The Fast-Mimicking Diet
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Live, Fast, Live Long
This is Dr. Valter Longo. He’s a biogerontologist and cell biologist, whose work has focused on fasting and nutrient response genes, and how we can leverage them against diseases and aging in general.
We reviewed his book recently:
What does he want us to know?
What to eat
Dr. Longo recommends a mostly plant-based diet (especially vegetables, whole grains, and legumes), but also having some fish. The bulk of our dietary fats, however, he says are best coming from olive oil and nuts.
He also advises aiming for nutritional density of vitamins and minerals in our diet, and/but supplementing with a multivitamin once every few days to cover any gaps.
If in doubt choosing between plant-based whole foods, he recommends that we choose those our ancestors will have eaten.
Read more: Longevity Diet For Adults
When to eat
Dr. Longo recommends time-restricted eating within a 12-hour window per day.
See also: Intermittent Fasting: We Sort The Science From The Hype
However, he also recommends (additionally or separately; it’s up to us; additionally is better but the point is it still has excellent benefits separately too) his “fast-mimicking diet” (FMD), which involves eating according to what we said in “What to eat”, but restricting it to 750 kcal per day, 5 days in a row, but not necessarily 5 days per week.
For example, the following was a 3-month study that involved doing this for only one 5-day cycle per month:
❝Three FMD cycles reduced body weight, trunk, and total body fat; lowered blood pressure; and decreased insulin-like growth factor 1 (IGF-1). No serious adverse effects were reported.
A post hoc analysis of subjects from both FMD arms showed that body mass index, blood pressure, fasting glucose, IGF-1, triglycerides, total and low-density lipoprotein cholesterol, and C-reactive protein were more beneficially affected in participants at risk for disease than in subjects who were not at risk.
Thus, cycles of a 5-day FMD are safe, feasible, and effective in reducing markers/risk factors for aging and age-related diseases.❞
~ Dr. Min Wei et al. ← Dr. Longo was
Note: the introduction mentions FMD in mice, but this is just referencing previous studies. This study is about FMD in humans!
Read in full: Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
Want to know more?
You might like this (text-based) interview with Dr. Longo, with the Health Sciences Academy:
Eat, fast and live longer? Interview with Professor Valter Longo
Take care!
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One More Reason To Prioritize Sleep To Fight Cognitive Decline
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We’ve talked sometimes at 10almonds about how important sleep is for many aspects of health, including for brain health, and including in later life.
There’s a common myth that older people require less sleep; the reality is that sleeping less and not dying of it does not equate to needing less.
See also: Sleep: Yes, You Really Do Still Need It!
And: How Sleep-Deprived Are You, Really?
Quantity is not everything though; quality absolutely matters too. We’ve written about that here:
The 6 Dimensions Of Sleep (And Why They Matter) ← duration is just one dimension out of the six
We’ve even gone into some more obscure, but still very important things, such as: How Your Sleep Position Changes Dementia Risk
We’ve also talked about the role of sleep in memory (and forgetting): How Your Brain Chooses What To Remember
With that in mind…
Some more recent science
This study was about spatial memory, but what’s important (in our opinion) is that it’s about solidifying recent learning.
Researchers measured brain activity in rats for up to 20 hours of sleep following spatial learning tasks. Initially, the neuronal patterns observed during sleep mirrored those from the learning phase. However, as sleep progressed, these patterns transformed to resemble the activity seen when the rats later recalled the locations of food rewards. Interestingly, this reorganization happened during non-REM sleep, which means it wasn’t just a case of “the rats were dreaming about their day” (which is a well-established way in which memories do get encoded), but rather, the newly-learned experiences were being actively encoded in the rest of sleep.
This is critical, because in age-related cognitive decline, it’s very common for very long-term memory (VLTM) to remain intact, while LTM and short-term memory (STM) crumble. For example, someone may remember many details of their life from 20 years ago, but forget where they currently live, or what happened in the conversation two minutes ago.
In other words, the biggest problem is not the storage of memories, but rather the encoding of them in the first place.
Which sleep facilitates!
And it’s also important to note that part about it being the rest of sleep, because when the brain is sleep-deprived, it’ll tend to prioritize REM sleep, which is important, but that means cutting back on other phases of sleep, and from this study, we can see that memory & learning will be amongst the things adversely affected by such cuts.
Here’s the paper, for those interested:
Sleep stages antagonistically modulate reactivation drift
And for those who prefer lighter reading, here’s a pop-science article about the same study, which explains it in more words than we can here:
But wait, there’s more!
Sleep resets neurons for new memories the next day, study finds
So, once again… It is absolutely critical to prioritize good sleep.
Want to know more?
Check out:
Calculate (And Enjoy) The Perfect Night’s Sleep
Take care!
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Ghanaian Red Bean & Sweet Potato Groundnut Stew
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This is a dish popular in principle throughout West Africa. We say “in principle” because that’s a big place, and there is a lot of regional variation. The archetypal peanut stew is from Senegal (as maafe) or Mali (as tigadèguèna), but for its more balanced nutritional profile we’ve chosen one from Ghana—and since there are regional variations within Ghana too, we should specify that this one is from the south.
If you are allergic to nuts, you can substitute a seed butter (or tahini) for the nut butter, and omit the nuts—this will work in culinary terms and be fine healthwise, but we can’t claim it would be the same dish, having lost its defining ingredient. If your allergy is solely to peanuts, then substituting with any oily nut would work. So, not almonds for example, but cashews or even walnuts would be fine.
You will need
- 1½ lbs sweet potatoes, peeled and cut into ½” cubes
- 2 cups low-sodium vegetable stock
- 2 cans kidney beans, drained, cooked, and rinsed (or 2 cups same; cooked, drained, and rinsed)
- 1 can chopped tomatoes
- ½ cup unsalted dry-roasted peanuts
- 1 onion, chopped
- 1 red bell pepper, deseeded and chopped
- ¼ bulb garlic, finely chopped
- 2 heaped tbsp unsalted peanut butter, minimal (ideally: no) additives
- 2 tsp white miso paste
- 2 tsp grated fresh ginger
- 1 tsp ground cumin
- 1 tsp cayenne pepper
- 1 tsp black pepper
- ½ tsp MSG or 1 tsp low-sodium salt
- ½ tsp coarsely ground nigella seeds
- Extra virgin olive oil
Method
(we suggest you read everything at least once before doing anything)
1) Heat some oil in a sauté pan, or other pan suitable for both frying and fitting the entire stew in. Fry the onions until softened, turn the heat down low, and add the garlic, ginger, red bell pepper, cumin, cayenne, black pepper, and MSG/salt.
2) Add ¼ cup of the vegetable stock, and the sweet potato, and turn the heat back up, on high for about 30 seconds to get it to temperature, and then take it down to a simmer.
3) Stir in the miso paste and chopped tomatoes.
4) Add most of the rest of the vegetable stock, keeping ¼ cup aside. Simmer for about 20 minutes.
5) Stir in the kidney beans, and simmer for about 30 minutes more—the sweet potato should be soft now; if it isn’t, let it simmer a while longer until it is.
6) Combine the peanut butter with the remaining ¼ cup vegetable stock, and blend until smooth. Stir it into the stew.
7) If the stew is looking more like a soup than a stew, take out 1 cup and blend this 1 cup to a purée, adding it back in.
8) Add half the peanuts unto the stew. Taste, and adjust the seasonings if necessary.
9) Crush the remaining peanuts using a pestle and mortar; not too much though; you want them broken into bits, not pulverised.
10) Garnish with the crushed nuts and nigella seeds, and serve.
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- Eat More (Of This) For Lower Blood Pressure
- Lycopene’s Benefits For The Gut, Heart, Brain, & More
- Our Top 5 Spices: How Much Is Enough For Benefits? ← we used 4/5 today!
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Can You Change Your Sleep Schedule?
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There is science to it:
To take arms against a sea of sleepiness and, by opposing, end it?
While people can be broadly categorized into “early birds” or “night owls”, most fall somewhere along a spectrum determined by their circadian system.
This circadian rhythm is regulated by nerve cell clusters in the hypothalamus, which detect light through your eyes and synchronize your body’s internal clock with the day-night cycle. This circadian system acts like a conductor, coordinating hormone release and helping organs function in sync, while managing the necessary transitions between wakefulness and sleep.
Note: the circadian system can’t directly force sleep, but it predicts when you’ll need rest based on your habitual light exposure and sleep patterns, then prepares your body by releasing hormones such as melatonin. This means that if you consistently go to bed at the same time, melatonin production typically begins about two hours beforehand to promote sleepiness.
Early birds vs night owls: early birds generally experience a cortisol surge just before waking, while night owls often reach peak cortisol levels around 30 minutes after getting up.
There is inherent difficulty in fighting biology: maintaining a schedule that strongly opposes your natural preferences is challenging, and a single disrupted night can quickly shift your circadian timing back towards its baseline.
So the options become:
- Go with the flow and end up wherever it takes you (can be dangerous if life’s responsibilities mean that this results in irregular sleep)
- Make small changes and shift your sleep schedule gradually to where you want it to be, then consciously maintain it there, by using light/dark cues and other “time anchors” that you can usually control, such as mealtimes and exercise times.
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Early Bird Or Night Owl? Genes vs Environment
Take care!
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The Surprising Link Between Serotonin & IBS
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These are two things that don’t usually appear in the same sentence much:
- Serotonin
- IBS
Yet, both are related to the gut (serotonin is mostly made there, and IBS is irritable bowel syndrome that can’t really live anywhere else), and that’s why this topic is…
More than a gut feeling
Researchers (Chiara H. Moretti) have identified two gut bacterial species (Limosilactobacillus mucosae and Ligilactobacillus ruminis) that work together to produce biologically active serotonin.
Importantly, people with IBS were found to have lower levels of Limosilactobacillus mucosae, suggesting the loss of this microbe may reduce serotonin production and disrupt normal bowel movement.
But how?
Serotonin controls gut movement! The gut’s nervous system uses serotonin to coordinate muscle contractions that push food through your intestines, so higher serotonin generally speeds transit while lower serotonin slows it.
In IBS, imbalanced serotonin signaling can make intestinal movement either too fast or too slow, contributing to…
- diarrhea-predominant IBS when serotonin activity is high, or
- constipation-predominant IBS when serotonin activity is low
Further, because the enteric (gut) nervous system communicates with the brain via the vagus nerve, changes in gut serotonin can influence both digestion and symptoms like pain or discomfort (see for example: The Vagus Nerve: The Brain-Gut Highway and The Brain-Gut Highway: A Two-Way Street)
To test this, Dr. Moretti and her team did a mouse study, and found that when the bacteria were introduced into germ-free mice with low serotonin levels and IBS, intestinal serotonin increased, the number of nerve cells in the colon rose, and intestinal transit time returned to normal.
You can read the paper itself, here: Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation
Want to learn more?
For other less well-known things that serotonin does for us, check out:
Serotonin For More Than Just Happiness
Take care!
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The Midlife Cyclist – by Phil Cavell
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Whether stationary cycling in your living room, or competing in the Tour de France, there’s a lot more to cycling than “push the pedals”—if you want to get good benefits and avoid injury, in any case.
This book explores the benefits of different kinds of cycling, the biomechanics of various body positions, and the physiology of different kinds of performance, and the impact these things have on everything from your joints to your heart to your telomeres.
The style is very much conversational, with science included, and a readiness to acknowledge in cases where the author is guessing or going with a hunch, rather than something being well-evidenced. This kind of honesty is always good to see, and it doesn’t detract from where the science is available and clear.
One downside for some readers will be that while Cavell does endeavour to cover sex differences in various aspects of how they relate to the anatomy and physiology (mostly: the physiology) of cycling, the book is written from a male perspective and the author clearly understands that side of things better. For other readers, of course, this will be a plus.
Bottom line: if you enjoy cycling, or you’re thinking of taking it up but it seems a bit daunting because what if you do it wrong and need a knee replacement in a few years or what if you hurt your spine or something, then this is the book to set your mind at ease, and put you on the right track.
Click here to check out The Midlife Cyclist, and enjoy the cycle of life!
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Before You Eat Breakfast: 3 Surprising Facts About Intermittent Fasting
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Dr. William Li is well-known for his advocacy of “eating to beat disease”, and/but today he has advice for us about not eating to beat disease. In moderation, of course, thus: intermittent fasting.
The easy way
Dr. Li explains the benefits of intermittent fasting; how it improves the metabolism and gives the body a chance to do much-needed maintainance, including burning off any excess fat we had hanging around.
However, rather than calling for us to do anything unduly Spartan, he points out that it’s already very natural for us to fast while sleeping, so we only need to add a couple of hours before and after sleeping (assuming an 8 hour sleep), to make it to a 12-hour fast for close to zero effort and probably no discomfort.
And yes, he argues that a 12-hour fast is beneficial, and even if 16 hours would be better, we do not need to beat ourselves up about getting to 16; what is more important is sustainability of the practice.
Dr. Li advocates for flexibility in fasting, and that it should be done by what manner is easiest, rather than trying to stick to something religiously (of course, if you do fast for religious reasons, that is another matter, and/but beyond the scope of this today).
For more information on each of these, as well as examples and tips, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
- Intermittent Fasting: What’s the truth?
- 16/8 Intermittent Fasting For Beginners
- Meal Timings & Health: How Important Is Breakfast?
Take care!
Don’t Forget…
Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!
Learn to Age Gracefully
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