Undo The Sun’s Damage To Your Skin

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It’s often said that our skin is our largest organ. Our brain or liver are the largest solid organs by mass (which one comes out on top will vary from person to person), our gut is the longest, and our lungs are the largest by surface area. But our skin is large, noticeable, and has a big impact on the rest of our health.

The sun is one of the main damaging factors for our skin; assorted toxins are also a major threat for many people, and once the skin barrier gets broken, it’s a field-day for bacteria.

So, what can we do about it?

Tretinoin: the skin’s rejuvenator

Tretinoin is also called retinoic acid, not to be mistaken for retinol, although they are both retinoids. Tretinoin is much stronger.

As for what it’s stronger at:

It’s usually prescribed for the treatment of sun-damage, acne, and wrinkles. Paradoxically, it works by inflaming the skin (and then making it better, and having done so, keeping it better).

In few words: it encourages your skin to speed up its life cycle, which means that cells die and are replaced sooner, which means the average age of skin cells will be considerably younger at any given time.

This is the same principle as we see at work when it comes to cellular apoptosis and autophagy in general, and specifically the same idea as we discussed when talking about senolytics, compounds that kill aging cells:

Fisetin: The Anti-Aging Assassin

About that paradoxical inflammation…

❝The topical use of tretinoin as an antiacne agent began almost a half century ago. Since that time it has been successfully used to treat comedonal and inflammatory acne.

Over the intervening years, the beneficial effects of tretinoin have grown from an understanding of its potent cornedolytie-related properties to an evolving appreciation of its antiinflammatory actions.

The topical use of clindamycin and tretinoin as a combination treatment modality that includes antibacterial, comedolytic, and antiinflammatoiy properties has proven to be a very effective therapy for treating the various stages of acne

It is now becoming increasingly clear that there may be good reasons for these observations.❞

~ Drs. Schmidt & Gans, lightly edited here for brevity

Read in full: Tretinoin: A Review of Its Anti-inflammatory Properties in the Treatment of Acne

Against damage by the sun

The older we get, the more likely sun damage is a problem than acne. And in the case of tretinoin,

❝In several well-controlled clinical trials, the proportion of patients showing improvement was significantly higher with 0.01 or 0.05% tretinoin cream than with placebo for criteria such as global assessment, fine and coarse wrinkling, pigmentation and roughness.

Improvements in the overall severity of photodamage were also significantly greater with tretinoin than with placebo.

Several placebo-controlled clinical studies have demonstrated that topical tretinoin has significant efficacy in the treatment of photodamaged skin. Improvements in subjective global assessment scores were recorded in:

49–100% of patients using once-daily 0.01% tretinoin,

68–100% of patients using 0.05% tretinoin, and

0–44% of patients using placebo.❞

~ Drs. Wagstaff & Noble

…which is quite compelling.

Read in full: Tretinoin: A Review of its Pharmacological Properties and Clinical Efficacy in the Topical Treatment of Photodamaged Skin

This is very well-established by now; here’s an old paper from when the mechanism of action was unknown (here in the current day, 17 mechanisms of action have been identified; beyond the scope of this article as we only have so much room, but it’s nice to see science building on science):

❝Tretinoin cream has been used extensively to reverse the changes of photoaging. It is the first topical therapy to undergo controlled clinical testing and proved to be efficacious. These results have been substantiated with photography, histopathologie examination, and skin surface replicas.

Tretinoin cream has an excellent safety record; a local cutaneous hypervitaminosis A reaction is the only common problem.❞

~ Dr. Goldfarb et al.

Read in full: Topical tretinoin therapy: Its use in photoaged skin

Is it safe?

For most people, when used as directed*, yes. However, it’s likely to irritate your skin at first, and that’s normal. If this persists more than a few weeks, or seems unduly severe, then you might want to stop and talk to your doctor again.

*See also: Scarring following inappropriate use of 0.05% tretinoin gel

(in the case of a young woman who used it 4x daily instead of 1x daily)

Want to try some?

Tretinoin is prescription-only, so speak with your doctor/pharmacist about that. Alternatively, retinal (not retinol) is the strongest natural alternative that works on the same principles; here’s an example product on Amazon 😎

Take care!

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  • Green Paneer Flatbreads

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    These are versatile little snacks that can be eaten alone or served as part of a buffet; great for warm summer nights!

    You will need

    • 1 lb block of paneer (you can also use our plant-based high-protein paneer recipe)
    • 7 oz unsweetened yogurt (your choice what kind; plant-based is fine; live cultured is best)
    • 1 tomato, thinly sliced
    • ½ red onion, thinly sliced
    • 2 oz spinach leaves
    • 1 tbsp lime juice
    • 1 tsp red chili powder
    • 4 wholewheat flatbreads

    And then the marinade:

    • 3 oz spinach
    • ½ bulb garlic
    • 1 tsp cumin seeds
    • 1 tsp coriander seeds
    • 1 tsp chili flakes
    • ½ tsp MSG or 1 tsp low-sodium salt (MSG being the preferable and healthier option)
    • 2 tbsp extra virgin olive oil
    • Juice of ½ lime

    Method

    (we suggest you read everything at least once before doing anything)

    1) Blend the marinade ingredients in a blender.

    2) Cut the paneer into long cuboid chapes (similar to fish fingers) and put them in a bowl. Pour ⅔ of the marinade over them, and gently mix to coat evenly.

    3) Heat a ridged griddle pan, and when hot, add the paneer and cook for 1–2 minutes each side without stirring, jiggling, or doing anything other than turning once per uncooked side.

    4) Combine the onion, tomato, spinach leaves, lime choice, and chili powder to make the salad.

    5) Add the remaining marinade to the yogurt to make a green dip.

    6) Toast your flatbreads under the grill.

    5) Assemble, putting the paneer and salad with a spoonful of the dip on the flatbread, and serve:

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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  • What Curiosity Really Kills

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Curiosity Kills The Neurodegeneration

    Of the seven things that Leonardo da Vinci considered most important for developing and maintaining the mind, number one on his list was curiosity, and we’re going to be focussing on that today.

    In case you are curious about what seven things made Leonardo’s* list, they were:

    1. Curiosità: an insatiably curious approach to life and an unrelenting quest for continuous learning
    2. Dimostrazione: a commitment to test knowledge through experience, persistence, and a willingness to learn from mistakes
    3. Sensazione: the continual refinement of the senses, especially sight, as a means to enliven experience
    4. Sfumato: (lit: “gone up in smoke”) a willingness to embrace ambiguity, paradox, and uncertainty
    5. Arte/Scienza: the curated balance of art and science, imagination and logic
    6. Corporalità: the cultivation of physical grace, ambidexterity, and fitness
    7. Connessione: a recognition of and appreciation for the interconnectedness of phenomena (systems-based thinking)

    *In case you are curious why we wrote “Leonardo” and not “da Vinci” as per our usual convention of shortening names to last names, da Vinci is not technically a name, in much the same way as “of Nazareth” was not a name.

    You can read more about all 7 of these in a book that we’ve reviewed previously:

    How to Think Like Leonardo da Vinci: Seven Steps to Genius Every Day – by Michael J. Gelb

    But for now, let’s take on “curiosity”!

    If you need an extra reason to focus on growing and nurturing your curiosity, it was also #1 of Dr. Daniel Levitin’s list of…

    The Five Keys Of Aging Healthily

    …and that’s from a modern-day neuroscientist whose research focuses on aging, the brain, health, productivity, and creativity.

    But how do we foster curiosity in the age of Google?

    Curiosity is like a muscle: use it or lose it

    While it’s true that many things can be Googled to satisfy one’s curiosity in an instant…

    • do you? It’s only useful if you do use it
    • is the top result on Google reliable?
    • there are many things that aren’t available there

    In short: douse “fast food information” sources, but don’t rely on them! Not just for the sake of having correct information, but also: for the actual brain benefits which is what we are aiming for here with today’s article.

    If you want the best brain benefits, dive in, and go deep

    Here at 10almonds we often present superficial information, with links to deeper information (often: scholarly articles). We do this because a) there’s only so much we can fit in our articles and b) we know you only have so much time available, and/but may choose to dive deeper.

    Think of it in layers, e.g:

    • Collagen is good for joints and bones
    • Collagen is a protein made of these amino acids that also requires these vitamins and minerals to be present in order to formulate it
    • Those amino acids are needed in these quantities, of which this particular one is usually the weakest link that might need supplementing, and those vitamins and minerals need to be within this period of time, but not these ones at the exact same time, or else it will disrupt the process of collagen synthesis

    (in case you’re curious, we covered this here and here and offered a very good, very in-depth book about it here)

    Now, this doesn’t mean that to have a healthy brain you need to have the equivalent knowledge of an anatomy & physiology degree, but it is good to have that level of curiosity in at least some areas of your life—and the more, the better.

    Top tips for developing a habit of curiosity

    As you probably know, most of our endeavors as humans go best when they are habits:

    How To Really Pick Up (And Keep!) Those Habits

    And as for specifically building a habit of curiosity:

    1. Make a deal with yourself that when someone is excited to tell you what they know about something (no matter whether it is your grandkid, or the socially awkward nerd at a party, or whoever), listen and learn, no matter the topic.
    2. Learn at least one language other than your native language (presumably English for most of our readers). Not only does learning a language convey a lot of brain benefits of its own, but also, it is almost impossible to separate language learning from cultural learning, and so you will learn a lot about another culture too, and have whole new worlds opened up to you. Again, more is better, but one second language is already a lot better than none.
    3. Make a regular habit of going to your local library, and picking out a non-fiction book to take home and read. This has an advantage over a bookshop, by the way (and not just that the library is free): since library books must be returned, you will keep going back, and build a habit of taking out books.
    4. Pick a skill that you’d like to make into a fully-fledged hobby, and commit to continually learning as much about it as you can. We already covered language-learning above, but others might include: gardening (perhaps a specific kind), cooking (perhaps a specific kind), needlecraft (perhaps a specific kind), dance (perhaps a specific kind). You could learn a musical instrument. Or it could be something very directly useful, like learning to be a first responder in case of emergencies, and committing to continually learning more about it (because there is always more to learn).

    And when it comes to the above choices… Pick things that excite you, regardless of how practical or not they are. Because that stimulation that keeps on driving you? That’s what keeps your brain active, healthy, and sharp.

    Enjoy!

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  • Chicken or Fish – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing chicken to fish, we picked the fish.

    Why?

    To understand the choice, we have to start a bit earlier on the decision tree. For most people most of the time, when it comes to a diet high in plants or high in animals, the plant-centric diet will generally be best:

    Do We Need Animal Products To Be Healthy?

    When it comes to animal meats, red meat is a fairly uncontroversial first thing to strike off the list:

    Eat To Beat Cancer

    …with pork and some other meats not being much better.

    But chicken? Poultry in general appears to be quite health-neutral. The jury is out and the science has mixed results, but the data is leaning towards “it’s probably fine”.

    See for example this huge (n=29,682) study:

    Associations of Processed Meat, Unprocessed Red Meat, Poultry, or Fish Intake With Incident Cardiovascular Disease and All-Cause Mortality

    this same paper shows that…

    ❝higher intake of processed meat, unprocessed red meat, or poultry, but not fish, was significantly associated with a small increased risk of incident CVD, whereas higher intake of processed meat or unprocessed red meat, but not poultry or fish, was significantly associated with a small increased risk of all-cause mortality❞

    So, since poultry isn’t significantly increasing all-cause mortality, and fish isn’t significantly increasing all-cause mortality or cardiovascular disease, fish comes out as the hands-down (fins-down?) winner.

    One more (this time, easy) choice to make, though!

    While fish in general (please, not fried, though!) is generally considered quite healthy, there is a big difference (more than you might think, and for reasons that are quite alarming), between…

    Health Risks & Nutrition: Farmed Fish vs Wild-Caught

    Enjoy, and take care!

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Related Posts

  • Bacopa Monnieri: A Well-Evidenced Cognitive Enhancer
  • Elderly loss of energy

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    ❝Please please give some information on elderly loss of energy and how it can be corrected. Please!❞

    A lot of that is the metabolic slump described above! While we certainly wouldn’t describe 60 as elderly, and the health impacts from those changes at 45–55 get a gentler curve from 60 onwards… that curve is only going in one direction if we don’t take exceptionally good care of ourselves.

    And of course, there’s also a degree of genetic lottery, and external factors we can’t entirely control (e.g. injuries etc).

    One factor that gets overlooked a lot, though, is really easy to fix: B-vitamins.

    In particular, vitamins B1, B5, B6, and B12. Of those, especially vitamins B1 and B12.

    (Vitamins B5 and B6 are critical to health too, but relatively few people are deficient in those, while many are deficient in B1 and/or B12, especially as we get older)

    Without going so detailed as to make this a main feature: these vitamins are essential for energy conversion from food, and they will make a big big difference.

    You might especially want to consider taking sulbutiamine, which is a synthetic version of thiamin (vitamin B1), and instead of being water-soluble, it’s fat-soluble, and it easily crosses the blood-brain barrier, which is a big deal.

    As ever, always check with your doctor because your needs/risks may be different. Also, there can be a lot of reasons for fatigue and you wouldn’t want to overlook something important.

    You might also want to check out yesterday’s sponsor, as they offer personalized at-home health testing to check exactly this sort of thing.

    ❝What are natural ways to lose weight after 60? Taking into account bad knees or ankles, walking may be out as an exercise, running certainly is.❞

    Losing weight is generally something that comes more from the kitchen than the gym, as most forms of exercise (except HIIT; see below) cause the metabolism to slow afterwards to compensate.

    However, exercise is still very important, and swimming is a fine option if that’s available to you.

    A word to the wise: people will often say “gentle activities, like tai chi or yoga”, and… These things are not the same.

    Tai chi and yoga both focus on stability and suppleness, which are great, but:

    • Yoga is based around mostly static self-support, often on the floor
    • Tai chi will have you very often putting most of your weight on one slowly-increasingly bent knee at a time, and if you have bad knees, we’ll bet you winced while reading that.

    So, maybe skip tai chi, or at least keep it to standing meditations and the like, not dynamic routines. Qigong, the same breathing exercises used in tai chi, is also an excellent way to improve your metabolism, by the way.

    Ok, back onto HIIT:

    You might like our previous article: How To Do HIIT* (Without Wrecking Your Body)

    *High-Intensity Interval Training (the article also explains what this is and why you want to do it)

    Don’t Forget…

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  • Sleep wrinkles are real. Here’s how they leave their mark

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    You wake up, stagger to the bathroom and gaze into the mirror. No, you’re not imagining it. You’ve developed face wrinkles overnight. They’re sleep wrinkles.

    Sleep wrinkles are temporary. But as your skin loses its elasticity as you age, they can set in.

    Here’s what you can do to minimise the chance of them forming in the first place.

    How side-sleeping affects your face

    Your skin wrinkles for a number of reasons, including ageing, sun damage, smoking, poor hydration, habitual facial expressions (such as grinning, pouting, frowning, squinting) and sleeping positions.

    When you sleep on your side or stomach, your face skin is squeezed and crushed a lot more than if you sleep on your back. When you sleep on your side or stomach, gravity presses your face against the pillow. Your face skin is distorted as your skin is stretched, compressed and pulled in all directions as you move about in your sleep.

    You can reduce these external forces acting on the face by sleeping on your back or changing positions frequently.

    Doctors can tell which side you sleep on by looking at your face

    In a young face, sleep wrinkles are transient and disappear after waking.

    Temporary sleep wrinkles can become persistent with time and repetition. As we age, our skin loses elasticity (recoil) and extensibility (stretch), creating ideal conditions for sleep wrinkles or lines to set in and last longer.

    The time spent in each sleeping position, the magnitude of external forces applied to each area of the face, as well as the surface area of contact with the pillow surface, also affects the pattern and rate of sleep wrinkle formation.

    Skin specialists can often recognise this. People who favour sleeping on one side of their body tend to have a flatter face on their sleeping side and more visible sleep lines.

    Can a night skincare routine avoid sleep wrinkles?

    Collagen and elastin are two primary components of the dermis (inner layer) of skin. They form the skin structure and maintain the elasticity of skin.

    Skin structure
    The dermis is the inner layer of skin. mermaid3/Shutterstock

    Supplementing collagen through skincare routines to enhance skin elasticity can help reduce wrinkle formation.

    Hyaluronic acid is a naturally occurring molecule in human bodies. It holds our skin’s collagen and elastin in a proper configuration, stimulates the production of collagen and adds hydration, which can help slow down wrinkle formation. Hyaluronic acid is one of the most common active ingredients in skincare creams, gels and lotions.

    Moisturisers can hydrate the skin in different ways. “Occlusive” substances produce a thin layer of oil on the skin that prevents water loss due to evaporation. “Humectants” attract and hold water in the skin, and they can differ in their capacity to bind with water, which influences the degree of skin hydration.

    Do silk pillowcases actually make a difference?

    Bed with silk sheets and pillowcases
    Can they help? New Africa/Shutterstock

    Silk pillowcases can make a difference in wrinkle formation, if they let your skin glide and move, rather than adding friction and pressure on a single spot. If you can, use silk sheets and silk pillows.

    Studies have also shown pillows designed to reduce mechanical stress during sleep can prevent skin deformations. Such a pillow could be useful in slowing down and preventing the formation of certain facial wrinkles.

    Sleeping on your back can reduce the risk of sleep lines, as can a nighttime routine of moisturising before sleep.

    Otherwise, lifestyle choices and habits, such quitting smoking, drinking plenty of water, a healthy diet (eating enough vegetables, fruits, nuts, seeds, healthy fats, yogurt and other fermented foods) and regular use of sunscreens can help improve the appearance of the skin on our face.

    Yousuf Mohammed, Dermatology researcher, The University of Queensland; Khanh Phan, Postdoctoral Research Fellow, Frazer Institute, The University of Queensland, and Vania Rodrigues Leite E. Silva, Honorary Associate Professor, Frazer Institute, The University of Queensland

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Rice vs Buckwheat – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing rice to buckwheat, we picked the buckwheat.

    Why?

    It’s a simple one today:

    • The vitamin and mineral profiles are very similar, so neither of these are a swaying factor
    • In terms of macros, rice is higher in carbohydrates while buckwheat is higher in fiber
    • Buckwheat also has more protein, but not by much
    • Buckwheat has the lower glycemic index, and a lower insulin index, too

    While buckwheat cannot always be reasonably used as a substitute for rice (often because the texture would not work the same), in many cases it can be.

    And if you love rice, well, so do we, but variety is also the spice of life indeed, not to mention important for good health. You know that whole “eat 30 different plants per week” thing? Grains count in that tally! So substituting buckwheat in place of rice sometimes seems like a very good bet.

    Not sure where to buy it?

    Here for your convenience is an example product on Amazon

    Want to know more about today’s topic?

    Check out: Carb-Strong or Carb-Wrong?

    Enjoy!

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