
Gut Health 2.0
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Gene Expression & Gut Health

This is Dr. Tim Spector. After training in medicine and becoming a consultant rheumatologist, he’s turned his attention to medical research, and is these days a specialist in twin studies, genetics, epigenetics, microbiome, and diet.
What does he want us to know?
For one thing: epigenetics are for more than just getting your grandparents’ trauma.
More usefully: there are things we can do to improve epigenetic factors in our body
DNA is often seen as the script by which our body does whatever it’s going to do, but it’s only part of the story. Thinking of DNA as some kind of “magical immutable law of reality” overlooks (to labor the metaphor) script revisions, notes made in the margins, directorial choices, and ad-lib improvizations, as well as the quality of the audience’s hearing and comprehension.
Hence the premise of one of Dr. Spector’s older books, “Identically Different: Why We Can Change Our Genes”
(*in fact, it was his first, from all the way back in 2013, when he’d only been a doctor for 34 years)
Gene expression will trump genes every time, and gene expression is something that can often be changed without getting in there with CRISPR / a big pair of scissors and some craft glue.
How this happens on the micro level is beyond the scope of today’s article; part of it has to do with enzymes that get involved in the DNA transcription process, and those enzymes in turn are despatched or not depending on hormonal messaging—in the broadest sense of “hormonal”; all the body’s hormonal chemical messengers, not just the ones people think of as hormones.
However, hormonal messaging (of many kinds) is strongly influenced by something we can control relatively easily with a little good (science-based) knowledge: the gut.
The gut, the SAD, and the easy
In broad strokes: we know what is good for the gut. We’ve written about it before at 10almonds:
Making Friends With Your Gut (You Can Thank Us Later)
This is very much in contrast with what in scientific literature is often abbreviated “SAD”, the Standard American Diet, which is very bad for the gut.
However, Dr. Spector (while fully encouraging everyone to enjoy an evidence-based gut-healthy diet) wanted to do one better than just a sweeping one-size-fits-all advice, so he set up a big study with 15,000 identical twins; you can read about it here: TwinsUK
The information that came out of that was about a lot more than just gene expression and gut health, but it did provide the foundation for Dr. Spector’s next project, ZOE.
ZOE crowdsources huge amounts of data including individual metabolic responses to standardized meals in order to predict personalized food responses based on individual biology and unique microbiome profile.
In other words, it takes the guesswork out of a) knowing what your genes mean for your food responses b) tailoring your food choices with your genetic expression in mind, and c) ultimately creating a positive feedback loop to much better health on all levels.
Now, this is not an ad for ZOE, but if you so wish, you can…
- Get the free ZOE gut health guide (this is good, but generic, gut health information)
- Take the ZOE home gut health test (quiz followed by offers of lab tests)
- Browse the ZOE Health Academy, its education wing
Want to know more?
Dr. Spector has a bunch of books out, including some that we’ve reviewed previously:
- Spoon-Fed: Why Almost Everything We’ve Been Told About Food Is Wrong
- The Diet Myth: The Real Science Behind What We Eat
- Food for Life: The New Science of Eating Well
You can also check out our own previous main feature, which wasn’t about Dr. Spector’s work but was very adjacent:
The Brain-Gut Highway: A Two-Way Street
Enjoy!
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100 Things Productive People Do – by Nigel Cumberland
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This is a book of a hundred small chapters (the book is 396 pages, so 2–3 pages per chapter) which makes for a feeling of quick reading, and definitely gives an option of “light bites”, dipping into the book here and there.
Cumberland offers a wide range of practical wisdom here, and while the book is (per the title) focused on productivity, it also includes all due weight to not burning out and/or breaking down. Because things productive people do does not, it turns out, include working themselves directly into an early grave.
But—despite the author’s considerable and obvious starting point of social privilege—nor is this a tome of “offer your genius leadership and otherwise just coast while everyone does your work for you”, either. This is a “brass tacks” book and highly relatable whether your to-do list most prominently features “personally manage the merger of these Fortune 500 companies” or “sort out that junk in the spare room”
Bottom line: we’d be surprised if this book with 100 pieces of advice failed to bring you enough value to more than pay for itself!
Pick up your copy of 100 Things Productive People Do from Amazon today!
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The Obesity Code – by Dr. Jason Fung
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Firstly, if you have already read Dr. Fung’s other book, The Diabetes Code, which we reviewed a little while ago, you can probably skip this one. It has mostly the same information, presented with a different focus.
While The Diabetes Code assumes you are diabetic, or prediabetic, or concerned about avoiding/reversing those conditions, The Obesity Code assumes you are obese, or heading in that direction, or otherwise are concerned about avoiding/reversing obesity.
What it’s not, though, is a weight loss book. Will it help if you want to lose weight? Yes, absolutely. But there is no talk here of weight loss goals, nor any motivational coaching, nor week-by-week plans, etc.
Instead, it’s more an informative textbook. With exactly the sort of philosophy we like here at 10almonds: putting information into people’s hands, so everyone can make the best decisions for themselves, rather than blindly following someone else’s program.
Dr. Fung explains why various dieting approaches don’t work, and how we can work around such things as our genetics, as well as most external factors except for poverty. He also talks us through how to change our body’s insulin response, and get our body working more like a lean machine and less like a larder for hard times.
Bottom line: this is a no-frills explanation of why your body does what it does when it comes to fat storage, and how to make it behave differently about that.
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Apple Cider Vinegar vs Apple Cider Vinegar Gummies – Which is Healthier?
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Our Verdict
When comparing apple cider vinegar (bottled) to apple cider vinegar (gummies), we picked the bottled.
Why?
There are several reasons!
The first reason is about dosage. For example, the sample we picked for apple cider vinegar gummies, boasts:
❝2 daily chewable gummies deliver 800 mg of Apple Cider Vinegar a day, equivalent to a teaspoon of liquid apple cider vinegar❞
That sounds good until you note that it’s recommended to take 1–2 tablespoons (not teaspoons) of apple vinegar. So this would need more like 4–8 gummies to make the dose. Suddenly, either that bottle of gummies is running out quickly, or you’re just not taking a meaningful dose and your benefits will likely not exceed placebo.
The other is reason about sugar. Most apple cider vinegar gummies are made with some kind of sugar syrup, often even high-fructose corn syrup, which is one of the least healthy foodstuffs (in the loosest sense of the word “foodstuffs”) known to science.
The specific brand we picked today was the best we can find; it used maltitol syrup.
Maltitol syrup, a corn derivative (and technically a sugar alcohol), has a Glycemic Index of 52, so it does raise blood sugars but not as much as sucrose would. However (and somewhat counterproductive to taking apple cider vinegar for gut health) it can cause digestive problems for many people.
And remember, you’re taking 4–8 gummies, so this is amounting to several tablespoons of the syrup by now.
On the flipside, apple cider vinegar itself has two main drawbacks, but they’re much less troublesome issues:
- many people don’t like the taste
- its acidic nature is not good for teeth
To this the common advice for both is to dilute it with water, thus diluting the taste and the acidity.
(this writer shoots hers from a shot glass, thus not bathing the teeth since it passes them “without touching the sides”; as for the taste, well, I find it invigorating—I do chase it with water, though to be sure of not leaving vinegar in my mouth)
Want to check them out for yourself?
Here they are:
Apple cider vinegar | Apple cider vinegar gummies
Want to know more about apple cider vinegar?
Check out:
- An Apple (Cider Vinegar) A Day…
- 10 Ways To Balance Blood Sugars
- How To Recover Quickly From A Stomach Bug
Take care!
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3 signs your diet is causing too much muscle loss – and what to do about it
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When trying to lose weight, it’s natural to want to see quick results. So when the number on the scales drops rapidly, it seems like we’re on the right track.
But as with many things related to weight loss, there’s a flip side: rapid weight loss can result in a significant loss of muscle mass, as well as fat.
So how you can tell if you’re losing too much muscle and what can you do to prevent it?
EvMedvedeva/Shutterstock Why does muscle mass matter?
Muscle is an important factor in determining our metabolic rate: how much energy we burn at rest. This is determined by how much muscle and fat we have. Muscle is more metabolically active than fat, meaning it burns more calories.
When we diet to lose weight, we create a calorie deficit, where our bodies don’t get enough energy from the food we eat to meet our energy needs. Our bodies start breaking down our fat and muscle tissue for fuel.
A decrease in calorie-burning muscle mass slows our metabolism. This quickly slows the rate at which we lose weight and impacts our ability to maintain our weight long term.
How to tell you’re losing too much muscle
Unfortunately, measuring changes in muscle mass is not easy.
The most accurate tool is an enhanced form of X-ray called a dual-energy X-ray absorptiometry (DXA) scan. The scan is primarily used in medicine and research to capture data on weight, body fat, muscle mass and bone density.
But while DEXA is becoming more readily available at weight-loss clinics and gyms, it’s not cheap.
There are also many “smart” scales available for at home use that promise to provide an accurate reading of muscle mass percentage.
Some scales promise to tell us our muscle mass. Lee Charlie/Shutterstock However, the accuracy of these scales is questionable. Researchers found the scales tested massively over- or under-estimated fat and muscle mass.
Fortunately, there are three free but scientifically backed signs you may be losing too much muscle mass when you’re dieting.
1. You’re losing much more weight than expected each week
Losing a lot of weight rapidly is one of the early signs that your diet is too extreme and you’re losing too much muscle.
Rapid weight loss (of more than 1 kilogram per week) results in greater muscle mass loss than slow weight loss.
Slow weight loss better preserves muscle mass and often has the added benefit of greater fat mass loss.
One study compared people in the obese weight category who followed either a very low-calorie diet (500 calories per day) for five weeks or a low-calorie diet (1,250 calories per day) for 12 weeks. While both groups lost similar amounts of weight, participants following the very low-calorie diet (500 calories per day) for five weeks lost significantly more muscle mass.
2. You’re feeling tired and things feel more difficult
It sounds obvious, but feeling tired, sluggish and finding it hard to complete physical activities, such as working out or doing jobs around the house, is another strong signal you’re losing muscle.
Research shows a decrease in muscle mass may negatively impact your body’s physical performance.
3. You’re feeling moody
Mood swings and feeling anxious, stressed or depressed may also be signs you’re losing muscle mass.
Research on muscle loss due to ageing suggests low levels of muscle mass can negatively impact mental health and mood. This seems to stem from the relationship between low muscle mass and proteins called neurotrophins, which help regulate mood and feelings of wellbeing.
So how you can do to maintain muscle during weight loss?
Fortunately, there are also three actions you can take to maintain muscle mass when you’re following a calorie-restricted diet to lose weight.
1. Incorporate strength training into your exercise plan
While a broad exercise program is important to support overall weight loss, strength-building exercises are a surefire way to help prevent the loss of muscle mass. A meta-analysis of studies of older people with obesity found resistance training was able to prevent almost 100% of muscle loss from calorie restriction.
Relying on diet alone to lose weight will reduce muscle along with body fat, slowing your metabolism. So it’s essential to make sure you’ve incorporated sufficient and appropriate exercise into your weight-loss plan to hold onto your muscle mass stores.
Strength-building exercises help you retain muscle. BearFotos/Shutterstock But you don’t need to hit the gym. Exercises using body weight – such as push-ups, pull-ups, planks and air squats – are just as effective as lifting weights and using strength-building equipment.
Encouragingly, moderate-volume resistance training (three sets of ten repetitions for eight exercises) can be as effective as high-volume training (five sets of ten repetitions for eight exercises) for maintaining muscle when you’re following a calorie-restricted diet.
2. Eat more protein
Foods high in protein play an essential role in building and maintaining muscle mass, but research also shows these foods help prevent muscle loss when you’re following a calorie-restricted diet.
But this doesn’t mean just eating foods with protein. Meals need to be balanced and include a source of protein, wholegrain carb and healthy fat to meet our dietary needs. For example, eggs on wholegrain toast with avocado.
3. Slow your weight loss plan down
When we change our diet to lose weight, we take our body out of its comfort zone and trigger its survival response. It then counteracts weight loss, triggering several physiological responses to defend our body weight and “survive” starvation.
Our body’s survival mechanisms want us to regain lost weight to ensure we survive the next period of famine (dieting). Research shows that more than half of the weight lost by participants is regained within two years, and more than 80% of lost weight is regained within five years.
However, a slow and steady, stepped approach to weight loss, prevents our bodies from activating defence mechanisms to defend our weight when we try to lose weight.
Ultimately, losing weight long-term comes down to making gradual changes to your lifestyle to ensure you form habits that last a lifetime.
At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can register here to express your interest.
Nick Fuller, Charles Perkins Centre Research Program Leader, University of Sydney
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Eat Your Vitamins – by Mascha Davis, RDN
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This book methodically discusses an assortment of vitamins, minerals, and other nutrients; the “other nutrients” category including amino acids (branched chain and essential), prebiotics and probiotics, and triglycerides of various kinds.
It makes the argument that we are better off getting these things from nature than from supplements, and in the category of criticism, it doesn’t make that argument very well. The truth is that yes, bioavailability of many nutrients is higher from food, the author is a little selective in problem recognition—for example, criticizing supplements as sometimes being contaminated with heavy metals, right after recommending fish (famously a rich source of heavy metals, along with actual nutrients).
In a similar vein, she does not pay a lot of attention to downsides of certain foods, so for example we will see her recommending beef as a source of many nutrients—which it is! It’s just also a top risk factor for heart disease, cancer, diabetes, and more. But, the author is a registered dietician-nutritionist and not a cardiologist, oncologist, epidemiologist, etc, and it shows.
On the other hand, a strength of this book is that it does elucidate what the various nutrients are and what they actually do, which conveys a level of understanding that very many people don’t otherwise have (your average person in the street is unlikely to be able to say what vitamin B3 actually does, for example).
The style is straightforward and clear, making this book an easy quick reference source, as well as being readable cover-to-cover if you so desire.
Bottom line: if you’d like to know more about the nutrients we humans need, this is a great book! Just watch out for the downsides of some foods though, as the author can be a bit overly generous in her recommendations.
Click here to check out Eat Your Vitamins, and indeed eat your vitamins!
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100 Ways to Change Your Life – by Liz Moody
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Sometimes we crave changing things up, just to feel something new. This can result in anything from bad haircut decisions or impulsive purchases, to crashing and burning-out of a job, project, or relationship. It doesn’t have to be that way, though!
This book brings us (as the title suggest) 100 evidence-based ways of changing things up in a good way—small things that can make a big difference in many areas of life.
In terms of format, these are presented in 100 tiny chapters, each approximately 2 pages long (obviously it depends on the edition, but you get the idea). Great to read in any of at least three ways:
- Cover-to-cover
- One per day for 100 days
- Look up what you need on an ad hoc basis
Bottom line: even if you already do half of these things, the other half will each compound your health happiness one-by-one as you add them. This is a very enjoyable and practical book!
Click here to check out 100 Ways to Change Your Life, and level-up yours!
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