cognitive decline = a decline of cognitive abilities, as measured by cognitive performance tests
- neurodegeneration = physical degeneration of neural tissue, typically specifically in the brain, as measured by various physical markers of neurodegeneration (tests range from brain scans to blood markers to biopsies and more, but the point is that it’s all physical stuff)
While based on the one-line summary we gave (“examined the relationship between sedentary behavior and cognitive decline / neurodegeneration”), this can sound a bit like a “examined whether water is wet” study, but in fact it becomes interesting when physical exercise is controlled for, since they found:
โReducing your risk for Alzheimer’s disease is not just about working out once a day. Minimizing the time spent sitting, even if you do exercise daily, reduces the likelihood of developing Alzheimer’s disease.โ
~ Dr. Marissa Gogniat
Too vague? Here’s the less vague version:
โIn cross-sectional models, greater sedentary time related to a smaller AD-neuroimaging signature (ฮฒ = -0.0001, p = 0.01) and worse episodic memory (ฮฒ = -0.001, p = 0.003). Associations differed by APOE-ฮต4 status. In longitudinal models, greater sedentary time related to faster hippocampal volume reductions (ฮฒ = -0.1, p = 0.008) and declines in naming (ฮฒ = -0.001, p = 0.03) and processing speed (ฮฒ = -0.003, p = 0.02; ฮฒ = 0.01, p = 0.01).โ
In other words:
- Those are very significant findings, statistically speaking; the causal association cannot be reasonably denied without some strong new evidence for why
- Greater sedentary behavior is related to neurodegeneration and worse cognition.
- Sedentary behavior is an independent* risk factor for Alzheimer’s disease.
- Associations differed by APOE-ฮต4 carrier status in cross-sectional models.
*as in, the sedentary risk factor stands (so to speak) regardless of whether you exercise a lot
With regard to “Associations differed by APOE-ฮต4 carrier status in cross-sectional models.”, that’s a little complicated, as …
โInterestingly, we only found a sedentary time x APOE-ฮต4 status interaction on occipital volume longitudinally (which did not survive correction for multiple comparisons) and no interactions on cognition. The significant effect on occipital lobe volume was driven by APOE-ฮต4 non-carriers, which does not align with our cross-sectional findings. APOE-ฮต4 carriers are thought to have accelerated gray matter volume loss, starting possibly in middle age. Therefore, while increased sedentary time may impact gray matter volume among APOE-ฮต4 carriers, this effect may be masked by the cumulative effect of APOE-ฮต4 on brain volume over the lifespan that is captured at baseline.โ
In other words: in all likelihood, having the APOE-ฮต4 mutation probably means it’s extra important for you to not be sedentary in your lifestyle, and (good news) being non-sedentary is probably disproportionately impactful for you in a positive way, but (bad news) the APOE-ฮต4 mutation causes such an increased risk already, that it’s difficult to 100% ascertain that statistically, without larger samples starting earlier in life.
You can read the paper in full here:
“What if have to spend a lot of time sitting down?”
A valid question, relevant for many.
For this, check out:
Stand Up For Your Health (Or Donโt) โ our main feature on this also includes more things you can do if you must sit, to make sitting less bad!
Take care!
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Vitamin D2 vs Vitamin D3: What You Would Benefit From Knowing
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Itโs Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where weโve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future tooโthereโs always more to say!
As ever: if the question/request can be answered briefly, weโll do it here in our Q&A Thursday edition. If not, weโll make a main feature of it shortly afterwards!
So, no question/request too big or small ๐
โHi, is there any important difference between vitamin d2 and vitamin d3? Is one better than the other?โ
There is indeed! And one is better than the other!
Where they come from
You’ll find a lot of sources that will tell you “Vitamin D2 is from plants, D3 is from animals”, and in fact only the second half of that is true.
In nature, there are no plants that are known to produce vitamin D.
Vitamin D2, however, is produced by many fungi, as well as algae, neither of which are part of the Kingdom Plantae.
Vitamin D3, meanwhile, is produced by many animals (including humans).
When “the sun” is sometimes considered a source of vitamin D, that’s true only insofar as the sun is also a source of tomatoes, for example, which required the sun to grow. While we humans (and other animals) cannot photosynthesize in general, producing vitamin D is something we can do if exposed to UV light (such as from the sun).
However, of course exposure to UV light (such as from the sun) comes with other problems, so… Should we get sun exposure or not?
We weighed up the balance of evidence, here: The Sun Exposure Dilemma
If, like this writer, you are a mostly crepuscular being who avoids the sun, we have good news: mushrooms can do the sunbathing for us!
โExposing mushrooms to UV (from sunlight or in a laboratory) increases the amount of vitamin D in mushrooms by nearly eightfold. Putting five store-bought button mushrooms in the sun, or just one portobello mushroom, produces 24 ยตg of vitamin D, which translates to nearly 1000 international units, providing the amount of vitamin D one needs in an entire day, and the equivalent found in most vitamin D supplements.
If youโre wondering if the vitamin D from mushrooms actually makes it into your bloodstream, it does. A recent meta-analysis of randomized controlled trials showed that tanned (UV-exposed) mushrooms may be effective in increasing active vitamin D levels in adults with low levels of vitamin D, and studies (randomised controlled trials) have shown that it may be just as effective as supplements at increasing vitamin D levels in the blood (here, and here).
Some research is very positive, saying that putting your mushrooms in direct sunlight for 10โ15 minutes may provide you with 100% of your daily vitamin D needs, and the vitamin D content in sunlight-exposed mushrooms may be retained with refrigeration for up to 8 days.
The production of vitamin D may be increased by a further 30% by placing them in the sun with the underside, or gills, facing up, or by 60% if you slice them.โ
Read all about it: Tan your mushrooms, not your skin
Which is better?
In few words: D3 is better.
They both do the exact same job, but with D3, you simply get more bang-for-buck:
โThe WMD in change in total 25(OH)D based on 12 daily dosed vitamin D2-vitamin D3 comparisons, analyzed using liquid chromatography-tandem mass spectrometry, was 10.39 nmol/L (40%) lower for the vitamin D2 group compared with the vitamin D3 group.
Vitamin D3 leads to a greater increase of 25(OH)D than vitamin D2, even if limited to daily dose studies, but vitamin D2 and vitamin D3 had similar positive impacts on their corresponding 25(OH)D hydroxylated forms.โ
Note: “WMD” here means “weighted mean difference”, not “weapons of mass destruction”
About that “and importance of BMI”, by the way: in persons with a BMI >25, there was no longer a difference between the two forms. Literally, no difference at all; the difference was reduced to 0%.
Another study found similarly, but with different numbers (finding a greater difference), and without recording BMI as a factor:
โD3 is approximately 87% more potent in raising and maintaining serum 25(OH)D concentrations and produces 2- to 3-fold greater storage of vitamin D than does equimolar D2.โ
See the paper: Vitamin D3 Is More Potent Than Vitamin D2 in Humans
“Well that sucks, because I’m vegan”
Fear not, you can get vegan D3 too.
Much like “you can’t get vegan B12” (but you can; it’s made by yeast), there are vegan D3 supplements, made by lichen.
The trouble with lichen, when it comes to classifying it, it that itโs actually a hybrid colony of many small, strange things (beyond the scope of this article, but they are fascinating, so this writer is holding herself back by the scruff of the neck from explaining in detail), some of which are technically part of Kingdom Animalia, but it is hard to find even the most ardent vegan who will object to consuming bacteria, for example.
Want to try some?
We don’t sell it, but here for your convenience is an example product on Amazon ๐
But watch out with the doses, if supplementing vitamin D in either form, because…
Vit D + Calcium: Too Much Of A Good Thing? โ this also talks about safe and effective doses, and what goes wrong if you take too much
Take care!
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