10 Ways To Delay Aging
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This is Dr. Colin Rose; he is a Senior Associate of the Royal Society of Medicine. He’s also a main contributor to EduScience, a program funded by the E.U. which is designed to enhance the teaching and learning of science in schools in Europe.
His most recent work has been about aging—and how to delay it. We also reviewed his latest book, here:
Delay Ageing – by Dr. Colin Rose
So, what does he want us to know? The key lies in his compilation of ten ways in which we age on a cellular level, and what we can to do slow each one of those:
Damage to DNA accumulates
While DNA can get damaged without any external stimulus to cause that, there are a lot of modifiable factors that we can do to reduce DNA damage. The list is easy: if it causes cancer, it causes aging.
Thus, check out: Stop Cancer 20 Years Ago
Cells become senescent
Our cells are replaced all the time; some sooner than others, but all of them at some point. The problem occurs when cells are outliving their usefulness. If a cell becomes completely immortal, that is cancer, but happily most don’t. Nevertheless, having senescent (aging) cells in the body means that those senescent cells are what get copied forwards by mitosis, and our DNA becomes like a photocopy of a tattered old photocopy of a tattered old photocopy. Which, needless to say, is not good for our health. So, the best thing to do is to kill them earlier:
Yes, really: Fisetin: The Anti-Aging Assassin
Mitochondria become dysfunctional
Without properly functional mitochondria, no living human cell can do its job properly.
Options: 7 Ways To Boost Mitochondrial Health To Fight Disease
Beneficial genes are switched off, harmful genes are on
It’s easy to think of our genes as being immutable, but epigenetics means that our environment (amongst other factors) can mean that our gene expression changes.
Imagine it this way: your genes are a set of instructions for your body. However, your body will act or not on those instructions, depending on other factors. Hormones often play a big part in this; for example sex hormones tell the body which set of genetic instructions to read (and thus what kind of body to build/rebuild), and cortisol or oxytocin can tell the body which set of contingency plans to activate or suppress (respectively). A milder example is gray hair; genes have the program for it, but many other factors inform the body when, if, and how to do it.
Of more concern when it comes to aging is what goes on with more critical systems, such as the brain, in which the aforementioned DNA damage can cause unhelpful instructions to get interpreted, resulting in epigenetic changes that in turn facilitate age-related degeneration.
As to what can be done, see : Klotho: Unzipping The Genes Of Aging?
Stem cells become exhausted
Stem cells can become different kinds of cells, and thus they’re very useful for maintaining a healthy body. However, they get depleted with age. We can slow down the rate of loss, though; for example, intermittent fasting can help:
Per Dr. Li’s 5 Ways To Beat Cancer (And Other Diseases)
And for more detail, see:
Doctor’s Tip: Regeneration (stem cells) — one of your body’s five defense systems
(complete with lists of foods to eat or avoid for stem cell health)
Cells fail to communicate properly
Cells need to talk to each other constantly, to continue doing their jobs. We are one big organism, after all, and not a haphazard colony of the countless cells that constitute such. However, cell signalling gets worse with age, which in turn precipitates others age-related problems. Fortunately, there are nutrients that can improve cellular communication.
For example: PS, We Love You ← this is about phosphatidylserine, also called “PS”
Telomeres become shorter
These protective caps on our DNA suffer the wear-and-tear so that our DNA doesn’t have to. However, as they get shorter, the DNA can start suffering damage. For this reason, telomere length is considered one of the most “Gold Standard” markers of cellular aging.
Here’s what can be done for that: The Stress Prescription (Against Aging!)
The body fails to sense nutritional intake properly
This is mostly about insulin signalling (though problems can occur in other systems too, but we only have so much room here), so it’s important to take care of that.
See: Turn Back The Clock On Insulin Resistance
Proteins accumulate errors
This is due to DNA damage, of course, but there are specific things that can reduce protein error accumulation; see for example:
A quick fix – preventing protein errors extends lifespan
See also: Rapamycin Can Slow Aging By 20% (But Watch Out)
The microbiome becomes unbalanced
We at 10almonds often mention that gut health affects pretty much every other kind of health, and it’s true for aging as well. So, take care of that microbiome!
Here’s a primer: Gut Health 101
Want to know more about delaying aging beyond the cellular level?
Check out: Age & Aging: What Can (And Can’t) We Do About It?
Take care!
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Inheritance – by Dr. Sharon Moalem
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We know genes make a big difference to a lot about us, but how much? And, the genes we have, we’re stuck with, right?
Dr. Sharon Moalem shines a bright light into some of the often-shadowier nooks and crannies of our genetics, covering such topics as:
- How much can (and can’t) be predicted from our parents’ genes—even when it comes to genetic traits that both parents have, and Gregor Mendel himself would (incorrectly) think obvious
- How even something so seemingly simple and clear as genetic sex, very definitely isn’t
- How traumatic life events can cause epigenetic changes that will scar us for generations to come
- How we can use our genetic information to look after our health much better
- How our life choices can work with, or overcome, the hand we got dealt in terms of genes
The style of the book is conversational, down to how there’s a lot of “I” and “you” in here, and the casual style belies the heavy, sharp, up-to-date science contained within.
Bottom line: if you’d like insight into the weird and wonderful nuances of genetics as found in this real, messy, perfectly chaotic world, this book is an excellent choice.
Click here to check out Inheritance, and learn more about yours!
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Palliative care as a true art form
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How do you ease the pain from an ailment amidst lost words? How can you serve the afflicted when lines start to blur? When the foundation of communication begins to crumble, what will be the pillar health-care professionals can lean on to support patients afflicted with dementia during their final days?
The practice of medicine is both highly analytical and evidence based in nature. However, it is considered a “practice” because at the highest level, it resembles a musician navigating an instrument. It resembles art. Between lab values, imaging techniques and treatment options, the nuances for individualized patient care so often become threatened.
Dementia, a non-malignant terminal illness, involves the progressive cognitive and social decline in those afflicted. Though there is no cure, dementia is commonly met in the setting of end-of-life care. During this final stage of life, the importance of comfort via symptomatic management and communication usually is a priority in patient care. But what about the care of a patient suffering from dementia? While communication serves as the vehicle to deliver care at a high level, medical professionals are suddenly met with a roadblock. And there … behind the pieces of shattered communication and a dampened map of ethical guidelines, health-care providers are at a standstill.
It’s 4:37 a.m. You receive a text message from the overnight nurse at a care facility regarding a current seizure. After lorazepam is ordered and administered, Mr. H, a quick-witted 76-year-old, stabilizes. Phenobarbital 15mg SC qhs was also added to prevent future similar events. You exhale a sigh of relief.
Mr. H. has been admitted to the floor 36 hours earlier after having a seizure while playing poker with colleagues. Since he became your patient, he’s shared many stories from professional and family life with you, along with as many jokes as he could fit in between. However, over the course of the next seven days, Mr. H. would develop aspiration pneumonia, progressing to ventilator dependency and, ultimately, multi-organ failure with rapid cognitive decline.
What strategies and tools would you use to maximize the well-being of your patient during his decline? How would you bridge the gap of understanding between the patient’s family and health-care team to provide the standard of care that all patients are owed?
To give Mr. H. the type of care he would have wanted, upon his hospital admission, he should have been questioned about his understanding of illness along with the goals of care of the medical team. The patient should have been informed that it is imperative to adhere to the medical regimen implemented by his team along with the risks of not doing so. In the event disease-related complications arose, advanced directives should have been documented to avoid any unnecessary measures.
It is important to note, that with each change in status of the patient’s health status, the goal of treatment must be reassessed. The patient or surrogate decision-maker’s understanding of these goals is paramount in maintaining the patient’s autonomy. It is often said that effective communication is the bedrock of a healthy relationship. This is true regardless of type of relationship.
This is why I and Megan Vierhout wrote Integrated End of Life Care in Dementia: A Comprehensive Guide, a book targeted at providing a much-needed road map to navigate the many challenges involved in end-of-life care for individuals with dementia. Ultimately, our aim is to provide a compass for both health-care professionals and the families of those affected by the progressive effects of dementia. We provide practical advice on optimizing communication with individuals with dementia while taking their cognitive limitations, preferences and needs into account.
I invite you to explore the unpredictable terrain of end-of-life care for patients with dementia. Together, we can pave a smoother, sturdier path toward the practice of medicine as a true art form.
This article is republished from healthydebate under a Creative Commons license. Read the original article.
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Life Extension Multivitamins vs Centrum Multivitamins – Which is Healthier
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Our Verdict
When comparing Life Extension Multivitamins to Centrum Multivitamins, we picked the Life Extension.
Why?
The clue here was on the label: “two per day”. It’s not so that they can sell extra filler! It’s because they couldn’t fit it all into one.
While the Centrum Multivitamins is a (respectably) run-of-the-mill multivitamin (and multimineral) containing reasonable quantities of most vitamins and minerals that people supplement, the Life Extension product has the same plus more:
- More of the vitamins and minerals; i.e. more of them are hitting 100%+ of the RDA
- More beneficial supplements, including:
- Inositol, Alpha lipoic acid, Bio-Quercetin phytosome, phosphatidylcholine complex, Marigold extract, Apigenin, Lycopene, and more that we won’t list here because it starts to get complicated if we do.
We’ll have to write some main features on some of those that we haven’t written about before, but suffice it to say, they’re all good things.
Main take-away for today: sometimes more is better; it just necessitates then reading the label to check.
Want to get some Life Extension Multivitamins (and/or perhaps just read the label on the back)? Here they are on Amazon
PS: it bears mentioning, since we are sometimes running brands against each other head-to-head in this section: nothing you see here is an advertisement/sponsor unless it’s clearly marked as such. We haven’t, for example, been paid by Life Extension or any agent of theirs, to write the above. It’s just our own research and conclusion.
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Machine-Dispensed Coffee & Heart Health
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We have written before about the health benefits (and risks) of coffee; for most people, the benefits far outweigh the risks, but individual cases may vary:
The Bitter Truth About Coffee (or is it?) ← this is a mythbusting edition
Speaking of bitterness; coffee has abundant polyphenols, which means…
- Coffee is the world’s biggest source of antioxidants
- 65% reduced risk of Alzheimer’s for coffee-drinkers
- 67% reduced risk of type 2 diabetes for coffee-drinkers
- 43% reduced risk of liver cancer for coffee-drinkers
- 53% reduced suicide risk for coffee-drinkers
See also: Why Bitter Is Better: Enjoy Bitter Foods For Your Heart & Brain ← while it says foods in the title, this does cover coffee too.
For mythbusting on caffeine specifically, enjoy: Caffeine: Cognitive Enhancer Or Brain-Wrecker?
There are also gut health benefits from drinking coffee, and what’s good for our gut is invariably good for our heart and brain:
Coffee & Your Gut ← gut bacteria do not, by the way, have a preference about how you make your coffee or whether it is caffeinated or not
The latest science on coffee and heart health
Specifically, on coffee and cholesterol levels, so for a quick primer on cholesterol, check out: Demystifying Cholesterol
High total cholesterol, and especially high LDL (“bad” cholesterol) is generally associated with cardiovascular disease, for the reasons outlined in the link above.
Recently, researchers at Uppsala University in Sweden examined the levels of cafestol and kahweol, which are both diterpenes, substances known to increase cholesterol levels, in coffee made by various methods, including those dispensed from coffee machines in workplaces.
Two samples were taken from each machine every 2–3 weeks, and the most common kinds of machines produced the highest concentrations of diterpenes. These machines are the ones that push hot water through a small amount of ground coffee, through a wide-gauge filter, dispensing coffee into a cup in about 30 seconds.
Actual espresso machines, which work on the same principle but usually with a finer filter, higher pressure, and slower dispensing of the drink, had widely varying results, quite possibly because there is (in most machines) a human element in how tightly the ground coffee is packed into the metal filter basket.
Simple filter coffee, whether made in a coffee percolator machine or made using the pour-over method, had the lowest concentrations of diterpenes.
You can read about this study here:
However!
We were curious as to how, exactly, cafestol and kahweol increase cholesterol levels.
It turns out that research in this area has been scant, because most mice aren’t affected by it in the way that most humans are, which has limited mouse model studies.
Scant does not mean non-existent, though, and the answer came by virtue of transgenic mice (specifically, apolipoprotein (apo) E*3-Leiden transgenic mice, which do have the same reaction to cafestol as humans), the paper title sums it up nicely:
You may be wondering: what does suppression of bile acid synthesis have to do with cholesterol levels?
To oversimplify it a bit: cafestol messes with cholesterol metabolism by interfering with the enzymes involved in cholesterol metabolism (specifically, regulatory enzymes found in bile acid).
As to what it actually does in that regard: it reduces LDLR (LDL receptor) mRNA levels by 37% (that figure’s an average of the specific enzymes, sterol 27-hydroxylase and oxysterol 7α-hydroxylase, which were reduced by 32% and 48%, respectively).
Why this matters in practical terms: cafestol does not add any cholesterol to our systems, it inhibits our ability to clear LDL cholesterol, thus promoting raised LDL cholesterol levels.
In other words: if you have little or no dietary cholesterol (no dietary cholesterol, for example, if you are vegan), then your body will only have the cholesterol that it made for itself because it needed it, and as such, the body won’t need to do the same kind of clean-up job that it would if you had that coffee with a double cheeseburger with extra bacon.
As such, if you have little or no dietary cholesterol, cafestol is unlikely to have anything like the same effect on cholesterol levels.
Disclaimer: this latter is technically a hypothesis, but based on sound reasoning:
It’s the same logic that says “if you do not drink alcohol, then eating a durian fruit, which inhibits aldehyde dehydrogenase, which the body uses to metabolize alcohol, will not cause alcohol-related problems for you”.
Want to know more?
We wrote previously on coffee and cafestol, along with some suggestions:
Health-Hack Your Coffee To Make Your Coffee Heart-Healthier!
Enjoy!
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Older, Faster, Stronger – by Margaret Webb
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The author, now in her 60s, made it her mission in her 50s to become the best runner she could. Before that, she’d been a keen runner previously, but let things slip rather in her 40s. But the book’s not about her 40s, it’s about her 50s and onwards, and other female runners in their 50s, 60s, 70s, 80s, and even 90s.
There’s a lot of this book that’s about people’s individual stories, and those should certainly be enough to prompt almost any reader that “if they can do it, I can”.
A lot, meanwhile, is about health and exercise science, training methods, and what has worked for various later-life athletes, including the author. So, it’s also partway instruction manual, with plenty of reference to science and medical considerations too.
Bottom line: sometimes, life throws us challenges. Sometimes, the best response is “Yeah? Bet” and surprise everyone.
Click here to check out Older, Faster, Stronger, and become all those cool things!
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Mediterranean Air Fryer Cookbook – by Naomi Lane
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There are Mediterranean Diet cookbooks, and there are air fryer cookbooks. And then there are (a surprisingly large intersection of!) Mediterranean Diet air fryer cookbooks. We wanted to feature one of them in today’s newsletter… And as part of the selection process, looked through quite a stack of them, and honestly, were quite disappointed with many. This one, however, was one of the ones that stood out for its quality of both content and clarity, and after a more thorough reading, we now present it to you:
Naomi Lane is a professional dietician, chef, recipe developer, and food writer… And it shows, on all counts.
She covers what the Mediterranean diet is, and she covers far more than this reviewer knew it was even possible to know about the use of an air fryer. That alone would make the book a worthy purchase already.
The bulk of the book is the promised 200 recipes. They cover assorted dietary requirements (gluten-free, dairy-free, etc) while keeping to the Mediterranean Diet.
The recipes are super clear, just what you need to know, no reading through a nostalgic storytime first to find things. Also no pictures, which will be a plus for some readers and a minus for others. The recipes also come complete with nutritional information for each meal (including sodium), so you don’t have to do your own calculations!
Bottom line: this is the Mediterranean Diet air fryer cook book. Get it, thank us later!
Get your copy of “Mediterranean Air Fryer Cookbook” on Amazon today!
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