Early Dementia Screening From Your Blood & More
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Dementia is, statistically speaking, the most feared disease in the US. Notwithstanding…
- heart disease killing more
- COVID being more of a lottery
- cancer being the “yes you can modify risk factors but it can come for anyone” life-changing (and often life-ending) disease,
…it’s still dementia that Americans report fearing the most.
And yet… Early dementia screening is seriously underused
It may be a case of a head-in-sand approach to avoid unwanted news, or it could be a case of not knowing what’s available.
So, with that in mind…
How to watch out: first line warning signs
You walk into a room of your house, and suddenly stop: “what did I come in here for?”, you wonder.
A moment later, you’re worrying whether this is a sign of age-related cognitive decline.
The good news: it usually isn’t. In fact, you did that when you were younger, too, you just didn’t pay enough attention at the time to remember it now.
Dementia-related memory loss is less “where did I put my car keys?”, and more “what is this thing for?” (it’s your car keys). Or at a less advanced stage: “whose are these car keys?” (they are yours).
You can read about some of the nuances here:
Is It Dementia? Spot The Signs (Because None Of Us Are Immune) ← If you’d like an objective test of memory and other cognitive impairments, this article also has a link to the industry’s gold standard test (it’s free)
(The Self-Administered Gerocognitive Exam (SAGE) is designed to detect early signs of cognitive, memory or thinking impairments)
Tests you can’t do at home
We wrote a little while back about how one kind of blood testing for Alzheimer’s disease works:
The Brain Alarm Signs That Warn Of Dementia
Why “Brain Alarm Signs” if it’s a blood test? Because the blood gets (in very lay terms) bits of broken brain in it. Or more specifically, they tested the blood for density of cerebrovascular endothelial extracellular vesicles (CEEVs), which are bits of the cells from the lining of blood vessels in the brain. These cerebrovascular endothelial extracellular vesicles should not, ideally, be falling off and riding around your bloodstream, and the greater the density of them, the greater likelihood of mild cognitive impairment now, and by extension, dementia later.
It’s not the only blood test available though, see:
Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid (CSF) tests ← this one checks the ratio of phosporylated-tau217 to non-phosphorylated tau (which is a protein antibody), which equalled or outperformed FDA-approved CSF tests in classifying amyloid-β positron emission topography (PET, as in a PET scan) status, with a confidence interval as high as, or better than, industry standards.
If you don’t like having your blood taken, trust us that you’d find having your cerebrospinal fluid taken even less enjoyable, so this is a very welcome improvement!
In case you’re curious about how the CSF test works, here you go: NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment ← NPTX2 is a protein biomarker of Alzheimer’s risk
…but again, we really think the blood test is preferable.
Tests beyond the physiological
There are, of course, psychological tests that can be done, including a linguistic analysis of your conversation, compared with a vast database of other people’s conversations, with and without various degrees of cognitive impairment
As Dr. Ioannis Paschalidis explains:
❝We wanted to predict what would happen in the next six years—and we found we can reasonably make that prediction with relatively good confidence and accuracy.
Rather than using acoustic features of speech, like enunciation or speed, the model is just pulling from the content of the interview—the words spoken, how they’re structured.
You can think of the score as the likelihood, the probability, that someone will remain stable or transition to dementia. It had significant predictive ability.
Digital is the new blood. You can collect it, analyze it for what is known today, store it, and reanalyze it for whatever new emerges tomorrow.❞
You can read the full paper here: Prediction of Alzheimer’s disease progression within 6 years using speech: A novel approach leveraging language models
See also: AI: The Doctor That Never Tires?
What if the news isn’t good?
While bad news is never welcome per se, it is preferable to not knowing, insofar as we can then take steps to manage the situation.
You may be wondering: what can be done that I wouldn’t already be doing to minimize my dementia risk in the first place?
And the answer is: yes, do continue those things of course, but there is more to do:
See: Beyond Guarding Against Dementia: When Age’s Brain-Changes Come Knocking
Take care!
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Chia Seeds vs Flax Seeds – Which is Healthier?
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Our Verdict
When comparing chia to flax, we picked the chia.
Why?
Both are great! And it’s certainly close. Both are good sources of protein, fiber, and healthy fats.
Flax seeds contain a little more fat (but it is healthy fat), while chia seeds contain a little more fiber.
They’re both good sources of vitamins and minerals, but chia seeds contain more. In particular, chia seeds have about twice as much calcium and selenium, and notably more iron and phosphorous—though flax seeds do have more potassium.
Of course the perfect solution is to enjoy both, but since for the purpose of this exercise we have to pick one, we’d say chia comes out on top—even if flax is not far behind.
Enjoy!
Learn more
For more on these, check out:
Take care!
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10 “Healthy” Foods That Are Often Worse Than You Think
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“This is healthy, it’s a…” is an easy mistake to make if one doesn’t read the labels. Here are 10 tricksters to watch out for in particular!
Don’t be fooled by healthy aesthetics on the packaging…
Notwithstanding appearances and in many cases reputations, these all merit extra attention:
- Yogurt: sweetened yogurts, especially “fruit at the bottom / in the corner” types, often have 15–30g of sugar per serving. Plain Greek yogurt is a better choice, offering 15–20g of protein with no added sugar. You can always add fresh fruits or spices like sweet cinnamon for flavor without added sugar.
- Oatmeal: prepackaged oatmeal can contain 12–15 grams of added sugar per serving, similar to a glazed donut. Additionally, finely milled oats (as in “instant” oatmeal) can cause blood sugar spikes by itself, due to the loss of fiber. Better is plain oats, and if you like, you can sweeten them naturally with sweet cinnamon and/or fresh fruit for a healthier breakfast.
- Sushi: while sushi contains nutritious fish, it often has too much white rice (and in the US, sushi rice is also often cooked with sugar to “improve” the taste and help cohesion) and sugary sauces. This makes many rolls much less healthy. So if fish (the sashimi component of sushi) is your thing, then focus on that, and minimize sugar intake for a more balanced meal.
- Baked beans: store-bought baked beans can have up to 25g of added sugar per cup, similar to soda. Better to opt for plain beans and prepare them at home so that nothing is in them except what you personally put there.
- Deli meats: deli meats are convenient but often are more processed than they look, containing preservatives linked to health risks. Fresh, unprocessed meats like chicken or turkey breast are healthier and can still be cost-effective when bought in bulk.
- Fruit juices: fruit juices lack fiber (meaning their own natural sugars also become harmful, with no fiber to slow them down) and often contain added sugars too. Eating whole fruits is a much better way to get fiber, nutrients, and controlled healthy sugar intake.
- Hazelnut spread: hazelnut spreads are usually 50% added sugar and contain unhealthy oils like palm oil. So, skip those, and enjoy natural nut butters for healthier fats and proteins.
- Granola: granola is often loaded with added sugars and preservatives, so watch out for those.
- Sports drinks: sports drinks, with 20–25g of added sugar per serving, are unnecessary and unhelpful (except, perhaps, in case of emergency for correcting diabetic hypoglycemia). Stick to water or electrolyte drinks—and even in the latter case, check the labels for added sugar and excessive sodium!
- Dark chocolate: dark chocolate with 80% or more cocoa has health benefits but still typically contains a lot of added sugar. Check labels carefully!
For more on each of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
From Apples to Bees, and High-Fructose Cs: Which Sugars Are Healthier, And Which Are Just The Same?
Take care!
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Building & Maintaining Mobility
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Building & Maintaining Mobility!
This is Juliet Starrett. She’s a CrossFit co-founder, and two-time white-water rafting world champion. Oh, and she won those after battling thyroid cancer. She’s now 50 years old, and still going strong, having put aside her career as a lawyer to focus on fitness. Specifically, mobility training.
The Ready State
Together with her husband Kelly, Starrett co-founded The Ready State, of which she’s CEO.
It used to be called “Mobility WOD” (the “WOD” stands for “workout of the day”) but they changed their name as other companies took up the use of the word “mobility”, something the fitness world hadn’t previously focussed on much, and “WOD”, which was also hardly copyrightable.
True to its origins, The Ready State continues to offer many resources for building and maintaining mobility.
Why the focus on mobility?
When was the last time you had to bench-press anything larger than a small child? Or squat more than your partner’s bodyweight? Or do a “farmer’s walk” with anything heavier than your groceries?
For most of us, unless our lifestyles are quite extreme, we don’t need ridiculous strength (fun as that may be).
You know what makes a huge difference to our quality of life though? Mobility.
Have you ever felt that moment of panic when you reach for something on a high shelf and your shoulder or back twinges (been there!)? Or worse, you actually hurt yourself and the next thing you know, you need help putting your socks on (been there, too!)?
And we say to ourselves “I’m not going to let that happen to me again”
But how? How do we keep our mobility strong?
First, know your weaknesses
Starrett is a big fan of mobility tests to pinpoint areas that need more work.
Most of her resources for this aren’t free, and we’re drawing heavily from her book here, so for your convenience, we’ll link to some third party sources for this:
- Timed Up and Go—start with this, before progressing to the next!
- Sit To Rise Test—not to be underestimated (this page also has excerpts from Starrett’s mobility book, by the way)
- Shoulders/Spine/Hips—7 quick tests; note any that you can’t do, or struggle with
Next, eliminate those weaknesses
Do mobility exercises in any weak areas, until they’re not weak:
Want to train the full body in one session?
Try out The Ready State’s 10-Minute Morning Mobility Routine
Want to learn more?
You might enjoy her book that we reviewed previously:
Built to Move: The Ten Essential Habits to Help You Move Freely and Live Fully
You might also enjoy The Ready State App, available for iOS and for Android:
The Ready State Virtual Mobility Coach
Enjoy!
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Wrong Arm Position = Wrong Measurement Of Blood Pressure
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This is especially important to know if you measure your own blood pressure at home.
Even if you don’t, it’s still good to know this as healthcare providers also can (and often will) do it wrong, especially if they are under time pressure (e.g. they need to get you out of their office and the next person in):
From the heart
Many things can change our blood pressure, and even gravity changes (considerably!) our blood pressure locally.
For example, even with good circulation, so long as we are in the Earth’s gravity under normal conditions (e.g. not skydiving, not riding a rollercoaster, etc), our blood pressure will always be higher below our heart, and lower above it, because gravity is pulling our blood downwards; this is also why if your circulation is not good, you may feel light-headed upon sitting up or standing up, as the bloodstream takes a moment to win a battle against gravity. This is also why blood rushes to your head if you are hanging upside down—increasing the local blood pressure in your head, which unlike your feet, isn’t used to it, so you feel it, and the effect may be visible from the outside, too.
When it comes to having your arm above or below your heart, the difference is less pronounced as it’s only a small change, but that small change can make a big difference:
- If the cuff is above heart level → Lower blood pressure reading.
- If the cuff is below heart level → Higher blood pressure reading.
- Every 1-inch difference causes a 2 mmHg change in readings.
For the reading to be accurate, the blood pressure cuff therefore needs to be at the same height as your heart.
You may be thinking: “my heart is bigger than an inch; do I aim for the middle?”
And the answer is: ideally the cuff should be at the same height as the right atrium of the heart, which is under the midpoint of the sternum.
However, your arm needs to be supported at that height, because if you have to keep it there using your own power, that will mean a tensing of your muscles, and increase in both heart rate and blood pressure. In fact, studies cited in the video found:
- Unsupported arm, in healthy patients → Systolic +8 mmHg, Diastolic +7 mmHg.
- Unsupported arm, in high blood pressure patients → Systolic +23 mmHg, Diastolic +10 mmHg.
Some other considerations; firstly, correct sitting posture:
- Sit upright with back support
- Feet flat on the floor, legs uncrossed
- Arm should be outward from the body and, as per the above explanation, supported (armrest, table, etc.)
And finally, you should be relaxed and at rest.
For example, your writer here is due for a regular checkup in a couple of weeks, and usually when I go there, I will have walked a couple of miles to get there, then bounced cheerfully up 6 flights of stairs. However, for this appointment, I will need to make sure to arrive early, so that I have time for my (so far as I know, happy and healthy) heart to return to its resting pulse and blood pressure.
Also, if you are anything like this writer, the blood pressure cuff activating is not a relaxing experience (and so invites a higher pulse and blood pressure), so it’s better to take three readings and then discard the first one, and record the average of the second two (I do it this way at home).
Similarly, if a medical environment in general is stressful for you, then taking two minutes to do a little mindfulness meditation, or even just breathing exercises, can be good.
For more on all of these, plus also comments on issues such as correct cuff size and tightness, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Common Hospital Blood Pressure Mistake (Don’t Let This Happen To You Or A Loved One)
Take care!
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How To Keep On Keeping On?
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How To Keep On Keeping On… Long Term!
For many when it comes to health-related goals and practices, it’s easy to find ourselves in a bit of a motivational dip around this time of year. The enthusiasm of new year’s resolutions has been and gone, and there’s not yet much of a drive to “get a beach body” or “be summer-ready”.
A word to the wise on those before moving on, though:
- How to get a beach body: take your body to a beach. Voilà. Beach body.
- Remember: the beach is there for your pleasure and entertainment, not the other way around!
- How to be summer-ready: the real question is, will summer be ready for you?
But what is this, demotivational rhetoric to discourage you from getting fit and healthy?
Not at all, but rather, to be sure that you’re pursuing your own goals and not just what you feel might be expected of you.
All that in mind, let’s get to the tips…
Focus on adding health
It can be tempting (and even, good) to cut down on unhealthy things. But when it comes to motivation, it’s harder to stay motivated for deprivation, than it is for some healthy addition to life.
So for example, this philosophy would advocate for:
- Instead of counting calories, count steps! Or even…
- Instead of counting calories, count colors! Eat the rainbow and all that. No, skittles do not count, but eating a variety of naturally different-colored foods will tend to result in adding different nutrients to your diet.
- Instead of cutting out sugar, add fruit! How many per day will you go for? If you don’t eat much fruit as it is, consider making it a goal to have even just one piece of fruit a day, then build up from there. Find fruit you like! If you pick the fruit you want instead of the fruit you think you “should” have, it’s basically a dessert snack.
We’ve recommended it before, and we’ll recommend it again, but if you’re interested in “adding health”, you should definitely check out:
Dr. Greger’s Daily Dozen (checklist, plus app if you want it)
More details: it’s a checklist of 12 things you should try to include in your diet, with a free streak-tracking app, if you want it, all based on the same scientific research as the best-selling book “How Not To Die”.
“Minimum effort!”
Did you see the movie “Deadpool”? The protagonist has a catch-phrase as he goes into battle, saying to himself “Maximum effort!”.
And, that’s all very well and good if your superpower is immediate recovery from pretty much anything, but for the rest of us, sometimes it’s good to hold ourselves to “minimum effort!”.
Sometimes, something worth doing is worth doing just a little a bit. It’s always better than nothing! Even if feels like you gained nothing from it, it’s the foundation of a habit, and the habit will grow and add up. Sometimes it may even take you by surprise…
Don’t feel like doing 20 bodyweight squats? Do literally just one. Make a deal with yourself: do just one, then you can stop if you like. Then after you’ve done one, you might think to yourself “huh, that wasn’t so bad”, and you try out a few more. Maybe after 5 you can feel your blood pumping a bit and you think “you know what, that’s enough for now”, and great, you did 5x as much exercise as you planned! Wonder what you’ll do tomorrow!
(personal note from your writer here: I’ve managed to “just extend this exercise a little bit more than last time” my way into hour-long exercise sessions before now; I started with “just 10 squats” or “just one sun salutation” etc, to get myself out of a no-exercise period that I’d slipped into, and it’s amazing how quickly adding just a little bit to the previous day’s “minimum effort!” adds up to a very respectable daily exercise session)
Wondering what a good, easy, respectable short term goal could be?
Check Out, For Example: The Seven-Minute Workout
(You might have heard of this one before; it’s an incredibly efficient well-optimized short complete workout that requires no special equipment, just a bit of floorspace and a wall—the above app allows for customizations of it per your preferences, but the basic routine is an excellent starting point for most people)
Commit to yourself (and do any self-negotiation up-front)
Really commit, though. No “or I will look silly because I told people I’d do it”, no “or I will donate x amount to charity” etc, just “I will do it and that’s that”. If you find yourself second-guessing yourself or renegotiating with yourself, just shut that down immediately and refuse to consider it.
Note: you should have break-clauses in this contract with yourself, though. For example, “unless I am ill or injured” is a sensible rule to have in advance for most exercise regimes that weren’t undertaken with your illness or injury in mind.
Make a “To-Don’t” list
Much like how addicts are often advised to not try to quit more than one thing at once, we must also be mindful of not taking on too much at once. It can be very tempting to think:
“I will turn my life around, now! I’ll quit alcohol and animal products and sugar and refined grains, and I’ll go for a run each morning, and I’ll do this and that and there, I’ve got it, here is the blueprint for my healthy perfect life from this day forth!”
And, it’s great to have any and all of that as your end goal if you want, but please, pick one or two things at most to start with, focus on those, and when those have become second nature to you and just a normal part of your life, then choose the next thing to work on.
(You can plan out the whole thing in advance if you want! i.e., I’ll do this, then this, then this, but just… make sure that you’ve really got each one down to a matter of comfort and ease before you take up the next one)
In summary:
- Focus on adding health, whatever that looks like to you
- Figure out what “minimum effort!” is for you, and let that be your baseline
- Commit to yourself (and do any self-negotiation up-front, not later)
- Decide what you’re not going to do yet, and stick to that, too.
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- How to get a beach body: take your body to a beach. Voilà. Beach body.
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An Underrated Tool Against Alzheimer’s
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Dementia in general, and Alzheimer’s in particular, affects a lot of people, and probably even more than the stats show, because some (estimated to be: about half) will go undiagnosed and thus unreported:
Alzheimer’s: The Bad News And The Good
At 10almonds, we often talk about brain health, whether from a nutrition standpoint or other lifestyle factors. For nutrition, by the way, check out:
Today we’ll be looking at some new science for an underrated tool:
Bilingualism as protective factor
It’s well-known that bilingualism offers brain benefits, but most people would be hard-pressed to name what, specifically, those brain benefits are.
As doctors Kristina Coulter and Natalie Phillips found in a recent study, one of the measurable benefits may be a defense against generalized (i.e. not necessarily language-related) memory loss Alzheimer’s disease.
Specifically,
❝We used surface-based morphometry methods to measure cortical thickness and volume of language-related and AD-related brain regions. We did not observe evidence of brain reserve in language-related regions.
However, reduced hippocampal volume was observed for monolingual, but not bilingual, older adults with AD. Thus, bilingualism is hypothesized to contribute to reserve in the form of brain maintenance in the context of AD.❞
Read in full: Bilinguals show evidence of brain maintenance in Alzheimer’s disease
This is important, because while language is processed in various parts of the brain beyond the scope of this article, the hippocampi* are where memory is stored.
*usually mentioned in the singular as “hippocampus”, but you have one on each side, unless some terrible accident or incident befell you.
What this means in practical terms: these results suggest that being bilingual means we will retain more of our capacity for memory, even if we get Alzheimer’s disease, than people who are monolingual.
Furthermore, while we’re talking practicality:
❝…our subsample may be characterized as mostly late bilinguals (i.e., learning an L2 after age 5), having moderate self-reported L2 ability, and relatively few participants reporting daily L2 use (33 out of 119)❞
(L2 = second language)
This is important, because it means you don’t have to have grown up speaking multiple languages, you don’t even have to speak it well, and you don’t have to be using your second language(s) on a daily basis, to enjoy benefits. Merely having them in your head appears to be sufficient to trigger the brain to go “oh, we need to boost and maintain the hippocampal volume”.
We would hypothesize that using second language(s) regularly and/or speaking second language(s) well offers additional protection, and the data would support this if it weren’t for the fact that the sample sizes for daily and high-level speakers are a bit small to draw conclusions.
But the important part is: simply knowing another language, including if you literally just learned it later in life, is already protective of hippocampal volume in the context of Alzheimer’s disease.
Here’s a pop-science article about the study, that goes into it in more detail than we have room to here:
Bilingualism linked to greater brain resilience in older adults
Want to learn a new language?
Here are some options where you can get going right away:
If you are thinking “sounds good, but learning a language is too much work”, then that is why we included that third option there. It’s specifically for one language, and that language is Esperanto, arguably the world’s easiest language and specifically designed to be super quick and easy to get good at. Also, it’s free!
Do, kial ne lerni novan lingvon rapide kaj facile? 😉
Want to know more?
For ways to reduce your overall Alzheimer’s risk according to science, check out:
Take care!
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