
Viruses, Bacteria, Allergens: One Nasal Spray To Stop Them All
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…and in the airways, fight them!
Scientists unveil a “universal vaccine”
Vaccines save millions of lives every year:
- WHO | Global immunization efforts have saved at least 154 million lives over the past 50 years
- CDC | Fast Facts on Global Immunization: Vaccination benefits
- Lancet | Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization
Since vaccines are not without their popular misunderstanders, we have written a little about that, here: Vaccine Mythbusting
However, they have limitations. Most notably, because they work by showing your immune system a recognizable piece of a specific pathogen, such as the spike protein of COVID, this runs into difficulties when viruses mutate, so surface antigens change, which is why COVID boosters, annual flu shots, and similar vaccines sometimes need updating.
Researchers (Dr. Mengyun Hu et al.) found a way to create a broad protection against many respiratory threats.
How it does that, in technical terms: the formulation GLA-3M-052-LS+OVA combines toll-like receptor 4 and 7/8 ligands with ovalbumin to recruit memory CD4+ and CD8+ T cells into your lungs and keep alveolar macrophages in a heightened defensive state.
Translating from sciencese: instead of targeting a specific antigen from one pathogen, the nasal spray boosts your lungs’ integrated innate and adaptive immune responses to provide broad protection.
Dr. Hu (what a cool name) and her team will be doing human trials soon, but the results so far from mouse studies are very promising:
- Against viruses: vaccinated mice enjoyed a 700-fold reduction in lung viral levels after SARS-CoV-2 exposure, avoided severe weight loss, and all survived*.
- Broad spectrum antivirus vaccines have been explored already, but they only work against certain kinds of viruses, e.g: The Ultimate Booster: Winning The Biological Arms Race
- Against bacteria: vaccinated mice were also protected for about 3 months against Staphylococcus aureus and Acinetobacter baumannii, both common causes of hospital-acquired pneumonia.
- On which note, since that kills many people, do check out: Pneumonia: Prevention Is Better Than Cure
- Against allergies: when exposed to house dust mite allergens, vaccinated mice developed a much weaker Th2 response (which in this context, is good) and maintained clear airways compared with unvaccinated mice.
- This is interesting, especially if we also bear in mind: The Anti-Allergy Nasal Spray That Kills COVID & More
*This is a big difference from what happened in unvaccinated mice, because while the unvaccinated mice had initially healthy immune systems, those unvaccinated immune systems had no instructions about what to do, and thus:
❝The immune system becomes so ready and so alert that it can launch the typical adaptive responses—virus-specific T cells and antibodies—in as little as three days, compared with about 2 weeks in unvaccinated mice❞
~ Dr. Violetta Horton, professor of microbiology and immunology, and colleague of Dr. Hu collaborating on this study
If it’s successful in human trials:
- It’s expected to require just two nasal doses
- It could replace multiple seasonal respiratory vaccines
- It should seriously boost rapid protection during future pandemics
You can find the study itself, here: Mucosal vaccination in mice provides protection from diverse respiratory threats
Want to do more meanwhile?
You might want to check out: Beyond Supplements: The Real Immune-Boosters! ← most people don’t know these things and the huge difference they make
And for that matter: Why Some People Get Sick More (And How To Not Be One Of Them) ← for a very prophylactic approach
Take care!
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Dr. Patrick Walsh’s Guide to Surviving Prostate Cancer – by Dr. Patrick Walsh & Janet Farrar Worthington
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Prostate cancer is not glamorous or fun, and neither is this book.
Nevertheless, it’s a disease that affects 12% of men in general, and 60% of men aged 60+, with that percentage climbing every year after that.
So, if you have a prostate or love someone who has one, this book is worthwhile reading—yes, even as a preventative.
Like many cancers, prostate cancer is easy to treat if caught very early, becomes harder to treat as it goes, and almost impossible to cure if it gets as far as metastasis (i.e., it spread). Like all cancers, it’s better off avoided entirely if possible.
This book covers all the stages:
- How to avoid it
- How to check for it
- How to “nip it in the bud”
- Why some might want to delay treatment (!)
- What options are available afterwards
This latter is quite extensive, and covers not just surgery, but radiation, thermo- or cryoablation, and hormone therapy.
And as for surgery, not just “remove the tumor”, but other options like radical prostatectomy, and even orchiectomy. Not many men will choose to have their testicles removed to stop them from feeding the prostate, but the point is that this book is comprehensive.
It’s asking whenever possible “is there another option?” and exploring all options, with information and without judgment, at each stage.
The writing style (likely co-author Worthington’s influence; she is an award-winning science-writer) is very “for the layman”, and that’s really helpful in demystifying a lot of what can be quite opaque in the field of oncology.
Bottom line: absolutely not an enjoyable read, but a potentially lifesaving one, especially given the odds we mentioned up top.
Click here to check out Dr. Patrick Walsh’s Guide To Surviving Prostate Cancer, and be prepared!
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Artichoke vs Bamboo Shoots – Which is Healthier?
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Our Verdict
When comparing artichoke to bamboo shoots, we picked the artichoke.
Why?
Both have their merits, but there is a clear winner:
In terms of macros, artichoke has more than 2x the fiber, for a little under 2x the carbs, and more protein, making it the more nutrient-dense option in this category.
In the category of vitamins, artichoke has more of vitamins B3, B5, B7, B9, C, and K, while bamboo has more of vitamins B1, B6, and E, yielding a 6:3 victory to artichoke here.
Looking at minerals, artichoke has more calcium, copper, iron, magnesium, and phosphorus, while bamboo has more potassium, selenium, and zinc, giving a 5:3 win to artichoke in this round.
In other considerations, artichoke is also higher in polyphenols, so that’s another point in its favor too.
Adding up the sections makes for a clear overall win for artichoke, but by all means do enjoy either or both, as diversity is best!
Want to learn more?
You might like:
Don’t Be Bamboozled By Bamboo! ← including how to eat bamboo, for those unfamiliar with such, as we have been asked about it 🙂
Enjoy!
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Banana vs Jackfruit – Which is Healthier?
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Our Verdict
When comparing banana to jackfruit, we picked the banana.
Why?
Both have their merits! But…
In terms of macros, bananas have nearly 2x the fiber while jackfruit has very slightly more protein (tiny difference, despite jackfruit being often used as a plant-based meat in recipes, it’s not actually much higher in protein than most fruits), and also very slightly more carbs, giving bananas the win here for all that fiber.
In the category of vitamins, bananas have more of vitamins B2, B5, B6, B7, and K, while jackfruit has more of vitamins A, B1, B9, B3, C, and E, giving jackfruit a slender win in this round.
Looking at minerals, bananas have more copper, iron, manganese, phosphorus, selenium, and zinc, while jackfruit has more calcium and potassium, making this round a 6:2 win for bananas.
Adding up the sections makes for an overall win for bananas, but by all means do enjoy either or both, as diversity is best!
Want to learn more?
You might like:
Why You’re Probably Not Getting Enough Potassium ← we can add jackfruit to the long list of fruits that have more potassium than bananas do
Enjoy!
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Passion Fruit vs Pomegranate – Which is Healthier?
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Our Verdict
When comparing passion fruit to pomegranate, we picked the passion fruit.
Why?
Both of these fruits have beaten a lot of other contenders, so it’s time to pit them against each other:
In terms of macros, passion fruit has more protein, carbs, and fiber, the ratio of which meaning also that passion fruit has the lower glycemic index. So, we say passion fruit wins on macros.
In the category of vitamins, things are more even; passion fruit has more of vitamins A, B2, B3, B6, and C, while pomegranate has more of vitamins B1, B5, B9, E, and K. In light of this 5:5 tie, and since passion fruit’s overall vitamin coverage is better (in terms of meeting RDA needs) but pomegranate’s vitamins are often in shorter supply in diet, we’re calling it a tie on vitamins.
Looking at minerals, passion fruit has more calcium, iron, magnesium, phosphorus, potassium, and selenium, while pomegranate has more copper, manganese, and zinc. That’s already an easy 6:3 win for passion fruit, before we even consider the fact that passion fruit’s minerals’ margin of difference is greater too.
Adding up the sections makes for a clear overall win for passion fruit, but by all means do enjoy either or both, as diversity is best!
Want to learn more?
You might like to read:
What’s Your Plant Diversity Score?
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Grapes vs Mango – Which is Healthier?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Our Verdict
When comparing grapes to mango, we picked the mango.
Why?
In terms of macros, grapes have more carbs while mangos have more fiber and protein, winning.
In the category of vitamins, grapes have more of vitamins B1, B2, and K, while mangos have more of vitamins A, B3, B5, B6, B7, B9, C, and E, winning easily again.
Looking at minerals, grapes have more calcium, iron, manganese, and potassium, while mangos have more copper, magnesium, phosphorus, selenium, and zinc, winning for a third time in a row.
In other considerations, grapes do have more polyphenols, so that is a point in their favor.
Adding up the sections makes for a clear overall win for mangos, but by all means do enjoy either or both, as diversity is best!
Want to learn more?
You might like:
Can We Drink To Good Health? ← while there are polyphenols such as resveratrol in red wine that per se would boost heart health, there’s so little per glass that you may need 100–1000 glasses per day to get the dosage that provides benefits in mouse studies.
If you’re not a mouse, you might even need more than that!
To this end, many people prefer resveratrol supplementation ← link is to an example product on Amazon, but there are plenty more so feel free to shop around 😎
Enjoy!
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What is ‘breathwork’? And do I need to do it?
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From “breathwork recipes” to breathing techniques, many social media and health websites are recommending breathwork to reduce stress.
But breathwork is not new. Rather it is the latest in a long history of breathing techniques such as Pranayama from India and qigong from China. Such practices have been used for thousands of years to promote a healthy mind and body.
The benefits can be immediate and obvious. Try taking a deep breath in through your nose and exhaling slowly. Do you feel a little calmer?
So, what’s the difference between the breathing we do to keep us alive and breathwork?
Taras Grebinets/Shutterstock Breathwork is about control
Breathwork is not the same as other mindfulness practices. While the latter focus on observing the breath, breathwork is about controlling inhalation and exhalation.
Normally, breathing happens automatically via messages from the brain, outside our conscious control. But we can control our breath, by directing the movement of our diaphragm and mouth.
The diaphragm is a large muscle that separates our thoracic (chest) and abdominal (belly) cavities. When the diaphragm contracts, it expands the thoracic cavity and pulls air into the lungs.
Controlling how deep, how often, how fast and through what (nose or mouth) we inhale is the crux of breathwork, from fire breathing to the humming bee breath.
Breathwork can calm or excite
Even small bits of breathwork can have physical and mental health benefits and complete the stress cycle to avoid burnout.
Calming breathwork includes diaphragmatic (belly) breathing, slow breathing, pausing between breaths, and specifically slowing down the exhale.
In diaphragmatic breathing, you consciously contract your diaphragm down into your abdomen to inhale. This pushes your belly outwards and makes your breathing deeper and slower.
You can also slow the breath by doing:
- box breathing (count to four for each of four steps: breathe in, hold, breathe out, hold), or
- coherent breathing (controlled slow breathing of five or six breaths per minute), or
- alternate nostril breathing (close the left nostril and breathe in slowly through the right nostril, then close the right nostril and breathe out slowly through the left nostril, then repeat the opposite way).
You can slow down the exhalation specifically by counting, humming or pursing your lips as you breathe out.
In contrast to these calming breathing practices, energising fast-paced breathwork increases arousal. For example, fire breathing (breathe in and out quickly, but not deeply, through your nose in a consistent rhythm) and Lion’s breath (breathe out through your mouth, stick your tongue out and make a strong “haa” sound).
What is happening in the body?
Deep and slow breathing, especially with a long exhale, is the best way to stimulate the vagus nerves. The vagus nerves pass through the diaphragm and are the main nerves of the parasympathetic nervous system.
Simulating the vagus nerves calms our sympathetic nervous system (fight or flight) stress response. This improves mood, lowers the stress hormone cortisol and helps to regulate emotions and responses. It also promotes more coordinated brain activity, improves immune function and reduces inflammation.
Taking deep, diaphragmatic breaths also has physical benefits. This improves blood flow, lung function and exercise performance, increases oxygen in the body, and strengthens the diaphragm.
Slow breathing reduces heart rate and blood pressure and increases heart rate variability (normal variation in time between heart beats). These are linked to better heart health.
Taking shallow, quick, rhythmic breaths in and out through your nose stimulates the sympathetic nervous system. Short-term, controlled activation of the stress response is healthy and develops resilience to stress.
Breathing in through the nose
We are designed to inhale through our nose, not our mouth. Inside our nose are lots of blood vessels, mucous glands and tiny hairs called cilia. These warm and humidify the air we breathe and filter out germs and toxins.
We want the air that reaches our airways and lungs to be clean and moist. Cold and dry air is irritating to our nose and throat, and we don’t want germs to get into the body.
Nasal breathing increases parasympathetic activity and releases nitric oxide, which improves airway dilation and lowers blood pressure.
Consistently breathing through our mouth is not healthy. It can lead to pollutants and infections reaching the lungs, snoring, sleep apnoea, and dental issues including cavities and jaw joint problems.
Breathing can be high and shallow when we are stressed. mi_viri/Shutterstock A free workout
Slow breathing – even short sessions at home – can reduce stress, anxiety and depression in the general population and among those with clinical depression or anxiety. Research on breathwork in helping post-traumatic stress disorder (PTSD) is also promising.
Diaphragmatic breathing to improve lung function and strengthen the diaphragm can improve breathing and exercise intolerance in chronic heart failure, chronic obstructive pulmonary disease and asthma. It can also improve exercise performance and reduce oxidative stress (an imbalance of more free radicals and/or less antioxidants, which can damage cells) after exercise.
Waiting at the lights? This could be your signal to do some breathwork. doublelee/Shutterstock A mind-body connection you can access any time
If you feel stressed or anxious, you might subconsciously take shallow, quick breaths, but this can make you feel more anxious. Deep diaphragmatic breaths through your nose and focusing on strong exhalations can help break this cycle and bring calm and mental clarity.
Just a few minutes a day of breathwork can improve your physical and mental health and wellbeing. Daily deep breathing exercises in the workplace reduce blood pressure and stress, which is important since burnout rates are high.
Bottom line: any conscious control of your breath throughout the day is positive.
So, next time you are waiting in a line, at traffic lights or for the kettle to boil, take a moment to focus on your breath. Breathe deeply into your belly through your nose, exhale slowly, and enjoy the benefits.
Theresa Larkin, Associate professor of Medical Sciences, University of Wollongong and Judy Pickard, Senior Lecturer, Clinical Psychology, University of Wollongong
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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