The Painkilling Power Of Opioids, Without The Harm?
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When it comes to painkilling medications, they can generally be categorized into two kinds:
- non-opioids (e.g. ibuprofen, paracetamol/acetaminophen, aspirin)
- ones that actually work for something more serious than a headache
That’s an oversimplification, but broadly speaking, when there is serious painkilling to be done, that’s when doctors consider it’s time to break out the opioids.
Nor are all opioids created equal—there’s a noteworthy difference between codeine and morphine, for instance—but the problems of opioids are typically the same (tolerance, addiction, and eventual likelihood of overdose when one tries to take enough to make it work after developing a tolerance), and it becomes simply a matter of degree.
See also: I’ve been given opioids after surgery to take at home. What do I need to know?
So, what’s the new development?
A team of researchers have found that the body can effectively produce its own targetted painkilling peptides, similar in function to benzodiazepines (an opioid drug), but—and which is a big difference—confined to the peripheral nervous system (PNS), meaning that it doesn’t enter the brain.
- The peptides killing the pain before it can reach the brain is obviously good because that means the pain is simply not experienced
- The peptides not having any effect on the brain, however, means that the mechanism of addiction of opioids simply does not apply here
- The peptides not having any effect on the brain also means that the CNS can’t be “put to sleep” by these peptides in the same way it can if a high dose of opioids is taken (this is what typically causes death in opioid overdoses; the heart simply beats too slowly to maintain life)
The hope, therefore, is to now create medications that target the spinal ganglia that produce these peptides, to “switch them on” at will.
Obviously, this won’t happen overnight; there will need to be first a lot of research to find a drug that does that (likely this will involve a lot of trial and error and so many mice/rats), and then multiple rounds of testing to ascertain that the drug is safe and effective for humans, before it can then be rolled out commercially.
But, this is still a big breakthrough; there arguably hasn’t been a breakthrough this big in pain research since various opioid-related breakthroughs in the 70s and 80s.
You can see a pop-science article about it here:
And you can see the previous research (from earlier this year) that this is now building from, about the glial cells in the spinal ganglia, here:
Peripheral gating of mechanosensation by glial diazepam binding inhibitor
But wait, there’s more!
Remember what we said about affecting the PNS without affecting the CNS, to kill the pain without killing the brain?
More researchers are already approaching the same idea to deal with the same problem, but from the angle of gene therapy, and have already had some very promising results with mice:
Structure-guided design of a peripherally restricted chemogenetic system
…which you can read about in pop-science terms (with diagrams!) here:
New gene therapy could alleviate chronic pain, researchers find
While you’re waiting…
In the meantime, approaches that are already available include:
- The 7 Approaches To Pain Management
- Managing Chronic Pain (Realistically!)
- Science-Based Alternative Pain Relief ← when painkillers aren’t helping, these things might!
Take care!
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Most People Do Seated Forward Fold Incorrectly (Do This Instead)
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This makes quite a difference:
Into the fold
What most people get wrong: focusing on touching their toes!
The reason is because this often shifts the stretch into your back, instead of your hamstrings.
Instead, here’s what to do, step by step:
- Sit down, bend your knees, and bring your belly towards your thighs, while keeping your spine straight
- Hold your toes, knees, or behind your thighs, to maintain a strong belly-to-thigh connection
- Slowly slide your feet forwards one at a time while keeping your spine straight and your belly connected to your thighs
- Stop sliding when you feel the tension in your hamstrings rather than your back
- Optimize the stretch by sending your tailbone backwards, which lengthens your hamstrings
- Inhale, then exhale and relax deeper into the stretch, using each exhale to slide slightly further forwards each time
- Make sure you don’t force your legs straight; instead, stay within your current limit and let breathing gradually increase your range!
Remember: bent knees allow you to tilt your pelvis correctly, so your hamstrings actually lengthen instead of your spine rounding. If nothing else, understand this 🙂
For more on all of this plus visual demonstrations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Tight Hamstrings? Here’s A Test To Know If It’s Actually Your Sciatic Nerve
Take care!
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Spreading Mental Health Awareness
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It’s Q&A Day at 10almonds!
Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small
Request: more people need to be aware of suicidal tendencies and what they can do to ward them off
That’s certainly a very important topic! We’ll cover that properly in one of our Psychology Sunday editions. In the meantime, we’ll mention a previous special that we did, that was mostly about handling depression (in oneself or a loved one), and obviously there’s a degree of crossover:
The Mental Health First-Aid That You’ll Hopefully Never Need
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Cantaloupe vs Lychees – Which is Healthier?
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Our Verdict
When comparing cantaloupe to lychees, we picked the cantaloupe.
Why?
Both have their merits and it was close!
In terms of macros, there’s no meaningful difference except that lychees have more carbs, so that could swing this any which way depending on how you feel about that. There’s enough fiber in both that it’s a non-issue metabolically though, so we call this round a tie.
In the category of vitamins, cantaloupe has more of vitamins A, B1, B3, B5, B7, B9, and K, while lychees have more of vitamins B2, B6, C, and E; a 7:4 win for cantaloupe.
Looking at minerals, cantaloupe has more calcium, magnesium, potassium, and zinc, while lychees have more copper, iron, phosphorus, and selenium, for a 4:4 tie in this round.
Adding up the sections makes for a modest overall win for cantaloupe, but by all means enjoy either or both, as diversity is good!
Want to learn more?
You might like:
Some Surprising Truths About Hunger And Satiety ← our main feature in which we examine the science of volumetrics, including a study that shows how water that is part of a food (but not served with a food) decreases caloric intake.
Another reason to enjoy melons!
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Mindfulness: An Eight-Week Plan – by Dr. Mark Williams & Dr. Danny Penman
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The authors, with their PhDs in psychology and biochemistry, respectively, bring the science that you might expect (and some that you might not!) to this book about mindfulness meditation and mindfulness in everyday life.
The book’s realism comes not just from studies, though, but also from a realistic perspective on modern life, in which many of us have sufficient responsibilities to afford us only limited downtime, and we certainly cannot all take time off for a mountaintop retreat.
What we can do, however, is enjoy this eight-week program for finding peace in a frantic world, while still going about our necessary business in that frantic world on a daily basis.
The eight weeks go as follows:
- Waking up to the autopilot
- Keeping the body in mind
- The mouse in the maze
- Moving beyond the rumor mill
- Turning toward difficulties
- Trapped in the past or living in the present?
- When did you stop dancing?
- Your wild and precious life
…with meditations, as well as reframes and other tools, for each.
The style is very easy-reading, with neither scientific jargon nor spiritual arcana, just clear explanations, instructions, and guidance.
Bottom line: if you’re the sort of person who tries to take each day as it comes, but sometimes several days gang up on you at once, then this book can help get things into order.
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The Core Program: – by Peggy Brill
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The author, a specialist women’s physiotherapist, has produced not only an exercise program, but also an explanation of various body-related matters can be easily neglected—but also, with the right knowledge and a small daily commitment of practice, easily addressed.
Thus, thus subtitular claim of “15 minutes a day that can change your life” is referring to a daily 15-minute exercise session, that’s very Pilates-like in its functional strength and mobility focus with little or no equipment, without actually being Pilates.
After some introductory chapters discussing the things we need to know in order to implement the program with full understanding, she gets into the program itself, which consists of three progressive parts:
- a foundation to get going
- an intermediate level to get things truly into good shape, and
- an advanced level for if one wants to take things further.
She also provides extra advice on maintaining what one gained, taking the program forwards for life.
The program is optimized for women, but there’s nothing truly exclusive to women here, just, occasional “this affects women more” things to include.
The style is a little dated (the book being published in 2003), but this does not meaningfully affect the content, as the information itself is timeless.
Bottom line: if you’d like to get into good condition without overcomplicating things and without needing a lot of resources, this book is quite a comprehensive course!
Click here to check out The Core Program, and get into shape sustainably!
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Algorithms to Live By – by Brian Christian and Tom Griffiths
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As humans, we subconsciously use heuristics a lot to make many complex decisions based on “fuzzy logic”. For example:
Do we buy the cheap shoes that may last us a season, or the much more expensive ones that will last us for years? We’ll—without necessarily giving it much conscious thought—quickly weigh up:
- How much do we like each prospective pair of shoes?
- What else might we need to spend money on now/soon?
- How much money do we have right now?
- How much money do we expect to have in the future?
- Considering our lifestyle, how important is it to have good quality shoes?
How well we perform this rapid calculation may vary wildly, depending on many factors ranging from the quality of the advertising to how long ago we last ate.
And if we make the wrong decision, later we may have buyer’s (or non-buyer’s!) remorse. So, how can we do better?
Authors Brain Christian and Tom Griffiths have a manual for us!
This book covers many “kinds” of decision we often have to make in life, and how to optimize those decisions with the power of mathematics and computer science.
The problems (and solutions) run the gamut of…
- Optimal stopping (when to say “alright, that’s good enough”)
- Overcoming cognitive biases
- Scheduling quandaries
- Bayes’ Theorem
- Game Theory
- And when it’s more efficient to just leave things to chance!
…and many more (12 main areas of decision-making are covered).
For all it draws heavily from mathematics and computer science, the writing style is very easy-reading. It’s a “curl up in the armchair and read for pleasure” book, no matter how weighty and practical its content.
Bottom line: if you improve your ability to make the right decisions even marginally, this book will have been worth your while in the long run!
Order your copy of “Algorithms To Live By” from Amazon today!
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