See what other 10almonds subscribers are asking!
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It’s Q&A Day at 10almonds!
Q: I would be interested in learning more about collagen and especially collagen supplements/powders and of course if needed, what is the best collagen product to take. What is collagen? Why do we need to supplement the collagen in our body? Thank you PS love the information I am receiving in the news letters. Keep it up
We’re glad you’re enjoying them! Your request prompted us to do our recent Research Review Monday main feature on collagen supplementation—we hope it helped, and if you’ve any more specific (or other) question, go ahead and let us know! We love questions and requests
Q: Great article about the health risks of salt to organs other than the heart! Is pink Himalayan sea salt, the pink kind, healthier?
Thank you! And, no, sorry. Any salt that is sodium chloride has the exact same effect because it’s chemically the same substance, even if impurities (however pretty) make it look different.
If you want a lower-sodium salt, we recommend the kind that says “low sodium” or “reduced sodium” or similar. Check the ingredients, it’ll probably be sodium chloride cut with potassium chloride. Potassium chloride is not only not a source of sodium, but also, it’s a source of potassium, which (unlike sodium) most of us could stand to get a little more of.
For your convenience: here’s an example on Amazon!
Bonus: you can get a reduced sodium version of pink Himalayan salt too!
Q: Can you let us know about more studies that have been done on statins? Are they really worth taking?
That is a great question! We imagine it might have been our recent book recommendation that prompted it? It’s quite a broad question though, so we’ll do that as a main feature in the near future!
Q: Is MSG healthier than salt in terms of sodium content or is it the same or worse?
Great question, and for that matter, MSG itself is a great topic for another day. But your actual question, we can readily answer here and now:
- Firstly, by “salt” we’re assuming from context that you mean sodium chloride.
- Both salt and MSG do contain sodium. However…
- MSG contains only about a third of the sodium that salt does, gram-for-gram.
- It’s still wise to be mindful of it, though. Same with sodium in other ingredients!
- Baking soda contains about twice as much sodium, gram for gram, as MSG.
Wondering why this happens?
Salt (sodium chloride, NaCl) is equal parts sodium and chlorine, by atom count, but sodium’s atomic mass is lower than chlorine’s, so 100g of salt contains only 39.34g of sodium.
Baking soda (sodium bicarbonate, NaHCO₃) is one part sodium for one part hydrogen, one part carbon, and three parts oxygen. Taking each of their diverse atomic masses into account, we see that 100g of baking soda contains 27.4g sodium.
MSG (monosodium glutamate, C₅H₈NO₄Na) is only one part sodium for 5 parts carbon, 8 parts hydrogen, 1 part nitrogen, and 4 parts oxygen… And all those other atoms put together weigh a lot (comparatively), so 100g of MSG contains only 12.28g sodium.
Q: Thanks for the info about dairy. As a vegan, I look forward to a future comment about milk alternatives
Thanks for bringing it up! What we research and write about is heavily driven by subscriber feedback, so notes like this really help us know there’s an audience for a given topic!
We’ll do a main feature on it, to do it justice. Watch out for Research Review Monday!
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I Contain Multitudes – by Ed Yong
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A little while back we reviewed a book (Planet of Viruses) about the role of viruses in our lives, beyond the obvious. Today’s book gives the same treatment to microbes in general—mostly bacteria.
We all know about pathogens, and we all know about gut microbiota and that some (hopefully the majority) there are good for our health. This book covers those things too, but also much more.
Pulitzer Prize-winning science writer Ed Yong takes a big picture view (albeit, of some very small things) and looks at the many ways microbes keep us alive, directly or indirectly. From the microbes that convert certain proteins in breast milk into a form that babies can digest (yes, this means we produce nutrients in breast milk that have been evolved solely to feed that bacterium), to those without which agriculture would simply not work, we’re brought to realize how much our continued existence is contingent on our trillions of tiny friends.
The style throughout is easy-reading pop-science, very accessible. There’s also plenty in terms of practical take-away value, when it comes to adjusting our modern lives to better optimize the benefits we get from microbes—inside and out.
Bottom line: if you’d like to learn about the role of microbes in our life beyond “these ones are pathogens” and “these ones help our digestion”, this is the book for you.
Click here to check out I Contain Multitudes, and learn more about yours and those around you!
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Metformin vs Cancer/Aging
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…and other items from this week’s health science news:
Metabolic health is more than most people think
Researchers (Dr. Emilie Lavallée et al.) found that ATP5I is a direct molecular target of metformin. This may not mean much to most readers, so: ATP5I is part of the enzyme complex that produces ATP, the primary “energy currency” of cells. Specifically it seems to help organize and assemble the ATP synthase machinery, rather than directly carrying out ATP production itself.
In other words: it helps your cellular energy mechanisms work better
As for why you should care about cellular energy mechanisms: you are made of cells, and the energy they have is the energy you have*.
*unless we want to get pedantic, in which case yes, you also have some gravitational potential energy due to your mass, including non-cellular mass, and its relationship to gravity. But that won’t help you get through your day, for the most part.
Usefully, this also highlights a likely reason why people who take metformin have a lower risk of many cancers, bearing in mind that while things like diabetes and heart disease are thought of as metabolic disorders (and they are), so are cancer and aging:
Read in full: Why metformin matters beyond diabetes: New target could reshape aging and cancer research
Related: How Metformin Reduces Long COVID Risk By 63%
Kidney disease is fast becoming epidemic
Bad news: early chronic kidney disease (CKD) often causes no noticeable symptoms, allowing kidney damage to progress for years before being detected.
Worse news: CKD has entered the world’s top 10 causes of death, with approximately 1.5 million deaths in the US attributed directly to the disease in 2023 (yes, science typically lags with numbers like that, because of peer review, here we are in 2026 at time of writing, reading stats from 2023, but it’s better to have correct stats from a couple of years ago than guess at more recent ones without appropriate scientific rigor).
Further, impaired kidney function contributed to about 12% of global cardiovascular deaths, making all-too-clear the strong connection between kidney disease and heart disease.
Underdiagnosis remains a major problem too: many people are never tested, so the true prevalence may be higher than current estimates suggest; researchers emphasized greater use of urine testing and kidney function screening in at-risk individuals.
Good news: treatment options are improving! Newer medications, including SGLT2 inhibitors, GLP-1–based therapies, and nonsteroidal mineralocorticoid receptor antagonists, can help protect kidney function and reduce cardiovascular risk in appropriate patients.
However, prevention definitely remains much better than treatment, so it’s as well to get ahead of things and check out our “related” link below to learn now:
Read in full: A silent kidney crisis is spreading far faster than experts expected
Related: Are your Kidneys Ok? Detect Early To Protect Kidney Health (Here’s How)
When industry has beef with scientists
Researchers (Dr. Katherine Sievert et al.) researchers reviewed 500 nutrition studies published between 2014 and 2023 that examined links between meat consumption and health outcomes, then compared study conclusions with declared funding sources, author affiliations, and conflicts of interest.
In few words: a lot of those 500 studies had some form of meat-industry involvement (i.e: the meat industry paid for those studies, in part or in full), and these studies were 16x more likely to conclude that meat was harmless, beneficial, or health-promoting than studies without such ties to the meat industry.
So, in other words: when encountering headlines claiming that meat is healthy, it is worth checking who funded the study, whether authors disclosed financial relationships, and whether the findings align with the broader body of independent evidence.
Read in full: How ‘big meat’ shapes science to give steak a healthy glow up
Related: What Health Difference Does Pasture-Raised Beef Actually Make?
Take care!
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The Great Nerve – by Dr. Kevin Tracey
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Regular 10almonds readers will doubtlessly be aware of the merits of tending to one’s vagus nerve for reasons of relaxation and general health (per accessing the body’s “rest and digest” mode, and/or at the very least exiting the body’s “fight or flight” mode, which can be great in a crisis, but usually not what one wants at one’s desk on a Tuesday morning).
So, what does this book offer that stands out?
In this case it is much more of a focus on active healing, rather than simply avoiding harm.
Dr. Tracey covers how the vagus nerve (in and of itself, and/or in its role as the primary means of gut-brain information exchange) can be used torebalance inflammation (i.e., reduce general inflammation while increasing the immune response where and when and how it’s actually needed), regulate weight, improve metabolism, and reap the many health benefits that come with those things, especially if one’s starting point in one or more of those categories is Not Good™.
In terms of practicalities, he recommends an array of tools: meditation and breathwork, cold and exercise, and technological gadgets, with notes on therapies for various conditions.
The style is formal in tone, with lots of stories, and feels a lot like a for-the-public scientific presentation by an academic whose goal is more to engage the audience than necessarily to educate with a lot of details, as one might with an audience of students of one’s field. There are no citation markers as we go, although there is a respectable-sized bibliography at the back. The lack of referencing as we go is however quite a flaw, since it makes it much more difficult to check the sources for claims. It’s the equivalent of “yes, there is evidence for this claim; if you don’t believe me, here’s the library”.
Bottom line: if you’re looking for clinical understanding, this isn’t the best book for you. If you’re looking for just the practicalities, this book will feel quite padded with anecdotes. If, however, you want to learn about the vagus nerve in storytime fashion while curled up in your armchair, then you’ll probably find this book quite enjoyable.
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How To Get Your First Pull-Up
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Pull-ups are a great compound exercise that works most of the upper body. However, it can be frustrating for many, if unable to do more than dangle and struggle while not going anywhere. That’s not actually bad, by the way! Of course it’s not great athletic performance, but in terms of exercise, “dangling and struggling while not going anywhere” is an isometric exercise that has plenty of benefits of its own. However, for those who would rather go up in the world, personal trainer Meg Gallagher shows the way:
The Only Way Is Up?
Gallagher offers a few methods; the first is simply an improvement on the “dangling and struggling while not going anywhere” method, but doing it with good form. It’s called the…
Hollow body hold:
- Hang from the bar with legs and feet together.
- Maintain a posterior pelvic tilt (i.e. don’t let your hips roll forwards, and don’t let your butt stick out more than is necessary by mere virtue of having a butt)
- Engage your core by shortening the space between your ribs and pelvis.
- Turn on your abs and lats, with your head slightly behind the bar.
- Practice the hollow body hang instead of dead hangs to build grip and core strength.
Another method is now moving on from the hollow body hold, and shows that in fact, up is not the only way. It’s called…
Negative pull-ups:
- Jump up to get your chin over the bar, then slowly lower yourself in a controlled manner.
- Prioritize negative pull-ups over other exercises to build strength.
- You can use modifications like resistance bands or feet assistance if necessary to extend the duration of your negative pull-up, but these are “crutches”, so try to move on from them as soon as you reasonably can—same if your gym has an “assisted pull-up” machine, consisting of a moving platform with a variable counterweight, mimicking how a pull-up would feel if your body were lighter.
- Practice resisting throughout the entire range of motion.
To give a sense of direction, Gallagher offers the following program:
- On day 1, test how long you can resist the negative pull-up (e.g., 10 seconds).
- For each session, multiply your time by 2 (e.g., 10 seconds × 2 = 20 seconds total).
- Break the total volume into as many sets as needed (e.g., 2 sets of 10 seconds or 4 sets of 5 seconds).
- After each session, add 2 seconds to the total volume for the next session.
- Aim for 3 sessions per week for 3–4 weeks, increasing by 2 seconds each session.
- When you reach about 25 seconds, you should be close to performing your first pull-up.
For more on all of this, plus a few other things to try, plus visual demonstrations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
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How does the drug abemaciclib treat breast cancer?
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The anti-cancer drug abemaciclib (also known as Vernezio) has this month been added to the Australian Pharmaceutical Benefits Scheme (PBS) to treat certain types of breast cancer.
This significantly reduces the cost of the drug. A patient can now expect to pay A$31.60 for a 28-day supply ($7.70 with a health care concession card). The price of abemaciclib without government subsidy is $4,250.
So what is abemaciclib, and how did we get to this point?
It stops cells dividing
Researchers at the pharmaceutical company Eli Lilly developed abemaciclib and published the first study on the drug (then known as LY2835219) in 2014.
Abemaciclib is a type of drug known as a “cyclin-dependent kinase inhibitor”. It’s taken as a pill twice a day.
To maintain our health, many of the cells in our bodies need to grow and divide to produce new cells. Cancers develop when cells grow and divide out of control. Therefore, stopping cells from dividing into new cells is one way that cancer can be fought.
When cells divide, they have to make a copy of their DNA to pass onto the new cell. “Cyclin-dependent kinases” (CDKs for short) are essential for this process. So, if you stop the CDKs, you stop the DNA copying, you stop cells dividing, and you fight the cancer.
However, there are different types of CDKs, and not all cancers need them all to grow. Abemaciclib specifically targets CDK4 and CDK6. Thankfully, a lot of cancers do need these CDKs, including some breast cancers.
The drug targets CDK4 and CDK6. Photoroyalty/Shutterstock But abemaciclib will only be effective against cancers that rely on CDK4 and CDK6 for continued growth. This specificity also means abemaciclib is fairly unique, so it can’t easily be replaced with a different drug.
Two other CDK4/6 inhibitors were developed around the same time as abemaciclib, and are called ribociclib and palbociclib. Both of these drugs are also on the PBS for specific types of breast cancer. As the drugs differ in their chemical structures, they have slight differences in the way they are taken up and processed by the body. The preferred drug given to a breast cancer patient will depend on their unique circumstances.
What are the side effects?
Research is still ongoing into the differences between each of these CDK4/6 inhibitors, but it is known that the side effects are largely similar, but can differ in severity.
The most common side effects of abemaciclib are fatigue, diarrhoea and neutropenia (reduced white blood cells). The gastrointestinal issues are generally more severe with abemaciclib.
If these side effects are too severe, abemaciclib treatment can be stopped.
What types of cancer has abemaciclib been approved for?
In 2017, the United States Food and Drug Administration (FDA) approved abemaciclib for the treatment of patients with metastatic HR+/HER2- (hormone receptor-positive and human epidermal growth factor receptor 2-negative) breast cancer who did not respond to standard endocrine therapy.
Australia’s Therapeutic Goods Administration (TGA) similarly approved abemaciclib in 2022 as an “adjuvant” therapy (after the initial surgery to remove the tumour) for patients with HR+/HER2- invasive early breast cancer which had spread to lymph nodes and was at high risk of returning.
The drug is approved for people with early breast cancer which is at high risk of returning. PeopleImages.com – Yuri A/Shutterstock As of May 1 2024, the PBS covers this use of abemaciclib in combination with endocrine therapy such as fulvestrant, which is also listed on the PBS. Endocrine therapy, also known as hormonal therapy, blocks hormone receptor positive (HR+) cancers from receiving the hormones they need to survive.
Could abemaciclib be used for other cancers in the future?
Abemaciclib is of great interest to scientists and medical practitioners, and testing is ongoing to assess the effectiveness of abemaciclib in treating a range of other cancers, including gastrointestinal cancers and blood cancers.
Abemaciclib may even be usable in brain cancers, as it has long been known to be capable of crossing the blood-brain barrier, a common stumbling block for potential anti-cancer drugs.
Time will tell whether the role of abemaciclib in health care will be expanded. But for now, its inclusion on the PBS is sure to bring some relief to breast cancer patients nationwide.
Sarah Diepstraten, Senior Research Officer, Blood Cells and Blood Cancer Division, Walter and Eliza Hall Institute and John (Eddie) La Marca, Senior Resarch Officer, Walter and Eliza Hall Institute
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Waist Size Worries: Age-Appropriate Solutions
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It’s Q&A Day at 10almonds!
Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small
❝My BMI is fine, but my waist is too big. What do I do about that? I am 5′ 5″ tall and 128 pounds and 72 years old.❞
It’s hard to say without knowing about your lifestyle (and hormones, for that matter)! But, extra weight around the middle in particular is often correlated with high levels of cortisol, so you might find this of benefit:
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