Gut Health 2.0

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Gene Expression & Gut Health

Dr. Tim Spector, a renowned expert in Gut Health 2.0, offers valuable insights and expertise on the latest advancements in improving gut health and overall well-being. With years of research and

This is Dr. Tim Spector. After training in medicine and becoming a consultant rheumatologist, he’s turned his attention to medical research, and is these days a specialist in twin studies, genetics, epigenetics, microbiome, and diet.

What does he want us to know?

For one thing: epigenetics are for more than just getting your grandparents’ trauma.

More usefully: there are things we can do to improve epigenetic factors in our body

DNA is often seen as the script by which our body does whatever it’s going to do, but it’s only part of the story. Thinking of DNA as some kind of “magical immutable law of reality” overlooks (to labor the metaphor) script revisions, notes made in the margins, directorial choices, and ad-lib improvizations, as well as the quality of the audience’s hearing and comprehension.

Hence the premise of one of Dr. Spector’s older books, “Identically Different: Why We Can Change Our Genes

(*in fact, it was his first, from all the way back in 2013, when he’d only been a doctor for 34 years)

Gene expression will trump genes every time, and gene expression is something that can often be changed without getting in there with CRISPR / a big pair of scissors and some craft glue.

How this happens on the micro level is beyond the scope of today’s article; part of it has to do with enzymes that get involved in the DNA transcription process, and those enzymes in turn are despatched or not depending on hormonal messaging—in the broadest sense of “hormonal”; all the body’s hormonal chemical messengers, not just the ones people think of as hormones.

However, hormonal messaging (of many kinds) is strongly influenced by something we can control relatively easily with a little good (science-based) knowledge: the gut.

The gut, the SAD, and the easy

In broad strokes: we know what is good for the gut. We’ve written about it before at 10almonds:

Making Friends With Your Gut (You Can Thank Us Later)

This is very much in contrast with what in scientific literature is often abbreviated “SAD”, the Standard American Diet, which is very bad for the gut.

However, Dr. Spector (while fully encouraging everyone to enjoy an evidence-based gut-healthy diet) wanted to do one better than just a sweeping one-size-fits-all advice, so he set up a big study with 15,000 identical twins; you can read about it here: TwinsUK

The information that came out of that was about a lot more than just gene expression and gut health, but it did provide the foundation for Dr. Spector’s next project, ZOE.

ZOE crowdsources huge amounts of data including individual metabolic responses to standardized meals in order to predict personalized food responses based on individual biology and unique microbiome profile.

In other words, it takes the guesswork out of a) knowing what your genes mean for your food responses b) tailoring your food choices with your genetic expression in mind, and c) ultimately creating a positive feedback loop to much better health on all levels.

Now, this is not an ad for ZOE, but if you so wish, you can…

Want to know more?

Dr. Spector has a bunch of books out, including some that we’ve reviewed previously:

You can also check out our own previous main feature, which wasn’t about Dr. Spector’s work but was very adjacent:

The Brain-Gut Highway: A Two-Way Street

Enjoy!

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  • What Cannabis Does For Your Sleep (& Your Mornings)
    Many people use cannabis to help them sleep (indeed, it’s even sometimes prescribed for some sleep disorders), and we’ve written about that here: Sweet Dreams Are Made of THC (Or Are They?) The short version is that it works to improve sleep in general, at the cost of reducing your REM sleep specifically, which has…

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  • Best Workouts for Women Over 40 To Give Your Metabolism A Makeover

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    After 40, the usual course of events goes: your lean muscle mass decreases, which slows your metabolism and makes it easier to gain fat. At the same time, bone density decreases, increasing the risk of osteoporosis and frailty. This leads to lower mobility, flexibility, and overall frustration.

    But it doesn’t have to be that way! Fitness coach Jessica Cooke explains how:

    It all depends on this

    Strength training helps counteract these effects by increasing lean muscle mass, which boosts metabolism and fat burning. It also improves bone density, reducing the risk of osteoporosis. Plus, it builds strength, fitness, and a toned physique.

    The best part? It doesn’t require long workouts—short, effective sessions work best.

    While walking is very beneficial for general health, it doesn’t provide the resistance needed to build muscle. Without resistance, your body composition won’t change, and so your metabolism will remain the same. Strength training is essential for burning fat at rest and improving overall fitness.

    You don’t have to do high-impact exercises or jumping to see results. Low-impact strength training is effective and gentle on the joints. Lifting weights or using your body weight in a controlled manner will help build muscle and improve strength.

    Many women only do cardio and neglect strength training, leading to minimal progress. Another common mistake is overcomplicating workouts—simple, consistent strength training is all you need.

    Aim to strength train three times per week for 20 minutes. Focus on compound movements that work multiple muscle groups, such as:

    • squats
    • lunges
    • deadlifts
    • press-ups
    • shoulder presses
    • upright rows
    • planks
    • glute bridges
    • sit-ups
    • Russian twists

    Start with light (e.g. 2-3 kg) weights and maintain proper form.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Don’t Let Menopause Run You Down: 4 Critical Things Female Runners Should Know

    Take care!

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  • Is Air-Fried Food Really Healthier?

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    Air-frying has a reputation for being healthy—and it generally is, provided it’s used carefully:

    Just one thing to watch out for

    An air-fryer is basically a small convection oven that uses circulating air rather than immersion in oil to cook food. The smallness of an air-fryer is a feature not a bug—if you get an air-fryer over a certain size, then congratulations, you just have a convection oven. The small size it what helps it to cook so efficiently. This is one reason that they’re not really used in industrial settings.

    The documentary-makers from this video had their food (chicken, fish, and fries) lab-tested (for fat, cholesterol, and acrylamide), and found:

    • Air-frying significantly reduced saturated fat (38–53%) and trans fats (up to 55%) in some foods.
    • Cholesterol reduction varied depending on the food type.
    • Acrylamide levels in air-fried potatoes were much higher due to cooking time and temperature.

    About that acrylamide: acrylamide forms in starchy foods at high temperatures and may pose cancer risks (the research is as yet unclear, with conflicting evidence). Air-frying can cause higher acrylamide levels if cooking is prolonged or temperatures are too high.

    Recommendations to reduce acrylamide:

    • Soak potatoes before cooking.
    • Use lower temperatures (e.g. 180℃/350℉) and shorter cooking times.
    • Avoid over-browning food.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Unlock Your Air-Fryer’s Potential!

    Take care!

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  • Is The 80:20 Rule Really A Good Idea?

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    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small 😎

    ❝What is your philsophy on eating 80% healthy and 20% not, is it better to try to eat 90% or 100% healthy?❞

    Short answer: what works for you, works for you (if it works for you)!

    More helpful answer: it depends on what each dietary approach ends up looking like for you. For example, there are important differences between:

    1. Someone who carefully measures their food to get 80% of calories from whole-foods plant-based nutrient-dense food, and the other 20% from anything they like, healthy or not
    2. Someone who eats what looks like a healthy diet for 80% of their diet, but falls for a lot of greenwashing and things that look healthier than they are, and then 20% things that look unhealthy (and probably are).
    3. Someone who considers that dessert is just one small part of the day’s eating, so that triple-chocolate ice cream caramel sundae with waffles and syrup and candy sprinkles must be fine (and then similar the next day, and the next, and…)
    4. Someone who works out their daily calories, and dutifully calculates “ok, I’m consuming 1600 kcal per day, so 1600/100 x20 = 320, so if I eat healthily the rest of the day, I can have 6 shots of vodka before bed daily
    5. Someone who applies the 80:20 rule in one of the above ways Monday to Friday, and then at the weekend, declares that 20% of the week and anything goes

    As you may gather, some of those are definitely overly optimistic in their understanding of what will bring (and maintain) good health.

    We’ll be clear: option 1 is not bad, 2 is next best, 3 and 4 are going wildly off-piste in similar but different ways and neither are doing their health* any favors, and 5 is using the 80:20 rule as an excuse to do whatever they want.

    *The main problems with 3 and 4 are the damage to the gut microbiome, the damage to the liver (and associated metabolic problems, which will ultimately hit the heart and pancreas, amongst other organs), and the increased risks of cardiovascular disease and cancer. Depending on alcohol tolerance, there is also an increased risk of harm by accident/incident in the alcohol version.

    Let us assume that you, dear reader, are not doing 3 or 4.

    What about 5?

    The thing with 5 is… If you want to eat that way, you don’t need an excuse. You don’t have to justify it to anyone, including yourself. Just, it might be better to make your peace with the fact that you have simply decided that eating healthily isn’t important to you. And that’s your choice!

    Practical example: there are many people who, for one reason or another, have good cause to believe they will die soon regardless of what they eat. It could be because of a terminal diagnosis, or very advanced age, or some other reason, but the relevant thing is: in such a position, there really is a limit to the worst that can happen from eating that triple-chocolate ice cream caramel sundae with waffles and syrup and candy sprinkles, even with a side-serving of 6 shots of vodka, if they so choose.

    If you, dear reader, are health-conscious and hoping (and reasonably expecting) to not die soon, then that leaves us with 1 and 2.

    2 will put you—guestimating here; we don’t have hard figures—easily into the top quartile of healthy people. That’s not bad at all. It could be better, and if you’re in that position, we’d say that the best thing you can do is exactly what you’re doing: gradually build your knowledge of what is actually healthy vs what just looks healthy, and gradually adjust your grocery-shopping habits accordingly.

    1 has a very wide range, but if you get about it in a smart way, it can be super-healthy. We say “it has a wide range” because technically, 1 in its broadest interpretation could include 4 (since the 6 shots of vodka will indeed fit in that 20%). But most people, hopefully, don’t do that.

    To go about it “in a smart way”: remember that the “whatever you want” doesn’t have to be unhealthy. It just means that if you’re going out for dinner, ordering a thin-crust pizza with mostly vegetable toppings isn’t going to derail your health plan. You can take a flute of champagne at that wedding, if you find yourself so inclined. And so forth.

    You don’t have to “fill” that 20% with unhealthy things. It’s just there if you need to dip into it to avoid inconveniencing yourself.

    The best tip

    Redefine what “treat” means for you. For this writer, for example, a treat on my birthday means I buy the more expensive coffee if I want to. On my last birthday (let’s just say, it was a number ending in zero, and thus merited extra attention) my main (and only) course of my birthday dinner was shchi ← Russian cabbage soup; sounds terrible, looks worse, yet is my favorite comfort food.

    Perhaps you don’t care for coffee and are alarmed at the prospect of eating cabbage soup on a special day.

    But, what do you love? For an ex of mine, it was prawn cocktail salad with pomegranate. How about you?

    The only limit is your imagination—it doesn’t have to be unhealthy to be good!

    Here be science

    There is some merit to avoiding slippery slopes by declaring an entire category of food/drink forbidden, so that you’re not tempted to have just a bit, and then more, and then more, and before you know it it’s your new habit, again.

    But there’s also merit to allowing wiggle-room for sustainability, because otherwise it’s easy to give up when things are difficult/inconvenient/unpleasant.

    Previously at 10almonds, we’ve looked at two fairly opposing schools of thought when it comes to managing what we eat, and the relevant science for each of them.

    First we looked at:

    What Flexible Dieting Really Means

    …and the notion of doing things imperfectly for greater sustainability, and reducing the cognitive load of dieting by measuring only the things that are necessary.

    And then in opposition to that,

    What Are The “Bright Lines” Of Bright Line Eating?

    …and the notion of doing things perfectly so as to not go astray, and reducing the cognitive load of dieting by having hard-and-fast rules that one does not second-guess or reconsider later when hungry.

    Either way, intuitive eating can be a very strong method. It means listening to one’s body, and responding to hunger signals, whether those signals are saying “time to eat” or “time to stop”.

    A common recommendation is to “check in” with one’s body several times per meal, reflecting on such questions as:

    • Do I have hunger pangs? Would I seek food now if I weren’t already at the table?
    • If I hadn’t made more food than I’ve already eaten so far, would that have been enough, or would I have to look for something else to eat?
    • Am I craving any of the foods that are still before me? Which one(s)?
    • How much “room” do I feel I still have, really? Am I still in the comfort zone, and/or am I about to pass into having overeaten?
    • Am I eating for pleasure only at this point? (This is not inherently bad, by the way—it’s ok to have a little more just for pleasure! But it is good to note that this is the reason we’re eating, and take it as a cue to slow down and remember to eat mindfully, and enjoy every bite)
    • Have I, in fact, passed the point of pleasure, and I’m just eating because it’s in front of me, or so as to “not be wasteful”?

    See also: Interoception: Improving Our Awareness Of Body Cues

    And for that matter: Mindful Eating: How To Get More Out Of What’s On Your Plate

    Finally, you can combine even seemingly opposing methods!

    For example, maybe you want to go with the WHO recommendation that “the only safe amount of alcohol is zero”, and consume no alcohol ever, but are happy to be flexible about other things.

    So, ultimately—after a detour through the methods, and now some links in this last section to the science of various approaches—we come back to our short answer up top:

    ❝What works for you, works for you (if it works for you)!❞

    So, just make sure that it does, and do it mindfully and with well-informed intent!

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  • The Bates Method for Better Eyesight Without Glasses − by Dr. William Bates

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    This is a very popular book and method, albeit not a very new one. It was first published in 1920; self-published by Dr. Bates, as the American Medical Association (AMA) considered it quackery.

    Of course, our understanding of eyesight has improved a lot in the past 100 years, so, with the benefit of an extra century of ophthalmological research, who was on the right side of history?

    As it turns out, all of Dr. Bates’ ideas have been firmly disproven, and eyes simply do not work the way he thought they do (for example, he believed that rather than adjusting the lens for focus, the muscles around the eye elongate the eyeball; this absolutely is not how focusing works, and while how much those muscles squeeze the eye does vary depending on some physiological factors, there are no known exercises that can change them).

    Nevertheless, for the interested, his techniques include such things as:

    • putting pressure on one’s eyes with one’s hands (which can increase glaucoma risk)
    • visualization, rather than actual viewing, of an eye chart (this is ironic, because the book cover promises that an eye chart is included; it is not; perhaps it was hoped that we would visualize it more vividly and thus see it?)
    • sunning, which is not only directly looking at the sun, but also using a burning glass to increase the focus of the sunlight onto one’s eye (please do not do this under any circumstances)

    His primary thesis in this work, though, is that eyesight problems of all kinds (from short- and long-sightedness, to more serious things like cataracts and glaucoma) are caused by the tension produced by reading books, so relaxation exercises are his prescription for this.

    The style is characteristic of its era and then some; bold claims are made with no evidence, there are no references, and the text is (ironically, given his opinions on tension being produced by reading books) quite dense. It certainly doesn’t lend itself well to skimming, for example, because something critical can easily be buried in a wall of text of what is, honestly, mostly waffle.

    Bottom line: if you’d like to improve your eyesight and reduce your dependency on glasses, then we absolutely cannot recommend this book, and would direct you instead to Vision for Life, Revised Edition – by Dr. Meir Schneider, which is much more consistent with actual science.

    Click here if you are, nonetheless, curious about Dr. Bates’ book and wish to check it out!

    PS: Dr. Bates certainly was an interesting fellow; he disappeared mysteriously, but was found working as a medical assistant a few weeks later by his wife, whom he now claimed to not recognize. Then he disappeared again two days later (his wife never found him, this time, despite trying for many years), only to show up again, 13 years later, shortly after his wife’s death, whereupon he remarried (to his long-time personal assistant). None of this has anything to do with his fascinating opinions on eyesight, but it’s a story worth mentioning.

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  • Cranberries vs Strawberries – Which is Healthier?

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    Our Verdict

    When comparing cranberries to strawberries, we picked the strawberries.

    Why?

    In terms of macros, cranberries start strong with slightly more fiber and carbs, winning the first round.

    In the category of vitamins, cranberries have more of vitamins A, B5, B6, E, and K, while strawberries have more of vitamins B1, B2, B3, B7, B9, and C, scoring them a marginal victory here.

    Looking at minerals, cranberries have a tiny touch more copper (as well as more sodium), while strawberries have notably more calcium, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc, winning another round easily.

    In other considerations, both have beneficial phytochemical properties, but cranberries’ health properties are a mixed bag of good and bad, while strawberries’ offerings in this regard (simply: a greater abundance of polyphenols) are solely good, so strawberries win this round too.

    Adding up the sections makes for a clear overall win for strawberries, but do enjoy either or both*, as diversity is best!

    *Unless one of the below contraindications applies for you, of course:

    Want to learn more?

    You might like:

    Health Benefits Of Cranberries (But: You’d Better Watch Out) ← cranberries’ bonus properties (including: famously very good at decreasing UTI risk) come with some warnings, including that they may increase the risk of kidney stones if you are prone to such, and also that cranberries have anti-clotting effects, which are great for heart health but can be a risk of you’re on blood thinners or have a bleeding disorder.

    Enjoy!

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  • What Happens When You Break A Bone?

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    Drs. Gurpreet Baht and Natalie Pang give us the insider info:

    To the bone

    About half of all people will break at least one bone during their lifetime, and the body’s 200+* bones come in several categories including short bones, long bones, flat bones, and irregular bones.

    *You may have heard different numbers. Popular numbers in the public consciousness include 215 (thanks to a famous line in the movie Terminator II: Judgment Day), and 206 which is a very popular reckoning with rather sounder reasoning, but 200 is the baseline unless you’re missing some. The reason for the variation is that humans start with 270–300 bones, but many of these fuse together in infancy (for example, much of the skull and coccyx, most of which fusing is done around ages 1–2 years), resulting in a smaller total number. Another reason for variation in total number is that some people have some extra bones, which is usually a case of a harmless copying error.

    Of these, long bones tend to fracture more frequently because they usually absorb the main force of impacts such as falls. However, in the case of somebody more frail than average (so, a lot of older people, for example), hips become quite common candidates, because upon falling: a) they’re often not falling from a great height than their own, so they didn’t break a leg b) they weren’t quick enough to put an arm out to try to break their fall, which means, if falling sideways, which there’s a 50% chance of being the case, the hip hits the floor full-force.

    Some quick notes on the physiology going on here:

    • On why it hurts quite so much: bones contain blood vessels and nerves that transmit intense pain signals during fractures, though scientists still don’t fully understand why broken bones hurt so much because these nerves are encased in hard tissue and difficult to study.
    • On how healing gets going: when a bone breaks the internal blood vessels rupture, causing bleeding and inflammation that begin the healing process.

    That process is a several-stage affair:

    1. Inflammatory phase: during roughly the first week immune cells clear damaged tissue and release signalling molecules that recruit stem cells to the injury site.
    2. Cartilage callus formation: recruited stem cells become chondrocytes that use the blood clot at the fracture site as a scaffold to quickly build a temporary cartilage callus.
    3. Bony callus formation and remodeling: some chondrocytes and stem cells become osteoblasts that create a stronger bony callus, after which specialized cells gradually reshape the bone over several months while osteoblasts lay down new bone tissue.
    4. Treatment and healing variability: healing time depends on factors such as diet, rest, and fracture severity, with clean breaks often treated using casts or splints while severe or displaced fractures may require surgery with pins, plates, or screws.
    5. Misaligned healing and final outcome: if a bone heals incorrectly surgeons may need to refracture and realign it, and although a small bump may remain temporarily after healing the bone typically becomes as strong as it was before.

    For more on all of this, plus some visual illustrations, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    5 Hip Exercises To Strengthen Bones & Improve Balance (Osteoporosis-Friendly)

    Take care!

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