The Great Nerve – by Dr. Kevin Tracey

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Regular 10almonds readers will doubtlessly be aware of the merits of tending to one’s vagus nerve for reasons of relaxation and general health (per accessing the body’s “rest and digest” mode, and/or at the very least exiting the body’s “fight or flight” mode, which can be great in a crisis, but usually not what one wants at one’s desk on a Tuesday morning).

So, what does this book offer that stands out?

In this case it is much more of a focus on active healing, rather than simply avoiding harm.

Dr. Tracey covers how the vagus nerve (in and of itself, and/or in its role as the primary means of gut-brain information exchange) can be used torebalance inflammation (i.e., reduce general inflammation while increasing the immune response where and when and how it’s actually needed), regulate weight, improve metabolism, and reap the many health benefits that come with those things, especially if one’s starting point in one or more of those categories is Not Good™.

In terms of practicalities, he recommends an array of tools: meditation and breathwork, cold and exercise, and technological gadgets, with notes on therapies for various conditions.

The style is formal in tone, with lots of stories, and feels a lot like a for-the-public scientific presentation by an academic whose goal is more to engage the audience than necessarily to educate with a lot of details, as one might with an audience of students of one’s field. There are no citation markers as we go, although there is a respectable-sized bibliography at the back. The lack of referencing as we go is however quite a flaw, since it makes it much more difficult to check the sources for claims. It’s the equivalent of “yes, there is evidence for this claim; if you don’t believe me, here’s the library”.

Bottom line: if you’re looking for clinical understanding, this isn’t the best book for you. If you’re looking for just the practicalities, this book will feel quite padded with anecdotes. If, however, you want to learn about the vagus nerve in storytime fashion while curled up in your armchair, then you’ll probably find this book quite enjoyable.

Click here to check out The Great Nerve, and soothe yours!

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  • Glutathione: More Than An Antioxidant

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    Glutathione’s Benefits: The Usual And The Unique

    Glutathione is a powerful antioxidant that does all the things we might reasonably expect an antioxidant to do, plus some beneficial quirks of its own.

    We do make glutathione in our bodies, but we can also get it from our diet, and of course, we can also supplement it.

    What foods is it in?

    It’s in a lot of foods, but some top examples include:

    • turmeric
    • avocado
    • asparagus
    • almonds
    • cruciferous vegetables
    • watermelon
    • garlic

    For a fuller list and discussion, see:

    Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review

    What does it do?

    Let’s start with the obvious; as with most things that are antioxidant, it is also anti-inflammatory. Increasing or decreasing glutathione levels is associated with decreased or increased inflammation, respectively. For example:

    Glutathione S-transferase theta 1 protects against colitis through goblet cell differentiation via interleukin-22

    It being anti-inflammatory also means it can be beneficial in calming autoimmune disorders:

    Glutathione: a key player in autoimmunity

    And to complete the triad of “those three things that generally go together”, yes, this means it also has anticancer potential, but watch out!

    ❝Although in healthy cells [glutathione] is crucial for the removal and detoxification of carcinogens, elevated [glutathione] levels in tumor cells are associated with tumor progression and increased resistance to chemotherapeutic drugs❞

    ~ Dr. Miroslava Cuperlovic-Culf et al.

    Read in full: Role of Glutathione in Cancer: From Mechanisms to Therapies

    So in other words, when it comes to cancer risk management, glutathione is a great preventative, but the opposite of a cure.

    What were those “beneficial quirks of its own”?

    They are mainly twofold, and the first is that it improves insulin sensitivity. There are many studies showing this, but here’s a recent one from earlier this year:

    The Role of Glutathione and Its Precursors in Type 2 Diabetes

    The other main “beneficial quirk of its own” is that it helps prevent and/or reverse non-alcoholic fatty liver disease, as in this study from last year:

    Glutathione: Pharmacological aspects and implications for clinical use in non-alcoholic fatty liver disease

    Because of glutathione’s presence in nuts, fruits, and vegetables, this makes it a great thing to work in tandem with a dietary approach to preventing/reversing NAFLD, by the way:

    How To Unfatty A Fatty Liver

    Anything else?

    It’s being investigated as a potential treatment for Parkinson’s disease symptoms, but the science is young for this one, so there is no definitive recommendation yet in this case. If you’re interested in that, though, do check out the current state of the science at:

    Potential use of glutathione as a treatment for Parkinson’s disease

    Is it safe?

    While there is no 100% blanket statement of safety that can ever be made about anything (even water can kill people, and oxygen ultimately kills everyone that something else doesn’t get first), glutathione has one of the safest general safety profiles possible, with the exception we noted earlier (if you have cancer, it is probably better to skip this one unless an oncologist or similar advises you otherwise).

    As ever, do speak with your doctor/pharmacist to be sure in any case, though!

    Want to try some?

    We don’t sell it, but here for your convenience is an example product on Amazon 😎

    Enjoy!

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  • What This Physio Did When He Got Sciatica

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    Will Harlow, the over-50s specialist physio, got a taste of his own medicine:

    How to bounce back (without bouncing your back)

    Sciatica is quite a pain, to say the least, not to mention a considerable inconvenience. And yet, it can strike even very healthy people, but if it does, it’s not the end of the world and there are things to do to fix it.

    When it happened to Will Harlow, lessons he quickly learned included:

    • his sciatica symptoms were unpredictable and chaotic
    • certain slight positions hurt more than larger movements
    • spinal compression from heavy loads often worsened symptoms
    • exercises or stretches that he knew “should” help actually worsened his symptoms too
      • in this latter case, his mistake was that he introduced them too early; he needed to get past the first stage of recovery first!

    So, he recommends to learn from his mistakes and stay as active as possible without provoking symptoms, prioritize walking throughout recovery, and/but modify gym training (light loads, focus on good form, keep a neutral spine where reasonably possible) rather than stopping entirely.

    Sleep positioning can be a big deal for sciatic (well, in general really, but especially in cases of sciatica), and side sleeping with a pillow between your knees can reduce nerve tension, improve pelvic alignment, and make sleep far more comfortable.

    For more on all of this and some specific exercise recommendations, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Healing Back Pain – by Dr. John Sarno

    Take care!

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  • How (And Why) To Train Your Pre-Frontal Cortex

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    Dr. Chapman’s Keys For Mental Focus

    This is Dr. Sandra Chapman; she’s a cognitive neuroscientist, on a mission to, in her words, further our understanding of:

    • what makes the brain stronger, faster and last longer
    • what enhances human cognitive capacity, and
    • what enhances the underlying brain systems across the lifespan.

    To this end, she’s also the founder and Chief Director of the Center For Brain Health, where she has worked on her mission for the past 25 years (clocking up hundreds of peer-reviewed publications to her name), as well as being a professor of Behavioral and Brain Sciences at UT Dallas.

    What does she want us to know?

    Get your brain into gear

    When it comes to your brainpower, it is “use it or lose it”, but it is also perfectly possible to use it and lose it.

    Why?

    Very often, what we are using our brains for is high-strain, low-yield stuff, such as multitasking, overthinking, or overthinking while multitasking. And to make it worse, we often do it without sufficient rest.

    This is the equivalent of owning a Ferrari but trying to drive it in second and third gear at once by switching between the two as rapidly as possible. And doing that for 18 hours each day.

    Suffice it to say, you’ll be going nowhere quickly.

    An alternative “use” of brainpower is low-strain, low-yield stuff, such as having to pay close attention to a boring conversation. It’s enough to stop your mind from doing anything else, but not enough to actually stimulate you.

    This is the equivalent of owning a Ferrari but keeping it idling. The wear and tear is minimal this time, but you’re not actually going anywhere either.

    Better, of course, are the other two quadrants:

    • low-strain, high-yield: consistently using our brain in relatively non-taxing ways that encourage its development
    • high-strain, high-yield: here the Ferrari metaphor definitely fails, because unlike cars, our bodies (including our brains) are machines that benefit from judicious regular progressive overloading (but just by a bit, and with adequate recovery time between overloads).

    See also: 12 Weeks To Measurably Boost Your Brain

    How to do the “low-strain, low-yield” part

    When it comes to “what’s the most important part of the brain to help in the face of cognitive decline?” the usual answer is either to focus on memory (hippocampi) or language (various parts, but for example Wernicke’s area and Broca’s area), since people most fear losing memory, and language is very important both socially and practically.

    Those are indeed critical, and we at 10almonds stand by them, but Dr. Chapman (herself having originally trained as speech and language pathologist!) makes a strong case for adding a third brain part to the list.

    Specifically, she advocates for strengthening the pre-frontal cortex, which is responsible for inhibition, task-switching, working memory, and cognitive flexibility. If that seems like a lot, do remember it’s a whole cortex and not one of the assorted important-but-small brain bits we mentioned above.

    How? She has developed training programs for this, based on what she calls Strategic Memory Advanced Reasoning Tactics (SMART), to support support attention, planning, judgment and emotional management.

    You can read more about those programs here:

    Center For Brain Health | Our Programs

    Participation in those is mostly not free, however, if you join their…

    Center For Brain Health | BrainHealth Project

    …then they will periodically invite you to join pilot programs, research programs, and the like, which will either be free or they-pay-you affairs—because this is how science is done, and you can read about yourself (anonymized, of course) later in peer-reviewed papers of the kind we often cite here.

    If you’re not interested in any of that though, we will say that according to Dr. Chapman, the keys are:

    Inhibition: be conscious of this function of your brain, and develop it. This is the function of your brain that stops you from making mistakes—or put differently: stops you from saying/doing something stupid.

    Switching: do this consciously; per “I am now doing this task, now I am switching to this other task”, rather than doing the gear-grinding thing we discussed earlier

    Working memory: this is effectively your brain’s RAM. Unlike the RAM of a computer (can be enhanced by adding another chip or replacing with a bigger chip), our brain’s RAM can be increased by frequent use, and especially by judicious use of progressive overloading (with rests between!) which we’ll discuss in the high-strain, high-yield section.

    Flexibility: this is about creative problem-solving, openness to new ideas, and curiosity

    See also: Curiosity Kills The Neurodegeneration

    How to do the “high-strain, high-yield” part

    Delighting this chess-playing writer, Dr. Chapman recommends chess. Although, similar games such as go (a Chinese game that looks simpler than chess but actually requires more calculation) work equally well too.

    Why?

    Games like chess and go cause structural changes that are particularly helpful, in terms of engaging in such foundational tasks as learning, abstract reasoning, problem-solving and self-control:

    Chess Practice as a Protective Factor in Dementia

    Basically, it checks (so to speak) a lot of boxes, especially for the pre-frontal cortex. Some notes:

    • Focusing on the game is required for brain improvement; simply pushing wood casually will not do it. Ideally, calculating several moves ahead will allow for strong working memory use (because to calculate several moves ahead, one will have to hold increasingly many possible positions in the mind while doing so).
    • The speed of play must be sufficiently slow as to allow not only for thinking, but also for what in chess is called “blunder-checking”, in other words, having decided on one’s move, pausing to consider whether it is a mistake, and actively trying to find evidence that it is. This is the crucial “inhibition habit”, and when one does it reflexively, one will make fewer mistakes. Tying this to dementia, see for example how one of the common symptoms of dementia is falling for scams that one wouldn’t have previously. How did cognitive decline make someone naïve? It didn’t, per se; it just took away their ability to, having decided what to do, pause to consider whether it was a mistake, and actively trying to find evidence that it is.
    • That “conscious switching” that we talked about, rather than multitasking? In chess, there is a difference between strategy and tactics. Don’t worry about what that difference is for now (learn it if you want to take up chess), but know that strong players will only strategize while it is their opponent’s turn, and only calculate (tactics) while it is their own turn. It’s very tempting to flit constantly between one and the other, but chess requires players to have the mental discipline be able to focus on one task or the other and stick with that task until it’s the appointed time to switch.

    If you feel like taking up chess, this site (and related app, if you want it) is free (it’s been funded by voluntary donations for a long time now) and good and even comes with free tuition and training tools: LiChess.org

    Here’s another site that this writer (hi, it’s me) personally uses—it has great features too, but many are paywalled (I’m mostly there just because I’ve been there nearly since its inception, so I’m baked into the community now): Chess.com

    Want to know more?

    You might like this book by Dr. Chapman, which we haven’t reviewed yet but it did inform large parts of today’s article:

    Make Your Brain Smarter: Increase Your Brain’s Creativity, Energy, and Focus – by Dr. Sandra Chapman

    Enjoy!

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  • How To Rebuild Your Neurons’ Myelin Sheaths

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    PS: We Love You

    Phosphatidylserine, or “PS” for short, is a phospholipid found in the brain. In other words, a kind of fatty compound that is such stuff as our brains are made of.

    In particular, it’s required for healthy nerve cell membranes and myelin (the protective sheath that neurons live in—basically, myelin sheaths do for neurons what telomere caps do for DNA).

    For an overview that’s more comprehensive than we have room for here, check out:

    Phosphatidylserine and the human brain

    Many people take it as a supplement.

    Does taking it as a supplement work?

    This is a valid question, as a lot of supplements can’t be absorbed well, and/or can’t pass the blood-brain barrier. But, as the above-linked study notes:

    ❝Exogenous PS (300-800 mg/d) is absorbed efficiently in humans, crosses the blood-brain barrier, and safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells. It supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports locomotor functions, especially rapid reactions and reflexes.❞

    ~ Glade & Smith.

    (“Exogenous” means “coming from outside of the body”, as opposed to “endogenous”, meaning “made inside the body”. Effectively, in this context “exogenous” means “taken as a supplement”.)

    Why do people take it?

    The health claims for phosphatidylserine fall into two main categories:

    1. Neuroprotection (helping your brain to avoid age-related decline in the long term)
    2. Cognitive enhancement (helping your brain work better in the short term)

    What does the science say?

    There’s a lot of science that’s been done on the neuroprotective properties of PS, and there are thousands of studies we could draw from here. The upshot is that regular phosphatidylserine supplementation (most often 300mg/day, but studies are also found for 100–500mg/day) is strongly associated with a reduction in cognitive decline over the course of 12 weeks (a common study duration). Here are a some spotlight studies showing this:

    Note: PS can be derived from various sources, with the two most common forms being bovine (i.e., from cow brains) or soy-derived.

    There is no established difference in the efficacy of these.

    There have been some concerns raised about the risk of CJD (the human form of BSE, as in “mad cow disease”) from consuming brain matter from cows, but studies have not found any evidence of this actually happening.

    There is also some evidence that phosphatidyserine significantly boosts cognitive performance, even in young people with no extant cognitive decline, for example:

    The effects of [phosphatidylserine supplementation] on cognitive function, mood and endocrine response before and following acute exercise

    (as the title suggests, they did also test for its effect on mood and endocrine response, but found it made no difference to those, just the cognitive function—which enjoyed a boost before exercise, as well as after it, meaning that the boost wasn’t dependent on the exercise)

    PS for cognitive enhancement in the young and healthy is not nearly so well-explored as its use as a later-life guard against age-related cognitive decline. However, just because the studies in younger people are dwarfed in number by the studies in older people, doesn’t detract from the validity of the studies in younger people.

    Basically: its use in older people has been studied the most, but all available evidence points to it being beneficial to brain health at all ages.

    Where can we get it?

    We don’t sell it (or anything else), but for your convenience, here’s an example product on Amazon.

    Enjoy!

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  • How The Arts Slow Biological Aging

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve previous discussed some specific health benefits (especially brain health) of some specific arts, for example:

    …as well as occasional guest articles, such as: Lost for words? Research shows art therapy brings benefits for mental health

    But what of the arts in general, as a category, and healthy aging beyond “just” brain health?

    Artfully dodging aging

    Researchers (Dr. Daisy Fancourt et al.) analyzed data from 3,556 UK adults and found that more frequent and more diverse arts and cultural engagement—such as reading, listening to music, or visiting museums—was associated with slower biological aging based on DNA methylation markers.

    And yes, Dr. Fancourt and her team did control for such things as wealth, income, educational level, and other potential confounding variables that may have otherwise caused misleading results of the kind that lead to headlines such as “Horse-riding found to be the sport that most extends longevity”. Should we all take up horse-riding to increase our lifespans? Probably not; the reality is that people who can afford horses can probably afford better than average healthcare, and lead easier, less stressful lives overall. The fact that people with horses typically have wealthier lifestyles than those without, is the confounding variable here.

    You can learn more about this sort of thing here: How Science News Outlets Can Lie To You (Yes, Even If They Cite Studies!)

    Back to Dr. Fancourt’s study that did better than that and did control for the confounding variables (and yes, in this case, the associations held regardless of those other factors, indicating it really was the arts engagement that made a difference), she and her team found the following outcomes:

    • Those who engaged in arts activities at least weekly appeared to age4% more slowly (a benefit comparable to exercising at least weekly versus doing no exercise).
    • On the PhenoAge clock (see link below for more on that),weekly arts engagement was associated with being biologically about one year younger on average than rare engagement, while weekly exercise was linked to being just over half a year younger.
    • These associations were most pronounced in people aged 40 and older, suggesting arts engagement becomes especially relevant in midlife and later years.

    As for how it works, it’s not known for sure, but hypotheses so far include that arts engagement, especially if varied, combines cognitive, emotional, social, and sometimes physical stimulation, reducing stress, inflammation, and cardiovascular risk—all of which have big implications for health and healthy aging, of course.

    You can read this paper in full, here: Does leisure activity matter for epigenetic ageing? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study

    Want to learn more?

    You might like this book we reviewed a while back:

    This Is Your Brain on Music – by Dr. Daniel Levitin

    Enjoy!

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  • The Pain-Free Mindset – by Dr. Deepak Ravindran

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    First: please ignore the terrible title. This is not the medical equivalent of “think and grow rich”. A better title would have been something like “The Pain-Free Plan”.

    Attentive subscribers may notice that this author was our featured expert yesterday, so you can learn about his “seven steps” described in our article there, without us repeating that in our review here.

    This book’s greatest strength is also potentially its greatest weakness, depending on the reader: it contains a lot of detailed medical information.

    This is good or bad depending on whether you like lots of detailed medical information. Dr. Ravindran doesn’t assume prior knowledge, so everything is explained as we go. However, this means that after his well-referenced clinical explanations, high quality medical diagrams, etc, you may come out of this book feeling like you’ve just done a semester at medical school.

    Knowledge is power, though, so understanding the underlying processes of pain and pain management really does help the reader become a more informed expert on your own pain—and options for reducing that pain.

    Bottom line: this, disguised by its cover as a “think healing thoughts” book, is actually a science-centric, information-dense, well-sourced, comprehensive guide to pain management from one of the leading lights in the field.

    Click here to check out The Pain-Free Mindset, and manage yours more comfortably!

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