It’s often said that our skin is our largest organ. Our brain or liver are the largest solid organs by mass (which one comes out on top will vary from person to person), our gut is the longest, and our lungs are the largest by surface area. But our skin is large, noticeable, and has a big impact on the rest of our health.

The sun is one of the main damaging factors for our skin; assorted toxins are also a major threat for many people, and once the skin barrier gets broken, it’s a field-day for bacteria.

So, what can we do about it?

Tretinoin: the skin’s rejuvenator

Tretinoin is also called retinoic acid, not to be mistaken for retinol, although they are both retinoids. Tretinoin is much stronger.

As for what it’s stronger at:

It’s usually prescribed for the treatment of sun-damage, acne, and wrinkles. Paradoxically, it works by inflaming the skin (and then making it better, and having done so, keeping it better).

In few words: it encourages your skin to speed up its life cycle, which means that cells die and are replaced sooner, which means the average age of skin cells will be considerably younger at any given time.

This is the same principle as we see at work when it comes to cellular apoptosis and autophagy in general, and specifically the same idea as we discussed when talking about senolytics, compounds that kill aging cells:

Fisetin: The Anti-Aging Assassin

About that paradoxical inflammation…

❝The topical use of tretinoin as an antiacne agent began almost a half century ago. Since that time it has been successfully used to treat comedonal and inflammatory acne.

Over the intervening years, the beneficial effects of tretinoin have grown from an understanding of its potent cornedolytie-related properties to an evolving appreciation of its antiinflammatory actions.

…

The topical use of clindamycin and tretinoin as a combination treatment modality that includes antibacterial, comedolytic, and antiinflammatoiy properties has proven to be a very effective therapy for treating the various stages of acne

…

It is now becoming increasingly clear that there may be good reasons for these observations.❞

~ Drs. Schmidt & Gans, lightly edited here for brevity

Read in full: Tretinoin: A Review of Its Anti-inflammatory Properties in the Treatment of Acne

Against damage by the sun

The older we get, the more likely sun damage is a problem than acne. And in the case of tretinoin,

❝In several well-controlled clinical trials, the proportion of patients showing improvement was significantly higher with 0.01 or 0.05% tretinoin cream than with placebo for criteria such as global assessment, fine and coarse wrinkling, pigmentation and roughness.

Improvements in the overall severity of photodamage were also significantly greater with tretinoin than with placebo.

…

Several placebo-controlled clinical studies have demonstrated that topical tretinoin has significant efficacy in the treatment of photodamaged skin. Improvements in subjective global assessment scores were recorded in:

49–100% of patients using once-daily 0.01% tretinoin,

68–100% of patients using 0.05% tretinoin, and

0–44% of patients using placebo.❞

~ Drs. Wagstaff & Noble

…which is quite compelling.

Read in full: Tretinoin: A Review of its Pharmacological Properties and Clinical Efficacy in the Topical Treatment of Photodamaged Skin

This is very well-established by now; here’s an old paper from when the mechanism of action was unknown (here in the current day, 17 mechanisms of action have been identified; beyond the scope of this article as we only have so much room, but it’s nice to see science building on science):

❝Tretinoin cream has been used extensively to reverse the changes of photoaging. It is the first topical therapy to undergo controlled clinical testing and proved to be efficacious. These results have been substantiated with photography, histopathologie examination, and skin surface replicas.

…

Tretinoin cream has an excellent safety record; a local cutaneous hypervitaminosis A reaction is the only common problem.❞

~ Dr. Goldfarb et al.

Read in full: Topical tretinoin therapy: Its use in photoaged skin

Is it safe?

For most people, when used as directed*, yes. However, it’s likely to irritate your skin at first, and that’s normal. If this persists more than a few weeks, or seems unduly severe, then you might want to stop and talk to your doctor again.

*See also: Scarring following inappropriate use of 0.05% tretinoin gel

(in the case of a young woman who used it 4x daily instead of 1x daily)

Want to try some?

Tretinoin is prescription-only, so speak with your doctor/pharmacist about that. Alternatively, retinal (not retinol) is the strongest natural alternative that works on the same principles; here’s an example product on Amazon 😎

Take care!

Resveratrol & Healthy Aging

Resveratrol is the compound found in red grapes, and thus in red wine, that have resulted in red wine being sometimes touted as a heart-healthy drink.

However, at the levels contained in red wine, you’d need to drink 100–1000 glasses of wine per day (depending on the wine) to get the dose of resveratrol that was associated with heart health benefits in mouse studies.

Which also means: if you are not a mouse, you might need to drink even more than that!

Further reading: can we drink to good health?

Resveratrol supplementation

Happily, resveratrol supplements exist. But what does resveratrol do?

It lowers blood pressure:

Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials

It improves blood lipid levels:

Consumption of resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial

It improves insulin sensitivity:

Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase

It has neuroprotective effects too:

Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides

Is it safe?

For most people, it is generally recognized as safe. However, if you are on blood-thinners or otherwise have a bleeding disorder, you might want to skip it:

Antiplatelet activity of synthetic and natural resveratrol in red wine

You also might want to check with your pharmacist/doctor, if you’re on blood pressure meds, anxiety meds, or immunosuppressants, as it can increase the amount of these drugs that will then stay in your system:

Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study

And as ever, of course, if unsure just check with your pharmacist/doctor, to be on the safe side.

Where to get it?

We don’t sell it, but here’s an example product on Amazon for your convenience

Enjoy!