Microplastics Now, Alzheimer’s/Parkinson’s Later?

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We’ve written about microplastics before, including:

We also have the guest articles:

Now, that last-listed article there concluded:

❝We don’t yet know the effects of microplastics in the human brain. Some laboratory experiments suggest microplastics increase brain inflammation and cell damage, alter gene expression and change brain structure.

But microplastics and their effects are difficult to study. In addition to their small size, there are so many different types of plastics in the environment. More than 13,000 different chemicals have been identified in plastic products, with more being developed every year.❞

…but that was mid-2024, and science has marched on a bit from there. For example…

A (plastic) wrench in the (biological) works

More recently, links to Alzheimer’s and Parkinson’s pathogenesis have been found (pathogenesis = how a disease starts), via 5 main pathways, namely;

  • Mitochondrial dysfunction
    • this is critical, because mitochondrial interference reduces ATP production, weakening neuron function and survival
  • Blood–brain barrier disruption
    • in other words, microplastics can make this protective barrier “leaky,” allowing even more bad things to enter the brain and cause even more damage.
  • Direct neuronal damage
    • because neurons are very delicate and have not evolved to have to deal with bits of plastic
  • Neuroinflammation
    • this may sound like the previous item, but this is more the brain’s immune system’s “friendly fire” (see also: The Inflamed Mind – by Dr. Edward Bullmore), whereas the previous was because of the microplastics themselves
  • Oxidative stress
    • this may sound trivial, but microplastic particles increase reactive oxygen species while weakening antioxidant defenses, leading to cellular damage

And, in particular, microplastics appear to promote beta-amyloid and tau buildup in Alzheimer’s, and α-synuclein aggregation plus dopaminergic neuron damage in Parkinson’s.

This is a problem, because adults ingest an average of around 250g (1 cup) of microplastics per year from sources like food, water, dust, plastic containers, and synthetic fabrics.

You can read the systematic review, here: Do microplastics play a role in the pathogenesis of neurodegenerative diseases? Shared pathophysiological pathways for Alzheimer’s and Parkinson’s disease

What to do about it?

If you want to reduce the aggregations of those unpleasantries, then there are avenues other the (the obvious) plastic reduction, such as: Spermine vs Alzheimer’s & Parkinson’s!

Or for a much deeper dive into the broader topic of avoiding the microplastics the industrial world is keen to throw our way, you might like this book that we reviewed a little while back:

Healthy Living in a Contaminated World – by Dr. Donald Hoernschemeyer

You might also consider this simpler, practical guide: Unprocess Your Life – by Rob Hobson

…and lastly, do check out those articles we linked up top, as you can learn more about how to reduce microplastics in your life from avenues other than the obvious ones.

Take care!

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  • Can you ‘boost’ your immune system?

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    As flu season and a likely winter COVID-19 wave approach, you may encounter both proven and unproven methods claiming to “boost” your immune system. Before you reach for supplements, learn more about how the immune system works, how vaccines give us the best protection against many illnesses, and how some lifestyle factors can help your immune system function properly.

    What is the immune system?

    The immune system is the body’s first line of defense against invaders like viruses, bacteria, or fungi. You develop immunity—or protection from infection—when your immune system has learned how to recognize an invader and attack it before it makes you sick.

    How can you boost your immune system?

    You can teach your immune system how to fight back against dangerous invaders by staying up to date on vaccines. This season’s updated flu and COVID-19 vaccines target newer variants and are recommended for everyone 6 months and older.

    Vaccines reduce your risk of getting sick and spreading illness to others. Even if you get infected with a disease after you’ve been vaccinated against it, the vaccine will still increase protection against severe illness, hospitalization, and death.

    People who have compromised immune systems due to certain health conditions or because they need to take immunosuppressant medications may need additional vaccine doses.

    Find out which vaccines you and your children need by using the CDC’s Adult Vaccine Assessment Tool and Child and Adolescent Vaccine Assessment Tool. Talk to your health care provider about the best vaccines for your family. 

    Find pharmacies offering updated flu and COVID-19 vaccines by visiting Vaccines.gov.

    Can supplements boost your immune system?

    Many vitamin, mineral, and herbal supplements that are marketed as “immune boosting” have little to no effect on your immune system. Research is split on whether some of these supplements—like vitamin C, vitamin D, and zinc—are capable of helping your body fight infections.

    Plus, the Food and Drug Administration typically does not review supplements until after they have reached store shelves, and companies can sell supplements without notifying the FDA. This means that supplements may not be accurately labeled.

    Eating a diverse diet rich in fruits and vegetables is the best way for most people to absorb nutrients that support optimal immune system function. People with certain health conditions and deficiencies may need specific supplements prescribed by a health care provider. For example, people with anemia may need iron supplements in order to maintain appropriate iron levels.

    Before you begin taking a new supplement, talk to your health care provider, as some supplements may interact with medications you are taking or worsen certain health conditions.

    Can lifestyle factors strengthen your immune system?

    Based on current evidence, there is no direct link between lifestyle changes and enhanced immunity to infections. However, maintaining a healthy lifestyle through the following practices can help ensure that your immune system functions as it should:

    Taking steps to avoid contact with germs also reduces your risk of getting sick. Safer sex barriers like condoms protect against HIV, while wearing a high-quality, well-fitting mask—especially in high-risk environments—protects against COVID-19. Both of these illnesses can reduce your production of white blood cells, which protect against infection. 

    For more information, talk to your health care provider.

    This article first appeared on Public Good News and is republished here under a Creative Commons license.

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  • STI rates are increasing among midlife and older adults. We need to talk about it

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Globally, the rates of common sexually transmissible infections (STIs) are increasing among people aged over 50. In some cases, rates are rising faster than among younger people.

    Recent data from the United States Centers for Disease Control and Prevention shows that, among people aged 55 and older, rates of gonorrhoea and chlamydia, two of the most common STIs, more than doubled between 2012 and 2022.

    Australian STI surveillance data has reflected similar trends. Between 2013 and 2022, there was a steady increase in diagnoses of chlamydia, gonorrhoea and syphilis among people aged 40 and older. For example, there were 5,883 notifications of chlamydia in Australians 40 plus in 2013, compared with 10,263 in 2022.

    A 2020 study of Australian women also showed that, between 2000 and 2018, there was a sharper increase in STI diagnoses among women aged 55–74 than among younger women.

    While the overall rate of common STIs is highest among young adults, the significant increase in STI diagnoses among midlife and older adults suggests we need to pay more attention to sexual health across the life course.

    Fit Ztudio/Shutterstock

    Why are STI rates rising among older adults?

    STI rates are increasing globally for all age groups, and an increase among midlife and older people is in line with this trend.

    However, increases of STIs among older people are likely due to a combination of changing sex and relationship practices and hidden sexual health needs among this group.

    The “boomer” generation came of age in the 60s and 70s. They are the generation of free love and their attitude to sex, even as they age, is quite different to that of generations before them.

    Given the median age of divorce in Australia is now over 43, and the internet has ushered in new opportunities for post-separation dating, it’s not surprising that midlife and older adults are exploring new sexual practices or finding multiple sexual partners.

    A middle-aged couple cooking.
    People may start new relationships later in life. Tint Media/Shutterstock

    It’s also possible midlife and older people have not had exposure to sexual health education in school or do not relate to current safe sex messages, which tend to be directed toward young people. Condoms may therefore seem unnecessary for people who aren’t trying to avoid pregnancy. Older people may also lack confidence negotiating safe sex or accessing STI screening.

    Hidden sexual health needs

    In contemporary life, the sex lives of older adults are largely invisible. Ageing and older bodies are often associated with loss of power and desirability, reflected in the stereotype of older people as asexual and in derogatory jokes about older people having sex.

    With some exceptions, we see few positive representations of older sexual bodies in film or television.

    Older people’s sexuality is also largely invisible in public policy. In a review of Australian policy relating to sexual and reproductive health, researchers found midlife and older adults were rarely mentioned.

    Sexual health policy generally targets groups with the highest STI rates, which excludes most older people. As midlife and older adults are beyond childbearing years, they also do not feature in reproductive health policy. This means there is a general absence of any policy related to sex or sexual health among midlife or older adults.

    Added to this, sexual health policy tends to be focused on risk rather than sexual wellbeing. Sexual wellbeing, including freedom and capacity to pursue pleasurable sexual experiences, is strongly associated with overall health and quality of life for adults of all ages. Including sexual wellbeing as a policy priority would enable a focus on safe and respectful sex and relationships across the adult life course.

    Without this priority, we have limited knowledge about what supports sexual wellbeing as people age and limited funding for initiatives to engage with midlife or older adults on these issues.

    One man, working in a home office, talking happily to another man.
    Midlife and older adults may have limited knowledge about STIs. Southworks/Shutterstock

    How can we support sexual health and wellbeing for older adults?

    Most STIs are easily treatable. Serious complications can occur, however, when STIs are undiagnosed and untreated over a long period. Untreated STIs can also be passed on to others.

    Late diagnosis is not uncommon as some STIs can have no symptoms and many people don’t routinely screen for STIs. Older, heterosexual adults are, in general, less likely than other groups to seek regular STI screening.

    For midlife or older adults, STIs may also be diagnosed late because some doctors do not initiate testing due to concerns they will cause offence or because they assume STI risk among older people is negligible.

    Many doctors are reluctant to discuss sexual health with their older patients unless the patient explicitly raises the topic. However, older people can be embarrassed or feel awkward raising matters of sex.

    Resources for health-care providers and patients to facilitate conversations about sexual health and STI screening with older patients would be a good first step.

    To address rising rates of STIs among midlife and older adults, we also need to ensure sexual health promotion is targeted toward these age groups and improve accessibility of clinical services.

    More broadly, it’s important to consider ways to ensure sexual wellbeing is prioritised in policy and practice related to midlife and older adulthood.

    A comprehensive approach to older people’s sexual health, that explicitly places value on the significance of sex and intimacy in people’s lives, will enhance our ability to more effectively respond to sexual health and STI prevention across the life course.

    Jennifer Power, Associate Professor and Principal Research Fellow, Australian Research Centre in Sex, Health and Society, La Trobe University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • 5 types of ‘wellness woo’ that borrow from mainstream medicine

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    What we consider “fringe” or “mainstream” changes over time. That applies to health and medicine too.

    For instance, massage was once considered a fringe therapy but in the 19th century it morphed into what we know today as physiotherapy.

    Likewise, Swiss doctor Maximilian Bircher-Benner wasn’t taken seriously when he said we should eat oats and fruit for breakfast. But he was onto something: he invented muesli.

    There has also been traffic in the other direction. Legitimate medical therapies have turned up in the weird health borderland of beauty and “wellness”.

    When untrained or barely trained people use these therapies, they can do real harm.

    Here are five examples of wellness trends that borrow from mainstream medicine.

    SimpleImages/Getty

    1. Ozone therapy

    Ozone (O₃) is a form of oxygen. Ordinary oxygen (O₂), sometimes with ozone added, can be applied to wounds via a bag or sealed chamber to help them heal. It does this by helping the body fight infection and form collagen.

    But “ozone therapy” – the weird, unlicensed version – puts ozone, or ozone and oxygen, directly into the person’s body. It can go in via the lungs, or via intravenous injection, or it can be pumped into the rectum or vagina.

    Practitioners claim it can reduce inflammation, or even treat cancer or HIV/AIDS, despite no evidence for such health benefits.

    It can also cause fatal air embolisms – bubbles of gas in the bloodstream that can block blood flow to vital organs.

    2. Vitamin drips

    If you don’t get enough of a certain vitamin or mineral through your diet, you can take a supplement. But if that doesn’t work, in some cases, you might need to go to hospital or a doctor’s surgery to get a medically supervised infusion that’s delivered into the vein (an IV infusion).

    For instance, iron infusions help people with serious iron deficiencies.

    But celebrity endorsements have helped fuel the rise of “vitamin drips” at wellness centres and therapy lounges. These drips promise all sorts of outcomes, from boosting your immune system, to treating pain or depression.

    IV needles in untrained hands can be dangerous. They can cause phlebitis (inflammation of the vein) and infiltration (when the IV fluid or medication leaks into the surrounding areas). They can also lead to infection.

    And unlike therapeutic vitamin IV infusions administered in hospital, these non-traditional treatments are not regulated by Australia’s Therapeutic Goods Administration. So you might also not be getting the magic IV potion you’re paying for.

    3. Botox

    The bacterium Clostridium botulinum produces a neurotoxin – a poison that affects nerves. For decades, it’s been used therapeutically to treat excess sweating and migraine, among other conditions. Today, we call this neurotoxin Botox.

    Since about the 1990s, health professionals have been injecting it into people’s faces to temporarily paralyse the muscles that cause wrinkles.

    It’s legal, it’s a registered product, and in trained hands it’s safe to use.

    But as of September 2 this year, it’s been wrapped in an extra layer of regulation.

    People who deliver any non-surgical cosmetic procedures – including Botox – will now be required to demonstrate higher skill levels under tougher policies.

    This comes after several cases where nurses allegedly imported injectables from overseas. But these products weren’t registered for use in Australia and may not have been safe to use.

    4. Apheresis

    Apheresis is the process of separating blood into its component parts by spinning it at high speed in a special machine.

    Clinicians use this process to separate out and remove specific molecules or antibodies in some diseases – what’s called “selective apheresis”.

    For example, if a person has very high cholesterol that doesn’t respond to normal treatments, they can undergo lipid apheresis to “wash out” harmful lipoproteins from their blood.

    It’s easy to see how the idea of “washing” your blood could be misunderstood and misapplied.

    English actor Orlando Bloom announced earlier this year that he’d undergone apheresis to remove microplastics from his blood.

    Microplastics in the body are a cause for concern – but there’s no evidence to suggest apheresis can cleanse human blood of them.

    5. Hyperbaric therapy

    When a diver gets “the bends” from too much nitrogen forming in their body, they can be treated in a hyperbaric oxygen chamber, where they receive 100% oxygen in a pressurised chamber.

    But hyperbaric therapy is also touted as a treatment for autism, Alzheimer’s disease, cancer, strokes, and post-traumatic stress disorder.

    There isn’t enough good science to back up any of these claims. There also isn’t enough science to suggest it makes your skin look younger.

    The key message?

    The history of medicine is full of stories about when mainstream forms of medicine have harmed instead of healed.

    Humans have also always wanted to manage their own health. This has been going on for centuries, with both risks and benefits.

    But just because a therapy has been used in a hospital for one reason doesn’t necessarily mean it works in a wellness clinic for another.

    People can be easily convinced by aggressively marketed wellness therapies, which can be magnified by social media and celebrity endorsements.

    However these therapies can come with a lack of evidence to support their wider uses, and they may harm.

    Caveat emptor – let the buyer beware.

    Philippa Martyr, Lecturer, Pharmacology, Women’s Health, School of Biomedical Sciences, The University of Western Australia

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Strawberries vs Raspberries – Which is Healthier?

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    Our Verdict

    When comparing strawberries to raspberries, we picked the raspberries.

    Why?

    They’re both very respectable fruits, of course! But it’s not even close, and there is a clear winner here…

    In terms of macros, the biggest difference is that raspberries have moderately more carbs, and more than 3x the fiber. Technically they also have 2x the protein, but that’s a case of “two times almost nothing is still almost nothing”. All in all, and especially for the “more than 3x the fiber” (6.5g/100g to strawberries’ 2g/100g), this one’s an easy win for raspberries.

    When it comes to vitamins, strawberries have more vitamin C, while raspberries have more of vitamins A, B1, B2, B3, B5, B6, E, K, and choline. Another clear and easy win for raspberries.

    In the category of minerals, guess what, raspberries win this hands-down, too: strawberries are higher in selenium, while raspberries have more calcium, copper, iron, magnesium, manganese, phosphorus, and zinc.

    Adding up all the individual wins (all for raspberries), it’s not hard to say that raspberries win the day. Still, of course, enjoy either or both; diversity is good!

    Want to learn more?

    You might like to read:

    From Apples to Bees, and High-Fructose Cs: Which Sugars Are Healthier, And Which Are Just The Same?

    Take care!

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  • Sesame Oil vs Almond Oil – Which is Healthier?

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    Our Verdict

    When comparing sesame oil to almond oil, we picked the almond.

    Why?

    We were curious about this one! Were you, or were you confident? You see, almonds tend to blow away all the other nuts with their nutritional density, but they’re far from the oiliest of nuts, and their greatest strengths include their big dose of protein and fiber (which don’t make it into the oil), vitamins (most of which don’t make it into the oil) and minerals (which don’t make it into the oil). So, a lot will come down to the fat profile!

    On which note, looking at the macros first, it’s 100% fat in both cases, but sesame oil has more saturated fat and polyunsaturated fat, while almond oil has more monounsaturated fat. Since the mono- and poly-unsaturated fats are both healthy and each oil has more of one or the other, the deciding factor here is which has the least saturated fat—and that’s the almond oil, which has close to half the saturated fat of sesame oil. As an aside, neither of them are a source of omega-3 fatty acids.

    In terms of vitamins, there’s not a lot to say here, but “not a lot” is not nothing: sesame oil has nearly 2x the vitamin K, while almond oil has 28x the vitamin E*, and 2x the choline. So, another win for almond oil.

    *which is worth noting, not least of all because seeds are more widely associated with vitamin E in popular culture, but it’s the almond oil that provide much more here. Not to get too distracted into looking at the values of the actual seeds and nuts, almonds themselves do have over 102x the vitamin E compared to sesame seeds.

    Now, back to the oils:

    In the category of minerals, there actually is nothing to say here, except you can’t get more than the barest trace of any mineral from either of these two oils. So it’s a tie on this one.

    Adding up the categories makes for a clear win for almond oil!

    Want to learn more?

    You might like to read:

    Avocado Oil vs Olive Oil – Which is Healthier?

    Take care!

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  • Turkish Saffron Salad

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    Summer is upon us, and we need salad options. Coleslaw’s all well and good, until you’re the 4th person to bring it to the pot luck. Tzatziki’s great—and healthier than a standard coleslaw, being based in yogurt rather than mayonnaise as most Western coleslaws are (Eastern European coleslaws, for example, more often use a vinaigrette), but today our tastebuds are traveling to Turkey for this gut-healthy, phytochemical-rich, delicious dish.

    You will need

    • 12 oz carrots, cut into very thin batons (alternatively: use a peeler to peel it into super-thin strips)
    • 2 oz chopped nuts (pistachios are traditional, almonds are also used sometimes; many other nuts would work too e.g. walnuts, hazelnuts, etc; not peanuts though)
    • 2 cups kefir yogurt (if unavailable, substitute any 2 cups plain unsweetened yogurt; comparable plant yogurt is fine if you’re vegan; those healthy bacteria love plant yogurts as much as animal ones)
    • 1 bulb garlic, grated
    • 1 tsp chili flakes
    • 1 pinch saffron, ground, then soaked in 1 tbsp warm water for a few hours
    • 2 tbsp olive oil for cooking; ideally Extra Virgin, but at least Virgin

    Method

    (we suggest you read everything at least once before doing anything)

    1) Put the olive oil and carrots into a saucepan and heat gently, stirring. You want to soften the carrots just a little and absorb the olive oil, without actually fully cooking the carrots; this will probably only take 2–3 minutes at most. Take it off the heat and transfer it to a bowl to cool.

    When the mixture has cooled…

    2) Add the kefir yogurt, garlic, chili flakes, and saffron water into the carrots, mixing thoroughly.

    3) Add the chopped nuts as a garnish

    (after mixing thoroughly, you will probably see more of the yogurt mixture and less of the carrots; that’s fine and correct))

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

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