Holding Back The Clock on Aging
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Holding Back The Clock on Aging
This is Dr. Eric Verdin, President and CEO of the Buck Institute of Research on Aging. He’s also held faculty positions at the University of Brussels, the NIH, and the Picower Institute for Medical Research. Dr. Verdin is also a professor of medicine at University of California, San Francisco.
Dr. Verdin’s laboratory focuses on the role of epigenetic regulators (especially the behaviors of certain enzymes) in the aging process. He studies how metabolism, diet, and chemical factors regulate the aging process and its associated diseases, including Alzheimer’s.
He has published more than 210 scientific papers and holds more than 15 patents. He is a highly cited scientist and has been recognized for his research with a Glenn Award for Research in Biological Mechanisms of Aging.
And that’s just what we could fit here! Basically, he knows his stuff.
What we can do
Dr. Verdin’s position is bold, but rooted in evidence:
❝Lifestyle is responsible for about 93% of our longevity—only about 7% is genetics. Based on the data, if implementing health lifestyle choices, most people could live to 95 in good health. So there’s 15 to 17 extra years of healthy life that is up for grabs❞
~ Dr. Eric Verdin
See for example:
- From discoveries in aging research to therapeutics for healthy aging
- Optimism, lifestyle, and longevity in a racially diverse cohort of women
- Well-being, food habits, and lifestyle for longevity—evidence from supercentenarians
How we can do it
Well, we all know “the big five”:
- Good diet (Mediterranean Diet as usual is recommended)
- Good exercise (more on this in a moment)
- Good sleep (more on this in a moment)
- Avoid alcohol (not controversial)
- Don’t smoke (need we say more)
When it comes to exercise, generally recognized as good is at least 150 minutes per week of moderate intensity exercise (for example, a brisk walk, or doing the gardening), and at least three small sessions a week of high intensity exercise, unless contraindicated by some medical condition.
As for Dr. Verdin’s take on this…
What Dr. Verdin recommends is:
- make it personalized
- make it pre-emptive
- make it better
The perfect exercise plan is only perfect if you actually do it. And if you actually can do it, for that matter.
Prevention is so much better (and easier) than cure for a whole array of maladies. So while there may be merit in thinking “what needs fixing”, Dr. Verdin encourages us to take extra care to not neglect factors of our health that seem “good enough”. Because, give them time and neglect, and they won’t be!
Wherever we’re at in life and health, there’s always at least some little way we could make it a bit better. Dr. Verdin advises us to seek out those little improvements, even if it’s just a nudge better here, a nudge better there, all those nudges add up!
About sleep…
It’s perhaps the easiest one to neglect (writer’s note: as a writer, I certainly feel that way!), but his biggest take-away tip for this is:
Worry less about what time you set an alarm for in the morning. Instead, set an alarm for the evening—to remind you when to go to bed.
Want to hear directly from the man himself?
Here he is speaking on progress we can expect for the next decade in the field of aging research, as part of the 100 Minutes of Longevity session at The Longevity Forum, a few months ago:
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The Compass of Pleasure – by Dr. David Linden
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There are a lot of books about addiction, so what sets this one apart?
Mostly, it’s that this one maintains that addiction is neither good nor bad per se—just, some behaviors and circumstances are. Behaviors and circumstances caused, directly or indirectly, by addiction.
But, Dr. Linden argues, not every addiction has to be so. Especially behavioral addictions; the rush of dopamine one gets from a good session at the gym or learning a new language, that’s not a bad thing, even if they can fundamentally be addictions too.
Similarly, we wouldn’t be here as a species without some things that rely on some of the same biochemistry as addictions; orgasms and eating food, for example. Yet, those very same urges can also inconvenience us, and in the case of foods and other substances, can harm our health.
In this book, the case is made for shifting our addictive tendencies to healthier addictions, and enough information is given to help us do so.
Bottom line: if you’d like to understand what is going on when you get waylaid by some temptation, and how to be tempted to better things, this book can give the understanding to do just that.
Click here to check out The Compass of Pleasure, and make yours work in your favor!
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5 Self-Care Trends That Are Actually Ruining Your Mental Health
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Ok, some of these are trends; some are more perennial to human nature. For example, while asceticism is not a new idea, the “dopamine detox” is, and “bed rotting” is not a trend that this writer has seen recommended anywhere, but on the other hand, there are medieval illustrations of it—there was no Netflix in sight in the medieval illustrations, but perhaps a label diagnosing it as “melancholy”, for example.
So without further ado, here are five things to not do…
Don’t fall into these traps
The 5 things to watch out for are:
- Toxic positivity: constantly promoting positivity regardless of the reality of a situation can shame or invalidate genuine emotions, preventing people from processing their real feelings and leading to negative mental health outcomes—especially if it involves a “head in sand” approach to external problems as well as internal ones (because then those problems will never actually get dealt with).
- Self-indulgence: excessive focus on personal desires can make you more self-centered, less disciplined, and ultimately dissatisfied, which hinders personal growth and mental wellness.
- Bed rotting: spending prolonged time in bed for relaxation or entertainment can decrease motivation, productivity, and lead to (or worsen) depression rather than promoting genuine rest and rejuvenation.
- Dopamine detox: abstaining from pleasurable activities to “reset” the brain simply does not work and can lead to loneliness, boredom, and worsen mental health, especially when done excessively.
- Over-reliance on self-help: consuming too much self-help content or relying on material possessions for well-being can lead to information overload, unrealistic expectations, and the constant need for self-fixing, rather than fostering self-acceptance and authentic growth. Useful self-help can be like taking your car in for maintenance—counterproductive self-help is more like having your car always in for maintenance and never actually on the road.
For more on all of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read, and yes these are pretty much one-for-one with the 5 items above, doing a deeper dive into each in turn,
- How To Get Your Brain On A More Positive Track (Without Toxic Positivity)
- Self-Care That’s Not Just Self-Indulgence
- The Mental Health First-Aid That You’ll Hopefully Never Need
- The Dopamine Myth
- Behavioral Activation Against Depression & Anxiety
Take care!
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Heal & Reenergize Your Brain With Optimized Sleep Cycles
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Sometimes 8 hours sleep can result in grogginess while 6 hours can result in waking up fresh as a daisy, so what gives? Dr. Tracey Marks explains, in this short video.
Getting more than Zs in
Sleep involves 90-minute cycles, usually in 4 stages:
- Stage 1: (drowsy state): brief muscle jerks; lasts a few minutes.
- Stage 2: (light sleep): sleep spindles for memory consolidation; 50% of total sleep.
- Stage 3 (deep sleep): tissue repair, immune support, brain toxin removal via the glymphatic system.
- Stage 4 (REM sleep): emotional processing, creativity, problem-solving, and dreaming.
Some things can disrupt some or all of those. To give a few common examples:
- Alcohol: impairs REM sleep.
- Caffeine: hinders deep sleep even if consumed hours before bed.
- Screentime: delays sleep onset due to blue light (but not by much); the greater problem is that it can also disrupt REM sleep due to mental stimulation.
To optimize things, Dr. Marks recommends:
- 90-minute rule: plan sleep to align with full cycles (e.g: 22:30 to 06:00 = 7½ hours, which is 5x 90-minute cycles).
- Smart alarms: use sleep-tracking apps with built-in alarm, to wake you up during light sleep phases.
- Strategic naps: keep naps to 20 minutes or a full 90-minute cycle.
- Pink noise: improves deep sleep.
- Meal timing: avoid eating within 3 hours of bedtime.
- Natural light: get morning light exposure in the morning to strengthen circadian rhythm.
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Calculate (And Enjoy) The Perfect Night’s Sleep
Take care!
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End Your Carb Confusion – by Dr. Eric Westman & Amy Berger
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Carbs can indeed be confusing! We’ve written about it ourselves before, but there’s more to be said than fits in a single article, and sometimes a book is in order. This one is such a book.
The authors (an MD and a nutritionist) explain the ins and outs of carbohydrates of various kinds, insulin responses, and what that means for the body. They also then look at the partly-similar, partly-different processes that occur with the metabolism of fats of various kinds, and what that means for the body, too.
Ultimately they advocate for a simple and clear low-carb approach broadly consistent with keto diet macro principles, without getting too overly focused on “is this fruit/vegetable ok?” minutiae. This has the benefit of putting it well aside from the paleo diet, for example (which focuses more on pseudo-historical foods than it does on macros), and also makes it a lot easier on a practical level.
The style is very textbook-like, which makes for an easy read with plenty of information that should stick easily in most reader’s minds, rather than details getting lost in wall-of-text formatting. So, we approve of this.
There is not, by the way, a recipes section. It’s “here’s the information, now go forth and enjoy” and leaves us all to find/make our own recipes, rather than trying to guess our culinary preferences.
Bottom line: if you’d like an easy-to-read primer on understanding how carbs work, what it means for you, and what to do about it, then this is a fine book.
Click here to check out End Your Carb Confusion, and end your carb confusion!
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The Whys and Hows of Cutting Meats Out Of Your Diet
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When it’s time to tell the meat to beat it…
Meat in general, and red meat and processed meat in particular, have been associated with so many health risks, that it’s very reasonable to want to reduce, if not outright eliminate, our meat consumption.
First, in case anyone’s wondering “what health risks?”
The aforementioned culprits tend to turn out to be a villain in the story of every second health-related thing we write about here. To name just a few:
- Processed Meat Consumption and the Risk of Cancer: A Critical Evaluation of the Constraints of Current Evidence from Epidemiological Studies
- Red Meat Consumption (Heme Iron Intake) and Risk for Diabetes and Comorbidities?
- Health Risks Associated with Meat Consumption: A Review of Epidemiological Studies
- Associations of Processed Meat, Unprocessed Red Meat, Poultry, or Fish Intake With Incident Cardiovascular Disease and All-Cause Mortality
- Meat consumption: Which are the current global risks? A review of recent (2010-2020) evidences
Seasoned subscribers will know that we rarely go more than a few days without recommending the very science-based Mediterranean Diet which studies find beneficial for almost everything we write about. The Mediterranean Diet isn’t vegetarian per se—by default it consists of mostly plants but does include some fish and a very small amount of meat from land animals. But even that can be improved upon:
- A Pesco-Mediterranean Diet With Intermittent Fasting
- Mediterranean, vegetarian and vegan diets as practical outtakes of EAS and ACC/AHA recommendations for lowering lipid profile
- A Mediterranean Low-Fat Vegan Diet to Improve Body Weight and Cardiometabolic Risk Factors: A Randomized, Cross-over Trial
So that’s the “why”; now for the “how”…
It’s said that with a big enough “why” you can always find a “how”, but let’s make things easy!
Meatless Mondays
One of the biggest barriers to many people skipping the meat is “what will we even eat?”
The idea of “Meatless Mondays” means that this question need only be answered once a week, and in doing that a few Mondays in a row, you’ll soon find you’re gradually building your repertoire of meatless meals, and finding it’s not so difficult after all.
Then you might want to expand to “meat only on the weekends”, for example.
Flexitarian
This can be met with derision, “Yes and I’m teetotal, apart from wine”, but there is a practical aspect here:
The idea is “I will choose vegetarian options, unless it’s really inconvenient for me to do so”, which wipes out any difficulty involved.
After doing this for a while, you might find that as you get more used to vegetarian stuff, it’s almost never inconvenient to eat vegetarian.
Then you might want to expand it to “I will choose vegan options, unless it’s really inconvenient for me to do so”
Like-for-like substitutions
Pretty much anything that can come from an animal, one can get a plant-based version of it nowadays. The healthiness (and cost!) of these substitutions can vary, but let’s face it, meat is neither the healthiest nor the cheapest thing out there these days either.
If you have the money and don’t fancy leaping to lentils and beans, this can be a very quick and easy zero-effort change-over. Then once you’re up and running, maybe you can—at your leisure—see what all the fuss is about when it comes to tasty recipes with lentils and beans!
That’s all we have time for today, but…
We’re thinking of doing a piece making your favorite recipes plant-based (how to pick the right substitutions so the meal still tastes and “feels” the same), so let us know if you’d like that? Feel free to mention your favorite foods/meals too, as that’ll help us know what there’s a market for!
You can do that by hitting reply to any of our emails, or using the handy feedback widget at the bottom!
Curious to know more while you wait?
Check out: The Vegan Diet: A Complete Guide for Beginners ← this is a well-sourced article from Healthline, who—just like us—like to tackle important health stuff in an easy-to-read, well-sourced format
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The Fascinating Truth About Aspartame, Cancer, & Neurotoxicity
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Is Aspartame’s Reputation Well-Deserved?
In Tuesday’s newsletter, we asked you for your health-related opinions on aspartame, and got the above-depicted, below-described, set of responses:
- About 47% said “It is an evil carcinogenic neurotoxin”
- 20% said “It is safe-ish, but has health risks that are worse than sugar”
- About 19% said “It is not healthy, but better than sugar”
- About 15% said “It’s a perfectly healthy replacement for sugar”
But what does the science say?
Aspartame is carcinogenic: True or False?
False, assuming consuming it in moderation. In excess, almost anything can cause cancer (oxygen is a fine example). But for all meaningful purposes, aspartame does not appear to be carcinogenic. For example,
❝The results of these studies showed no evidence that these sweeteners cause cancer or other harms in people.❞
~ NIH | National Cancer Institute
Source: Artificial Sweeteners and Cancer
Plenty of studies and reviews have also confirmed this; here are some examples:
- Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria
- Aspartame, low-calorie sweeteners and disease: Regulatory safety and epidemiological issues
- Aspartame: A review of genotoxicity data
Why then do so many people believe it causes cancer, despite all the evidence against it?
Well, there was a small study involving giving megadoses to rats, which did increase their cancer risk. So of course, the popular press took that and ran with it.
But those results have not been achieved outside of rats, and human studies great and small have all been overwhelmingly conclusive that moderate consumption of aspartame has no effect on cancer risk.
Aspartame is a neurotoxin: True or False?
False, again assuming moderate consumption. If you’re a rat being injected with a megadose, your experience may vary. But a human enjoying a diet soda, the aspartame isn’t the part that’s doing you harm, so far as we know.
For example, the European Food Safety Agency’s scientific review panel concluded:
❝there is still no substantive evidence that aspartame can induce such effects❞
~ Dr. Atkin et al (it was a pan-European team of 21 experts in the field)
Source: Report on the Meeting on Aspartame with National Experts
See also,
❝The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the hypothesis that aspartame in the human diet will affect nervous system function, learning or behavior.
The weight of existing evidence is that aspartame is safe at current levels of consumption as a nonnutritive sweetener.❞
and
❝The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive.
When all the research on aspartame, including evaluations in both the premarketing and postmarketing periods, is examined as a whole, it is clear that aspartame is safe, and there are no unresolved questions regarding its safety under conditions of intended use.❞
Source: Regulatory Toxicology & Pharmacology | Aspartame: Review of Safety
Why then do many people believe it is a neurotoxin? This one can be traced back to a chain letter hoax from about 26 years ago; you can read it here, but please be aware it is an entirely debunked hoax:
Urban Legends | Aspartame Hoax
Take care!
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