Progesterone Menopausal HRT: When, Why, And How To Benefit

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Progesterone doesn’t get talked about as much as other sex hormones, so what’s its deal? Dr. Heather Hirsch explains:

Menopausal progesterone

Dr. Hirsch considers progesterone essential for menopausal women who are taking estrogen and have an intact uterus, to keep conditions at bay such as endometriosis or even uterine cancer.

However, she advises it is not critical in those without a uterus, unless there was a previous case of one of the above conditions.

10almonds addition: on the other hand, progesterone can still be beneficial from a metabolic and body composition standpoint, so do speak with your endocrinologist about it.

As an extra bonus: while not soporific (it won’t make you sleepy), taking progesterone at night will improve the quality of your sleep once you do sleep, so that’s a worthwhile thing for many!

Dr. Hirsch also discusses the merits of continuous vs cyclic use; continuous maintains the above sleep benefits, for example, while cyclic use can help stabilize menstrual patterns in late perimenopause and early menopause.

For more on these things, plus discussion of different types of progesterone, enjoy:

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  • How light tells you when to sleep, focus and poo

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    This is the next article in our ‘Light and health’ series, where we look at how light affects our physical and mental health in sometimes surprising ways. Read other articles in the series.

    Exposure to light is crucial for our physical and mental health, as this and future articles in the series will show.

    But the timing of that light exposure is also crucial. This tells our body to wake up in the morning, when to poo and the time of day to best focus or be alert. When we’re exposed to light also controls our body temperature, blood pressure and even chemical reactions in our body.

    But how does our body know when it’s time to do all this? And what’s light got to do with it?

    nymphoenix/Shutterstock

    What is the body clock, actually?

    One of the key roles of light is to re-set our body clock, also known as the circadian clock. This works like an internal oscillator, similar to an actual clock, ticking away as you read this article.

    But rather than ticking you can hear, the body clock is a network of genes and proteins that regulate each other. This network sends signals to organs via hormones and the nervous system. These complex loops of interactions and communications have a rhythm of about 24 hours.

    In fact, we don’t have one clock, we have trillions of body clocks throughout the body. The central clock is in the hypothalamus region of the brain, and each cell in every organ has its own. These clocks work in concert to help us adapt to the daily cycle of light and dark, aligning our body’s functions with the time of day.

    However, our body clock is not precise and works to a rhythm of about 24 hours (24 hours 30 minutes on average). So every morning, the central clock needs to be reset, signalling the start of a new day. This is why light is so important.

    The central clock is directly connected to light-sensing cells in our retinas (the back of the eye). This daily re-setting of the body clock with morning light is essential for ensuring our body works well, in sync with our environment.

    In parallel, when we eat food also plays a role in re-setting the body clock, but this time the clock in organs other than the brain, such as the liver, kidneys or the gut.

    So it’s easy to see how our daily routines are closely linked with our body clocks. And in turn, our body clocks shape how our body works at set times of the day.

    What time of day?

    Matt Garrow/The Conversation. Adapted from Delos, CC BY

    Let’s take a closer look at sleep

    The naturally occurring brain hormone melatonin is linked to our central clock and makes us feel sleepy at certain times of day. When it’s light, our body stops making melatonin (its production is inhibited) and we are alert. Closer to bedtime, the hormone is made, then secreted, making us feel drowsy.

    Our sleep is also partly controlled by our genes, which are part of our central clock. These genes influence our chronotype – whether we are a “lark” (early riser), “night owl” (late sleeper) or a “dove” (somewhere in between).

    But exposure to light at night when we are supposed to be sleeping can have harmful effects. Even dim light from light pollution can impair our heart rate and how we metabolise sugar (glucose), may lead to psychiatric disorders such as depression, anxiety and bipolar disorder, and increases the overall risk of premature death.

    The main reason for these harmful effects is that light “at the wrong time” disturbs the body clock, and these effects are more pronounced for “night owls”.

    This “misaligned” exposure to light is also connected to the detrimental health effects we often see in people who work night shifts, such as an increased risk of cancer, diabetes and heart disease.

    How about the gut?

    Digestion also follows a circadian rhythm. Muscles in the colon that help move waste are more active during the day and slow down at night.

    The most significant increase in colon movement starts at 6.30am. This is one of the reasons why most people feel the urge to poo in the early morning rather than at night.

    The gut’s day-night rhythm is a direct result of the action of the gut’s own clock and the central clock (which synchronises the gut with the rest of the body). It’s also influenced by when we eat.

    6.30 on digital display
    At 6.30am, your gut really begins to get going for the day. Rendra Dria Septia Aji/Shutterstock

    How about focusing?

    Our body clock also helps control our attention and alertness levels by changing how our brain functions at certain times of day. Attention and alertness levels improve in the afternoon and evening but dip during the night and early morning.

    Those fluctuations impact performance and can lead to decreased productivity and an increased risk of errors and accidents during the less-alert hours.

    So it’s important to perform certain tasks that require our attention at certain times of day. That includes driving. In fact, disruption of the circadian clock at the start of daylight savings – when our body hasn’t had a chance to adapt to the clocks changing – increases the risk of a car accident, particularly in the morning.

    What else does our body clock control?

    Our body clock influences many other aspects of our biology, including:

    • physical performance by controlling the activity of our muscles
    • blood pressure by controlling the system of hormones involved in regulating our blood volume and blood vessels
    • body temperature by controlling our metabolism and our level of physical activity
    • how our body handles drugs and toxins by controlling enzymes involved in how the liver and kidneys eliminate these substances from the body.
    Driving at night in wet conditions
    If you can, avoid driving long distances at night, as you’ll be less alert. trendobjects/Shutterstock

    Morning light is important

    But what does this all mean for us? Exposure to light, especially in the morning, is crucial for synchronising our circadian clock and bodily functions.

    As well as setting us up for a good night’s sleep, increased morning light exposure benefits our mental health and reduces the risk of obesity. So boosting our exposure to morning light – for example, by going for a walk, or having breakfast outside – can directly benefit our mental and metabolic health.

    However, there are other aspects about which we have less control, including the genes that control our body clock.

    Frederic Gachon, Associate Professor, Physiology of Circadian Rhythms, Institute for Molecular Bioscience, The University of Queensland and Benjamin Weger, NHMRC Emerging Leadership Fellow Institute for Molecular Bioscience, The University of Queensland

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • The End of Alzheimer’s – by Dr. Dale Bredesen

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    This one didn’t use the “The New Science Of…” subtitle that many books do, and this one actually is a “new science of”!

    Which is exciting, and/but comes with the caveat that the overall protocol itself is still undergoing testing, but the results so far are promising. The constituent parts of the protocol are for the most already well-established, but have not previously been put together in this way.

    Dr. Bredesen argues that Alzheimer’s Disease is not one condition but three (medical consensus agrees at least that it is a collection of conditions, but different schools of thought slice them differently), and outlines 36 metabolic factors that are implicated, and the good news is, most of them are within our control.

    Since there’s a lot to put together, he also offers many workarounds and “crutches”, making for very practical advice.

    The style of the book is on the hard end of pop-science, that is to say while the feel and tone is very pop-sciencey, there are nevertheless a lot of words that you might know but your spellchecker probably wouldn’t. He does explain everything along the way, but this does mean that if you’re not already well-versed, you can’t just dip in to a later point without reading the earlier parts.

    Bottom line: even if you only implement half the advice in this book, you’ll be doing your long-term cognitive health a huge favor.

    Click here to check out The End of Alzheimer’s, and keep cognitive decline at bay!

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  • Thinner Leaner Stronger – by Michael Matthews

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    First, the elephant in the training room: this book does assume that you want to be thinner, leaner, and stronger. This is the companion book, written for women, to “Bigger, Stronger, Leaner”, which was written for men. Statistically, these assumptions are reasonable, even if the generalizations are imperfect. Also, this reviewer has a gripe with anything selling “thinner”. Leaner was already sufficient, and “stronger” is the key element here, so “thinner” is just marketing, and marketing something that’s often not unhealthy, to sell a book that’s actually full of good advice for building a healthy body.

    In other words: don’t judge a book by the cover, however eyeroll-worthy it may be.

    The book is broadly aimed at middle-aged readers, but boasts equal worth for young and old alike. If there’s something Matthews knows how to do well in his writing, it’s hedging his bets.

    As for what’s in the book: it’s diet and exercise advice, aimed at long-term implementation (i.e. not a crash course, but a lifestyle change), for maximum body composition change results while not doing anything silly (like many extreme short-term courses do) and not compromising other aspects of one’s health, while also not taking up an inordinate amount of time.

    The dietary advice is sensible, broadly consistent with what we’d advise here, and/but if you want to maximise your body composition change results, you’re going to need a pocket calculator (or be better than this writer is at mental arithmetic).

    The exercise advice is detailed, and a lot more specific than “lift things”; there are programs of specifically how many sets and reps and so forth, and when to increase the weights and when not to.

    A strength of this book is that it explains why all those numbers are what they are, instead of just expecting the reader to take on faith that the best for a given exercise is (for example) 3 sets of 8–10 reps of 70–75% of one’s single-rep max for that exercise. Because without the explanation, those numbers would seem very arbitrary indeed, and that wouldn’t help anyone stick with the program. And so on, for any advice he gives.

    The style is… A little flashy for this reader’s taste, a little salesy (and yes he does try to upsell to his personal coaching, but really, anything you need is in the book already), but when it comes down to it, all that gym-boy bravado doesn’t take away from the fact his advice is sound and helpful.

    Bottom line: if you would like your body to be the three things mentioned in the title, this book can certainly help you get there.

    Click here to check out Thinner Leaner Stronger, and become thinner, leaner, stronger!

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  • Should You Go Light Or Heavy On Carbs?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Carb-Strong or Carb-Wrong?

    A bar chart showing the number of people who are interested in social media and heavy carbs.

    We asked you for your health-related view of carbs, and got the above-depicted, below-described, set of responses

    • About 48% said “Some carbs are beneficial; others are detrimental”
    • About 27% said “Carbs are a critical source of energy, and safer than fats”
    • About 18% said “A low-carb diet is best for overall health (and a carb is a carb)”
    • About 7% said “We do not need carbs to live; a carnivore diet is viable”

    But what does the science say?

    Carbs are a critical source of energy, and safer than fats: True or False?

    True and False, respectively! That is: they are a critical source of energy, and carbs and fats both have an important place in our diet.

    ❝Diets that focus too heavily on a single macronutrient, whether extreme protein, carbohydrate, or fat intake, may adversely impact health.

    ~ Dr. Russel de Souza et al.

    Source: Low carb or high carb? Everything in moderation … until further notice

    (the aforementioned lead author Dr. de Souza, by the way, served as an external advisor to the World Health Organization’s Nutrition Guidelines Advisory Committee)

    Some carbs are beneficial; others are detrimental: True or False?

    True! Glycemic index is important here. There’s a big difference between eating a raw carrot and drinking high-fructose corn syrup:

    Which Sugars Are Healthier, And Which Are Just The Same?

    While some say grains and/or starchy vegetables are bad, best current science recommends:

    • Eat some whole grains regularly, but they should not be the main bulk of your meal (non-wheat grains are generally better)
    • Starchy vegetables are not a critical food group, but in moderation they are fine.

    To this end, the Mediterranean Diet is the current gold standard of healthful eating, per general scientific consensus:

    A low-carb diet is best for overall health (and a carb is a carb): True or False?

    True-ish and False, respectively. We covered the “a carb is a carb” falsehood earlier, so we’ll look at “a low-carb diet is best”.

    Simply put: it can be. One of the biggest problems facing the low-carb diet though is that adherence tends to be poor—that is to say, people crave their carby comfort foods and eat more carbs again. As for the efficacy of a low-carb diet in the context of goals such as weight loss and glycemic control, the evidence is mixed:

    ❝There is probably little to no difference in weight reduction and changes in cardiovascular risk factors up to two years’ follow-up, when overweight and obese participants without and with T2DM are randomised to either low-carbohydrate or balanced-carbohydrate weight-reducing diets❞

    ~ Dr. Celeste Naud et al.

    Source: Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk

    ❝On the basis of moderate to low certainty evidence, patients adhering to an LCD for six months may experience remission of diabetes without adverse consequences.

    Limitations include continued debate around what constitutes remission of diabetes, as well as the efficacy, safety, and dietary satisfaction of longer term LCDs❞

    ~ Dr. Joshua Goldenberg et al.

    Source: Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission

    ❝There should be no “one-size-fits-all” eating pattern for different patient´s profiles with diabetes.

    It is clinically complex to suggest an ideal percentage of calories from carbohydrates, protein and lipids recommended for all patients with diabetes.❞

    ~Dr. Adriana Sousa et al.

    Source: Current Evidence Regarding Low-carb Diets for The Metabolic Control of Type-2 Diabetes

    We do not need carbs to live; a carnivore diet is viable: True or False?

    False. For a simple explanation:

    The Carnivore Diet: Can You Have Too Much Meat?

    There isn’t a lot of science studying the effects of consuming no plant products, largely because such a study, if anything other than observational population studies, would be unethical. Observational population studies, meanwhile, are not practical because there are so few people who try this, and those who do, do not persist after their first few hospitalizations.

    Putting aside the “Carnivore Diet” as a dangerous unscientific fad, if you are inclined to meat-eating, there is some merit to the Paleo Diet, at least for short-term weight loss even if not necessarily long-term health:

    What’s The Real Deal With The Paleo Diet?

    For longer-term health, we refer you back up to the aforementioned Mediterranean Diet.

    Enjoy!

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  • Why Curcumin (Turmeric) Is Worth Its Weight In Gold

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Curcumin (Turmeric) is worth its weight in gold

    Not financially! But, this inexpensive golden spice has an impressive list of well-studied health benefits, for something so freely available in any supermarket, and there’s a reason it gets a place in “Dr. Greger’s Daily Dozen”, right up there with things like “leafy greens” and “berries” when it comes to superfoods.

    Let’s do a quick run-down:

    In short, it’s—like we said—worth its weight in gold.

    Quick advice though before we move on…

    If you take curcumin with black pepper, it allows your body to use the curcumin around 2,000% better. This goes whether you’re cooking with both, or take them as a supplement (they’re commonly sold as a combo-capsule for this reason).

    Want to get some?

    Click Here To Check It Out On Amazon

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  • This Is When Your Muscles Are Strongest

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    Dr. Karyn Esser is a professor in the Department of Physiology and Aging at the University of Florida, where she’s also the co-director of the University of Florida Older Americans Independence Center, and she has insights to share on when it’s best to exercise:

    It’s 4–5pm

    Surprise, no clickbait or burying the lede!

    This goes regardless of age or sex, but as we get older, it’s common for our circadian rhythm to weaken, which may result in a tendency to fluctuate a bit more.

    However, since it’s healthy to keep one’s circadian rhythm as stable as reasonably possible, this is a good reason to try to keep our main exercise focused around that time of day, as it provides a sort of “anchor point” for the rest of our day to attach to, so that our body can know what time it is relative to that.

    It’s also the most useful time of day to exercise, because most exercises give benefits proportional to progressive overloading, so training at our peak efficiency time will give the most efficient results. So much for those 5am runs!

    On which note: while the title says “strongest” and the thumbnail has dumbbells, this does go for all different types of exercises that have been tested.

    For more details on all of the above, enjoy:

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    Want to learn more?

    You might also like to read:

    The Circadian Rhythm: Far More Than Most People Know

    Take care!

    Don’t Forget…

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