Fix Chronic Fatigue & Regain Your Energy, By Science

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Chronic fatigue is on the rise. A lot of it appears to be Long COVID-related, but whether that’s the case for you or not, one thing that will make a big difference to your energy levels is something that French biochemist Jessie Inchauspé is here to explain:

Mitochondrial management

Inchauspé explains it in terms of a steam train; to keep running, it must have coal burning in its furnace. However, if more coal is delivered to the engine room faster than it can be put in the furnace and burned, and the coal just keeps on coming, the worker there will soon be overwhelmed trying to find places to put it all; the engine room will be full of coal, and the furnace will sputter and go out because the worker can’t even reach it on account of being buried in coal.

So it is with our glucose metabolism also. If we get spikes of glucose faster than our body can deal with them, it will overload the body’s ability to process that energy at all. Just like the steam train worker, our body will try! It’ll stuff that extra glucose wherever it can (storing as glycogen in the liver is a readily available option that’s easy to do and/but also gives you non-alcoholic fatty liver disease and isn’t quickly broken down into useable energy), and meanwhile, your actual mitochondria aren’t getting what they need (which is: a reliable, but gentle, influx of glucose).

You can imagine that the situation we described in the steam train isn’t good for the engine’s longevity, and the corresponding situation in the human body isn’t good for our mitochondria either (or our pancreas, or our liver, or… the list goes on). Indeed, damaged mitochondria affect exercise capacity and stress resilience—as well as being a long-term driver of cancer.

The remedy, of course, is blood sugar management. Specifically, avoiding glucose spikes. She has a list of 10 ways to do this (small changes to how we eat; what things to eat with what, in which order, etc) that make a huge measurable difference. For your convenience, we’ve linked those ten ways below; first though, if you’d like to hear it from Inchauspé directly (her style is very pleasant), enjoy:

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Want to learn more?

You might also like to read:

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  • The Stress Prescription (Against Aging!)

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    The Stress Prescription (Against Aging!)

    This is Dr. Elissa Epel, whose work has for the past 20 years specialized in the effect of stress on aging. She’s led groundbreaking research on cortisol, telomeres, and telomerase, all in the context of aging, especially in women, as well as the relationship between stress and weight gain. She was elected member of the National Academy of Medicine for her work on stress pathways, and has been recognized as a key “Influencer in Aging” by the Alliance for Aging Research.

    Indeed, she’s also been named in the top 0.1% of researchers globally, in terms of publication impact.

    What’s that about stress and aging?

    In her words,

    ❝Women with the highest levels of perceived stress have telomeres shorter on average by the equivalent of at least one decade of additional aging compared to low stress women❞

    Source: Accelerated telomere shortening in response to life stress

    We say “in her words”, as she is the top-listed author on this paper—an honour reserved for the lead researcher of any given study/paper.

    However, we’d be remiss not to note that the second-listed author is Nobel Prize Laureate Dr. Elizabeth Blackburn. What a team! Maybe we’ll do a spotlight feature on Dr. Blackburn’s work one of these days, but for now, back to Dr. Epel…

    What does she want us to do about it?

    She has the following advice for us:

    Let go of what we can’t control

    This one is simple enough, and can be as simple as learning how to set anxiety aside, and taking up the practice of radical acceptance of what we cannot control.

    Be challenged, not afraid

    This is about eustress, and being the lion, not the gazelle. Dr. Epel uses the example of how when lions are hunting gazelles, both are stressed, but both are feeling the physiological effects of that stress in terms of the augmentation to their immediate abilities, but only one of them is suffering by it.

    We’ll let her explain how to leverage this:

    TED ideas | Here’s how you can handle stress like a lion, not a gazelle | Dr. Elissa Epel

    Build resilience through controlled discomfort

    Don’t worry, you don’t have to get chased by lions. A cold shower will do it! This is about making use of hormesis, the body’s ability to build resilience to stressors by small doses of controlled cortisol release—as for example when one undergoes thermal shock, which sounds drastic, but for most people, a cold shower (or even an ice bath) is safe enough.

    You can read more about this here:

    A Cold Shower A Day Keeps The Doctor Away

    Connect with nature

    You don’t have to hug a tree, but you do have get to a natural (or at least, natural-seeming) environment once in a while. Simply put, we did not evolve to be in the urban or even suburban settings where most of us spend most of our time. Getting to be around greenery with at least some kind of regularity is hugely beneficial. It doesn’t have to be a national park; a nice garden or local park can suffice, and potted plants at home are better than nothing. Even spending time in virtual reality “nature” is an option:

    Effect of Virtual Reality on Stress Reduction and Change of Physiological Parameters Including Heart Rate Variability in People With High Stress: An Open Randomized Crossover Trial

    (you can see an example there, of the kind of scenery this study used)

    Breathe deeply, and rest deeply

    Mindful breathing, and good quality sleep, are very strongly evidence-based approaches to reduce stress, for example:

    Practice gratitude to build optimism

    Optimism has a huge positive impact on health outcomes, even when other factors (including socioeconomic factors, pre-existing conditions, and general reasons for one person to be more optimistic than another) are controlled for.

    Read: Optimism and Cause-Specific Mortality: A Prospective Cohort Study

    There are various ways to increase optimism, and practising gratitude is one of them—but that doesn’t necessarily mean abandoning realism, either:

    How To Practise (Non-Toxic) Positivity

    There are other ways too, though, and Dr. Epel discusses some with her friend and colleague, Dr. Elizabeth Blackburn, here:

    TED ideas | Could your thoughts make you age faster? And can we reverse that? | Dr. Elizabeth Blackburn & Dr. Elissa Epel

    Want to learn more from Dr. Epel?

    We reviewed one of her books, The Telomere Effect, previously. It’s about what we can do to lengthen our telomeres (a key factor in health aging; effectively, being biologically younger). You also might enjoy her newer book, The Stress Prescription, as well as her blog.

    Enjoy!

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  • Shredded Wheat vs Organic Crunch – Which is Healthier?

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    Our Verdict

    When comparing Shredded Wheat to Organic Crunch, we picked the Shredded Wheat.

    Why?

    In this battle of the cereals, it comes down to the ingredients:

    • The Shredded Wheat cereal has two ingredients: wheat (shredded), and BHT. The latter is a phenolic compound and antioxidant.
    • The Organic Crunch cereal has lots of ingredients, of which the first two are wheat flour, and sugar.

    This means that, per serving…

    • The Shredded Wheat cereal has 7g fiber and 0g sugar
    • The Organic Crunch cereal has 3g fiber and 12g sugar

    Quite a difference! Sometimes, the “Organic Crunch” of a product comes from crunchy sugar.

    You can check them out side-by-side here:

    Shredded Wheat | Organic Crunch

    Want to know more?

    There’s a popular view that the only way to get fiber is to eat things that look (and potentially taste) like cardboard. Not so! There are delicious options:

    Level-Up Your Fiber Intake! (Without Difficulty Or Discomfort)

    Enjoy!

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  • The Checklist Manifesto – by Dr. Atul Gawande

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    Dr. Gawande, himself a general surgeon, uses checklists a lot. He is, unequivocally, an expert in his field. He “shouldn’t” need a checklist to tell him to do such things as “Check you have the correct patient”. But checklists are there as a safety net. And, famously, “safety regulations are written in blood”, after all.

    And, who amongst us has never made such a “silly” error? From forgetting to turn the oven on, to forgetting to take the handbrake off, it takes only a momentary distraction to think we’ve done something we haven’t.

    You may be wondering: why a whole book on this? Is it just many examples of the usefulness of checklists? Because I’m already sold on that, so, what else am I going to get out of it?

    Dr. Gawande also explains in clear terms:

    • How to optimize “all necessary steps” with “as few steps as possible”
    • The important difference between read-do checklists and do-confirm checklists
    • To what extent we should try to account for the unexpected
    • How to improve compliance (i.e., making sure you actually use it, no matter how tempting it will be to go “yeah this is automatic for me now” and gloss over it)
    • The role of checklists in teams, and in passing on knowledge

    …and more.

    Bottom line: if you’ve ever tried to make tea without putting the tea-leaves in the pot, this is the book that will help you avoid making more costly mistakes—whatever your area of activity or interest.

    Click here to check out the Checklist Manifesto, and make fewer mistakes!

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  • The Keys to Good Mental Wellbeing

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    The Nine Keys To Good Mental Wellbeing

    Today’s main feature is a bit “pop psychology”, but it has its underpinnings in actual psychology, and is especially useful if approached from that angle.

    What it’s most popularly enjoyed as:

    • A personality-typing system.
    • People love little quizzes and identifiers and such.

    What it’s actually really useful as:

    • A tool for understanding why people (including ourselves) are the way we are
    • A foundational knowledge for living better ourselves, and helping others too

    This stems from the fairly simple principle, uncontroversial in psychology:

    • We have needs, desires, and aversions
    • We act in a way that tries to get our needs met and avoid suffering
    • Thus: Need/Fear → Motivation → Action

    The Enneagram

    The Enneagram (ἐννέα = “nine” in Ancient Greek) system posits that we each have one fundamental need/fear (from a list of nine) that’s strongest for us. A deep-seated insecurity/longing, that we’ll go to almost any lengths to try to meet. Sometimes, in good ways, sometimes, bad.

    The Nine Basic Fears/Insecurities, And Their Corresponding Needs/Desires:

    1. Fear of being a fundamentally bad, wrong person / Need to be good and correct
    2. Fear of being fundamentally unloveable / Need to be loved
    3. Fear of being fundamentally worthless / Need to be valued
    4. Fear of being like everyone else / Need to be different
    5. Fear of being useless / Need to be useful
    6. Fear of being outcast / Need to have a set place in the group
    7. Fear of missing out / Need to experience things
    8. Fear of being hurt or controlled / Need to be in control
    9. Fear of conflict / Need to be at peace

    Of course, most of us have most of these fears/needs to some extent, though usually one will stand out—especially if we aren’t managing it well. The less healthy our coping mechanisms, the more obvious it is how we’re trying to overcompensate in some fashion. For example:

    1. A person who fears being wrong and so becomes a perfectionist rules-abider to a fault
    2. A person who fears being unloveable, and so exaggerates problems to get pity, as the next best thing
    3. A person who fears being worthless, and so exaggerates their accomplishments in order to be admired and valued
    4. A person who fears being like everyone else, and so descends into a “nobody could ever possibly understand me” black hole of pathos.
    5. A person who fears being useless, so burns themself out trying to be an omnicompetent Leonardo da Vinci without ever actually taking the time to stop and smell the flowers as Leonardo did.
    6. A person who fears being outcast, so becomes clingy, passive-aggressive, and suspicious
    7. A person who fears missing out, so tries to experience all the things all the time, ruining their health with dizzying highs and crushing lows.
    8. A person who fears being hurt or controlled, so becomes aggressive and domineering
    9. A person who fears conflict, so shuts down at the slightest hint of it

    If we have healthier coping mechanisms, these same nine people can look a lot different, but in much more subtle ways because we’re not trying to overcompensate so badly:

    1. A person who lives their life rationally by principles that can be adapted as they learn
    2. A person who loves and is loved, as perhaps the most notable part of their character
    3. A person who sets reasonable goals and accomplishes them, and seeks to uplift others
    4. A person who creates and innovates, enriching their own life and the lives of others
    5. A person who is simply very competent and knowledgeable, without overstretching
    6. A person who is dependable and loyal, and a reliable part of something bigger than themself
    7. A person who is fun to be around and loves trying new things, while also knowing how to relax
    8. A person who develops their leadership skills and is a tower of strength for others
    9. A person who knows how to make peace and does so—by themself, and with others

    By being aware of our own fears/insecurities that may drive our motivations and thus underpin our behaviors, we can usually manage them in a much more mindful fashion. Same goes when it comes to managing interactions with other people, too:

    • Letting the Type 3 know you value them, not their accomplishments or what they can do for you.
    • Appreciating the Type 5’s (varied or specialist) skills and knowledge.
    • Giving love to a Type 2 unprompted, but on your own terms, with your own boundaries.
    • And so on for other types

    Or for yourself…

    • As a Type 8, remembering that you can let go sometimes and let someone else be in charge.
    • As a Type 1, catching yourself holding yourself (or others) to impossible standards, and then easing up on that a little.
    • As a Type 9, remembering to stand up for yourself and others, however gently, but firmly.
    • And so on for other types

    If you’re unsure what to focus on, ask yourself: what’s your worst nightmare or greatest daydream? Then work out what it is about that, that makes it feel so bad or good.

    Then, approach things mindfully. Catch yourself in your unhealthy coping mechanisms, and find healthy ones instead.

    What if I get my type wrong? Or I get someone else’s type wrong?

    Obviously it’s better to get them right for maximum effect, but you can never go too far wrong anyway… because we all have all nine of those qualities in us, it’s just a matter of how strong a factor each is for us. So in the worst case scenario, you’ll make someone feel more secure about something that was only a very minor insecurity for them, for example.

    Or in the case of your own type, you may mistakenly think you’re acing being the world’s healthiest Type 5, until you realize you’re actually a Type 3 who thought learning all those things would make you more worthy (spoiler: those things are great, but you’re worthy already). Again, not the end of the world! No matter what, you’re learning and growing, and that’s good.

    Want to delve further?

    Read: The Nine Enneagram Type Descriptions (Basic, but more detailed descriptions than the above)

    Read: How The Enneagram System Works (More complex. Now we’re getting into the more arcane stuff we didn’t have time for today—wings and lines, triads, health levels, directions of integration and disintegration, and more)

    Like learning from books? Here are our top two picks, depending on your learning style:

    We’d love to offer a quick free test here, but all the tests we could find either require paid registration or are wildly inaccurate, so we’ll not waste your time.

    However, we do also think that working it out for yourself is better, as it means you have a handle on what those ideas, fears, insecurities, desires, needs, really mean to you—that way you can actually use the information!

    We’ll close by repeating our previous advice: If you’re unsure what to focus on, ask yourself: what’s your worst nightmare or greatest daydream? Then work out what it is about those scenarios that make them so bad or good. That’ll help you find your real fears/needs, such that you can work on them.

    Good luck!

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  • Why Chronic Obstructive Pulmonary Disease (COPD) Is More Likely Than You Think

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    Chronic Obstructive Pulmonary Disease (COPD): More Likely Than You Think

    COPD is not so much one disease, as rather a collection of similar (and often overlapping) diseases. The main defining characteristic is that they are progressive lung diseases. Historically the most common have been chronic bronchitis and emphysema, though Long COVID and related Post-COVID conditions appear to have been making inroads.

    Lung cancer is generally considered separately, despite being a progressive lung disease, but there is crossover too:

    COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

    COPD can be quite serious:

    Life expectancy and years of life lost in Chronic Obstructive Pulmonary Disease: Findings from the NHANES III Follow-up Study

    “But I don’t smoke”

    Great! In fact we imagine our readership probably has disproportionately few smokers compared to the general population, being as we all are interested in our health.

    But, it’s estimated that 30,000,000 Americans have COPD, and approximately half don’t know it. Bear in mind, the population of the US is a little over 340,000,000, so that’s a little under 9% of the population.

    Click here to see a state-by-state breakdown (how does your state measure up?)

    How would I know if I have it?

    It typically starts like any mild respiratory illness. Likely shortness of breath, especially after exercise, a mild cough, and a frequent need to clear your throat.

    Then it will get worse, as the lungs become more damaged; each of those symptoms might become stronger, as well as chest tightness and a general lack of energy.

    Later stages, you guessed it, the same but worse, and—tellingly—weight loss.

    The reason for the weight loss is because you are getting less oxygen per breath, making carrying your body around harder work, meaning you burn more calories.

    What causes it?

    Lots of things, with smoking being up at the top, or being exposed to a lot of second-hand smoke. Working in an environment with a lot of air pollution (for example, working around chemical fumes) can cause it, as can inhaling dust. New Yorkers: yes, that dust too. It can also develop from other respiratory illnesses, and some people even have a genetic predisposition to it:

    Alpha-1 antitrypsin deficiency: a commonly overlooked cause of lung disease

    Is it treatable?

    Treatment varies depending on what form of it you have, and most of the medical interventions are beyond the scope of this article. Suffice it to say, there are medications that can be taken (including bronchodilators taken via an inhaler device), corticosteroids, antibiotics and antivirals of various kinds if appropriate. This is definitely a “see your doctor” item though, because there are is far too much individual variation for us to usefully advise here.

    However!

    There are habits we can do to a) make COPD less likely and b) make COPD at least a little less bad if we get it.

    Avoiding COPD:

    • Don’t smoke. Just don’t.
      • Avoid second-hand smoke if you can
    • Avoid inhaling other chemicals/dust that may be harmful
    • Breathe through your nose, not your mouth; it filters the air in a whole bunch of ways
      • Seriously, we know it seems like nostril hairs surely can’t do much against tiny particles, but tiny particles are attracted to them and get stuck in mucous and dealt with by our immune system, so it really does make a big difference

    Managing COPD:

    • Continue the above things, of course
    • Exercise regularly, even just light walking helps; we realize it will be difficult
    • Maintain a healthy weight if you can
      • This means both ways; COPD causes weight loss and that needs to be held in check. But similarly, you don’t want to be carrying excessive weight either; that will tire you even more.
    • Look after the rest of your health; everything else will now hit you harder, so even small things need to be taken seriously
    • If you can, get someone to help / do your household cleaning for you, ideally while you are not in the room.

    Where can I get more help/advice?

    As ever, speak to your doctor if you are concerned this may be affecting you. You can also find a lot of resources via the COPD Foundation’s website.

    Take care of yourself!

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  • Move over, COVID and Flu! We Have “Hybrid Viruses” To Contend With Now

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    Move over, COVID and Flu! We have “hybrid viruses” to contend with now

    COVID and influenza viruses can be serious, of course, so let’s be clear up front that we’re not being dismissive of those. But, most people are hearing a lot about them, whereas respiratory syncytial virus (RSV) has flown under a lot of radars.

    Simply put, until recently it hasn’t been considered much of a threat except to the young, the old, or people with other respiratory illnesses. Only these days, the prevalence of “other respiratory illnesses” is a lot higher than it used to be!

    It’s not just a comorbidity

    It’s easy to think “well of course if you have more than one illness at once, especially similar ones, that’s going to suck” but it’s a bit more than that; it produces newer, more interesting, hybrid viruses. Here’s a research paper from last year’s “flu season”:

    Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles

    Best to be aware of this if you’re in the “older” age-range

    It’s not just that the older we are, the more likely we are to get it. Critically, the older we are, the more likely we are to be hospitalized by it.

    And..the older we are, the less likely we are to come back from hospital if hospitalized by it.

    Some years back, the intensive care and mortality rates for people over the age of 65 were 8% and 7%, respectively:

    Respiratory syncytial virus infection in elderly and high-risk adults

    …but a new study this year has found the rates like to be 2.2x that, i.e. 15% intensive care rate and 18% mortality, respectively:

    Adjusting for Case Under-Ascertainment in Estimating RSV Hospitalisation Burden of Older Adults in High-Income Countries: a Systematic Review and Modelling Study

    Want to know more?

    Here are some hot-off-the-press news articles on the topic:

    And as for what to do…

    Same general advice as for COVID and Flu, just, ever-more important:

    • Try to keep to well-ventilated places as much as possible
    • Get any worrying symptoms checked out quickly
    • Mask up when appropriate
    • Get your shots as appropriate

    See also:

    Harvard Health Review | Fall shots: Who’s most vulnerable to RSV, COVID, and the flu, and which shots are the right choice for you to help protect against serious illness and hospitalization?

    Stay safe!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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