The Age-Proof Brain – by Dr. Marc Milstein

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Biological aging is not truly just one thing, but rather the amalgam of many things intersecting—and most of them are modifiable. The cells of your body neither know nor care how many times you have flown around the sun; they just respond to the stimuli they’re given.

Which is what fuels this book. The idea is to have a brain that is less-assailed by the things that would make it age, and more rejuvenated by the things that can make it biologically younger.

Dr. Milstein doesn’t neglect the rest of the body, and indeed notes the brain’s connections with the immune system, the heart, the gut, and more. But everything in this book is done with the brain in mind and its good health as the top priority outcome of all the things he advises.

On which note, yes, there is plenty of practical, implementable advice here. For a book that is consistently full of study paper citations, he does take care to make everything useful to the reader, and makes everything as easy as possible for the layperson along the way.

Bottom line: if you would like your brain to age less, this is an excellent, very evidence-based, guidebook.

Click here to check out The Age-Proof Brain, and age-proof your brain!

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Recommended

  • Bone on Bone – by Dr. Meredith Warner
  • Be Your Future Self Now – by Dr. Benjamin Hardy
    “Be Your Future Self Now” offers a sound psychological approach to intentional transformation, teaching readers how to take conscious control of their lives.

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  • Getting to Neutral – by Trevor Moawad

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    We all know that a pessimistic outlook is self-defeating… And yet, toxic positivity can also be a set-up for failure! At some point, reckless faith in the kindly nature of the universe will get crushed, badly. Sometimes that point is a low point in life… sometimes it’s six times a day. But one thing’s for sure: we can’t “just decide everything will go great!” because the world just doesn’t work that way.

    That’s where Trevor Moawad comes in. “Getting to neutral” is not a popular selling point. Everyone wants joy, abundance, and high after high. And neutrality itself is often associated with boredom and soullessness. But, Moawad argues, it doesn’t have to be that way.

    This book’s goal—which it accomplishes well—is to provide a framework for being a genuine realist. What does that mean?

    “I’m not a pessimist; I’m a realist” – every pessimist ever.

    ^Not that. That’s not what it means. What it means instead is:

    1. Hope for the best
    2. Prepare for the worst
    3. Adapt as you go

    …taking care to use past experiences to inform future decisions, but without falling into the trap of thinking that because something happened a certain way before, it always will in the future.

    To be rational, in short. Consciously and actively rational.

    Feel the highs! Feel the lows! But keep your baseline when actually making decisions.

    Bottom line: this book is as much an antidote to pessimism and self-defeat, as it is to reckless optimism and resultant fragility. Highly recommendable.

    Click here to check out “Getting to Neutral” and start creating your best, most reason-based life!

    PS: in this book, Moawad draws heavily from his own experiences of battling adversity in the form of cancer—of which he died, before this book’s publication. A poignant reminder that he was right: we won’t always get the most positive outcome of any given situation, so what matters the most is making the best use of the time we have.

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  • Move over, COVID and Flu! We Have “Hybrid Viruses” To Contend With Now

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    Move over, COVID and Flu! We have “hybrid viruses” to contend with now

    COVID and influenza viruses can be serious, of course, so let’s be clear up front that we’re not being dismissive of those. But, most people are hearing a lot about them, whereas respiratory syncytial virus (RSV) has flown under a lot of radars.

    Simply put, until recently it hasn’t been considered much of a threat except to the young, the old, or people with other respiratory illnesses. Only these days, the prevalence of “other respiratory illnesses” is a lot higher than it used to be!

    It’s not just a comorbidity

    It’s easy to think “well of course if you have more than one illness at once, especially similar ones, that’s going to suck” but it’s a bit more than that; it produces newer, more interesting, hybrid viruses. Here’s a research paper from last year’s “flu season”:

    Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles

    Best to be aware of this if you’re in the “older” age-range

    It’s not just that the older we are, the more likely we are to get it. Critically, the older we are, the more likely we are to be hospitalized by it.

    And..the older we are, the less likely we are to come back from hospital if hospitalized by it.

    Some years back, the intensive care and mortality rates for people over the age of 65 were 8% and 7%, respectively:

    Respiratory syncytial virus infection in elderly and high-risk adults

    …but a new study this year has found the rates like to be 2.2x that, i.e. 15% intensive care rate and 18% mortality, respectively:

    Adjusting for Case Under-Ascertainment in Estimating RSV Hospitalisation Burden of Older Adults in High-Income Countries: a Systematic Review and Modelling Study

    Want to know more?

    Here are some hot-off-the-press news articles on the topic:

    And as for what to do…

    Same general advice as for COVID and Flu, just, ever-more important:

    • Try to keep to well-ventilated places as much as possible
    • Get any worrying symptoms checked out quickly
    • Mask up when appropriate
    • Get your shots as appropriate

    See also:

    Harvard Health Review | Fall shots: Who’s most vulnerable to RSV, COVID, and the flu, and which shots are the right choice for you to help protect against serious illness and hospitalization?

    Stay safe!

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  • Treadmill vs Road

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    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small 😎

    ❝Why do I get tired much more quickly running outside, than I do on the treadmill? Every time I get worn out quickly but at home I can go for much longer!❞

    Short answer: the reason is Newton’s laws of motion.

    In other words: on a treadmill, you need only maintain your position in space relative the the Earth while the treadmill moves beneath you, whereas on the road, you need to push against the Earth with sufficient force to move it relative to your body.

    Illustrative thought experiment to make that clearer: if you were to stand on a treadmill with roller skates, and hold onto the bar with even just one finger, you would maintain your speed as far as the treadmill’s computer is concerned—whereas to maintain your speed on a flat road, you’d still need to push with your back foot every few yards or so.

    More interesting answer: it’s a qualitatively different exercise (i.e. not just quantitively different). This is because of all that pushing you’re having to do on the road, while on a treadmill, the only pushing you have to do is just enough to counteract gravity (i.e. to keep you upright).

    As such, both forms of running are a cardio exercise (because simply moving your legs quickly, even without having to apply much force, is still something that requires oxygenated blood feeding the muscles), but road-running adds an extra element of resistance exercise for the muscles of your lower body. Thus, road-running will enable you to build-maintain muscle much more than treadmill-running will.

    Some extra things to bear in mind, however:

    1) You can increase the resistance work for either form of running, by adding weight (such as by wearing a weight vest):

    Weight Vests Against Osteoporosis: Do They Really Build Bone?

    …and while road-running will still be the superior form of resistance work (for the reasons we outlined above), adding a weight vest will still be improving your stabilization muscles, just as it would if you were standing still while holding the weight up.

    2) Stationary cycling does not have the same physics differences as stationary running. By this we mean: an exercise bike will require your muscles to do just as much pushing as they would on a road. This makes stationary cycling an excellent choice for high intensity resistance training (HIRT):

    HIIT, But Make It HIRT

    3) The best form of exercise is the one that you will actually do. Thus, when it’s raining sidewise outside, a treadmill inside will get exercise done better than no running at all. Similarly, a treadmill exercise session takes a lot less preparation (“switch it on”) than a running session outside (“get dressed appropriately for the weather, apply sunscreen if necessary, remember to bring water, etc etc”), and thus is also much more likely to actually occur. The ability to stop whenever one wants is also a reassuring factor that makes one much more likely to start. See for example:

    How To Do HIIT (Without Wrecking Your Body)

    Take care!

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Related Posts

  • Bone on Bone – by Dr. Meredith Warner
  • Anti-Inflammatory Diet 101 (What to Eat to Fight Inflammation)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Chronic inflammation is a cause and/or exacerbating factor in very many diseases. Arthritis, diabetes, and heart disease are probably top of the list, but there are lots more where they came from. And, it’s good to avoid those things. So, how to eat to avoid inflammation?

    Let food be thy medicine

    The key things to keep in mind, the “guiding principles” are to prioritize whole, minimally-processed foods, and enjoy foods with plenty of antioxidants. Getting a healthy balance of omega fatty acids is also important, which for most people means getting more omega-3 and less omega-6.

    Shopping list (foods to prioritize) includes:

    • fruits and vegetables in a variety of colors (e.g. berries, leafy greens, beats)
    • whole grains, going for the most fiber-rich options (e.g. quinoa, brown rice, oats)
    • healthy fats (e.g. avocados, nuts, seeds)
    • fatty fish (e.g. salmon, mackerel, sardines) ← don’t worry about this if you’re vegetarian/vegan though, as the previous category can already cover it
    • herbs and spices (e.g. turmeric, garlic, ginger)

    Noping list (foods to avoid) includes:

    • refined carbohydrates
    • highly processed and/or fried foods
    • red meats and/or processed meats (yes, that does mean that organic grass-fed farmers’ pinky-promise-certified holistically-raised beef is also off the menu)
    • dairy products, especially if unfermented

    For more information on each of these, plus advice on transitioning away from an inflammatory diet, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    How to Prevent (or Reduce) Inflammation

    Take care!

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  • The Herbal Supplement That Rivals Prozac

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Flower Power: St. John’s Wort’s Drug-Level Effectiveness

    St. John’s wort is a small yellow flower, extract of which can be bought inexpensively off-the-shelf in pretty much any pharmacy in most places.

    It’s sold and used as a herbal mood-brightener.

    Does it work?

    Yes! It’s actually very effective. This is really uncontroversial, so we’ll keep it brief.

    The main findings of studies are that St. John’s wort not only gives significant benefits over placebo, but also works about as well as prescription anti-depressants:

    A systematic review of St. John’s wort for major depressive disorder

    They also found that fewer people stop taking it, compared to how many stop taking antidepressants. It’s not known how much of this is because of its inexpensive, freely-accessible nature, and how much might be because it gave them fewer adverse side effects:

    Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis

    How does it work?

    First and foremost, it’s an SSRI—a selective serotonin reuptake inhibitor. Basically, it doesn’t add serotonin, but it makes whatever serotonin you have, last longer. Same as most prescription antidepressants. It also affects adenosine and GABA pathways, which in lay terms, means it promotes feelings of relaxation, in a similar way to many prescription antianxiety medications.

    Mechanism of action of St John’s wort in depression: what is known?

    Any problems we should know about?

    Yes, definitely. To quote directly from the National Center for Complementary and Integrative Health:

    St. John’s wort can weaken the effects of many medicines, including crucially important medicines such as:

    • Antidepressants
    • Birth control pills
    • Cyclosporine, which prevents the body from rejecting transplanted organs
    • Some heart medications, including digoxin and ivabradine
    • Some HIV drugs, including indinavir and nevirapine
    • Some cancer medications, including irinotecan and imatinib
    • Warfarin, an anticoagulant (blood thinner)
    • Certain statins, including simvastatin

    Click here for a more comprehensive list of interactions, contraindications, and potential side effects

    I’ve read all that, and want to try it!

    As ever, we don’t sell it (or anything else), but here’s an example product on Amazon.

    Please be safe and do check with your doctor and/or pharmacist, though!

    Don’t Forget…

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    Learn to Age Gracefully

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  • The Immune System Recovery Plan – by Dr. Susan Blum

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The subtitle of the book is “A Doctor’s 4-Step Program to Treat Autoimmune Disease”, so we’ll not keep the four steps a secret; they are:

    1. Using food as medicine
    2. Understanding the stress connection
    3. Healing your gut and digestive system
    4. Optimizing liver function

    Each of these sections gives a primer in the relevant science, worksheets for personalizing your own plan to your own situation, condition, and goals, and of course lots of practical advice.

    This is important and perhaps the book’s greatest strength, since there are dozens of possible autoimmune conditions, and getting a professional diagnosis is often a long, arduous process. So while this book can’t necessarily speed that up, what it can do is give you a good head-start on managing your symptoms based on things that are most likely to help, and certainly, there will be no harm trying.

    While it’s not primarily a recipe book, there are also recipes targeting each part of the whole, as well as an extensive herb and supplement guide, before getting into lots of additional resources.

    Bottom line: if you are, or suspect you are, suffering from an autoimmune condition, the information in this book can make your life a lot easier.

    Click here to check out The Immune System Recovery Plan, and help yours to help you!

    Don’t Forget…

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    Learn to Age Gracefully

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