10 Ways To Delay Aging

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This is Dr. Colin Rose; he is a Senior Associate of the Royal Society of Medicine. He’s also a main contributor to EduScience, a program funded by the E.U. which is designed to enhance the teaching and learning of science in schools in Europe.

His most recent work has been about aging—and how to delay it. We also reviewed his latest book, here:

Delay Ageing – by Dr. Colin Rose

So, what does he want us to know? The key lies in his compilation of ten ways in which we age on a cellular level, and what we can to do slow each one of those:

Damage to DNA accumulates

While DNA can get damaged without any external stimulus to cause that, there are a lot of modifiable factors that we can do to reduce DNA damage. The list is easy: if it causes cancer, it causes aging.

Thus, check out: Stop Cancer 20 Years Ago

Cells become senescent

Our cells are replaced all the time; some sooner than others, but all of them at some point. The problem occurs when cells are outliving their usefulness. If a cell becomes completely immortal, that is cancer, but happily most don’t. Nevertheless, having senescent (aging) cells in the body means that those senescent cells are what get copied forwards by mitosis, and our DNA becomes like a photocopy of a tattered old photocopy of a tattered old photocopy. Which, needless to say, is not good for our health. So, the best thing to do is to kill them earlier:

Yes, really: Fisetin: The Anti-Aging Assassin

Mitochondria become dysfunctional

Without properly functional mitochondria, no living human cell can do its job properly.

Options: 7 Ways To Boost Mitochondrial Health To Fight Disease

Beneficial genes are switched off, harmful genes are on

It’s easy to think of our genes as being immutable, but epigenetics means that our environment (amongst other factors) can mean that our gene expression changes.

Imagine it this way: your genes are a set of instructions for your body. However, your body will act or not on those instructions, depending on other factors. Hormones often play a big part in this; for example sex hormones tell the body which set of genetic instructions to read (and thus what kind of body to build/rebuild), and cortisol or oxytocin can tell the body which set of contingency plans to activate or suppress (respectively). A milder example is gray hair; genes have the program for it, but many other factors inform the body when, if, and how to do it.

Of more concern when it comes to aging is what goes on with more critical systems, such as the brain, in which the aforementioned DNA damage can cause unhelpful instructions to get interpreted, resulting in epigenetic changes that in turn facilitate age-related degeneration.

As to what can be done, see : Klotho: Unzipping The Genes Of Aging?

Stem cells become exhausted

Stem cells can become different kinds of cells, and thus they’re very useful for maintaining a healthy body. However, they get depleted with age. We can slow down the rate of loss, though; for example, intermittent fasting can help:

Per Dr. Li’s 5 Ways To Beat Cancer (And Other Diseases)

And for more detail, see:

Doctor’s Tip: Regeneration (stem cells) — one of your body’s five defense systems

(complete with lists of foods to eat or avoid for stem cell health)

Cells fail to communicate properly

Cells need to talk to each other constantly, to continue doing their jobs. We are one big organism, after all, and not a haphazard colony of the countless cells that constitute such. However, cell signalling gets worse with age, which in turn precipitates others age-related problems. Fortunately, there are nutrients that can improve cellular communication.

For example: PS, We Love You ← this is about phosphatidylserine, also called “PS”

Telomeres become shorter

These protective caps on our DNA suffer the wear-and-tear so that our DNA doesn’t have to. However, as they get shorter, the DNA can start suffering damage. For this reason, telomere length is considered one of the most “Gold Standard” markers of cellular aging.

Here’s what can be done for that: The Stress Prescription (Against Aging!)

The body fails to sense nutritional intake properly

This is mostly about insulin signalling (though problems can occur in other systems too, but we only have so much room here), so it’s important to take care of that.

See: Turn Back The Clock On Insulin Resistance

Proteins accumulate errors

This is due to DNA damage, of course, but there are specific things that can reduce protein error accumulation; see for example:

A quick fix – preventing protein errors extends lifespan

See also: Rapamycin Can Slow Aging By 20% (But Watch Out)

The microbiome becomes unbalanced

We at 10almonds often mention that gut health affects pretty much every other kind of health, and it’s true for aging as well. So, take care of that microbiome!

Here’s a primer: Gut Health 101

Want to know more about delaying aging beyond the cellular level?

Check out: Age & Aging: What Can (And Can’t) We Do About It?

Take care!

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  • What Is “75 Hard”?

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    This is Andy Frisella. He’s not a doctor, scientist, nutritionist, personal trainer, or professional athlete, but he has kicked off a viral fitness challenge, so let’s take a look at it:

    What it is

    Firstly, Frisella asserts that it’s not a fitness challenge, but rather, he describes it as a “transformative mental toughness program”.

    Here’s what it consists of:

    • Follow a healthy diet plan with no deviations from it (i.e. no “cheat days”)
    • Abstain from alcohol
    • Exercise 2x per day, 45 minutes each
    • One of the exercise sessions each day must be outside
    • No rest days
    • Drink 3.5 liters of water per day

    And the duration? 75 days, hence the name of the fitness challenge transformative mental toughness program.

    Why it is

    Frisella’s rationale is:

    • we must cultivate mental toughness by doing hard things
    • allowing ourselves any deviation would be a sign of mental weakness
    • if we allow ourselves to deviate, it becomes a habit

    For this reason, he does not “allow” any substitutions, for example if somebody wants to do such-and-such a thing slightly differently instead. We put “allow” in quotation marks because of course, he’s not the boss of you, but per the rules of his challenge, at least.

    These reasonings are in and of themselves somewhat sound, however, we at 10almonds would argue:

    • before doing hard things, it is good to first consider “is it a good idea?” (amputating your leg using only a spork is a “hard thing”, and demonstrates incredible mental toughness, but that doesn’t make it a good idea)
    • while being able to decide to do a thing and then do it is great characteristic to have, it’s good to first consider science; for example, restrictive diets with no flexibility simply do not work, and our bodies do require adequate rest, especially if being pushed through hard things, or problems will happen (injuries, illnesses, etc).
    • while it’s true that allowing ourselves to deviate can become a habit, it’s good to first consider what habits we want to make, and make those habits, instead of potentially unsustainable or even simply unpleasant ones.

    See also: What Flexible Dieting Really Means: When Flexibility Is The Dish Of The Day

    And for that matter: How To Really Pick Up (And Keep!) Those Habits

    Want a “75 Gentle” instead?

    If you like the idea of making new habits, but are not sure if extreme (and perhaps arbitrary) standards are the ones you want to hold, check out:

    Cori Lefkowith’s 25 Healthy Habits That Will Change Your Life

    Take care!

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  • Genital herpes is on the rise. Here’s what to know about this common infection

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The World Health Organization (WHO) recently released new estimates suggesting around 846 million people aged between 15 and 49 live with a genital herpes infection.

    That’s equivalent to one in every five people from that age group.

    At least one person each second (42 million people annually) contracts a new genital herpes infection.

    So what is genital herpes, and are cases on the rise? Here’s what to know about this common infection.

    Peakstock/Shutterstock

    First, what causes genital herpes?

    Genital herpes is a sexually transmitted infection (STI) caused by the herpes simplex virus, which also causes cold sores.

    There are two types of herpes simplex virus, HSV-1 and HSV-2 (and it’s possible to be infected by both at the same time).

    HSV-1 most commonly spreads through oral contact such as kissing or sharing infected objects such as lip balm, cups or utensils, and presents as cold sores (or oral herpes) around the mouth. But it can also be sexually transmitted to cause a genital herpes infection.

    An estimated 3.8 billion people under the age of 50 (64%) globally have HSV-1.

    HSV-2 is less prevalent, but almost always causes a genital herpes infection. Some 520 million people aged 15–49 (13%) worldwide are believed to have HSV-2.

    The initial episode of genital herpes can be quite painful, with blisters, ulcers and peeling skin around the genitals over 7–10 days.

    Not all people have severe (or any) initial symptoms. This means a person might not know they have been infected with a herpes virus.

    Herpes is a lifelong infection, which means once you contract the virus, you have it forever. After an initial episode, subsequent episodes can occur, but are usually less painful or even symptom free.

    Both oral and genital herpes are particularly easy to spread when you have active lesions (cold sores or genital ulcers). But even with no symptoms, herpes can still be spread to a partner.

    And although relatively rare, oral herpes can be transmitted to the genital area, and genital herpes can be transmitted to the mouth through oral sex.

    If an expectant mother exhibits a genital herpes infection close to childbirth, there are risks to the baby. A herpes infection can be very serious in a baby, and the younger the infant, the more vulnerable they are. This is also one reason why you should avoid kissing a baby on the mouth.

    Changing trends

    WHO’s recent figures brought together data from around the world to estimate the prevalence of genital herpes in 2020, compared with previous estimates in 2012 and 2016.

    This data shows no significant difference in the prevalence of genital herpes caused by HSV-2 since 2016, but does highlight increases in genital herpes infections caused by HSV-1.

    The estimated number of genital HSV-1 infections globally was nearly twice as high in 2020 compared with 2016 (376 million compared with 192 million).

    A 2022 study looking at Australia, New Zealand and Canada found more than 60% of genital herpes infections are still caused by HSV-2. But this is declining by about 2% each year while new genital infections that result from HSV-1 are rising.

    A woman holding her crotch area.
    Genital herpes can be quite painful, presenting as sores and lesions that in severe cases, may take up to a month to fully heal. Christian Moro

    There’s no simple fix, but safe sex is important

    Genital herpes causes a substantial disease burden and economic cost to health-care services.

    With such a large proportion of the world’s population infected with HSV-1, evidence this virus is increasingly causing genital herpes is concerning.

    There’s no cure for genital herpes, but some medications, such as antivirals, can help reduce the amount of virus present in the system. While this won’t kill it completely, it helps to prevent symptomatic genital herpes recurrences, improve quality of life, and minimise the risk of transmission.

    To prevent the spread of genital herpes and other STIs, practise safe sex, particularly if you’re not sure of your partner’s sexual health. You need to use a barrier method such as condoms to protect against STIs (a contraceptive such as the pill won’t work). This includes during oral sex.

    As herpes is now so common, testing is not usually included as part of a regular sexual health check-up, except for in specific circumstances such as during pregnancy or severe episodes.

    So it’s wise not to let your guard down, even if your partner insists they have received the all-clear from a recent check-up.

    If there are herpes lesions present around the genitals, avoid sex entirely. Even condoms are not fully effective at these times, as exposed areas can still transmit the infection.

    A woman happily embracing a man.
    Practising safe sex can help prevent the spread of herpes. cottonbro studio/Pexels

    Immune health

    If you are infected with HSV-1 or HSV-2 it’s more likely symptoms will appear when you’re stressed, tired or overwhelmed. During these times, our immune system may not be as functional, and dormant viruses such as herpes can start to develop quickly in our bodies.

    To reduce the risk of recurrent herpes infections, try to eat healthily, get at least seven hours of sleep each night if possible, and look out for when your body may be telling you to take a step back and relax. This self-care can go a long way towards keeping latent viruses at bay.

    While the prevalence has increased significantly in recent years, we have not lost the war on genital herpes just yet. Safe sexual practices, education and awareness can help reduce its spread, and the stigma around it.

    If you have personal concerns, you should discuss them with a medical professional.

    Christian Moro, Associate Professor of Science & Medicine, Bond University and Charlotte Phelps, Senior Teaching Fellow in Medicine, Bond University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • I’ve recovered from a cold but I still have a hoarse voice. What should I do?

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    Cold, flu, COVID and RSV have been circulating across Australia this winter. Many of us have caught and recovered from one of these common upper respiratory tract infections.

    But for some people their impact is ongoing. Even if your throat isn’t sore anymore, your voice may still be hoarse or croaky.

    So what happens to the voice when we get a virus? And what happens after?

    Here’s what you should know if your voice is still hoarse for days – or even weeks – after your other symptoms have resolved.

    Why does my voice get croaky during a cold?

    A healthy voice is normally clear and strong. It’s powered by the lungs, which push air past the vocal cords to make them vibrate. These vibrations are amplified in the throat and mouth, creating the voice we hear.

    The vocal cords are two elastic muscles situated in your throat, around the level of your laryngeal prominence, or Adam’s apple. (Although everyone has one, it tends to be more pronounced in males.) The vocal cords are small and delicate – around the size of your fingernail. Any small change in their structure will affect how the voice sounds.

    When the vocal cords become inflamed – known as laryngitis – your voice will sound different. Laryngitis is a common part of upper respiratory tract infections, but can also be caused through misuse.

    Two drawn circles comparing normal vocal cords with inflamed, red vocal cords.
    Viruses such as the common cold can inflame the vocal cords. Pepermpron/Shutterstock

    Catching a virus triggers the body’s defence mechanisms. White blood cells are recruited to kill the virus and heal the tissues in the vocal cords. They become inflamed, but also stiffer. It’s harder for them to vibrate, so the voice comes out hoarse and croaky.

    In some instances, you may find it hard to speak in a loud voice or have a reduced pitch range, meaning you can’t go as high or loud as normal. You may even “lose” your voice altogether.

    Coughing can also make things worse. It is the body’s way of trying to clear the airways of irritation, including your own mucus dripping onto your throat (post-nasal drip). But coughing slams the vocal cords together with force.

    Chronic coughing can lead to persistent inflammation and even thicken the vocal cords. This thickening is the body trying to protect itself, similar to developing a callus when a pair of new shoes rubs.

    Thickening on your vocal cords can lead to physical changes in the vocal cords – such as developing a growth or “nodule” – and further deterioration of your voice quality.

    Diagram compares healthy vocal cords with cords that have nodules, two small bumps.
    Coughing and exertion can cause inflamed vocal cords to thicken and develop nodules. Pepermpron/Shutterstock

    How can you care for your voice during infection?

    People who use their voices a lot professionally – such as teachers, call centre workers and singers – are often desperate to resume their vocal activities. They are more at risk of forcing their voice before it’s ready.

    The good news is most viral infections resolve themselves. Your voice is usually restored within five to ten days of recovering from a cold.

    Occasionally, your pharmacist or doctor may prescribe cough suppressants to limit additional damage to the vocal cords (among other reasons) or mucolytics, which break down mucus. But the most effective treatments for viral upper respiratory tract infections are hydration and rest.

    Drink plenty of water, avoid alcohol and exposure to cigarette smoke. Inhaling steam by making yourself a cup of hot water will also help clear blocked noses and hydrate your vocal cords.

    Rest your voice by talking as little as possible. If you do need to talk, don’t whisper – this strains the muscles.

    Instead, consider using “confidential voice”. This is a soft voice – not a whisper – that gently vibrates your vocal cords but puts less strain on your voice than normal speech. Think of the voice you use when communicating with someone close by.

    During the first five to ten days of your infection, it is important not to push through. Exerting the voice by talking a lot or loudly will only exacerbate the situation. Once you’ve recovered from your cold, you can speak as you would normally.

    What should you do if your voice is still hoarse after recovery?

    If your voice hasn’t returned to normal after two to three weeks, you should seek medical attention from your doctor, who may refer you to an ear nose and throat specialist.

    If you’ve developed a nodule, the specialist would likely refer you to a speech pathologist who will show you how to take care of your voice. Many nodules can be treated with voice therapy and don’t require surgery.

    You may have also developed a habit of straining your vocal cords, if you forced yourself to speak or sing while they were inflamed. This can be a reason why some people continue to have a hoarse voice even when they’ve recovered from the cold.

    In those cases, a speech pathologist may play a valuable role. They may teach you to exercises that make voicing more efficient. For example, lip trills (blowing raspberries) are a fun and easy way you can learn to relax the voice. This can help break the habit of straining your voice you may have developed during infection.

    Yeptain Leung, Postdoctoral Research and Lecturer of Speech Pathology, School of Health Sciences, The University of Melbourne

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Related Posts

  • Brain Food? The Eyes Have It!
  • Inverse Vaccines for Autoimmune Diseases

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Inverse Vaccines for Autoimmune Diseases

    This is Dr. Jeffrey Hubbell. He’s a molecular engineer, with a focus on immunotherapy, immune response, autoimmune diseases, and growth factor variants.

    He’s held 88 patents, and was the recipient of the Society for Biomaterials’ Founders Award for his “long-term, landmark contributions to the discipline of biomaterials”, amongst other awards and honours that would make our article too long if we included them all.

    And, his latest research has been about developing…

    Inverse Vaccines

    You may be thinking: “you mean diseases; he’s engineering diseases?”

    And no, it’s not that. Here’s how it works:

    Normally in the case of vaccine, it’s something to tell the body “hey, if you see something that looks like this, you should kill it on sight” and the body goes “ok, preparing countermeasures according to these specifications; thanks for the heads-up”

    In the case of an inverse vaccine, it’s the inverse. It’s something to tell the body “hey, this thing you seem to think is a threat, it’s actually not, and you should leave it alone”.

    Why this matters for people with autoimmune diseases

    Normally, autoimmune diseases are treated in one or more of the following ways:

    • Dampen the entire immune system (bad for immunity against actual diseases, obviously, and is part of why many immunocompromised people have suffered and died disproportionately from COVID, for example)
    • Give up and find a workaround (a good example of this is Type 1 Diabetes, and just giving up on the pancreas not being constantly at war with itself, and living on exogenous insulin instead)

    Neither of those are great.

    What inverse vaccines do is offer a way to flag the attacked-in-error items as acceptable things to have in the body. Those might be things that are in our body by default, as in the case of many autoimmune diseases, or they may even be external items that should be allowed but aren’t, as in the case of gluten, in the context of Celiac disease.

    The latest research is not yet accessible for free, alas, but you can read the abstract here:

    Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses

    Or if you prefer a more accessible pop-science approach, here’s a great explanatory article:

    “Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases

    Where can we get such inverse vaccines?

    ❝There are no clinically approved inverse vaccines yet, but we’re incredibly excited about moving this technology forward❞

    ~ Dr. Jeffrey Hubbell

    But! Lest you be disappointed, you can get in line already, in the case of the Celiac disease inverse vaccine, if you’d like to be part of their clinical trial:

    Click here to see if you are eligible to be part of their clinical trial

    If you’re not up for that, or if your autoimmune disease is something else (most of the rest of their research is presently focusing on Multiple Sclerosis and Type 1 Diabetes), then:

    • The phase 1 MS trial is currently active, estimated completion in summer 2024.
    • They are in the process of submitting an investigational new drug (IND) application for Type 1 Diabetes
      • This is the first step to starting clinical safety and efficacy trials

    …so, watch this space!

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    Learn to Age Gracefully

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  • The Mindgym: Wake Your Mind Up – by Dr. Sebastian Bailey and Octavius Black

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Since this reviewer got her copy, the subtitle and marketing of the book have changed, but the content has not. It’s now being marketed as “achieve more by thinking differently” like a pop-psychology business book. But it’s not that. What, then, is it?

    It’s 20 chapters of exercises for different kinds of thinking. And yes, the exercises will help those hungry 25–35-year-old MBAs too, but it’s more of a complete how-to-think overhaul.

    Its exercises cover psychology and philosophy, creativity and communication, logic and relaxation, cognition and motivation, and lots more.

    The style of the book is that of a workbook, and as such, it’s very clearly laid-out; one can go through them methodically, or get an overview and then dive in to whatever one wants/needs most at the moment.

    Bottom line: if you’d like a book that’s a one-stop shop for honing many different kinds of thinking, this is the book for you.

    Click here to check out The Mindgym, and get training yours!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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  • Where Nutrition Meets Habits!

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    Where Nutrition Meets Habits…

    This is Claudia Canu, MSc., INESEM. She’s on a mission to change the way we eat:

    Often, diet is a case of…

    • Healthy
    • Easy
    • Cheap

    (choose two)

    She wants to make it all three, and tasty too. She has her work cut out for her, but she’s already blazed quite a trail personally:

    Nine months before turning 40 years old, I set a challenge for myself: Arrive to the day I turn 40 as the best possible version of myself, physically, mentally and emotionally.❞

    ~ Claudia Canu

    In Her Own Words: My Journey To My Healthy 40s

    And it really was quite a journey:

    For those of us who’d like the short-cut rather than a nine-month quasi-spiritual journey… based on both her experience, and her academic and professional background in nutrition, her main priorities that she settled on were:

    • Making meals actually nutritionally balanced, which meant re-thinking what she thought a meal “should” be
    • Making nutritionally balanced meals that didn’t require a lot of skill and/or resources
    • That’s it!

    But, easier said than done… Where to begin?

    She shares an extensive list of recipes, from meals to snacks (I thought I was the only one who made coffee overnight oats!), but the most important thing from her is:

    Claudia’s 10 Guiding Principles:

    1. Buy only fresh ingredients that you are going to cook yourself. If you decide to buy pre-cooked ones, make sure they do not have added ingredients, especially sugar (in all its forms).
    2. Use easy and simple cooking methods.
    3. Change ingredients every time you prepare your meals.
    4. Prepare large quantities for three or four days.
    5. Store the food separately in tightly closed Tupperware.
    6. Organize yourself to always have ready-to-eat food in the fridge.
    7. When hungry, mix the ingredients in the ideal amounts to cover the needs of your body.
    8. Chew well and take the time to taste your food.
    9. Eat foods that you like and enjoy.
    10. Do not overeat but don’t undereat either.

    We have only two quibbles with this fine list, which are:

    About Ingredients!

    Depending on what’s available around you, frozen and/or tinned “one-ingredient” foods can be as nutritional as (if not more nutritional than) fresh ones. By “one-ingredient” foods here we mean that if you buy a frozen pack of chopped onions, the ingredients list will be: “chopped onions”. If you buy a tin of tomatoes, the ingredients will say “Tomatoes” or at most “Tomatoes, Tomato Juice”, for example.

    She does list the ingredients she keeps in; the idea that with these in the kitchen, you’ll never be in the position of “oh, we don’t have much in, I guess it’s a pizza delivery night” or “well there are some chicken nuggets at the back of the freezer”.

    Check Out And Plan: 10 Types Of Ingredients You Should Always Keep In Your Kitchen

    Here Today, Gone Tomorrow?

    Preparing large quantities for three or four days can result in food for one or two days if the food is unduly delicious

    But! Claudia has a remedy for that:

    Read: How To Eliminate Food Cravings And What To Do When They Win

    Anyway, there’s a wealth of resources in the above-linked pages, so do check them out!

    Perhaps the biggest take-away is to ask yourself:

    “What are my guiding principles when it comes to food?”

    If you don’t have a ready answer, maybe it’s time to tackle that—whether Claudia’s way or your own!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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