Science-Based Alternative Pain Relief

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When Painkillers Aren’t Helping, These Things Might

Maybe you want to avoid painkillers, or maybe you’ve already maxed out what you can have, and want more options as an extra help against the pain.

Today we’ll look at some science-backed alternative pain relief methods:

First: when should we try to relieve pain?

There is no such thing as “this pain is not too much”. The correct amount of pain is zero. Maybe your body won’t let you reach zero, but more than that is “too much” already.

You don’t have to be suffering off the scale to deserve relief from pain!

So: if it hurts, then if you can safely get relief from the pain, it’s already wise to do so.

A couple of things we covered previously

CBD and THC are technically drugs, but are generally considered “alternative” pain relief, so we’ll give a quick mention here:

Short version:

  • CBD can treat some kinds of treatment-resistant pain well (others, not so much—try it and find out if it works for you)
  • THC can offer some people respite not found from other methods—but beware, because there are many health risks to consider.

Acupuncture

Pain relief appears to be its strongest suit:

Pinpointing The Usefulness Of Acupuncture

Cloves

Yes, just like you can get from the supermarket.

In its medicinal uses, it’s most well-known as a toothache remedy, but it has a local analgesic effect wherever you put it (i.e., apply it topically to where the pain is), thanks to its eugenol content:

Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities

Boswellia (frankincense)

The resin of the Boswellia serrata tree, this substance has an assortment of medicinal properties, including pain relief, anti-inflammatory effect, and psychoactive (anxiolytic and antidepressant) effects:

Frankincense is psychoactive: new class of antidepressants might be right under our noses

And as for physical pain? Here’s how it faired against the pain of osteoarthritis (and other OA symptoms, but we’re focusing on pain today), for example:

Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis

Here’s an example product on Amazon, but feel free to shop around as there are many options, including for example this handy roll-on

Further reading

Intended for chronic pain, but in large part applicable to acute pain also:

Managing Chronic Pain (Realistically!)

Take care!

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  • No-Exercise Exercise!

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    Do you love to go to the gym?

    If so, today’s article might not be for you so much. Or maybe it will, because let’s face it, exercise is fun!

    At least… It can be, and should be 😎

    So without further ado, here’s a slew of no-exercise exercise ideas; we’re willing to bet that somewhere in the list there’s at least some you haven’t tried before, and probably some you haven’t done in a while but might enjoy making a reprise!

    Walking

    No surprises here: walking is great. Hopefully you have some green spaces near you, but if you don’t, [almost] any walking is better than no walking. So unless there’s some sort of environmental disaster going on outside, lace up and get stepping.

    If you struggle to “walk for walking’s sake” give yourself a little mission. Walk to the shop to buy one item. Walk to the park and find a flower to photograph. Walk to the library and take out a book. Whatever works for you!

    See also: The Doctor Who Wants Us To Exercise Less, And Move More

    Take the stairs

    This one doesn’t need many words, just: make it a habit.

    Treat the elevators as though they aren’t there!

    See also: How To Really Pick Up (And Keep!) Those Habits

    Dance

    Dance is amazing! Any kind of dance, whatever suits your tastes. This writer loves salsa and tango, but no matter whether for you it’s zouk or zumba, breakdancing or line dancing, whatever gets you moving is going to be great for you.

    If you don’t know how, online tutorials abound, and best of all is to attend local classes if you can, because they’re always a fun social experience too.

    Make music

    Not something often thought of as an exercise, but it is! Most instruments require that we be standing or siting with good posture, focusing intently on our movements, and often as not, breathing very mindfully too. And yes, it’s great for the brain as well!

    Check out: This Is Your Brain on Music: The Science of a Human Obsession – by Dr. Daniel Levitin

    Take a stand

    If you spend a lot of time at a desk, please consider investing in a standing desk; they can be truly life-changing. Not only is it so much better for your back, hips, neck, and internal organs, but also it burns hundreds more calories than sitting, due to the no-exercise exercise that is keeping your body constantly stabilized while on your feet.

    (or, if you’re like this writer: on your foot. I do have two feet, I just spend an inordinate amount of time at my desk standing on one leg at a time; I’m a bit of a flamingo like that)

    See also: Deskbound: Standing Up to a Sitting World – by Kelly Starrett and Glen Cordoza

    Sit, but…

    Sit in a sitting squat! Sometimes called a Slav squat, or an Asian squat, or a resting squat, or various other names:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Alternatively, sitting in seiza (the traditional Japanese sitting position) is also excellent, but watch out! While it’s great once your body is accustomed to it, if you haven’t previously sat this way much, you may cut off your own circulation, hurt your knees, and (temporarily) lose feeling in your feet. So if you don’t already sit in seiza often, gradually work up the time period you spend sitting in seiza, so that your vasculature can adapt and improve, which honestly, is a very good thing for your legs and feet to have.

    Breathe

    Perhaps the absolute most “no-exercise exercise” there is. And yes, of course you are (hopefully) breathing all the time, but how you are breathing matters a lot:

    The Inside Job Of Fixing Our Breathing: Exercises That Can Fix Sinus Problems (And More)

    Clean

    This doesn’t have to mean scrubbing floors like a sailor—even merely giving your house the Marie Kondo treatment counts, because while you’re distracted with all the objects, you’re going to be going back and forth, getting up and down, etc, clocking up lots of exercise that you barely even notice!

    PS, check out: The Life-Changing Manga Of Tidying Up – by Marie Kondo

    Garden

    As with the above, it’s lots of activity that doesn’t necessarily feel like it (assuming you’re doing more pruning and weeding etc, and less digging ditches etc), and as a bonus, there are a stack of mental health benefits to being in a green natural environment and interacting with soil:

    Read more: The Antidepressant In Your Garden

    Climb

    Depending on where you live, this might mean an indoor climbing wall, but give it a go! They have color-coded climbs from beginner to advanced, so don’t worry about being out of your depth.

    And the best thing is, the beginner climbs will be as much a workout to a beginner as the advanced climbs will be to an advanced climber, because at the end of the day, you’re still clinging on for dear life, no matter whether it’s a sizeable handhold not far from the ground, or the impression of a fingernail crack in an overhang 100ft in the air.

    Video games (but…)

    Less in the category of Stardew Valley, and more in the category of Wii Fit.

    So, dust off that old controller (or treat yourself to one if you didn’t have one already), and get doing a hundred sports and other physical activities in the comfort of your living room, with a surprisingly addictive gaming system!

    Sex!

    You probably don’t need instructions here, and if you do, well honestly, we’re running out of space today. But the answer to “does xyz count?” is “did it get your heart racing?” because if so, it counts

    Take care!

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  • Allen Carr’s Easy Way to Quit Emotional Eating – by Allen Carr

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve reviewed books before on quitting drinking; is this book about emotional eating so different?

    There are overlaps, but important points of contrast, too. After all, alcohol and junk food are both often unhealthy coping mechanisms for other things, though:

    • Alcohol has in principle the stronger grip (making it harder to give up)
    • Junk food is so much easier to justify (making it harder to give up)

    Author Allen Carr is of course most well-known for his debut book about quitting smoking, and he brings a lot of that expertise to bear on the slightly different beast that is emotional eating.

    Focused on reframing quitting as being less about self-denial and more about self-liberation, he helps readers to understand that giving up a substance (in this case, junk food) does not mean giving up happiness—rather, it means finding happiness beyond it.

    If this book has a downside, it’s that some parts can be a little repetitive, and it can sometimes seem like one of those “this book could have been an article” situations.

    On the other hand, many people benefit from repeated messages to truly inculcate an idea, so this could be a positive for a lot of readers.

    Bottom line: if you’ve tried to eat more healthily but find that you keep reaching for an unhealthy comfort food, then this book may make a difference that other methods didn’t.

    Click here to check out The Easy Way To Quit Emotional Eating, and find your own freedom!

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  • What Happens Every Day When You Quit Sugar For 30 Days

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We all know that sugar isn’t exactly a health food, but it can be hard to quit. How long can cravings be expected to last, and when can we expect to see benefits? Today’s video covers the timeline in a realistic yet inspiring fashion:

    What to expect on…

    Day 1: expect cravings and withdrawal symptoms including headaches, fatigue, mood swings, and irritability—as well as tiredness, without the crutch of sugar.

    Days 2 & 3: more of the same, plus likely objections from the gut, since your Candida albicans content will not be enjoying being starved of its main food source.

    Days 4–7: reduction of the above symptoms, better energy levels, improved sleep, and likely the gut will be adapting or have adapted.

    Days 8–14: beginning of weight loss, clearer skin, improved complexion; taste buds adapt too, making foods taste sweeter. Continued improvement in energy and focus, as well.

    Days 15–21: more of the same improvements, plus the immune system will start getting stronger around now. But watch out, because there may still be some cravings from time to time.

    Days 22–30: all of the above positive things, few or no cravings now, and enhanced metabolic health as a whole.

    For more specificity on each of these stages, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    The Not-So-Sweet Science Of Sugar Addiction

    Take care!

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    Ready For Cyborgization?

    A bar chart showing the percentage of people who use social media, emphasizing its safety.

    In yesterday’s newsletter, we asked you for your views on Brain-Computer Interfaces (BCIs), such as the Utah Array and Neuralink’s chips on/in brains that allow direct communication between brains and computers, so that (for example) a paralysed person can use a device to communicate, or manipulate a prosthetic limb or two.

    We didn’t get as many votes as usual; it’s possible that yesterday’s newsletter ended up in a lot of spam filters due to repeated use of a word in “extra ______ olive oil” in its main feature!

    However, of the answers we did get…

    • About 54% said “It’s bad enough that our phones spy on us, without BCI monitoring our thoughts as well!”
    • About 23% said “Sounds great in principle, but I don’t think we’re there yet safetywise”
    • About 19% said “Sign me up for technological telepathy! I am ready for assimilation”
    • One (1) person said “Electrode outside the skull are good; chips on the brain are bad”

    But what does the science say?

    We’re not there yet safetywise: True or False?

    True, in our opinion, when it comes to the latest implants, anyway. While it’s very difficult to prove a negative (it could be that everything goes perfectly in human trials), “extraordinary claims require extraordinary evidence”, and so far this seems to be lacking.

    The stage before human trials is usually animal trials, starting with small creatures and working up to non-human primates if appropriate, before finally humans.

    • Good news: the latest hot-topic BCI device (Neuralink) was tested on animals!
    • Bad news: to say it did not go well would be an understatement

    The Gruesome Story of How Neuralink’s Monkeys Actually Died

    The above is a Wired article, and we tend to go for more objective sources, however we chose this one because it links to very many objective sources, including an open letter from the Physicians’ Committee for Responsible Medicine, which basically confirms everything in the Wired article. There are lots of links to primary (medical and legal) sources, too.

    Electrodes outside the skull are good; chips on/in the brain are bad: True or False?

    True or False depending on how they’re done. The Utah Array (an older BCI implant, now 20 years old, though it’s been updated many times since) has had a good safety record, after being used by a few dozen people with paralysis to control devices:

    How the Utah Array is advancing BCI science

    The Utah Array works on the same general principle as Neuralink, but the mechanics of its implementation are very different:

    • The Utah Array involves a tiny bundle of microelectrodes (held together by a rigid structure that looks a bit like a nanoscale hairbrush) put in place by a brain surgeon, and that’s that.
    • The Neuralink has a dynamic web of electrodes, implanted by a little robot that acts like a tiny sewing machine to implant many polymer threads, each containing its own a bunch of electrodes.

    In theory, the latter is much more advanced. In practice, so far, the former has a much better safety record.

    I am right to be a little worried about giving companies access to my brain: True or False?

    True or False, depending on the nature of your concern.

    For privacy: current BCI devices have quite simple switches operated consciously by the user. So while technically any such device that then runs its data through Bluetooth or WiFi could be hacked, this risk is no greater than using a wireless mouse and/or keyboard, because it has access to about the same amount of information.

    For safety: yes, probably there is cause to be worried. Likely the first waves of commercial users of any given BCI device will be severely disabled people who are more likely to waive their rights in the hope of a life-changing assistance device, and likely some of those will suffer if things go wrong.

    Which on the one hand, is their gamble to make. And on the other hand, makes rushing to human trials, for companies that do that, a little more predatory.

    Take care!

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  • What is Ryeqo, the recently approved medicine for endometriosis?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    For women diagnosed with endometriosis it is often a long sentence of chronic pain and cramping that impacts their daily life. It is a condition that is both difficult to diagnose and treat, with many women needing either surgery or regular medication.

    A medicine called Ryeqo has just been approved for marketing specifically for endometriosis, although it was already available in Australia to treat a different condition.

    Women who want the drug will need to consult their local doctor and, as it is not yet on the Pharmaceutical Benefits Scheme, they will need to pay the full cost of the script.

    What does Ryeqo do?

    Endometriosis affects 14% of women of reproductive age. While we don’t have a full understanding of the cause, the evidence suggests it’s due to body tissue that is similar to the lining of the uterus (called the endometrium) growing outside the uterus. This causes pain and inflammation, which reduces quality of life and can also affect fertility.

    Ryeqo is a tablet containing three different active ingredients: relugolix, estradiol and norethisterone.

    Relugolix is a drug that blocks a particular peptide from releasing other hormones. It is also used in the treatment of prostate cancer. Estradiol is a naturally occurring oestrogen hormone in women that helps regulate the menstrual cycle and is used in menopausal hormone therapy. Norethisterone is a synthetic hormone commonly used in birth control medications and to delay menstruation and help with heavy menstrual bleeding.

    All three components work together to regulate the levels of oestrogen and progesterone in the body that contribute to endometriosis, alleviating its symptoms.

    Relugolix reduces the overall levels of oestrogen and progesterone in the body. The estradiol compensates for the loss of oestrogen because low oestrogen levels can cause hot flushes (also called hot flashes) and bone density loss. And norethisterone blocks the effects of estradiol on the uterus (where too much tissue growth is unwanted).

    Is it really new?

    The maker of Ryeqo claims it is the first new drug for endometriosis in Australia in 13 years.

    But individually, all three active ingredients in Ryeqo have been in use since 2019 or earlier.

    Ryeqo has been available in Australia since 2022, but until now was not specifically indicated for endometriosis. It was originally approved for the treatment of uterine fibroids, which share some common symptoms with endometriosis and have related causes.

    In addition to Ryeqo, current medical guidance lists other drugs that are suitable for endometriosis and some reformulations of these have also only been recently approved.

    The oral medicine Dienogest was approved in 2021, and there have been a number of injectable drugs for endometriosis recently approved, such as Sayana Press which was approved in a smaller dose form for self-injection in 2023.

    hands taking pill out of contraceptive blister pack
    You can’t take the contraceptive pill with Ryeqo but the endometriosis drug could replace it.
    Shutterstock

    How to take it and what not to do

    Ryeqo is a once-a-day tablet. You can take it with, or without food, but it should be taken about the same time each day.

    It is recommended you start taking Ryeqo within the first five days after the start of your next period. If you start at another time during your period, you may experience initial irregular or heavier bleeding.

    Because it contains both synthetic and natural hormones, you can’t use the contraceptive pill and Ryeqo together. However, because Ryeqo does contain norethisterone it can be used as your contraception, although it will take at least one month of use to be effective. So, if you are on Ryeqo, you should use a non-hormonal contraceptive – such as condoms – for a month when starting the medicine.

    Ryeqo may be incompatible with other medicines. It might not be suitable for you if you take medicines for epilepsy, HIV and AIDS, hepatitis C, fungal or bacterial infections, high blood pressure, irregular heartbeat, angina (chest pain), or organ rejection. You should also not take Ryeqo if you have a liver tumour or liver disease.

    The possible side effects of Ryeqo are similar to those of oral contraceptives. Blood clots are a risk with any medicine that contains an oestrogen or a progestogen, which Ryeqo does. Other potential side effects include bone loss, a reduction in menstrual blood loss or loss of your period.

    It’s costly for now

    Ryeqo can now be prescribed in Australia, so you should discuss whether Ryeqo is right for you with the doctor you usually consult for your endometriosis.

    While the maker has made a submission to the Pharmaceutical Benefits Advisory Committee, it is not yet subsidised by the Australian government. This means that rather than paying the normal PBS price of up to A$31.60, it has been reported it may cost as much as $135 for a one-month supply. The committee will make a decision on whether to subsidise Ryeqo at its meeting next month.

    Correction: this article has been updated to clarify the recent approval of specific formulations of drugs for endometriosis.The Conversation

    Nial Wheate, Associate Professor of the School of Pharmacy, University of Sydney and Jasmine Lee, Pharmacist and PhD Candidate, University of Sydney

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • How to Use Topical Estrogen Cream For Aging Skin

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Sam Ellis, dermatologist, explains:

    Tackling the cause

    Estrogen is important for very many aspects of health beyond the sexual aspects. When it comes to skin, a drop in estrogen (usually because of menopause) leads to changes like collagen loss, dryness, reduced elasticity, and slower wound healing. Applying estrogen creams to the skin can reverse these changes.

    If your estrogen levels are already within normal pre-menopausal female ranges, by the way, there isn’t so much science to indicate its benefit when used topically. If you are already on systemic HRT (i.e., you take estrogen already to raise your blood estrogen levels and affect your body in its entirety), you may or may not gain extra benefits from the topical cream, depending on factors such as your estrogen dose, your route of administration, your cardiovascular health, and other factors.

    For those with lower estrogen and not currently on HRT, you may be wondering: can topical estrogen cream affect systemic estrogen levels? And the answer is that it mostly depends on the dose. In other words: it’s definitely possible, but for most people it’s unlikely.

    As ever, if thinking of taking up any hormonal treatment, do consult an endocrinologist and/or gynecologist, and if you have an increased breast cancer risk (for example genetically or prior history), then an oncologist too, just to be safe.

    That sounds like a lot of scary things, but mostly it’s just to be on the safe side. The dose of estrogen is very low in topical creams, and even then, only a tiny amount is used per day.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

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    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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