Two Awesome Hours – by Dr. Josh Davis
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The brain is an amazing and powerful organ, with theoretically unlimited potential in some respects. So why doesn’t it feel that way a lot of the time?
The truth is that not only are we often tired, dehydrated, or facing other obvious physiological challenges to peak brain health, but also… We’re simply not making the best use of it!
What Dr. Davis does is outline for us how we can create the conditions for “two awesome hours” of effective mental performance by:
- Recognizing when to most effectively flip the switch on our automatic thinking
- Scheduling tasks based on their “processing demand” and recovery time
- Learning how to direct attention, rather than avoid distractions
- Feeding and moving our bodies in ways that prep us for success
- Identifying what matters in our environment to be at the top of our mental game
Why only two hours? Why not four, or eight, or more?
Well, our brains need recovery time too, so we can’t be “always on” and operating and peak efficiency. But, what we can do is optimize a couple of hours for absolute peak efficiency, and then enjoy the rest of time with lower cognitive-load activities.
Bottom line: if the idea of what you could accomplish if you could just be guaranteed two schedulable hours (your preference when!) of peak cognitive performance per day, then this is a great book for you.
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Eggplant vs Tomato – Which is Healthier?
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Our Verdict
When comparing eggplant to tomato, we picked the eggplant.
Why?
Both have their merits! But…
In terms of macros, eggplant has nearly 3x the fiber, as well as slightly more carbs and protein, making it the most nutritionally dense option in the macros category.
In the category of vitamins, eggplant has more of vitamins B1, B2, B3, B5, B6, B9, and choline, while tomatoes have more of vitamins A, C, E, and K. So, very different vitamin coverage from each one, and/but by the numbers, eggplant wins.
When it comes to minerals, eggplant has more copper, magnesium, manganese, and selenium, while tomatoes have more calcium and iron. The margins of difference are very small in all cases, and they’re equal in phosphorus, potassium, and zinc. So this one’s very close, but by the numbers, eggplant scrapes a marginal victory.
Looking at phytochemicals, they’re about equal on polyphenols, though it’s worth mentioning that tomatoes are a famously good source of lycopene, which isn’t a polyphenol, but it is a very beneficial carotenoid, so we’ll say tomatoes get the win this round.
Adding up the sections, though, makes for an overall win for eggplant, but tomatoes are great too, and mostly in different ways than eggplant, which makes them extra good to enjoy together (salad, ratatouille, etc) for their very complementary health benefits!
Want to learn more?
You might like:
Lycopene’s Benefits For The Gut, Heart, Brain, & More
Enjoy!
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Apple vs Gooseberries – Which is Healthier?
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Our Verdict
When comparing apple to gooseberries, we picked the apple.
Why?
These two fruits are popular contenders for losing most head-to-head contests on here, but…
In terms of macros, gooseberries have more than 2x the fiber, scoring them a first-round win.
When it comes to vitamins, apples are not higher in any vitamins, while gooseberries are higher in vitamins A, B1, B2, B3, B5, B6, B7, B9, C, E, and K, sweeping this category.
Looking at minerals, apples are not higher in any minerals, while gooseberries have more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc, winning overwhelmingly again.
Adding up the sections makes for a clear overall win for gooseberries, but by all means enjoy either or both, as diversity is best!
Want to learn more?
You might like:
Are You Getting The Right Kinds Of Flavonoids? ← while both of these fruits today are quite modest in their polyphenol content, they have different ones, which is another reason to get a variety
Enjoy!
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Which gut drugs might end up in a lawsuit? Are there really links with cancer and kidney disease? Should I stop taking them?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Common medicines used to treat conditions including heartburn, reflux, indigestion and stomach ulcers may be the subject of a class action lawsuit in Australia.
Lawyers are exploring whether long-term use of these over-the-counter and prescription drugs are linked to stomach cancer or kidney disease.
The potential class action follows the settlement of a related multi-million dollar lawsuit in the United States. Last year, international pharmaceutical company AstraZeneca settled for US$425 million (A$637 million) after patients made the case that two of its drugs caused significant and potentially life-threatening side effects.
Specifically, patients claimed the company’s drugs Nexium (esomeprazole) and Prilosec (omeprazole) increased the risk of kidney damage.
Doucefleur/Shutterstock Which drugs are involved in Australia?
The class of drugs we’re talking about are “proton pump inhibitors” (sometimes called PPIs). In the case of the Australian potential class action, lawyers are investigating:
- Nexium (esomeprazole)
- Losec, Asimax (omeprazole)
- Somac (pantoprazole)
- Pariet (rabeprazole)
- Zoton (lansoprazole).
Depending on their strength and quantity, these medicines are available over-the-counter in pharmacies or by prescription.
They have been available in Australia for more than 20 years and are in the top ten medicines dispensed through the Pharmaceutical Benefits Scheme.
They are used to treat conditions exacerbated by stomach acid. These include heartburn, gastric reflux and indigestion. They work by blocking the protein responsible for pumping acid into the stomach.
These drugs are also prescribed with antibiotics to treat the bacterium Helicobacter pylori, which causes stomach ulcers and stomach cancer.
This class of drugs is also used with antibiotics to treat Helicobacter pylori infections. nobeastsofierce/Shutterstock What do we know about the risks?
Appropriate use of proton pump inhibitors plays an important role in treating several serious digestive problems. Like all medicines, there are risks associated with their use depending on how much and how long they are used.
When proton pump inhibitors are used appropriately for the short-term treatment of stomach problems, they are generally well tolerated, safe and effective.
Their risks are mostly associated with long-term use (using them for more than a year) due to the negative effects from having reduced levels of stomach acid. In elderly people, these include an increased risk of gut and respiratory tract infections, nutrient deficiencies and fractures. Long-term use of these drugs in elderly people has also been associated with an increased risk of dementia.
In children, there is an increased risk of serious infection associated with using these drugs, regardless of how long they are used.
How about the cancer and kidney risk?
Currently, the Australian consumer medicine information sheets that come with the medicines, like this one for esomeprazole, do not list stomach cancer or kidney injury as a risk associated with using proton pump inhibitors.
So what does the evidence say about the risk?
Over the past few years, there have been large studies based on observing people in the general population who have used proton pump inhibitors. These studies have found people who take them are almost two times more likely to develop stomach cancer and 1.7 times more likely to develop chronic kidney disease when compared with people who are not taking them.
In particular, these studies report that users of the drugs lansoprazole and pantoprazole have about a three to four times higher risk than non-users of developing chronic kidney disease.
While these observational studies show a link between using the drugs and these outcomes, we cannot say from this evidence that one causes the other.
Researchers have not yet shown these drugs cause kidney disease. crystal light/Shutterstock What can I do if I’m worried?
Several digestive conditions, especially reflux and heartburn, may benefit from simple dietary and lifestyle changes. But the overall evidence for these is not strong and how well they work varies between individuals.
But it may help to avoid large meals within two to three hours before bed, and reduce your intake of fatty food, alcohol and coffee. Eating slowly and getting your weight down if you are overweight may also help your symptoms.
There are also medications other than proton pump inhibitors that can be used for heartburn, reflux and stomach ulcers.
These include over-the-counter antacids (such as Gaviscon and Mylanta), which work by neutralising the acidic environment of the stomach.
Alternatives for prescription drugs include nizatidine and famotidine. These work by blocking histamine receptors in the stomach, which decreases stomach acid production.
If you are concerned about your use of proton pump inhibitors it is important to speak with your doctor or pharmacist before you stop using them. That’s because when you have been using them for a while, stopping them may result in increased or “rebound” acid production.
Nial Wheate, Professor and Director – Academic Excellence, Macquarie University; Joanna Harnett, Senior Lecturer – Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, and Wai-Jo Jocelin Chan, Pharmacist and Associate Lecturer, University of Sydney
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Fisetin: The Anti-Aging Assassin
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Out With The Old…
Fisetin is a flavonoid (specifically, a flavonol), but it’s a little different than most. While it has the usual antioxidant, anti-inflammatory, and anti-cancer properties you might reasonably expect from flavonoids, it has an extra anti-aging trick up its sleeve that most don’t.
❝Fisetin is a flavonol that shares distinct antioxidant properties with a plethora of other plant polyphenols. Additionally, it exhibits a specific biological activity of considerable interest as regards the protection of functional macromolecules against stress which results in the sustenance of normal cells cytoprotection. Moreover, it shows potential as an anti-inflammatory, chemopreventive, chemotherapeutic and recently also senotherapeutic agent❞
~ Dr. Grynkiewicz & Dr. Demchuk
Let’s briefly do some due diligence on its expected properties, and then we’ll take a look at its bonus anti-aging effects.
The flavonol that does-it-ol
Because of the similar mechanisms involved, there are three things that often come together, which are:
- Antioxidant
- Anti-inflammatory
- Anticancer
This list often gets expanded to also include:
- Anti-aging
…although that is usually the last thing to get tested out of that list.
In today’s case, let’s kick it off with…
❝Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects❞
Read more: Fisetin and Its Role in Chronic Diseases
Understanding its anticancer mechanisms
The way that fisetin fights cancer is basically “all the ways”, and this will be important when we get to its special abilities shortly:
❝Being a potent anticancer agent, fisetin has been used to inhibit stages in the cancer cells (proliferation, invasion),prevent cell cycle progression, inhibit cell growth, induce apoptosis, cause polymerase (PARP) cleavage, and modulate the expressions of Bcl‐2 family proteins in different cancer cell lines (HT‐29, U266, MDA‐MB‐231, BT549, and PC‐3M‐luc‐6), respectively. Further, fisetin also suppresses the activation of the PKCα/ROS/ERK1/2 and p38 MAPK signaling pathways, reduces the NF‐κB activation, and down‐regulates the level of the oncoprotein securin. Fisetin also inhibited cell division and proliferation and invasion as well as lowered the TET1 expression levels. ❞
Read more: Fisetin: An anticancer perspective
There’s also more about it than we even have room to quote, here:
Now For What’s New And Exciting: Senolysis
All that selectivity that fisetin exhibits when it comes to “this cell gets to live, and this one doesn’t” actions?
It makes a difference when it comes to aging, too. Because aging and cancer happen by quite similar mechanisms; they’re both DNA-copying errors that get copied forward, to our detriment.
- In the case of cancer, it’s a cell line that accidentally became immortal and so we end up with too many of them multiplying in one place (a tumor)
- In the case of aging, it’s the cellular equivalent of “a photocopy of a photocopy of a photocopy” gradually losing information as it goes
In both cases…
The cell must die if we want to live
Critically, and which quality differentiates it from a lot of other flavonoids, fisetin has the ability to selectively kill senescent cells.
To labor the photocopying metaphor, this means there’s an office worker whose job it is to say “this photocopy is barely legible, I’m going to toss this, and then copy directly from the clearest copy we have instead”, thus keeping the documents (your DNA) in pristine condition.
In fisetin’s case, this was first tested in mouse (in vivo) studies, and in human tissue (in vitro) studies, before moving to human clinical studies:
❝Of the 10 flavonoids tested, fisetin was the most potent senolytic.
The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit.❞
~ Dr. Matthew Yousefzadeh et al.
Read in full: Fisetin is a senotherapeutic that extends health and lifespan
There’s lots more science that’s been done to it since that first groundbreaking study though; here’s a more recent example:
Want some?
We don’t sell it, but here for your convenience is an example product on Amazon
Enjoy!
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Longevity… Simplified – by Dr. Howard Luks
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In the spirit of the book itself, we’ll keep this one simple:
The information in this book will not be new to regular readers of 10almonds, or at least, not if you’ve been with us for a while (because we can only cover so much per day, so long-time readers will have accumulated more knowledge).
On the other hand, the information is clear, correct, and very much stripped down to the most important basics. Not the very simplest basics, which would be an oversimplification to the point of inutility, but the most important basics.
To take an example, when it comes to exercise, he doesn’t say “exercise more” but rather that “a complete exercise program has four pillars: aerobic training, resistance training, balance training, and high-intensity interval training (HIIT)”, and then he goes about explaining, in clear and simple terms, how to do those.
The style is similar when it comes to diet, sleep, and body-part-specific chapters such as about heart health, brain health, and so forth.
Bottom line: if you’re a long-time 10almonds reader, you probably don’t need this one, but it’d be a great book for someone else who has expressed an interest in getting healthier, as it really is a top-tier “primer” in increasing health and healthspan.
Click here to check out Longevity… Simplified, and enjoy simplified longevity!
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Anti-Inflammatory Piña Colada Baked Oats
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If you like piña coladas and getting songs stuck in your head, then enjoy this very anti-inflammatory, gut-healthy, blood-sugar-balancing, and frankly delicious dish:
You will need
- 9 oz pineapple, diced
- 7 oz rolled oats
- 3 oz desiccated coconut
- 14 fl oz coconut milk (full fat, the kind from a can)
- 14 fl oz milk (your choice what kind, but we recommend coconut, the kind for drinking)
- Optional: some kind of drizzling sugar such as honey or maple syrup
Method
(we suggest you read everything at least once before doing anything)
1) Preheat the oven to 350℉ / 180℃.
2) Mix all the ingredients (except the drizzling sugar, if using) well, and put them in an ovenproof dish, compacting the mixture down gently so that the surface is flat.
3) Drizzle the drizzling sugar, if drizzling.
4) Bake in the oven for 30–40 minutes, until lightly golden-brown.
5) Serve hot or cold:
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- Bromelain vs Inflammation & Much More ← as found (uniquely!) in pineapple
- Can Saturated Fats Be Healthy? ← coconut certainly can!
- The Best Kind Of Fiber For Overall Health? ← it’s β-glucan, as found in abundance in oats
Take care!
Don’t Forget…
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Learn to Age Gracefully
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