PS, We Love You

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Phosphatidylserine (PS), we love you. With good reason!

There are nearly 20,000 studies on PS listed on PubMed alone, and its established benefits include:

We’ll explore some of these studies and give an overview of how PS does what it does. Just like the (otherwise unrelated) l-theanine we talked about a couple of weeks ago, it does do a lot of things.

PS = Cow Brain?!

Let’s first address a concern. You may have heard something along the lines of “hey, isn’t PS made from cow brain, and isn’t that Very Bad™ for humans, mad cow disease and all?”. The short answer is:

Firstly: ingesting cow brain tissue is indeed generally considered Very Bad™ for humans, on account of the potential for transmission of Bovine Spongiform Encephalopathy (BSE) resulting in its human equivalent, Creutzfeldt–Jakob Disease (CJD), whose unpleasantries are beyond the scope of this newsletter.

Secondly (and more pleasantly): whilst PS can be derived from bovine brain tissue, most PS supplements these days derive from soy—or sometimes sunflower lecithin. Check labels if unsure.

Using PS to Improve Other Treatments

In the human body, the question of tolerance brings us a paradox (not the tolerance paradox, important as that may also be): we must build and maintain a strong immune system capable of quickly adapting to new things, and then when we need medicines (or even supplements), we need our body to not build tolerance of them, for them to continue having an effect.

So, we’re going to look at a very hot-off-the-press study (Feb 2023), that found PS to “mediate oral tolerance”, which means that it helps things (medications, supplements etc.) that we take orally and want to keep working, keep working.

In the scientists’ own words (we love scientists’ own words because they haven’t been distorted by the popular press)…

❝This immunotherapy has been shown to prevent/reduce immune response against life-saving protein-based therapies, food allergens, autoantigens, and the antigenic viral capsid peptide commonly used in gene therapy, suggesting a broad spectrum of potential clinical applications. Given the good safety profile of PS together with the ease of administration, oral tolerance achieved with PS-based nanoparticles has a very promising therapeutic impact.❞

Nguyen et al, Feb 2023

In other words, to parse those two very long sentences into two shorter bullet points:

  • It allows a lot of important treatments to continue working—treatments that the body would otherwise counteract
  • It is very safe—and won’t harm the normal function of your immune system at large

This is also very consistent with one of the benefits we mentioned up top—PS helps avoid rejection of implants, something that can be a huge difference to health-related quality of life (HRQoL), never mind sometimes life itself!

What is PS Anyway, and How Does It Work?

Phosphatidylserine is a phospholipid, a kind of lipid, found in cell membranes. More importantly:

It’s a signalling agent, mainly for apoptosis, which in lay terms means: it tells cells when it’s time to die.

Cellular death sounds like a bad thing, but prompt and efficient cellular apoptosis (death) and resultant prompt and efficient autophagy (recycling) reduce the risk of your body making mistakes when creating new cells from old cells.

Think about photocopying:

  • Situation A: You have a document, and you want to copy it. If you copy it before it gets messed up, your copy will look almost, if not exactly, like the original. It’ll be super easy to read.
  • Situation B: You have a document, and you want to copy it, but you delay doing so for so long that the original is all scuffed and creased and has a coffee stain on it. These unwanted changes will get copied onto the new document, and any copy made of that copy will keep the problems too. It gets worse and worse each time.

So, using this over-simplifier analogy, the speed of ‘copying’ is a major factor in cellular aging. The sooner cells are copied, before something gets damaged, the better the copy will be.

So you really, really want to have enough PS (our bodies make it too, by the way) to signal promptly to a cell when its time is up.

You do not want cells soldiering on until they’re the biological equivalent of that crumpled up, coffee-stained sheet of paper.

Little wonder, then, that PS’ most commonly-sought benefit when it comes to supplementation is to help avoid age-related neurodegeneration (most notably, memory loss)!

Keeping the cells young means keeping the brain young!

PS’s role as a signalling agent doesn’t end there—it also has a lot to say to a wide variety of the body’s immunological cells, helping them know what needs to happen to what. Some things should be immediately eaten and recycled; other things need more extreme measures applied to them first, and yet other things need to be ignored, and so forth.

You can read more about that in Elsevier’s publication if you’re curious 🙂

Wow, what a ride today’s newsletter has been! We started at paracetamoxyfrusebendroneomycin, and got down to the nitty gritty with a bunch of hopefully digestible science!

We love feedback, so please let us know if we’re striking the balance right, and/or if you’d like to see more or less of something—there’s a feedback widget at the bottom of this email!

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  • Your Health Audit, From Head To Toe

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    Health Audit Time

    Here at 10almonds, we often cover quite specific things, ranging from “the effect of sodium on organs other than your heart” to “make this one small change to save your knees while driving”.

    But, we’re each a whole person, and we need to take care of the whole organism that makes up the wonderful being that we each are. If we let one part of it drop in health too much, the others will soon follow suit because of the knock-on effects.

    So, let’s do a quick self-check-up, and see what can be done for each! How’s your…

    Mental Health

    We’re doing this audit head-to-to, so let’s start it here, because mental health is also just health, and it’s difficult to tackle the others without having this one at least under control!

    Are you experiencing chronic stress? Anxiety? Depression? Joy?

    If you answered “no” to “joy” but also “no” to “depression”, you might want to rethink your answer to “depression”, by the way. Life should be a joyous thing!

    Some resources to address your mental health:

    Brain Health

    Your brain is a big, powerful organ. It uses more of your daily energy (in the physiological sense of the word, we’re talking calories and mitochondria and ATP) than any other organ, by far.

    And when it comes to organ failure, if your brain fails, then having the best joints in the world won’t help you, for example.

    Some resources to address your brain health:

    Heart Health

    Everything depends on your heart, head to toe. Tirelessly pumping blood with oxygen, nutrients, and agents of your immune system all around your body, all day every day for your entire life.

    What’s your resting heart rate like? How about your blood pressure? And while we’re on the topic of blood… how’s your blood sugar health?

    These are all important things to a) know about and b) keep on top of!

    Some resources to address your heart health:

    Gut Health

    By cell count, we’re about 10% human and 90% bacteria. By gene count, also. Pretty important, therefore, that we look after our trillions of tiny friends that keep our organism working.

    Most people in N. America, for example, get vastly under the recommended daily amount of fiber, and that’s just the most basic courtesy we could do for these bugs that keep us alive (they need that fiber to live, and their process of consuming it is beneficial to us in a stack of ways).

    Some resources to address your gut health:

    Hormonal Health

    Hormones are weird and wonderful and affect so much more than the obvious sex-related functions (but yes, those too). A lot of people don’t realize it, but having our hormones in good order or not can make the difference between abject misery and a happy, fulfilling life.

    Some resources to address your hormonal health:

    Bone/Joint Health

    Fear nothing! For you are a ghost operating a skeleton clad in flesh. But also, you know, look after that skeleton; you only get one! Being animals, we’re all about movement, and being humans, we’ve ended up with some lifestyle situations that aren’t great for that mobility. We sit too much; we walk too little; we cramp ourselves into weird positions (driving, anyone?), and we forget the range of motion we’re supposed to have. But let’s remember…

    Some resources to address your bone/joint health:

    Lastly…

    While it’s good to do a little self-audit like this every now and again, it’s even better to get a professional check-up!

    As engineers say: if you don’t schedule time for maintenance, your equipment will schedule it for you.

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  • Can you ‘microdose’ exercise?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Microdosing” originally meant taking tiny amounts of psychedelics (such as mushrooms) to enhance mood or performance, with fewer side effects.

    But the term has taken off to mean anything where you incorporate a much lower “dose” of something – and still reap the benefits.

    So, does this work for exercise? If you can’t make time for a 30-minute run, will shorter bursts of activity do anything for your health?

    Here’s what the evidence says.

    Natalia Lebendinskaia/Getty

    The minimum you should move

    According to the World Health Organization (WHO), adults should aim each week for either a minimum of 150 minutes of moderate intensity aerobic exercise – meaning it’s hard to hold a conversation – or 75 minutes of vigorous intensity – you are gasping for air at the end of it. Or you can do a combination of moderate and vigorous activity.

    This can include activities such as brisk walking, cycling, running, swimming or rowing, and team sports such as football and basketball.

    If you exercise every day, you’d need to do 20–30 minutes of these activities. Or you might do a couple of longer training sessions or matches two or three times a week.

    WHO guidelines also recommend including muscle-strengthening activities (such as lifting weights, or high-impact exercise like sprinting) at least twice a week.

    What counts as exercise?

    Incidental activity – unplanned or everyday movement, such as playing with kids or walking to the bus stop – may contribute to your physical activity levels over the week.

    So, yes, housework can count. For example, chores like mopping and vacuuming tend to have a similar physical demand as going for a walk.

    While this activity wouldn’t be considered vigorous, it could contribute to your moderate intensity minutes.

    So, do smaller chunks work?

    Yes, the good news is doing small amounts of exercise throughout the day is just as effective as doing one long session.

    In fact, it may have some additional benefits.

    A 2019 review of 19 studies looked at this question, involving more than 1,000 participants. It found multiple, shorter “chunks” of exercise in a day improved heart and lung fitness and blood pressure as much as doing one longer session.

    And there was some evidence these chunks actually led to more weight loss and lower cholesterol.

    The most common way this exercise was compared in the 19 studies was with one group doing three ten-minute bouts of exercise five days a week, and another doing one 30-minute session, five days a week.

    Even very short bouts might help

    Another 2019 study in young adults examined the effect of short “exercise snacks” on fitness. While small, it had some interesting and positive results.

    The exercise “snack” group did three very short sessions per day, three times a week, for six weeks. Each session involved a light two-minute warm-up, followed by a 20-second maximal effort sprint – where you push as hard as you can – and then a one-minute cool-down.

    In total: just three minutes and 20 seconds of exercise, three times a day, three days a week.

    The control group did one session a day, three days a week, but it was longer – a total of ten minutes. It involved a two-minute warm-up, followed by three  20-second sprints, with three minutes of light recovery between sprints, then a one-minute cool-down.

    The “snack” group saw significant improvements in aerobic fitness, which is one of the strongest predictors of your risk of dying early and overall health.

    Similar research has suggested this same approach can have positive effects on lowering cholesterol levels. However, it may not provide enough total exercise time to lose weight.

    Shorter – but harder?

    The research outlined above suggests the shorter your exercise session, the harder you need to push.

    So you might need to adapt your exercise to increase intensity. For example, one minute of maximal intensity exercise might be worth two minutes of moderate intensity exercise.

    Basically, if you’re short on time you will get more bang-for-your-buck by going harder.

    So, is it worth still doing longer sessions?

    For health and general fitness, the research suggests there aren’t downsides to breaking a long workout into smaller chunks.

    But there are some reasons you might still want to keep exercising longer.

    If you are training for a longer duration event (maybe a 10 kilometre run, a 30km ride, or even a marathon), you will need to do some longer sessions. This will ensure your muscles and joints are prepared to tolerate the demands of the event, and help your body adapt to maximise performance on the day.

    For mental health, there is also some evidence to suggest doing more than the recommended minimum exercise might be better.

    For example, two recent meta-analyses (studies which review the available evidence) found that around one hour of moderate intensity exercise a day can significantly improve anxiety and depression symptoms.

    But these studies didn’t compare the benefits of one session versus chunks, so it’s likely you can still break up your exercise across the day and feel an effect.

    The bottom line

    Any exercise is better than none. If you struggle for time, as little as three minutes a day, spread across three sessions, can have a positive effect on our health.

    But don’t forget – the shorter the session, the harder it needs to be.

    Hunter Bennett, Lecturer in Exercise Science, University of South Australia

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • 6 Blood Markers That Predict Disease Years Before Symptoms Appear

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    Do you have these 6 done?

    When “normal” isn’t helpful

    Most of the most common blood tests are designed to confirm established disease, not detect the slow, early biological drift that occurs years before symptoms appear.

    Here are 6 that do better:

    1. High-sensitivity CRP: persistently elevated hs-CRP within the “normal” range reflects chronic low-grade inflammation that predicts cardiovascular disease, stroke, diabetes, cancer, and dementia long before diagnosis.
    2. Fasting insulin: elevated fasting insulin with normal glucose reveals early insulin resistance, a reversible stage that predicts type 2 diabetes, cardiovascular disease, and often even Alzheimer’s disease years in advance.
    3. ApoB: apolipoprotein B directly counts atherogenic particles and predicts heart attack and stroke risk more accurately than LDL cholesterol, especially in people with metabolic dysfunction.
    4. Homocysteine: raised homocysteine damages blood vessels and brain tissue, increasing risks of cardiovascular disease and dementia, and is often correctable with adequate B-vitamin status.
    5. HbA1c trajectory: trends and position within the normal range matter more than cut-offs, with gradual rises over years signalling worsening metabolic health and cumulative glycation damage.
    6. GlycA: this little-known marker reflects long-term inflammatory burden and predicts cardiovascular disease, diabetes, and mortality more strongly than many traditional tests.

    Lastly, Dr. Wibberly advises us that patterns that can be noted from repeated measurements over time reveal true risk, whereas isolated “normal” results can hide a worsening biological trajectory.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Early Dementia Screening From Your Blood & More

    And for a much more comprehensive overview of blood tests in general:

    Common Sense Labs: Blood Labs Demystified – by Dr. Ken Berry & Kim Howerton

    Take care!

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  • An apple cider vinegar drink a day? New study shows it might help weight loss

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Made from fermented apples and naturally high in acetic acid, apple cider vinegar has been popular in recent years for its purported health benefits – from antibacterial properties to antioxidant effects and potential for helping manage blood sugars.

    Its origins as a health tonic stretch much further back. Hippocrates used it to treat wounds, fever and skin sores.

    An experimental study, released today, looks into whether apple cider vinegar could be effective for weight loss, reduce blood glucose levels and reduce blood lipids (cholesterol and triglycerides).

    The results suggest it could reduce all three – but it might not be as simple as downing an apple cider vinegar drink a day.

    What did they do?

    A group of scientists in Lebanon did a double-blinded, randomised, clinical trial in a group of overweight and obese young people aged from 12–25 years.

    Researchers randomly placed 30 participants in one of four groups. The participants were instructed to consume either 5, 10 or 15ml of apple cider vinegar diluted into 250ml of water each morning before they ate anything for 12 weeks. A control group consumed an inactive drink (a placebo) made (from lactic acid added to water) to look and taste the same.

    Typically this sort of study provides high quality evidence as it can show cause and effect – that is the intervention (apple cider vinegar in this case) leads to a certain outcome. The study was also double-blinded, which means neither the participants or the scientists involved with collecting the data knew who was in which group.

    So, what did they find?

    After a period of three months apple cider vinegar consumption was linked with significant falls in body weight and body mass index (BMI). On average, those who drank apple cider vinegar during that period lost 6–8kg in weight and reduced their BMI by 2.7–3 points, depending on the dose. They also showed significant decreases in the waist and hip circumference.

    The authors also report significant decreases in levels of blood glucose, triglycerides, and cholesterol in the apple cider groups. This finding echoes previous studies. The placebo group, who were given water with lactic acid, had much smaller decreases in weight and BMI. There were also no significant decreases in blood glucose and blood lipids.

    From animal studies, it is thought the acetic acid in apple cider vinegar may affect the expression of genes involved in burning fats for energy. The new study did not explore whether this mechanism was involved in any weight loss.

    Is this good news?

    While the study appears promising, there are also reasons for caution.

    Firstly, study participants were aged from 12 to 25, so we can’t say whether the results could apply to everyone.

    The statistical methods used in the study don’t allow us to confidently say the same amount of weight loss would occur again if the study was done again.

    And while the researchers kept records of the participants’ diet and exercise during the study, these were not published in the paper. This makes it difficult to determine if diet or exercise may have had an impact. We don’t know whether participants changed the amount they ate or the types of food they ate, or whether they changed their exercise levels.

    The study used a placebo which they tried to make identical in appearance and taste to the active treatment. But people may still be able to determine differences. Researchers may ask participants at the end of a study to guess which group they were in to test the integrity of the placebo. Unfortunately this was not done in this study, so we can’t be certain if the participants knew or not.

    Finally, the authors do not report whether anyone dropped out of the study. This could be important and influence results if people who did not lose weight quit due to lack of motivation.

    open glass of liquid with cloudy substance at bottom, surrounded by apples
    Is that you mother? The enzymes in apple cider vinegar might be health-giving.
    Shutterstock

    Any other concerns?

    Apple cider vinegar is acidic and there are concerns it may erode tooth enamel. This can be a problem with any acidic beverages, including fizzy drinks, lemon water and orange juice.

    To minimise the risk of acid erosion some dentists recommend the following after drinking acidic drinks:

    • rinsing out your mouth with tap water afterwards
    • chewing sugar-free gum afterwards to stimulate saliva production
    • avoiding brushing your teeth immediately after drinking because it might damage the teeth’s softened top layer
    • drink with a straw to minimise contact with the teeth.
    woman holds glass of water and has full cheeks
    Rinsing with water could prevent acid damaging your teeth.
    Shutterstock

    Down the hatch?

    This study provides us with some evidence of a link between apple cider vinegar and weight loss. But before health professionals can recommend this as a weight loss strategy we need bigger and better conducted studies across a wider age range.

    Such research would need to be done alongside a controlled background diet and exercise across all the participants. This would provide more robust evidence that apple cider vinegar could be a useful aid for weight loss.

    Still, if you don’t mind the taste of apple cider vinegar then you could try drinking some for weight loss, alongside a healthy balanced and varied dietary intake. This study does not suggest people can eat whatever they like and drink apple cider vinegar as a way to control weight. The Conversation

    Evangeline Mantzioris, Program Director of Nutrition and Food Sciences, Accredited Practising Dietitian, University of South Australia

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Glycine: The Cheapest Anti-Aging Supplement That Actually Works

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Leonid Kim explains glycine’s role in anti-aging:

    The essential non-essential

    Glycine is a “non-essential” amino acid (i.e., our body is able to synthesize it, so we don’t die quickly and horribly if it’s not in our diet, which is what happens if “essential” amino acids are missing) that’s nonetheless essential (in the sense of being necessary) for many things including collagen formation, liver support, neurotransmitter regulation, and glutathione production, which latter protects your cells from oxidative stress and mitochondrial damage—in other words, aging.

    A quick side-note about glutathione: glutathione is made from glutamate, cysteine, and glycine; glycine and cysteine are often rate-limiting, so low levels of either can reduce your antioxidant capacity

    And a side-side-note about cysteine: cysteine is unstable and often in short supply during stress or illness; n-acetylceysteine (NAC) delivers usable cysteine, allowing glycine to complete glutathione synthesis—this is why the combined approach (glyNAC) is sometimes preferred.

    That said, glycine alone is typically enough for healthy younger people using it mainly for sleep, while glyNAC may be more appropriate if you have insulin resistance, diabetes, fatty liver, PCOS, high blood pressure, high cholesterol, chronic inflammation, or an autoimmune condition.

    As for what to expect:

    • Metabolic and anti-inflammatory actions: evidence suggests glycine can help with inflammation and can even become conditionally essential during metabolic disease in particular, illness in general, and/or chronic inflammation. Glycine levels also tend to be lower in people with insulin resistance or other metabolic syndrome considerations, so may benefit extra from supplementing in those cases, too.
    • Sleep effects: glycine before bed can improve sleep quality by helping you fall asleep more quickly, cooling your core temperature, calming orexin (wakefulness) receptor neurons, regulating serotonin, and supporting full muscle relaxation during REM sleep, for greater restfulness.

    As for dosing if doing it one way or the other:

    • Dosing for glycine: the most studied dose is 3 g taken 30–60 minutes before sleep; it tastes sweet, dissolves easily in water, and is generally well tolerated; very high doses used in schizophrenia studies (40–90 g per day) looked tolerable short-term but aren’t advisable due to unclear long-term safety and possible neurobehavioral or cardiovascular concerns.
    • Dosing for glyNAC: published human studies typically use 100 mg/kg glycine + 100 mg/kg NAC per day (about 7 g of each for a 70-kg person), usually split into two doses; many people start around 3 g per day and increase slowly.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Take care!

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  • What Nobody Teaches You About Strengthening Your Knees

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    Strengthening unhappy knees can seem difficult, because many obvious exercises like squats may hurt, and can feel like they are doing harm (and if your knees are bad enough, maybe they are; it depends on many factors). Here’s a way to improve things:

    The muscle nobody talks about

    Well, not nobody. But, it’s a muscle that’s rarely talked about; namely, the tibialis anterior.

    It plays a key role in decelerating knee motion—in other words, the movement that hurts if you have bad knees. It’s essential for absorbing shock during activities like walking, climbing stairs, and stepping off curbs

    So, of course, strengthening this muscle supports knee health.

    The exercise this video recommends for strengthening it involves leaning against a wall with feet about a foot away (closer feet make it easier, further makes it harder). Note, this is a lean, not a “Roman chair”.

    The exercise involves squeezing the quadriceps, lifting toes toward the nose, and engaging the tibialis anterior muscle. If you’re wondering what to do with your hands, they can be held out with palms open to work on posture, or hanging by the sides. Do this for about 1½–2 minutes.

    For more on all this, plus a visual demonstration, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    When Bad Joints Stop You From Exercising (5 Things To Change)

    Take care!

    Don’t Forget…

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