Kava vs Anxiety
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Kava, sometimes also called “kava kava” but we’re just going to call it kava once for the sake of brevity, is a heart-shaped herb that bestows the powers of the Black Panther is popularly enjoyed for its anxiolytic (anxiety-reducing) effects. Despite the similarity of the name in many languages, it is unrelated to coffee (except insofar as they are both plants), and its botanical name is Piper methysticum.
Does it work?
Yes! At least in the short-term; more on that later.
Firstly, you may be wondering how it works; it works by its potentiation of GABA receptors in the brain. GABA (or gamma-aminobutyric acid, to give it its full name), as you may recall, is a neurotransmitter that is associated with feelings of calm; we wrote about it here:
So, what does “potentiation of GABA receptors” mean? It means… Scientists don’t for 100% sure know how it works yet, but it does make GABA receptors fire more. It’s possible that to some degree GABA fits the “molecular lock” of the receptors and causes them to say “GABA is here”; it’s also possible that they just make them more sensitive to the real GABA that is there, or there could be another explanation as yet undiscovered. Either way, it means that taking kava has a similar effect to having increased GABA levels in the brain:
As for how much to use, 20–300mg appears to be an effective dose, and most sources recommend 80–250mg:
Kava as a Clinical Nutrient: Promises and Challenges
This review of clinical trials found that it was more effective than placebo in only 3 of 7 trials; specifically, it was beneficial in the short-term and not in the long-term. For these reasons, the researchers concluded:
❝Kava Kava appears to be a short-term treatment for anxiety, but not a replacement for prolonged anti-anxiety use. Although not witnessed in this review, liver toxicity is especially possible if taken longer than 8 weeks.❞
Another review of clinical trials found better results over the course of 11 clinical trials, though again, short-term treatment only was considered to be where the “safe and effective” claim can be placed:
❝Compared with placebo, kava extract appears to be an effective symptomatic treatment option for anxiety. The data available from the reviewed studies suggest that kava is relatively safe for short-term treatment (1 to 24 weeks), although more information is required. Further rigorous investigations, particularly into the long-term safety profile of kava are warrant❞
Source: Kava extract for treating anxiety
Is it safe?
Nope! It has been associated with liver damage:
The likely main mechanism of toxicity is that it simply monopolizes the liver’s metabolic abilities, meaning that while it’s metabolizing the kava, it’s not metabolizing other things (such as alcohol or other medications), which will then build up, and potentially overwhelm the liver:
Constituents in kava extracts potentially involved in hepatotoxicity: a review
However, traditionally-prepared kava has not had the same effect as modern extracts; at first it seemed the difference was the traditional aqueous extracts vs modern acetonic/ethanolic extracts, but eventually that was found not to be the case, as toxicity occurred with industrial aqueous extracts too. The conclusion so far is that it is about the quality of the source ingredients, and the problems inherent to mass-production:
Meanwhile, short-term use doesn’t seem to have this problem, if you’re not drinking alcohol or taking medications that affect the liver:
Mechanisms/risk factors – kava-associated hepatotoxicity ← you’ll need to scroll down to 4.2.4 to read about this
Want to try it?
If the potential for hepatotoxicity doesn’t put you off, here’s an example product on Amazon ← we do not recommend it, but we are not the boss of you, and maybe you’re confident about your liver and want to use it only very short-term?
Take care!
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Winter Wellness & The Pills That Increase Your Alzheimer’s Risk
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This week in health news…
Do not go gentle into that good night
As wildfires rage in California, snow is falling from Texas to Georgia, meaning that a lot of people are facing weather they’re not accustomed to, in houses that were not built for it. And that’s the lucky ones; there are many thousands of people who are homeless, of whom many will die.
Hopefully all our readers are safe, but it pays to watch out for the signs of hypothermia as it is a condition that really sneaks up on people and, in the process, takes away their ability to notice the hypothermia. You and your loved ones are not immune to this, so it’s good to keep an eye on each other, looking out for:
- Shivering, first ← when this stops, assuming it’s not because the temperature has risen, it is often a sign of hypothermia entering a later stage, in which the body is no longer responding appropriately to the cold
- Slurred speech or mumbling
- Slow, shallow breathing
- A weak pulse
- Clumsiness or lack of coordination
- Drowsiness or very low energy
- Confusion or memory loss
- Loss of consciousness
- In infants, bright red, cold skin
How cold is too cold? It doesn’t even have to be sub-zero. According to the CDC, temperatures of 4℃ (40℉) can be low enough to cause hypothermia.
Read in full: The warning signs to notice if someone has hypothermia
Related: Cold Weather Health Risks
Lethal lottery of pathogens
In Minnesota, hospital emergency room waiting times have skyrocketed since yesterday (at time of writing), with 40% of Minnesota’s 1,763 flu-related hospitalizations this fall and winter occurring in the same week, according to yesterday’s report. To put it further into perspective, 17 out of 20 of this season’s flu outbreaks have occurred in the past two weeks.
And that’s just the flu, without considering COVID, RSV, and Norovirus, which are also all running rampant in MN right now.
The advice presently is:
❝Go to the ER if you are super-sick. If you are not super-sick, go to urgent care, go to your clinic, schedule a virtual appointment.❞
And if you’re not in Minneapolis? These stats won’t apply, but definitely consider, before going to the hospital, whether you might leave sicker than you arrived, and plan accordingly, making use of telehealth where reasonably possible.
Read in full: Minnesota ERs stressed by “quad-demic” of COVID, flu, RSV, norovirus
Related: Move over, COVID and Flu! We Have “Hybrid Viruses” To Contend With Now
Sleep, but at what cost?
This was a study looking at the effects of sleeping pills on the brain, specifically zolpidem (most well-known by its brand name of Ambien).
What they found is that while it does indeed effectively induce sleep, part of how it does that is suppressing norepinephrine oscillations (which might otherwise potentially wake you up, though in healthy people these oscillations and the micro-arousals that they cause shouldn’t disrupt sleep at all, and are just considered part of our normal sleep cycles), which oscillations are necessary to generate the pumping action required to move cerebrospinal fluid through the glymphatic system while asleep.
This is a big problem, because the glymphatic system is almost entirely responsible for keeping the brain free from waste products such as beta-amyloids (whose build-up is associated with Alzheimer’s disease and is considered to be a significant part of Alzheimer’s pathogensesis) and alpha-synuclein (same but for Parkinson’s disease), amongst others:
Read in full: Common sleeping pill may pave way for disorders like Alzheimer’s
Related: How To Clean Your Brain (Glymphatic Health Primer)
Take care!
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The Unchaste Berry
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A Chasteberry, By Any Other Name…
Vitex agnus castus, literally “chaste lamb vine”, hence its modern common English name “chasteberry”, gets its name from its traditional use as an anaphrodisiac for monks (indeed, it’s also called “monk’s pepper”), which traditional use is not in the slightest backed up by modern science.
Nor is its second most popular traditional use (the increase in production of milk) well-supported by science either:
❝Its traditional use as a galactagogue (i.e., a substance that enhances breast milk production) is not well supported in the literature and should be discouraged. There are no clinical data to support the use of chasteberry for reducing sexual desire, which has been a traditional application❞
Source: American Family Physician | Chasteberry
Both of those supposed effects of the chasteberry go against the fact that it has a prolactin-lowering effect:
❝It appears that [chasteberry] may represent a potentially useful and safe phytotherapic option for the management of selected patients with mild hyperprolactinaemia who wish to be treated with phytotherapy.❞
Source: Vitex agnus castus effects on hyperprolactinaemia
Prolactin, by the way, is the hormone that (as the name suggests) stimulates milk production, and also reduces sexual desire (and motivation in general)
- In most women, it spikes during breastfeeding
- In most men, it spikes after orgasm
- In both, it can promote anhedonic depression, as it antagonizes dopamine
In other words, the actual pharmacological effect of chasteberry, when it comes to prolactin, is the opposite of what we would expect from its traditional use.
Ok, so it’s an unchaste berry after all…. Does it have any other claims to examine?
Yes! It genuinely does help relieve PMS, for those who have it, and reduce menopause symptoms, for those who have those, for example:
❝Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome.❞
❝That [Vitex agnus castus] trial indicated strong symptomatic relief of common menopausal symptoms❞
Source: Vitex agnus castus essential oil and menopausal balance: a research update
Is it safe?
Generally speaking, yes. It has been described as “well-tolerated” in the studies we mentioned above, which means it has a good safety profile.
However, it may interfere with some antipsychotic medications, certain kinds of hormone replacement therapy, or hormonal birth control.
As ever, speak with your doctor/pharmacist if unsure!
Where can I get some?
We don’t sell it, but here for your convenience is an example product on Amazon
Enjoy!
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The Starch Solution – by Dr. John McDougall & Mary McDougall
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Carb-strong or carb-wrong? We’ve written about this ourselves before, and it comes down to clarifying questions of what and how and why. Even within the general field of carbs, even within the smaller field of starch, not all foods are equal. A slice of white bread and a baked potato are both starchy, but the latter also contains fiber, vitamins, minerals, and suchlike.
The authors make the case for a whole-foods plant-based diet in which one need not shy away from starchy foods in general; one simply must enjoy them discriminately—whole grains, and root vegetables that have not been processed to Hell and back, for examples.
The style is “old-school pop-sci” but with modern science; claims are quite well-sourced throughout, with nine pages of bibliography at the end. Right after the ninety-nine pages of recipes!
Bottom line: if you’re a carb-enjoyer, all is definitely not lost healthwise, and in fact on the contrary, this can be the foundation of a very healthy and nutrient-rich diet.
Click here to check out The Starch Solution, and enjoy the foods you love, healthily!
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The Real Reason Most Women Don’t Lose Belly Fat
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Notwithstanding the title, this does also go for men too, by the way—while hormones count, they count differently. People with an estrogen-based metabolism (so usually: women) will usually have more body fat, which can make it harder to get visible muscletone, for those who want that. But people with a testosterone-based metabolism (so usually: men) will have different fat storage patterns, and belly-fat is more testosterone-directed than estrogen-directed (estrogen will tend to put it more to the thighs, butt, back, breasts, etc).
So the advice here is applicable to all…
Challenges and methods
The biggest barrier to success: many people give up when results are not immediate, especially if our body has been a certain way without change for a long time.
- “Oh, I guess it’s just genetics”
- “Oh, I guess it’s just age”
- “Oh, I guess it’s just because of [chronic condition]”
…and such things can be true! And yet, in each of the cases, persisting is still usually what the body needs.
So, should we give ourselves some “tough love” and force ourselves through discomfort?
Yes and no, Lefkowith says. It is important to be able to push through some discomfort, but it’s also important that whatever we’re doing should be sustainable—which means we do need to push, while also allowing ourselves adequate recovery time, and not taking unnecessary risks.
In particular, she advises to:
- remember that at least half the work is in the kitchen not the gym, and to focus more on adding protein than reducing calories
- enjoy a regular but varied core exercise routine
- stimulate blood flow to stubborn areas, which can aid in fat mobilization
- focus on getting nutrient-dense foods
- prioritize recovery and strategic rest
For more details on these things and more, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Visceral Belly Fat: What It Is & How To Lose It
Take care!
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Age & Aging: What Can (And Can’t) We Do About It?
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How old do you want to be?
We asked you how old you are, and got an interesting spread of answers. This wasn’t too surprising; of course we have a general idea of who our readership is and we write accordingly.
What’s interesting is the gap for “40s”.
And, this wasn’t the case of a broken poll button, it’s something that crops up a lot in health-related sociological research. People who are most interested in taking extra care of their body are often:
- Younger people full of optimism about maintaining this perfectly healthy body forever
- Older people realizing “if I don’t want to suffer avoidable parts of age-related decline, now is the time to address these things”
In between, we often have a gap whereby people no longer have the optimism of youth, but do not yet feel the pressure of older age.
Which is not to say there aren’t 40-somethings who do care! Indeed, we know for a fact we have some subscribers in their 40s (and some in their 90s, too), just, they evidently didn’t vote in this poll.
Anyway, let’s bust some myths…
Aging is inevitable: True or False?
False, probably. That seems like a bold (and fortune-telling) claim, so let’s flip it to deconstruct it more logically:
Aging is, and always will be, unstoppable: True or False?
That has to be “False, probably”. To say “true” now sounds like an even bolder claim. Just like “the moon will always be out of reach”.
- When CPR was first developed, first-aiders were arrested for “interfering with a corpse”.
- Many diseases used to be death sentences that are now “take one of these in the morning”
- If you think this is an appeal to distant history, HIV+ status was a death sentence in the 90s. Now it’s “take one of these in the morning”.
But, this is an appeal to the past, and that’s not always a guarantee of the future. Where does the science stand currently? How is the research and development doing on slowing, halting, reversing aging?
We can slow aging: True or False?
True! There’s a difference between chronological age (i.e., how much time has passed while we’ve been alive) and biological age (i.e., what our diverse markers of aging look like).
Biological age often gets talked about as a simplified number, but it’s more complex than that, as we can age in different ways at different rates, for example:
- Visual markers of aging (e.g. wrinkles, graying hair)
- Performative markers of aging (e.g. mobility tests)
- Internal functional markers of aging (e.g. tests for cognitive decline, eyesight, hearing, etc)
- Cellular markers or aging (e.g. telomere length)
- …and more, but we only have so much room here
There are things we can do to slow most of those, including:
- Good nutrition (e.g. collagen and lutein, to keep specific parts of the body functioning “like those of a younger person” ranging from the joints to the eyes and brain)
- Anti-oxidant activity (e.g. eating anti-oxidant foods, supplementing with anti-oxidants or other things that mitigate oxidative stress, and avoiding foods that hasten oxidative stress which causes many kinds of aging)
- Getting good sleep (not to be underestimated for its restorative importance)
- Taking care of our cognitive health
- Taking care of our mental health (especially: reducing stress)
- Taking care of our mobility (prevention is better than cure!)
In the case of cognitive decline particularly, check out our previous article:
How To Reduce Your Alzheimer’s Risk
It’s too early to worry about… / It’s too late to do anything about… True or False?
False and False!
Many things that affect our health later in life are based on early-life choices and events. So it’s important for young people to take advantage of that. The earlier one adopts a healthy lifestyle, the better, because, and hold onto your hats for the shocker here: aging is cumulative.
However, that doesn’t mean that taking up healthy practices (or dropping unhealthy ones) is pointless later in life, even in one’s 70s and beyond!
Read about this and more from the National Institute of Aging:
What Do We Know About Healthy Aging?
We can halt aging: True or False?
False, for now at least. Our bodies are not statues; they are living organisms, constantly rebuilding themselves, constantly changing, every second of every day, for better or for worse. Every healthy or unhealthy choice you make, every beneficial or adverse experience you encounter, affects your body on a cellular level.
Your body never, ever, stops changing for as long as you live.
But…
We can reverse aging: True or False?
True! Contingently and with limitations, for now at least.
Remember what we said about your body constantly rebuilding itself? That goes for making itself better as well as making itself worse.
- If yesterday you couldn’t touch your toes and today you can, congratulations, you just got younger by a biological marker of aging.
- If you stopped drinking/smoking/eating a certain way last year, and this year your skin has fewer wrinkles, congratulations, you got younger by a biological marker of aging.
- If you’ve been exercising and now your heart rate variability and VO2 max are better than last month, congratulations, you got younger by a biological marker aging.
- If you took supplements that reduce and/or mitigate oxidative stress (e.g. resveratrol, CoQ10, l-theanine, etc), and you took up intermittent fasting, and now your telomeres are longer than they were six months ago, congratulations, you got younger by a biological marker of aging.
But those aren’t really being younger, we’ll still die when our time is up: True or False?
False and True, respectively.
Those kinds of things are really being younger, biologically. What else do you think being biologically younger is?
We may indeed die when our time is up, but (unless we suffer fatal accident or incident first) “when our time is up” is something that is decided mostly by the above factors.
Genetics—the closest thing we have to biological “fate”—accounts for only about 25% of our longevity-related health*.
Genes predispose, but they don’t predetermine.
*Read more: Human longevity: Genetics or Lifestyle? It takes two to tango
(from the Journal of Immunity and Ageing)
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How To April Fool Yourself Into Having A Nutrient-Dense Diet!
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These nutrient-dense foods pack such a punch you only need a bit added to your meal…
- “Have 5 servings of fruit per day”—popular wisdom in the West
- “Have 7 servings of fruit per day!”—generally held as the norm in Japan
- “Have these 12 things that are mostly fruit & veg & nuts each day”—Dr. Greger’s Daily Dozen
- “Does the pickle that comes with a burger count?”—an indication of how much many people struggle.
For what it’s worth: pickles are a good source of some minerals (and some healthy gut bacteria too), but are generally too high in sodium to be healthy for most people beyond in the most modest moderation.
But! It can be a lot easier, and without sitting down to a salad buffet every day!
Here are some sneaky tips:
(call it our nod to April Fool’s Day, because tricking yourself into eating more healthily is a top-tier prank)
Beyond soups and smoothies
Soups and smoothies are great, because we can take a lot of nutrients that way without actually oing much eating. And if we’ve a want or need to hide something, blending it does a fine job. However, we’re confident you already know how to make soups and smoothies. So…
Sauces are another excellent place to put nutrients—and as a bonus, homemade sauces will mean skipping on the store-bought sauces whose ingredients all-too-often look something like “sugar, water, spirit vinegar, glucose-fructose syrup, modified maize starch, maltodextrin, salt…”
Top things to use as a main base ingredient in sauces:
- Tomato purée—so much lycopene, and great vitamins too! Modest flavour, but obviously only sensible for what you intend to be a tomato-based sauce. Use it to make anything from marinara sauce to ketchup, sweet-and-sour to smoky barbecue.
- Lentils/beans—if unsure, red lentils or haricot beans have a very mild taste, and edamame beans are almost not-there, flavor-wise. But cooked and blended smooth, these are high-protein, iron-rich, flavonoid-heavy, and a good source of fiber too. Can be used as the base of so many savory creamy sauces!
- Corn—that yellow color? It’s all the lutein. Home-made creamed corn goes great as a dipping sauce! Added spices optional.
Vegetables that punch above their weight
Sometimes, you might not want to eat much veg, but a small edible side-dish could be appealing, or even a generous garnish. In those cases, if you choose wisely, you can have a lot of nutrients in a tiny portion. Here are some that have an absurd nutrient-to-size ratio:
Cacao nibs—one for the dessert-lovers here, but can also garnish a frothy coffee, your morning overnight oats, or if we’re honest, can also just be snacked on! And they keep for ages. Botanically technically a fruit, but we’re going to throw it in here. As for health qualities? Where to begin…
They:
- are full of antioxidants and fight inflammation
- boost immune health
- help control blood sugar levels
- improve vascular function and heart health
- and even fight cancer, which is a many-headed beast, but for example:
…which is starting to look like a pattern, isn’t it? It’s good against cancer.
Brussels sprouts—if your knee-jerk reaction here wasn’t one of great appeal, then consider: these are delicious if done right.
Buy them fresh, not frozen (nothing nutritionally wrong with frozen if you like them—we’re just doing the extra-level tastiness here). Wash them and peel them, then cut twice from the top to almost-the-bottom, to quarter them in a way that they still stay in one piece. Rub them (or if you’re going easier on the fats, spray them) with a little olive oil, a tiny touch of lemon juice, and sprinkle a little cracked black pepper. Sautée them. We know people will advise roasting, which is also great, but try the sautée approach, and thank us later.
Four sprouts is already a sufficient daily serving of cruciferous vegetables, and provides so many health benefits, with not just a stack of vitamins and minerals, but also have anti-cancer properties, are great for your heart in multiple ways, and reduce inflammation too. They’re literally one of the healthiest foods out there and you only need a tiny portion to benefit.
Kale—Don’t like the taste/texture? That’s OK, read on… No surprises here, but it’s crammed with vitamins and minerals.
- If you don’t care for the bitter taste, cooking it (such as by steaming it) takes that away.
- If you don’t care for the texture, baking it with a little sprayed-on olive oil changes that completely (and is how “kale chips” are made).
- If you don’t care for either? Do the “kale chips” thing mentioned above, but do it on a lower heat for longer—dry it out, basically. Then either blend it in a food processor, or by hand with a pestle and mortar (it turns to powder very easily, so this won’t be hard work), and you now have a very nutrient-dense powder that tastes of very little. While fries are not a health food, an example here is that you can literally dust fries with it and they won’t taste any different but you got a bunch of vitamins and minerals added from a whole food source.
- If going for the above approach, do it in batch and make yourself a jar of it to keep handy with your seasonings collection!
Bell peppers—Working hard to justify their high prices in the grocery store, these are very high in vitamins, especially rich in carotenoids, including lutein, and as a bonus, they’re also full of antioxidants. So, slice some and throw them at whatever else you’re cooking, and you’ve added a lot of nutrients for negligible effort.
Garlic—once you’ve done the paperwork, garlic not only makes bland meals delicious, but is also a treasure trove of micronutrients. It has a stack of vitamins and minerals, and also contains allicin. If you’ve not heard of that one, it’s the compound in garlic that is so good for blood pressure and heart health. See for example:
- Lipid-lowering effects of time-released garlic
- Garlic extract lowers blood pressure in patients with hypertension
- Garlic extract reduces blood pressure in hypertensives
If an apple a day keeps the doctor away, just imagine what a bulb of garlic can do (come on, we can’t be the only ones who measure garlic by the bulb instead of by the clove, right?)!
But in seriousness: measure garlic with your heart—have lots or a little, per your preference. The whole point here is that even a little of these superfoods can make a huge difference to your health!
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